Clinical trials: Recurrent Pregnancy Loss
Abortion, Spontaneous
Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk
This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han.
- Trial name
- NCT02633475
- Testing
- IL-10 polymorphism
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fourth Affiliated Hospital of Guangxi Medical University
Preterm Birth Complication, Preterm Birth
Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities
The goal of this clinical trial is to learn if a personalized prenatal support program [(Personalized Toolkit Building a Comprehensive Approach to Resource optimization and Empowerment in Pregnancy \& Beyond, (PTBCARE+)] works to…
- Conditions
- Preterm Birth Complication, Preterm Birth, Preterm Birth Recurrence, Preeclampsia
- Trial name
- PTBCARE+ (NCT06915428)
- Testing
- Care coordination, Electronic massage, support gift #1
- Where
- United States
- Volunteers
- 1,228 people
- Sponsor
- University of North Carolina, Chapel Hill
Miscarriage, Recurrent, Premature Labor
PAR Family Polymorphisms and Placental Invasion Disorders
The present study will be undertaken to establish whether genetic variations of PAR1 could be involved in the occurrence of any of the "placental syndromes" of preterm delivery, preeclampsia, and/or small for gestational age…
- Trial name
- NCT00425867
- Testing
- PAR1 polymoprhisms and placental invasion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Recurrent Pregnancy Loss, Anxiety Disorders
Right Prefrontal Autonomic Mapping in Recurrent Pregnancy Loss With Comorbid Anxiety
Recurrent pregnancy loss is often accompanied by substantial anxiety and may also be associated with autonomic imbalance and increased long-term cardiovascular vulnerability.
- Trial name
- NCT06968026
- Testing
- repetitive transcranial magnetic stimulation(rTMS)
- Where
- 4 sites in China
- Volunteers
- 55 people
- Sponsor
- Shenyang Jinghua Hospital
Recurrent Abortion
Low-molecular-weight Heparin (LMWH) Versus Unfractionated Heparin (UFH) in Pregnant Women With Recurrent Abortion Secondary to Antiphospholipid Syndrome
The aim of this study is to compare the efficacy and safety of Low molecular weight heparin (LMWH) plus low dose aspirin (LDA) with unfractionated heparin(UFH) plus LDA in women with recurrent pregnancy loss associated with…
- Trial name
- NCT01051778
- Testing
- enoxaparin 40mg plus low dose aspirin, Heparin calcium5,000 U twice daily plus low dose aspirin
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Ovarian Cancer, Epithelial Ovarian Cancer
A Study of Rucaparib in Patients With Platinum-Sensitive, Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARIEL2)
The purpose of this study is to determine which patients with ovarian, fallopian tube, and primary peritoneal cancer will best respond to treatment with rucaparib.
- Conditions
- Ovarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- ARIEL2 (NCT01891344)
- Testing
- Oral rucaparib
- Where
- 75 sites in United States, Australia and 4 more
- Volunteers
- 491 people
- Sponsor
- pharmaand GmbH
Recurrent Pregnancy Loss
Biweekly Follow-Up and At-Home Ultrasound Reduce Anxiety in Women With Recurrent Pregnancy Loss
Spontaneous pregnancy loss is a relatively common phenomenon, with 10-15% of clinically recognized pregnancies ending in miscarriage.1 Recurrent pregnancy loss (RPL) is a disorder defined by two or more failed pregnancies2.
- Trial name
- NCT05656846
- Testing
- PulseNmore ES™, Standard Ultrasound
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Miscarriage, Recurrent
Unexplained Recurrent Pregnancy Loss: New Therapeutic Perspectives
Evaluation of gut permeability and endometrial inflammasome NLRP3 in women with unexplaid recurrent pregnancy loss before-after administration of Bifidobacteriumlongum ES1.
- Trial name
- NCT06867900
- Testing
- Bifidobacterium Longum ES1
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Recurrent Pregnancy Loss Without Current Pregnancy
HOPE Trial hCG or Progesterone Effect on Recurrent Pregnancy Loss
Up to half of all cases of recurrent pregnancy loss are unexplained (uRPL). Evidence points towards endometriosis and progesterone resistance as an underlying cause of uRPL.
- Trial name
- HOPE (NCT05365464)
- Testing
- Progesterone Pill, hCG
- Sponsor
- Wake Forest University Health Sciences
Recurrent Miscarriage, First Trimester Abortion
Hydroxychloroquine for Prevention of Recurrent Miscarriage.
