Clinical trials: Recurrent Respiratory Papillomatosis
Respiratory Tract Diseases, Neoplasms
Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP)
Background: Recurrent respiratory papillomatosis (RRP) is a rare disease that causes wart-like growths in the airways. These growths come back when removed; some people may need 2 or more surgeries per year to keep their airways…
- Conditions
- Respiratory Tract Diseases, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Glandular and Epithelial
- Trial name
- NCT05797246
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Recurrent Respiratory Papillomatosis
Multi-Center, Randomized Trial of the Pulsed Dye Laser for JORRP
The purpose of this study is to determine whether the 585-nm pulse dye laser can decrease the time interval between surgeries and improve voice outcomes in children with severe RRP.
- Trial name
- NCT00550914
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Respiratory Recurrent Papillomatosis (RRP), Human Papillomavirus (HPV)
Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP)
Background: Recurrent respiratory papillomatosis (RRP) is a rare disease that causes wart-like growths called papillomas to grow in the airway, most often in the voice box, windpipe, or lungs.
- Conditions
- Respiratory Recurrent Papillomatosis (RRP), Human Papillomavirus (HPV), Papillomavirus Infection, Laryngeal Diseases
- Trial name
- NCT07756840
- Testing
- PRGN-2012, Bevacizumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer, Malignant Mesothelioma
Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease
RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells.
- Conditions
- Lung Cancer, Malignant Mesothelioma, Metastatic Cancer, Nonmalignant Neoplasm
- Trial name
- NCT00733252
- Testing
- bronchoscopic and lung imaging studies, diagnostic bronchoscopy, histopathologic examination
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Recurrent Respiratory Papillomatosis, Pulmonary Neoplasm
The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)
Recurrent respiratory papillomatosis (RRP) is an orphan disease that affects approximately 20,000 people in the United States and is caused by infection with human papillomavirus (HPV) types 6 and 11.
- Trial name
- NCT06412172
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Human Papilloma Virus, Recurrent Respiratory Papillomatosis
Merck IIT: RRP Pembro and Lenvatinib
This research study is studying Lenvatinib in combination with Pembrolizumab in people with human papillomavirus (HPV)-associated recurrent respiratory papillomatosis (RRP).
- Conditions
- Human Papilloma Virus, Recurrent Respiratory Papillomatosis, Pulmonary Disease
- Trial name
- NCT04645602
- Testing
- Lenvatinib, Pembrolizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Recurrent Respiratory Papillomatosis
Therapeutic Treatment With Human Papillomavirus Quadrivalent Vaccine for Recurrent Respiratory Papillomatosis
The purpose of this study is to determine if administration of the HPV quadrivalent vaccine in patients diagnosed with RRP has a therapeutic effect on their clinical course.
- Trial name
- NCT00829608
- Testing
- Human Papillomavirus Vaccine
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Recurrent Respiratory Papillomatosis
Use of Cidofovir for Recurrent Respiratory Papillomatosis
Recurrent respiratory papillomatosis (RRP) is the most common benign neoplasm of the larynx in the pediatric population. The impact of the disease on patients and families can be tremendous due to the need for frequent treatment.
- Trial name
- NCT00205374
- Testing
- Cidofovir
- Volunteers
- 19 people
- Sponsor
- University of Wisconsin, Madison
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Juvenile Recurrent Respiratory Papillomatosis
Juvenile Recurrent Respiratory Papillomatosis: Establishment of a French National Cohort (PRR : National Cohort " REPA ")
Recurrent respiratory papillomatosis (RRP) is a rare disease. However, it is the most common benign laryngeal tumor in children. To date, no epidemiological data are available in France.
- Trial name
- REPA (NCT06000527)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Imagine Institute
Laryngeal Papilloma, Recurrent
Optiflow vs. Convential Anesthesia During Pediatric Laryngeal Papilloma Removal
This is a randomized cross over study of high flow oxygen delivery via nasal cannula vs. conventional tubeless anesthesia for patients undergoing dubulking surgery for laryngeal papilloma.
- Trial name
- NCT05215249
- Testing
- Transnasal humidified high-flow oxygen delivery
- Sponsor
- Massachusetts Eye and Ear Infirmary
Recurrent Respiratory Papillomatosis (RRP)
Efficacy of Booster Injection With Gardasil-9 Vaccine on Intersurgical Interval* for Adults With Recurrent Respiratory Papillomatosis*
The investigators propose the study titled "Efficacy of booster injection with Gardasil-9 vaccine on intersurgical interval (ISI) for adults with recurrent respiratory papillomatosis (RRP)".
- Trial name
- *ISI *RRP (NCT07339163)
- Testing
- GARDASIL®9 (Human Papillomavirus 9-valent Vaccine, Recombinant)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Recurrent Respiratory Papillomatosis
Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis
Juvenile onset recurrent respiratory papillomatosis (JORRP) is a rare, difficult to treat, benign tumor of the pediatric airway.
- Trial name
- NCT01058317
- Testing
- Propranolol
- Sponsor
- Massachusetts Eye and Ear Infirmary