Clinical trials: Recurrent Pericarditis
Recurrent Pericarditis
CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)
Multi-center, randomized, double-blind, placebo-controlled, phase-3 Trial. Patients with a history of recurrent pericarditis who are being treated with an IL-1 blocker for at least 12 months, scheduled to be discontinued, will be…
- Trial name
- MAVERIC (NCT06708299)
- Testing
- CardiolRx
- Where
- 27 sites in United States, Canada and 2 more
- Volunteers
- 110 people
- Sponsor
- Cardiol Therapeutics Inc.
Pericarditis, Pericarditis Acute
Phase 2/3 Study of Participants With Recurrent Pericarditis Evaluating the Efficacy and Safety of KPL-387
This study is being done to demonstrate whether KPL-387 is an effective and safe treatment for recurrent pericarditis.
- Conditions
- Pericarditis, Pericarditis Acute, Recurrent Pericarditis
- Trial name
- PASTORALE (NCT07010159)
- Testing
- KPL-387
- Where
- 66 sites in United States, Canada and 8 more
- Volunteers
- 325 people
- Sponsor
- Kiniksa Pharmaceuticals International, plc
Recurrent Pericarditis
Therapy Management in Patients Treated With Anakinra Due to Recurrent Pericarditis
To determine the utility of serial cardiac magnetic resonance (CMR) imaging for guidance of therapy management in patients treated with anakinra due to recurrent pericarditis (RP), compared with c-reactive protein (CRP) assay…
- Trial name
- NCT06071156
- Testing
- Anakinra
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Pericarditis, Recurrence
Study of Colchicine to Treat and Prevent Recurrent Pericarditis After Failure of Conventional Treatment.
The purpose of the study is to determine whether colchicine is safe and effective in treatment and prevention of recurrent pericarditis after failure of conventional treatment.
- Trial name
- CORP 2 (NCT00235079)
- Testing
- Colchicine
- Where
- 4 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Sanitaria Locale 3, Torino
Recurrent Pericarditis
Impact of CardiolRxTM on Recurrent Pericarditis (MAvERIC-Pilot)
Patients with recurrent pericarditis who are refractory or intolerant to current therapeutic management options or who require long-term administration of corticosteroids to control their disease are particularly challenging to…
- Trial name
- NCT05494788
- Testing
- CardiolRx
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- Cardiol Therapeutics Inc.
Recurrent Pericarditis
REgiStry Of the NAtural History of recurreNt periCarditis in pEdiatric and Adult Patients
The registry will focus on furthering the understanding of the natural history of recurrent pericarditis (RP), as well as document RP-related clinical, health-related quality of life (HRQoL), and economic burden and will assist…
- Trial name
- RESONANCE (NCT04687358)
- Where
- 29 sites in United States
- Volunteers
- 500 people
- Sponsor
- Kiniksa Pharmaceuticals International, plc
Acute Pericarditis, Pericardial Effusion
Pericardial Fluid Analysis in Recurrent Pericarditis
This clinical trial aims to examine the biochemical and cytological features of pericardial effusion during acute and recurrent pericarditis and to understand the molecular factors responsible for pathogenesis.
- Conditions
- Acute Pericarditis, Pericardial Effusion, Pericardial Disease, Pericardial Fluid Exudate
- Trial name
- PEFLANA (NCT06293924)
- Testing
- Pericardiocentesis, Pericardiotomy, Cytofluorometry and Gene expression analysis
- Where
- Italy
- Volunteers
- 432 people
- Sponsor
- ASST Fatebenefratelli Sacco
Pericarditis
Pericardial Imaging Study
The pericardium is a thin, double-layered sac around the heart that helps reduce friction as the heart moves. When this sac gets inflamed, it is called pericarditis, which can cause serious health problems and even be…
- Trial name
- NCT07245849
- Testing
- 18F-FDG PET/CT
- Volunteers
- 44 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Recurrent Pericarditis
Efficacy and Safety of RPH-104 Treatment in Patients With Recurrent Pericarditis
The primary purpose of this study is the evaluation of the efficacy and safety of RPH-104 treatment in patients with recurrent pericarditis.
- Trial name
- NCT05107934
- Testing
- RPH-104
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- R-Pharm Overseas, Inc.
Idiopathic Recurrent Pericarditis
AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP)
Recent findings suggest that recurrent pericarditis (RP) may be a previously unrecognized autoinflammatory disease. The pivotal pathogenic role of interleukin (IL)-1 in RP has been shown by the achievement of complete responses…
- Trial name
- AIR TRIP (NCT02219828)
- Testing
- Anakinra
- Where
- 3 sites in Italy
- Volunteers
- 21 people
- Sponsor
- Massimo Imazio
Postpericardiotomy Syndrome
Study of Colchicine to Prevent the Postpericardiotomy Syndrome
The purpose of the study is to determine whether colchicine is safe and effective in the prevention of the postpericardiotomy syndrome.
- Trial name
- NCT00128427
- Testing
- Colchicine (for 1 month)
- Where
- 6 sites in Italy
- Volunteers
- 360 people
- Sponsor
- Azienda Sanitaria Locale 3, Torino
Recurrent Pericarditis
A Pilot Study of KPL-914 in Recurrent Pericarditis
The purpose of this study is to assess the preliminary efficacy and safety of KPL-914 treatment in participants with recurrent pericarditis.
- Trial name
- NCT03980522
- Testing
- KPL-914
- Where
- 14 sites in United States
- Volunteers
- 26 people
- Sponsor
- Kiniksa Pharmaceuticals (UK), Ltd.
Recurrent Pericarditis, Heart Diseases
Transition to KPL-387 Monotherapy Dosing & Administration Study
The primary objective of this study is to characterize the efficacy and safety of dosing regimens used to transition from prior pericarditis therapies to KPL-387 monotherapy in participants with well-controlled recurrent…
- Conditions
- Recurrent Pericarditis, Heart Diseases, Pericarditis
- Trial name
- NCT07288216
- Testing
- KPL-387
- Where
- 47 sites in United States, Canada and 8 more
- Volunteers
- 120 people
- Sponsor
- Kiniksa Pharmaceuticals International, plc
Recurrent Pericarditis
Study to Assess the Efficacy and Safety of Rilonacept Treatment in Participants With Recurrent Pericarditis
The primary objective of this study was to assess the efficacy of rilonacept treatment in participants with recurrent pericarditis.
- Trial name
- RHAPSODY (NCT03737110)
- Testing
- Rilonacept
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 86 people
- Sponsor
- Kiniksa Pharmaceuticals (UK), Ltd.
Idiopathic Recurrent Pericarditis
Pericarditis: Auto-Inflammation in Recurrent Disease
Pericarditis is swelling of the sac that surrounds the heart, the pericardium, causing chest pain. For most patients, the condition improves with simple anti-inflammatory medications like colchicine and ibuprofen.
- Trial name
- PAIReD (NCT04996108)
- Where
- 2 sites in United Kingdom
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- King's College London
Pericarditis
Study of Colchicine to Treat Acute Pericarditis and Prevent Recurrences
The purpose of the study is to determine whether colchicine is safe and effective in the treatment of acute pericarditis and the prevention of subsequent recurrences.
- Trial name
- NCT00128453
- Testing
- Colchicine (for 3 months)
- Where
- 4 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Sanitaria Locale 3, Torino
Pericarditis
RUDRA Registry (Real-World Clinical Registry for Patients With Recurrent Pericarditis)
А multicenter, non-interventional real world clinical registry of patients with recurrent pericarditis. The main goal of the registry is to epidemiologically assess the pattern, clinical outcomes, and approaches to therapy in…
- Trial name
- NCT06517966
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Eurasian Association of Therapists
Pericarditis
Study to Evaluate the Efficacy and Safety of RPH-104 Treatment in Patients With Idiopathic Recurrent Pericarditis
The goal of this study was to evaluate the Efficacy and Safety of RPH-104 Treatment in patients in comparison to placebo with Idiopathic Recurrent Pericarditis
- Trial name
- NCT04692766
- Testing
- RPH-104
- Where
- 2 sites in Russia
- Volunteers
- 20 people
- Sponsor
- R-Pharm International, LLC
Pericarditis Idiopathic Recurrent
Hydroxychloroquine in Colchicine-Resistant Glucocorticoid-Dependent Idiopathic Recurrent Pericarditis
Among patients with colchicine-resistant glucocorticoid-dependent idiopathic RP (idiopathic recurrent pericarditis during at least a second recurrence, having met the 2015 European Society of Cardiology criteria for pericarditis…
- Trial name
- RESTORE (NCT05737680)
- Testing
- Hydroxychloroquine, Colchicine
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Hippocration General Hospital
Pericarditis
Benign Acute Pericarditis: Brief Versus Longer Treatment Using Aspirin
Treatment of pericarditis largely remains empirical due to the relative lack of randomized controlled trials. Nevertheless, some recommendations have been formulated to guide management and follow-up of acute pericarditis.
- Trial name
- pericardite (NCT00946907)
- Testing
- Aspirin
- Where
- 12 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Brest