Clinical trials: Recurrent Implantation Failure
Recurrent Implantation Failure
Platelet Rich Plasma and Recurrent Implantation Failure
This study is a randomized controlled clinical trial to compare the pregnancy outcomes of infertile women with recurrent implantation failure.
- Trial name
- NCT03996837
- Testing
- Intra uterine infusion of platelet rich plasma
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Recurrent Implantation Failure
Role of Atosiban in Recurrent Implantation Failure
ET is the final stage of IVF which independently influences the treatment outcome. Successful embryo implantation is dependent on uterine receptivity.
- Trial name
- RIF (NCT04118959)
- Where
- Bahrain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al Baraka Fertility Hospital
Infertility (IVF Patients), Acupuncture
Evaluation of Acupuncture's Effectiveness on Pregnancy Outcomes in Women with Recurrent Implantation Failure RIF: a Large Cohort Study
Title: Evaluating the Effectiveness of Acupuncture on Pregnancy Outcomes in Recurrent Implantation Failure (RIF) Patients Undergoing In Vitro Fertilization (IVF): A Large Cohort Study Objective: This study aims to assess the…
- Trial name
- AcupunctureRIF (NCT06708923)
- Testing
- Intervention Name: Acupuncture Therapy Before and After Embryo Transfer Description: The intervention involves acupuncture therapy performed at two key time points during the IVF cycle: 25 minutes be
- Where
- Vietnam
- Volunteers
- 1,969 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
Infertility
Failure of Implantation After Recurrent Embryo Transfers
We will investigate maternal and embryonic factors in women with recurrent implantation failure, undergoing IVF/ ICSI treatment.
- Trial name
- NCT00351481
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Recurrent Implantation Failure
hCG-activated PBMC-therapy in RIF Patients
Despite the many research done in the field of infertility and in vitro fertilization (IVF), more than half of the embryos transmitted in the IVF and intracytoplasmic sperm injection (ICSI) do not implant successfully.
- Trial name
- NCT03267797
- Testing
- Peripheral Blood Monouclear Cell, Phosphate Baffer Saline
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- SCARM Institute, Tabriz, Iran
Recurrent Implantation Failure, In Vitro Fertilization
Azathioprine in Recurrent Implantation Failure
Azathioprine increase pregnancy rate in patients with recurrent implantation failure
- Conditions
- Recurrent Implantation Failure, In Vitro Fertilization, Intracytoplsmic Sperm Injection
- Trial name
- NCT03498703
- Testing
- Azathioprine Pill
- Where
- 2 sites in Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Endometrial Injury, Hysteroscopy
The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of RIF
The investigators checked the hypothesis whether endometrial injury performed during the cycle before a frozen embryo transfer in women with RIF can improve pregnancy rates
- Conditions
- Endometrial Injury, Hysteroscopy, Repeated Implantation Failures
- Trial name
- NCT04597463
- Testing
- Endometrial injury
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Infertility
Intralipid Therapy for Women 35-40 Years With Positive Natural Killer Cells Undergoing Intracytoplasmic Sperm Injection (ICSI)
Intralipid can suppress natural killer cells that are known to be involve in repeated implantation failure and recurrent miscarriages.Intralipid is made of purified soybean oil, egg phospholipids, glycerol and water.
- Trial name
- NCT01916798
- Testing
- Intralipid infusion
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Asherman Syndrome, Atrophic Endometrium
Bone Marrow Derived Stem Cells Mobilization for Treatment of Abnormal Endometrium
This study will assess the use of autologous bone marrow stem cells mobilization using 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane (PLERIXAFOR) as an effective medical therapy for the treatment of…
- Conditions
- Asherman Syndrome, Atrophic Endometrium, Recurrent Implantation Failure
- Trial name
- NCT05343572
- Testing
- Plerixafor
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hugh Taylor
Repeated Embryo Implantation Failure, Recurrent Miscarriage
Immune Profile Analysis and Biomarker Identification in Women With Repeated Implantation Failure or Unexplained Recurrent Spontaneous Miscarriage
Implantation is a determining step in human reproduction which requires the transition from a pro-inflammatory state to an anti-inflammatory state allowing the implantation of a competent embryo within a receptive endometrium…
- Conditions
- Repeated Embryo Implantation Failure, Recurrent Miscarriage, Immune System
- Trial name
- ERIM (NCT05648136)
- Testing
- blood sample
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Repetitive Implantation Failure
ERA Test in Patients With Recurrent Implantation Failure
The purpose of this study is to demonstrate the clinical efficiency of the Endometrial Receptivity Array (ERA) diagnostic tool in patients with repetitive implantation failure (RIF), leading to the new concept of the personalized…
- Trial name
- ERA (NCT01668693)
- Testing
- ERA (Endometrial Receptivity Array), Personalized Embryo Transfer, Second ERA
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Igenomix
Recurrent Implantation Failure
PRP in Recurrent Implantation Failure
The endometrial function and endometrial receptivity have been accepted to be major limiting factors in the establishment of pregnancy.
