Clinical trials: Recurrence of Atrial Fibrillation
Sleep Apnea, Atrial Fibrillation
Atrial Fibrillation Recurrence in Sleep Apnea
This randomized, controlled trial is designed to test whether treatment of sleep disordered breathing (SDB) with positive airway pressure (PAP) therapy alters the natural history of atrial fibrillation (AF).
- Trial name
- NCT00263757
- Testing
- Adaptive Servo-Ventilation, Usual Care
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Recurrent Persistent Atrial Fibrillation
Recurrent Persistent Atrial Fibrillation:In-situ Ablation Vs Extensive Ablation
This is an open label, randomized parallel control clinical trial, to compare extra-PV extensive ablation with in-situ ablation as two strategies for the treatment of PerAF to identify the mechanisms of PerAF recurrence.
- Trial name
- NCT06829446
- Testing
- Extra-PV extensive ablation, Repeat same PVI and linear ablation as the first procedure
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Shanghai Chest Hospital
Essential Hypertension, Atrial Fibrillation
Efficacy of Perindopril to Prevent Recurrence of Atrial Fibrillation in Patients With Essential Hypertension
The purpose of this 7- to 13-month study is to determine the efficacy of 8 mg/day oral perindopril to prevent the recurrence of atrial fibrillation (AF) in patients with essential hypertension.
- Trial name
- CTAF-2 (NCT00461903)
- Testing
- Perindopril
- Where
- Canada
- Volunteers
- 316 people
- Sponsor
- Montreal Heart Institute
Diabetes Mellitus, Atrial Fibrillation (AF)
Evaluation Of The Effect Of SGLT-2 Inhibitors On Atrial Fibrillation Recurrence In Diabetic Patients
Consecutive DCCV was performed until to achieve 120 patients in SR (60 DM patients who used SGLT-2 inhibitors and 60 DM patients who did not use SGLT-2 inhibitors).
- Trial name
- NCT06951737
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Postgraduate Hospital
Atrial Fibrillation
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patients With Structural Heart Disease
This is a prospective comparative study, conducted at Cardiology Department, Aswan University Hospital on AF patients with structural heart disease.
- Trial name
- NCT06556732
- Testing
- Eplereone
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Atrial Fibrillation (AF)
Efficacy and Safety of Dapagliflozin in Preventing Atrial Fibrillation Recurrence After Catheter Ablation
Atrial fibrillation (AF) is a common arrhythmia, particularly prevalent in the elderly population. Catheter ablation is a common treatment for AF, but post-ablation recurrence of arrhythmias remains a significant clinical…
- Trial name
- NCT06740786
- Testing
- Dapagliflozin Treatment Group
- Volunteers
- 250 people
- Sponsor
- Xu Liu
Paroxysmal Atrial Fibrillation
Addition of Six Short Lines on Pulmonary Vein Isolation
We randomly assigned 390 patients with symptomatic, paroxysmal AF to undergo catheter ablation with PVI (PVI group) alone or combined with 6 additional ablation lines extended outside the PVI circumferences at 1, 3 and 6 o'clock…
- Trial name
- NCT02637453
- Testing
- PVI, CPVI+6L
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Persisent Atrial Fibrillation, Reversal of Atrial Enlargement
Left Atrial Volume Changes Who Underwent Cardioversion and Recurrence of AF After RF Ablation in Persistent AF (SAFE-AF)
Electrical/pharmacological cardioversion improves structural remodeling of left atrium. We hypothesize that persistent atrial fibrillation (AF) patients with more significant left atrial size reduction after cardioversion have…
- Conditions
- Persisent Atrial Fibrillation, Reversal of Atrial Enlargement, Recurrence of Atrial Fibrillation
- Trial name
- SAFE-AF-ABL (NCT06523738)
- Testing
- 1. electrical/pharmacological cardioversion. 2.pulmonary vein isolation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Atrial Fibrillation
Effect of Prolonged Use of Dronedarone on Recurrence in Patients With Non-paroxysmal Atrial Fibrillation After Radiofrequency Ablation
Recurrence rate remains high after radiofrequency ablation in patients with non-paroxysmal atrial fibrillation(AF). Prolonged use of anti-arrhythmic drugs (AAD) beyond the post-ablation blanking has been adopted as a solution but…
- Trial name
- DORIS (NCT05655468)
- Testing
- Dronedarone
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Shanghai East Hospital
Stroke, Acute Cerebrovascular Accident
Radiofrequency and Cryoablation of the Posterior Wall of the Left Atrium
Atrial fibrillation (AF) is the cause of 20% of strokes, and the risk of stroke in a person suffering from this arrhythmia increases by 5 times.
- Conditions
- Stroke, Acute Cerebrovascular Accident, Transient Ischemic Attack, Death
- Trial name
- NCT06253000
- Testing
- Cryoablation, Radiofrequency ablation
- Where
- Russia
- Volunteers
- 158 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Atrial Fibrillation
Long-term Recurrence Rates of Atrial Fibrillation Following New-onset Atrial Fibrillation During ICU Admission
The Primary Objective of the study is to establish the One-year recurrence rates of atrial fibrillation (AF) following new-onset atrial fibrillation during intensive care unit (ICU) admission.
- Trial name
- NCT05151523
- Volunteers
- 100 people
- Sponsor
- Katia Orvin
Persistent Atrial Fibrillation
Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial Fibrillation Ablation
This prospective, randomized, single-center study will compare sevoflurane inhalational anesthesia with propofol intravenous anesthesia in patients undergoing intracardiac echocardiography-guided radiofrequency catheter ablation…
- Trial name
- NCT07877116
- Testing
- Sevoflurane, propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Hüseyin Ulaş Pinar
Atrial Fibrillation
Early Versus Late DC-cardioversion of Persistent Atrial Fibrillation. Effect on Atrial Remodeling,Inflammatory and Neurohumoral Markers and Recurrence of Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia present in 1% of population under 60 years of age and reaching up to 15% at 80 years.
- Trial name
- NCT01593150
- Testing
- Pradaxa, TEE, Compare TEE guided cardioversion to Dabigatran + DC cardioversion
- Where
- Denmark
- Volunteers
- 141 people
- Sponsor
- Odense University Hospital
Persistent Atrial Fibrillation
Withdrawal Versus Continuation of Amiodarone in Successfully Treated Patients With Persistent Atrial Fibrillation
Amiodarone is considered to be the most effective antiarrhythmic drug in the prevention of persistent atrial fibrillation. It can however cause many adverse events, both cardiac and non-cardiac.
- Trial name
- WISDOM (NCT00845780)
- Testing
- withdrawal or continuation of amiodarone therapy
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation, Atrial Fibrillation Recurrent
Effect of Dronedarone on Atrial Fibrosis Progression and Atrial Fibrillation Recurrence
Patients who have undergone cardiac ablation will be randomized and blinded to one of two groups; one group will receive dronedarone while the other group will receive a placebo.
- Trial name
- EDORA (NCT04704050)
- Testing
- dronedarone 400 mg Oral Tablet
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Tulane University School of Medicine
Recurred Atrial Fibrillation
Comparison of Circumferential Pulmonary Vein Isolation and Complex Pulmonary Vein Isolation Additional Linear Ablation for Recurred Atrial Fibrillation After Previous Catheter Ablation: Prospective Randomized Trial (RILI Trial)
The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for repeat ablation procedure among the patients with recurred atrial fibrillation after de novo catheter ablation.
- Trial name
- NCT02747498
- Testing
- Procedure with circumferential pulmonary vein isolation, Procedure with linear ablation in addiction to pulmonary vein isolation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Moxonidine for Prevention of Post-ablation AFib Recurrences
Hypothesis: Modulation of central nervous sympathetic activation by administration of moxonidine, a centrally acting medication which decreases the sympathetic nervous system activity, can lead to a decrease in atrial…
- Trial name
- NCT01791699
- Testing
- Moxonidine
- Where
- 3 sites in Greece
- Volunteers
- 150 people
- Sponsor
- Spyridon Deftereos
Atrial Fibrillation, Recurrence
Ablation of Complex Fractionated Electrograms With or Without Additional Linear Lesions for Persistent Atrial Fibrillation
While there is a consensus to perform pulmonary vein isolation (PVI) as a cornerstone for paroxysmal and persistent atrial fibrillation (AF), different additional ablation approaches are used for substrate modification: linear…
- Trial name
- ADLINE (NCT02059369)
- Testing
- PVI+CFAE+DCC, PVI, CFAE, anterior and roof line, DCC
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction (HFpEF)
Tirzepatide on Atrial Fibrillation Recurrence After Catheter Ablation in Patients With Obesity and HFpEF
This multicenter, randomized, open-label, blinded-endpoint trial evaluates whether weekly subcutaneous tirzepatide for 12 months reduces atrial fibrillation (AF) recurrence after catheter ablation in adults with obesity and heart…
- Conditions
- Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction (HFpEF), Tirzepatide
- Trial name
- TEAR-AF-HFpEF (NCT07630454)
- Testing
- Tirzepatide, Structured Lifestyle Intervention
- Where
- China
- Volunteers
- 602 people
- Sponsor
- Yunlong Wang
Paroxysmal Atrial Fibrillation
Baroreflex Sensitivity in Patients Undergoing Ablation of Atrial Fibrillation
Atrial fibrillation is the most common arrhythmia. The posterior surface of the left atrium is covered by an extensive network belonging to the autonomic nervous system that can be damaged during the ablation.
- Trial name
- BARO-AF (NCT04503122)
- Testing
- pulmonary vein isolation
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Poitiers University Hospital