Recurrent miscarriage (RM) defined by >=3 consecutive losses affects 1% of fertile couples. Most women have recurrent early loss with a failure of development before 10 weeks' gestation.
- Trial name
- BBQ (NCT03165136)
- Testing
- Hydroxychloroquine
- Where
- 18 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Recurrent Pregnancy Loss, Overweight , Obesity
Effects of High-frequency Left Dorsolateral Prefrontal rTMS on Heart-brain Coupling in Women With Recurrent Pregnancy Loss and Elevated BMI
This randomized, sham-controlled mechanistic trial will examine whether a single session of high-frequency repetitive transcranial magnetic stimulation, rTMS, applied to the left dorsolateral prefrontal cortex can modify…
- Conditions
- Recurrent Pregnancy Loss, Overweight , Obesity, Heart-Brain Coupling
- Trial name
- NEURO-CARD-BMI (NCT07561931)
- Testing
- Real repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenyang Medical College
Infertility, Recurrent Pregnancy Loss
Comparison of Standard ART Practice vs. Trophectoderm Biopsy and Whole Chromosome Analysis
We propose to perform a clinical randomized trial to evaluate the effect of blastocyst biopsy and whole chromosome analysis by Next Generation Sequencing (NGS) in comparison to standard Assisted Reproductive Technologies (ART)…
- Trial name
- NCT01946945
- Testing
- Next Generation Sequencing after Blastocyst biopsy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Reprogenetics
Secondary Recurrent Miscarriage
Trial of the Efficacy of Intravenous Immunoglobulin for Treating Women With Unexplained Secondary Recurrent Miscarriage
The investigators want to test whether infusions of intravenous immunoglobulin - a blood product known to modify immune responses - in early pregnancy will increase the chance of a subsequent live birth in women with three or…
- Trial name
- NCT00722475
- Testing
- Intravenous immunoglobulin, Human albumin
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Recurrent Miscarriage
Habitual Abortion Study: Oral Dydrogesterone Treatment During Pregnancy in Women With Recurrent Miscarriage
The purpose of this clinical study is to demonstrate the shift from inflammatory cytokines to non-inflammatory cytokines in women suffering from habitual abortion treated with dydrogesterone (Duphaston).
- Trial name
- NCT00193674
- Testing
- Dydrogesterone
- Where
- 3 sites in Austria, Poland
- Volunteers
- 71 people
- Sponsor
- Abbott Products
Recurrent Pregnancy Loss
The Epidemiology of Recurrent Spontaneous Abortion Associated With Thrombophilla
RSA is a multifactorial disorder resulting from genetic factors, anatomic factors, autoimmune disorders, endocrine dysfunction, thrombophilia, life style factors, and maternal infections.
- Trial name
- NCT02990390
- Where
- China
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- Shanghai First Maternity and Infant Hospital
Undifferentiated Connective Tissue Disease, Recurrent Pregnancy Loss
Immunosuppressant Regimens for Living Fetuses Study
Undifferentiated connective tissue diseases (UCTD) are known to increase the risk of pregnancy morbidities, including recurrent pregnancy loss.
- Trial name
- NCT03671174
- Testing
- Prednisone, Hydroxychloroquine, Aspirin
- Where
- China
- Volunteers
- 420 people
- Sponsor
- RenJi Hospital
Recurrent Pregnancy Loss, Endoplasmic Reticulum Stress
Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss
To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured.
- Trial name
- NCT04455256
- Testing
- x box binding protein
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Abortion, Spontaneous, Abortion, Habitual
Intralipid for Recurrent Miscarriage
Intralipid infusion can improve the outcome in NK cells positive females with history of recurrent miscarriages undergoing IVF/ICSI cycles.
- Trial name
- NCT01788540
- Testing
- Intralipid
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Pre-Eclampsia
Hydroxychloroquine May be Beneficial for Preeclampsia
The purpose of this research is to investigate the impact of hydroxychloroquine on the incidence of hypertensive pregnancy disorders in women with a history of recurrent spontaneous abortion (RSA).
- Trial name
- NCT06020378
- Testing
- Hydroxychloroquine
- Where
- China
- Volunteers
- 462 people
- Sponsor
- RenJi Hospital
Abortion, Habitual
RECAB-ASA; Treatment of Recurrent Abortion With Aspirin
The aim of this study is to examine whether treatment with 75 mg aspirin daily compared with placebo could reduce the risk for a new miscarriage.
- Trial name
- RECAB-ASA (NCT02823743)
- Testing
- Aspirin
- Volunteers
- 400 people
- Sponsor
- Göteborg University