Clinical trials: Recurrent Abortion
Cerclage, Cervical, Cervical Insufficiency
Long-Term Patient-Reported Maternal Outcomes Following Abdominal Cerclage for the Prevention of Preterm Birth
This study aims to explore the maternal patient reported outcomes on pelvic pain sexual health anxiety and depression bladder discomfort foreign body sensation trust in the cerclage, and how these parameters affect the general…
- Trial name
- NCT06875401
- Testing
- Abdominal cerclage (open or laparoscopic)
- Where
- Denmark
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Abortion, Spontaneous
Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk
This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han.
- Trial name
- NCT02633475
- Testing
- IL-10 polymorphism
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fourth Affiliated Hospital of Guangxi Medical University
Abortion, Habitual, Nutritional Status
Nutritional Deficiencies About Recurrent Miscarriage
The study plans to recruit patients with recurrent miscarriage and detect their niacin, thiamine, vitamin A, vitamin B6, vitamin B12, vitamin D levels in plasma, evaluating if some lack exists.
- Trial name
- NCT04064931
- Testing
- Detection of niacin and other vitamins in plasma
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Recurrent Miscarriage
Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage.
In recurrent miscarriage, the male factor has been poorly evaluated. In fact, in the vast majority of clinical protocols of recurrent miscarriage, the sperm is not considered or assessed.
- Trial name
- NCT00447395
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Preterm Labor
Use of Pessary in Case of Cervical Insufficiency and Short Cervix
Prematurity is the most important cause of obstetric morbidity and mortality. Health centers and obstetricians are trying to reduce the preterm birth rate by taking into account the permanent effects of premature birth on human…
- Trial name
- NCT03096691
- Testing
- cervical pessary
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2
Cerclage for Twins With Short Cervix
A prospective randomized control trial that will compare cervical cerclage plus vaginal progesterone to vaginal progesterone along in twin pregnancies complicate by a short cervix (</= 15.0mm) between 16w0d to 25w6d.
- Conditions
- Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2, Cervical Incompetence, Cervical Shortening
- Trial name
- NCT03077633
- Testing
- Cervical Cerclage placement, Vaginal Progesterone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Infertility, Recurrent Pregnancy Loss
TNFα and MFG-E8: Novel Biomarkers to Predict Implantation Failure
Question: Can implantation failure (IF) be predicted prior to in vitro fertilization (IVF)? A pilot, non-interventional, clinical study Prospective, controlled, cohort study
- Trial name
- NCT02386384
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Recurrent Pregnancy Loss
Effectiveness of Aspirin in Compare With Heparin Plus Aspirin in Recurrent Pregnancy Loss Treatment
This study evaluated the effect of anticoagulant treatment on the live-birth rate in women with a history of at least two continuous unexplained miscarriages or thrombophilia.
- Trial name
- NCT01542411
- Where
- Iran
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Yazd Medical University
Recurrent Pregnancy Loss, Endoplasmic Reticulum Stress
Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss
To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured.
- Trial name
- NCT04455256
- Testing
- x box binding protein
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Obesity, Inflammation
Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage
The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation.
- Trial name
- NCT04275674
- Where
- Taiwan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Vitamin D Deficiency, Recurrent Spontaneous Abortion
Study on Clinical Value of Vitamin D in Recurrent Spontaneous Abortion
The observational study is to compare vitamin D deficiency and related indicators among different spontaneous abortions in describe female reproductive health.The main question aim to answer is: the possible pathogenesis of…
- Trial name
- NCT06002035
- Testing
- Binom Vitamin D drops
- Where
- China
- Volunteers
- 1,421 people, healthy volunteers welcome
- Sponsor
- Jianmei Xia
Cervical Insufficiency
Relation of the Area of Cerclage With Preterm Birth
This study is planned prospectively in pregnancies who applied to Etlik Zübeyde Hanım Women's Health Care, Training and Research Hospital which is a teritiary hospital with 15.000 births anually, between January 2022 and January…
- Trial name
- NCT05220839
- Testing
- Type of cerclage procedure Mc Donald
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Miscarriage
Mucosal-Associated Invariant T Cells in Cases of Miscarriage
Miscarriage is the most frequently encountered complication of pregnancy ranging from 10% to 30%. The etiology of recurrent spontaneous miscarriage (RSM) in 40%-50% of cases cannot be identified.
- Trial name
- NCT04492098
- Testing
- MAIT cells
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Thyroid, Infertility
Thyroid Autoimmunity and Reproductive Failure in Danish Women
The present Ph.D.-study investigates the mechanisms behind the association between thyroid autoimmunity and reproductive failure.
- Conditions
- Thyroid, Infertility, Autoantibodies, Autoimmunity
- Trial name
- NCT02912442
- Where
- Denmark
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Miscarriage, Recurrent, Infertility
The Role of NLRP Gene Family (NLRP1~14) in Recurrent Miscarriage and Infertility
Development of mole was not associated with segregation of mutated NLRP7 allele in the haploid oocyte. We hypothesize NLRP7 is a maternal factor involved in regulating early embryo development or embryo-uterine interaction.
- Trial name
- NCT04141618
- Where
- Taiwan
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Cervical Incompetence
Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC)
The investigator aimed to compare the effect of anesthesia on overall postoperative outcomes including post-operative pain score and the fetal well-being (heart rate) in patients undergoing transabdominal cervico isthmic…
- Trial name
- NCT03636048
- Testing
- Bupivacaine Hcl 0.5% Inj, Propofol 10 milligram/ML
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Pregnancy; Habitual Aborter, Weeks of Gestation 37 or More
Accuracy and Reliability of Fetal Heart Rate and Uterine Contraction Monitoring Method
Clinical Investigation Protocol for a study designed to determine the equivalence of the Monica AN24 monitor to Philips 50XM for fetal heart rate (FHR) and uterine contraction (UC) monitoring during labor.
- Trial name
- NCT01280357
- Testing
- Monica AN24 (K101081), Philips 50XM
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Monica Healthcare Ltd
Abortion, Habitual
Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia
The prevalence of insulin resistance is increased in women with recurrent miscarriage compared with matched fertile controls,Insulin resistance (IR) in this syndrome is not only implicated toward early pregnancy loss (EPL) but…
- Trial name
- MetRPL (NCT01718340)
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Recurrent Miscarriage
3D Ultrasound to Assess in Recurrent Miscarriage
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
- Trial name
- 3D-ARM (NCT06164015)
- Testing
- 3D Ultrasound scan with power Doppler angiography
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Recurrent Pregnancy Loss, Not Pregnant, Vaginal Microbiome
Uterine Microbiome in Recurrent Pregnancy Loss
The female genital tract microbiome may reflect female reproductive health and may be related to pregnancy outcomes. Disturbances in this microbiome may be associated with adverse reproductive outcomes.
- Trial name
- NCT05510622
- Testing
- Vaginal swab and endometrial biopsy
- Where
- 2 sites in Vietnam
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital