Clinical trials: Rectum Neoplasms
Colorectal Cancer
Studying a Quality of Life Questionnaire in Patients With Colorectal Cancer
RATIONALE: Collecting information about the quality of life of patients with colorectal cancer may help doctors learn more about the disease.
- Trial name
- NCT00564694
- Testing
- psychosocial assessment and care, quality-of-life assessment
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 350 people
- Sponsor
- National Cancer Institute (NCI)
Anal Squamous Intraepithelial Neoplasia
Seville Cohort of People Living With HIV at Risk for Anal Cancer
There is increasing awareness of augmenting risk of anal cancer in people living with HIV, especially among men who have sex with men (MSM).
- Trial name
- SeVIHanal (NCT03713229)
- Testing
- Screening for anal squamous intraepithelial lesions
- Where
- Spain
- Volunteers
- 3,000 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Rectal Cancer
Nurse-or Surgeon-led Follow-up After Rectal Cancer
Follow-up programmes consume a large amount of resources with less time for the surgeon to take on new patients. The aim of this randomised study was to compare patient satisfaction, resource utilisation, and medical safety in…
- Trial name
- NCT01045200
- Testing
- Comparison of follow-up
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Centrallasarettet Västerås
Rectal Cancer
Simultaneous Integrated Boost Preoperative Radiotherapy for Rectum Cancer
The investigators propose a randomized non-inferiority trial that compares preoperative Fluoro Uracil (FU)-based chemoradiotherapy to radiotherapy with a simultaneous integrated boost.
- Trial name
- RectumSIB (NCT01224392)
- Testing
- Chemoradiotherapy, Radiotherapy with boost
- Where
- 2 sites in Belgium
- Volunteers
- 156 people
- Sponsor
- Universitair Ziekenhuis Brussel
Colo-rectal Cancer
Total Neoadjuvant Treatment Without Surgery For Locally Advanced Rectal Cancer
NO-CUT is a one-stage phase II trial seeking to establish whether an oxaliplatin-based chemotherapy preceding standard neo-adjuvant fluoropyrimidines-based chemo radiotherapy, can safely spare demolitive surgical intervention in…
- Trial name
- NO-CUT (NCT03565029)
- Testing
- XELOX, Radiotherapy
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Niguarda Hospital
Anal Cancer, Squamous Cell Carcinoma, Radiation Exposure
Safety Study of BMX-001 (Radio-protector) in Patients With Newly Diagnosed Anal Cancer
Over 80% of anal cancers are squamous cell carcinoma (SCC). Current standard treatment for locally advanced squamous cell carcinoma of the anal canal is a combination of radiation therapy (RT) and concurrent chemotherapy.
- Trial name
- NCT03386500
- Testing
- BMX-001
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Nebraska
Anal Cancer Squamous Cell
Prebiotics and Probiotics During Definitive Treatment With Chemotherapy-radiotherapy SCC of the Anal Canal (BISQUIT)
Phase II randomized study of the use of pre-and probiotics during the definitive treatment of chemotherapy-radiotherapy (Ch-RT) for patients with localized anal canal squamous cell cancer (ACSCC) with the objective of increasing…
- Trial name
- BISQUIT (NCT03870607)
- Testing
- prebiotics in combination with probiotics
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- AC Camargo Cancer Center
Colorectal Cancer
Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan hydrochloride, fluorouracil, and leucovorin calcium, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from…
- Trial name
- FOLFERA (NCT01205711)
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- 4 sites in United Kingdom
- Volunteers
- 111 people
- Sponsor
- Cardiff University
Anastomosis, Rectal Cancer
Electric Tubular Anastomosis in Rectal Cancer
Compared with traditional manual suturing, mechanical anastomosis can reduce the error caused by human factors. The electric anastomotic device can improve the automation and accuracy of anastomosis, reduce the requirements for…
- Trial name
- NCT05879172
- Testing
- electric tubular anastomotic device, traditional anastomotic device
- Where
- China
- Volunteers
- 400 people
- Sponsor
- LI XIN-XIANG
Low Anterior Resection Syndrome
Transanal Irrigation to Prevent Major Low Anterior Resection Syndrome
Bowel dysfunction after rectal cancer resection comprises a vast array of bowel symptoms and associated quality-of-life impairment, collectively termed as low anterior resection syndrome (LARS).
- Trial name
- TAILARS (NCT04758195)
- Testing
- Transanal irrigation, Best supportive therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Anal Cancer, Human Papilloma Virus (HPV)
Swabs in Screening for HPV (SWISH)
This trial aims to evaluate if self-collected anal swabs (SCS) can be used for anal cancer screening. Currently, only clinician-collected anal swabs (CSC) are recommended for anal cancer screening, and this may be a barrier for…
- Trial name
- SWISH (NCT07790601)
- Testing
- Self-collected anal swab
- Where
- 10 sites in Australia
- Volunteers
- 700 people
- Sponsor
- Kirby Institute
Colorectal Surgery, Rectal Cancer
Early and Late Removal of the Urinary Catheter After Rectum Resection
It was aimed to investigate the need for urinary retention and recatheterization in the postoperative period by removing the urinary catheter in patients undergoing low anterior resection, in the early or late period.
- Conditions
- Colorectal Surgery, Rectal Cancer, Urinary Retention Postoperative
- Trial name
- NCT05020613
- Testing
- Procedure: Early removal group, Procedure: Late removal group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Marmara University
Rectal Neoplasms
Predicting RadIotherapy ReSponse of Rectal Cancer With MRI and PET
The purpose of this study is to investigate if PET/CT and MRI scans performed early in treatment and six weeks after treatment can predict the response of rectal cancer following chemotherapy and radiotherapy.
- Trial name
- PRISM (NCT02233374)
- Testing
- Early MRI and PET/CT - 2 weeks after commencing chemo/RT, Late MRI and PET/CT 6 weeks post chemo/RT
- Where
- Australia
- Volunteers
- 27 people
- Sponsor
- Royal North Shore Hospital
Rectal Neoplasms
Rectrospect - a Retrospective Study of Treatment Response
Biopisies from patients diagnosed with rectal cancer between 2007-2019 will be cut into 4-6 micrometer thin sections for morphology and immunostaining.
- Trial name
- Rectrospect (NCT04787523)
- Testing
- Radiotherapy
- Where
- Sweden
- Volunteers
- 170 people
- Sponsor
- Sahlgrenska University Hospital
Male Breast Cancer, Stage IV Breast Cancer
Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer
This phase I trial is studying the side effects and best dose of cediranib maleate when given together with whole brain radiation therapy in treating patients with brain metastases from non-small cell lung cancer.
- Conditions
- Male Breast Cancer, Stage IV Breast Cancer, Stage IV Melanoma, Stage IV Non-small Cell Lung Cancer
- Trial name
- NCT00937482
- Testing
- cediranib maleate, whole-brain radiation therapy
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Low Anterior Resection Syndrome, Rectal Cancer
The Safety and Efficacy of Transanal Irrigation in Patients With Sleep Disturbance From Low Anterior Resection Syndrome After Rectal Cancer Surgery (TraLARS)
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer, Insomnia, Sleep Disorder
- Trial name
- TraLARS (NCT06222255)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Seoul National University Hospital
Colonic Cancer, Rectal Cancer
Chinese Colorectal Cancer Database
1. To establish the Chinese people's own clinical data database of colorectal cancer, reflecting the law and characteristics of colorectal cancer patients in China. 2.
- Conditions
- Colonic Cancer, Rectal Cancer, Prospective Studies
- Trial name
- CCCD (NCT05434026)
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- Beijing Friendship Hospital
Anal Cancer
A Prospective, Open-Label, Multi-center Comparison of Lymphoseek Identified Lymph Nodes and Clinically Identified Lymph Nodes of Subjects With Known Cancer of the Anus
Prospective, open-label, within-subject, multi-center pilot study of Lymphoseek in the detection of lymph nodes in subjects with known squamous cell carcinoma of the anus.
- Trial name
- NCT02857608
- Testing
- Lymphoseek
- Sponsor
- Cardinal Health 414, LLC
Rectal Cancer
Hartmann's Versus Intersphincetric APE: A Prospective, Multicentre Study
14,000 new cases of rectal cancer are diagnosed each year, frail and elderly patients represent a rising proportion of these patients.
- Trial name
- HiP (NCT02702089)
- Testing
- Rectal cancer surgery
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Countess of Chester NHS Foundation Trust
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
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