Clinical trials: Recurrent Disease
Crohn Disease, Recurrence
Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease.
The study is looking at the role of the mesentery in disease recurrence for ileocolic Crohn's disease. It is a prospective study that has been designed to perform extended mesenteric excision on patients undergoing their first…
- Conditions
- Crohn Disease, Recurrence, Crohn's Ileocolitis
- Trial name
- NCT04539665
- Testing
- Extended mesenteric resection.
- Where
- 2 sites in Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Montreal General Hospital
Glioblastoma Multiforme, Anaplastic Astrocytoma
Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma
This study will offer a safe treatment for patients with relapsing recurring glioblastoma (GBM) or anaplastic astrocytoma (AA). The trial will test the hypothesis that Erlotinib (Tarceva, OSI-774) can be safely used up to a dose…
- Trial name
- NCT00301418
- Testing
- Erlotinib
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Ewing Sarcoma
RAPID: Phase 2 Platform Trial Of Promising Drugs For AYA Patients With R/R Ewing Sarcoma & DSRCT
The goal of this clinical research study is to learn if new anticancer drugs or drug combinations can help to control relapsed/refractory ES, DSRCT, or SRCS.
- Trial name
- NCT07781891
- Testing
- LX-101
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Low Back Pain, Recurrent, Degenerative Disc Disease
GDS Muscle and Articulation Chain Treatment for Chronic LBP and Spinal Stenosis
Our purpose is to conduct a pilot study to evaluate GDS muscle and articulation chain treatment for inoperable spine patients with degenerative changes in the lumbar spine, compared to "standard treatment" (any other chosen…
- Trial name
- GDS (NCT04436003)
- Testing
- Muscle and articulation chains GDS method
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Hospital of Vestfold
Smoking ( Cigarette), Breastfeeding
Prevention of Postpartum Smoking Relapse and Related Health Consequences by Breastfeeding Promotion
The objective of this randomized controlled trial is to examine the efficacy of a new intervention to prevent postpartum smoking relapse and related health consequences through breastfeeding promotion.
- Trial name
- NCT07661550
- Testing
- Breastfeeding promotion
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Recurrent Herpes Simplex Labialis
A Multicenter Study of NB-001 in the Treatment of Recurrent Herpes Labialis
Demonstrate the safety and efficacy of NB-001 in subjects with recurrent herpes labialis (RHL).
- Trial name
- SHaRCS (NCT01321359)
- Testing
- Vehicle versus NB-001
- Where
- 35 sites in United States
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- NanoBio Corporation
IVF, Embryo Loss
The Use of High Concentration Hyaluronic Acid (HA) Transfer Medium in Repeated Implantation Failure (RIF) Patients
This is a pilot study with the aim to investigate the beneficial effect of bicarbonate buffered medium containing hyaluronan and recombinant human albumin (EmbryoGlue®, Vitrolife) in patients with documented repeated implantation…
- Conditions
- IVF, Embryo Loss, Miscarriage, Recurrent
- Trial name
- RIFLE (NCT04709796)
- Testing
- EmbryoGlue®, Vitrolife, Conventional Transfer
- Where
- Belgium
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Depression, Bipolar Disorder
Neuro-computational Study of Thymic Fluctuations in Mood Disorders
Depression and bipolar disorder are frequent, debilitating conditions. Both are thought to be primarily caused by an impaired regulation of mood, which is why they are sometimes referred to as "mood disorders".
- Conditions
- Depression, Bipolar Disorder, Recurrent Depression, Mood Disorders
- Trial name
- MOODELING (NCT07033923)
- Testing
- Brain magnetic resonance imaging (MRI) with structural (anatomical) and functional sequences (optional), Computerized cognitive tests, Daily longitudinal monitoring by mobile MOODELING application
- Where
- 2 sites in France
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Anorexia Nervosa
Metabolic Diet for Relapse Prevention in Anorexia Nervosa
This is an interventional study that will test the safety, tolerability, and efficacy of the Metabolic Diet, which was designed as a treatment for women with anorexia nervosa to remain weight-stable after they have been restored…
- Trial name
- NCT05197309
- Testing
- Metabolic Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gastric (Stomach) Cancer
Fecal DNA Methylation and Helicobacter Pylori SNPs Tests for Gastric Cancer
Based on the detection technology of methylation sites in feces, combined or not combined with Helicobacter pylori gastric cancer susceptibility gene detection, an early diagnosis and detection system for gastric cancer is…
- Trial name
- NCT07312500
- Testing
- Diagnostic Test: fecal methylation site-based testing and fecal Helicobacter pylori gastric cancer susceptibility gene-based testing
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Cannabis, Memory
Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 1
This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users.
- Conditions
- Cannabis, Memory, Electroencephalography
- Trial name
- COBRA (NCT05868213)
- Testing
- Cannabis (smoked flower)
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Cigarette Smoking
Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)
The central objective of the project is to evaluate the effect of incorporating smoking related contexts into very low nicotine content (VLNC) cigarette extinction trials on clinically relevant, smoking-related outcomes.
- Trial name
- VLNCCue (NCT02538042)
- Testing
- Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (0.07 mg), MCE+
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Francis McClernon, Ph.D.
Plasmodium Falciparum Malaria
Artemisinin-resistant Malaria in Cambodia
Background: Artemisinin-based combination therapies (ACTs) are the first-line treatments for malaria. ACTs are highly effective, but malaria caused by the Plasmodium falciparum parasite is becoming resistant to some ACTs.
- Trial name
- NCT01736319
- Where
- Cambodia
- Volunteers
- 561 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non-small Cell Lung Cancer
Circulating DNA in Surgically Treated NSCLC
The investigators will prospectively recruit 100 NSCLC patients. The cfDNA samples will be gathered before the surgery and postoperatively 4-6 weeks after surgery and at 6 and 12 months follow-up visits.
- Trial name
- NCT04037150
- Testing
- Circulating tumor DNA
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Recurrent Miscarriages
Maternal Embryo Interaction in Recurrent Miscarriages
Background of the study: The etiology of recurrent miscarriage (RM, defined as three or more consecutive miscarriages without any proven maternal or fetal cause), remains undiagnosed in more than 50% of cases.
- Trial name
- MEER (NCT03156491)
- Where
- Netherlands
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Urinary Tract Infection, Recurrent Urinary Tract Infection
Effects of Antibiotic Prophylaxis on Recurrent UTI in Children
Approximately, 3% of males and 8% of females will develop a urinary tract infection (UTI) during childhood, and most of these will be effectively treated by short-term antibiotic therapy.
- Trial name
- NCT02357758
- Testing
- Antibiotic Prophylaxis
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Addiction Opiate
Comparison Between Different Psychotherapy Interventions Regarding Their Effect on Substance Craving
the study aim is to compare betwenn the effect of mindfulness based relapse prevention and other evidence based psychotherapy interventions regaring substance craving.
- Trial name
- NCT05256485
- Testing
- cognitive behavioral therapy,mindfulness based relapse prevention,twelve-step therapy
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sara Harby
Recurrent Pterygia
Amniotic Membrane Associated With Conjunctival Autograft Versus Conjunctival Autograft for Recurrent Pterygia
The purpose of this study is to compare amniotic membrane associated with conjunctival autograft versus conjunctival autograft alone in the treatment of recurrent pterygia.
- Trial name
- NCT00802620
- Testing
- Conjunctival autograft versus conjunctival autograft treatment for recurrent pterygia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Equinus Deformity
Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral Palsy
This research will lead to the first evaluation of intrinsic and dynamic joint and muscle mechanics of equinus in cerebral palsy. It would provide a direct cause and effect relationship between equinus and bone deformity.
- Trial name
- EQUINUS (NCT02814786)
- Testing
- MRI scanner, Gait analysis
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Colonic Polyp, Colonoscopy
Endoscopic Resection of Large Colorectal Polyps: An Observational Cohort Study
This protocol describes a prospective cohort study. It addresses an important challenge in the prevention of colorectal cancer and duodenal cancer: how to safely and effectively remove large polyps.
- Conditions
- Colonic Polyp, Colonoscopy, Complication, Recurrence
- Trial name
- NCT04220905
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- White River Junction Veterans Affairs Medical Center