- Trial name
- NCT04085783
- Testing
- PRP
- Where
- Bahrain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dr. Kamal Rageh
Uterine Adenomyosis, Recurrent Implantation Failure
Aromatase Plus GnRH Analogue Versus GnRH Analog Alone in Adenomyosis
With this study the investigators want to test which is the best medical treatment for symptomatic adenomyosis affecting women undergoing IVF and with previous implantation failure, between Aromatase inhibitor plus GnRH analog…
- Conditions
- Uterine Adenomyosis, Recurrent Implantation Failure, Menstrual Pain
- Trial name
- NCT03421639
- Testing
- GnRH analog (11.25mg Leuprolide acetate), Aromatase inhibitor and GnRH analog, Aromatase and GnRH analog (11.25mg Leuprolide acetate)
- Where
- 3 sites in Albania, Bulgaria and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre for Endocrinology and Reproductive Medicine, Italy
Repeated Implantation Failure, Normal Fertile
Uterine Microbiome in Women with Repeated Implantation Failure and Normal Fertile Women
Characterization of the uterine microbiome in women with repeated implantation failure as well as in normal fertile women.
- Trial name
- NCT03405883
- Testing
- Vaginal swab + endometrial biopsy
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Infertility, Recurrent Implantation Failure
Endometrial Biopsy Protocol for In Vitro Fertilization (IVF)
Endometrial biopsy has been shown to improve IVF pregnancy and live birth rates. The optimal time of performing the biopsy is yet to be established.
- Trial name
- NCT01278706
- Testing
- endometrial biopsy/ies
- Where
- 2 sites in Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Infertility
Use of Granulocyte Colony-stimulating Factor for the Treatment of Recurrent Implantation Failure in IVF Patients
The investigators use granulocyte colony-stimulating factor (GCSF) for the treatment of recurrent implantation failure in IVF patient with cause unknown or due to thin endometrium.
- Trial name
- NCT01315470
- Testing
- neupogen administration for women with recurrent IVF failure
- Where
- 2 sites in Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Infertility
Platelet Rich Plasma for Patients With Recurrent Implantation Failure
Patients with recurrent implantation failure are among the most difficult patients to treat, with no proven standard treatment. Platelet rich plasma stimulates cellular processes involved in endometrial regeneration, and in a…
- Trial name
- NCT03379649
- Testing
- Platelet rich plasma
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Infertility
Effects of Embryogen in RIF Patients
The purpose of this study was to investigate the potential effects of Granulocyte-Macrophage Stimulating-Colony Factor (GM-CSF) supplementation in embryo culture for patients with repeated implantation failure (RIF)
- Trial name
- RIF (NCT02250768)
- Testing
- GM-CSF
- Where
- 2 sites in Vietnam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vietnam National University
Infertility Due to Nonimplantation
Effect Of Intravenous IntralipidTherapyon Pregnancy Outcome in Women With History of Recurrent Implantation Failure Undergoing Intracytoplasmic Sperm Injection-Embryo Transfer Cycle: A Randomized Controlled Trial
To evaluate the effect ofempiricintralipidinfusion therapy on pregnancy outcomes in patient withunexplained recurrentimplantation failure (RIF) undergoIntracytoplasmic sperm injection (ICSI).
- Trial name
- NCT03374163
- Testing
- intralipid 20%
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- King Fahad Medical City
Abortion, Spontaneous, Abortion, Habitual
Intralipid for Recurrent Miscarriage
Intralipid infusion can improve the outcome in NK cells positive females with history of recurrent miscarriages undergoing IVF/ICSI cycles.
- Trial name
- NCT01788540
- Testing
- Intralipid
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt