Clinical trials: Recurrent Tumor
Recurrent Patellar Dislocation
Arthroscopic Clinical Study of Double Bundle Anatomical Reconstruction of Medial Patellofemoral Ligament
Objective: To study the clinical effect of double-beam anatomical reconstruction of medial patellofemoral ligament under arthroscopy.
- Trial name
- NCT04456881
- Testing
- Patients with patellar dislocation undergo patellar femoral medial reconstruction
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Stage IIIB, IV, Recurrent, and Metastatic Breast Cancer
Psychosocial Treatment for Improving Chances of Survival in Women With Breast Cancer
This study will investigate the influence of psychosocial treatment on psychological outcomes and survival among women with metastatic or recurrent breast cancer.
- Trial name
- NCT00226928
- Testing
- Supportive-Expressive Group Therapy plus education, Education
- Volunteers
- 125 people
- Sponsor
- Stanford University
Locally Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma
Brigatinib and Bevacizumab for the Treatment of ALK-Rearranged Locally Advanced, Metastatic, or Recurrent NSCLC
This phase Ib trial studies the side effects and best dose of brigatinib and how well it works with bevacizumab in treating patients with ALK-rearranged non-small cell lung cancer that has spread to nearby tissues or lymph nodes…
- Conditions
- Locally Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
- Trial name
- NCT04227028
- Testing
- Bevacizumab, Brigatinib
- Where
- 6 sites in United States
- Volunteers
- 5 people
- Sponsor
- City of Hope Medical Center
HSV-2
Safety Study of HSV2 DNA Vaccine to Treat Patients With Recurrent Genital Herpes Caused by HSV-2
The purpose of this study is to evaluate how well the vaccine is tolerated at sites where administrations are given and any effects it may have on subjects' wellbeing.
- Trial name
- NCT00274300
- Testing
- pPJV7630 administered by PMED
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- PowderMed
Relapsed/Refractory B-cell Malignancies
IASO208 Injection in the Treatment of Relapsed/Refractory B-cell Malignancies
This is an investigator-initiated, single-arm, open-label clinical study. It employs a dose-escalation design to evaluate the safety, pharmacokinetics, and preliminary efficacy of IASO208 injection in relapsed/refractory B-cell…
- Trial name
- NCT07309900
- Testing
- IASO208 injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lung Cancer
Comparison of Nicotine Inhaler and/or Bupropion in Helping People to Stop Smoking and Prevent the Recurrence of Smoking
RATIONALE: Use of a nicotine inhaler and/or bupropion may be effective in helping people stop smoking and prevent them from starting smoking again.
- Trial name
- NCT00033592
- Testing
- bupropion hydrochloride, nicotine
- Where
- 25 sites in United States, Canada
- Volunteers
- 1,708 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Epstein-Barr Virus Positive, Metastatic Nasopharyngeal Carcinoma
Durvalumab and Epacadostat for Treatment of Unresectable, Recurrent, or Metastatic Epstein-Barr Virus Positive Nasopharyngeal Cancer
This phase II trial studies how well durvalumab and epacadostat work in treating patients with Epstein-Barr virus positive nasopharyngeal cancer that cannot be removed by surgery (unresectable), has come back (recurrent), or has…
- Conditions
- Epstein-Barr Virus Positive, Metastatic Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma, Stage III Nasopharyngeal Carcinoma
- Trial name
- NCT04231864
- Testing
- Durvalumab, Epacadostat
- Sponsor
- Alain Algazi
Chronic Lymphocytic Leukemia
Bendamustine Versus Fludarabine in Chronic Lymphocytic Leukemia (CLL)
Bendamustine demonstrated clinical activity in pre-treated hematological malignancies due to its unique mechanism of action distinct from standard alkylating agents.
- Trial name
- NCT01423032
- Testing
- bendamustine, Fludarabine
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- WiSP Wissenschaftlicher Service Pharma GmbH
NK Cell, B-cell Lymphoma Recurrent
Safety and Efficacy of Autologous NK Cell Adjuvant Therapy for Relapsed/Refractory Non-Hodgkin's B-cell Lymphoma
This study was a single-arm trial of autologous NK cell adjuvant therapy for relapsed/refractory non-Hodgkin's B-cell lymphoma. The locations isXiangyang No.1 People's Hospital, Hubei University of Medicine.
- Conditions
- NK Cell, B-cell Lymphoma Recurrent, B-cell Lymphoma Refractory
- Trial name
- NCT05909098
- Testing
- autologous NK cell
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Xiangyang No.1 People's Hospital
Lymphoma, Neutropenia
Peripheral Stem Cell Transplantation to Prevent Neutropenia in Patients Receiving Chemotherapy for Relapsed or Refractory Non-Hodgkin's Lymphoma
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill cancer cells.
- Trial name
- NCT00005787
- Testing
- epoetin alfa, filgrastim, recombinant flt3 ligand
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Colorectal Cancer
Liposome-encapsulated Irinotecan Hydrochloride PEP02 or Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil as Second-Line Therapy in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as liposome-encapsulated irinotecan hydrochloride PEP02, irinotecan hydrochloride, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either…
- Trial name
- PEPCOL (NCT01375816)
- Testing
- FOLFIRI 1-Bevacizumab, fluorouracil, irinotecan hydrochloride
- Where
- France
- Volunteers
- 55 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Prostate Cancer, Prostate Adenocarcinoma
Study of 18F-DCFPyL PET/CT Imaging in Patients With Suspected Recurrence of Prostate Cancer
This study evaluates the diagnostic performance and safety of 18F-DCFPyL (PyL) PET/CT imaging in patients with suspected recurrence of prostate cancer who have negative or equivocal findings on conventional imaging.
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Recurrent, Prostate Cancer Metastatic
- Trial name
- CONDOR (NCT03739684)
- Testing
- 18F-DCFPyL, PET/CT Imaging
- Where
- 14 sites in United States, Canada
- Volunteers
- 208 people
- Sponsor
- Progenics Pharmaceuticals, Inc.
Uterine Fibroids (Leiomyoma)
FATIMA Trial: EGCG and Vitamin D3 for Prevention of Fibroid Recurrence
The aim of this randomized controlled clinical trial is to evaluate the efficacy of green tea (EGCG) and vitamin D3 supplementation in preventing uterine fibroid recurrence following fibroid removal.
- Trial name
- FATIMA (NCT07647198)
- Testing
- Vitamin D and Green Tea
- Where
- United Arab Emirates
- Volunteers
- 240 people
- Sponsor
- Sheikh Shakhbout Medical City
Immunoglobulin A Nephropathy, Kidney Diseases
A Study of the Safety and Activity of Sparsentan for the Treatment of Patients With Immunoglobulin A Nephropathy
To determine the nephroprotective potential of treatment with sparsentan in (1: Cohort A) patients newly-diagnosed with immunoglobulin A nephropathy (IgAN) (ie, incident patients) who have not received prior…
- Conditions
- Immunoglobulin A Nephropathy, Kidney Diseases, Glomerulonephritis, IGA, Glomerulonephritis
- Trial name
- SPARTAN (NCT04663204)
- Testing
- Sparsentan
- Where
- 6 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Leicester
Renal Cell Carcinoma
iConquerFear Program for the Treatment of Fear of Cancer Recurrence in Patients With Localized Renal Cell Carcinoma
This trial investigates whether an online intervention, iConquerFear, can reduce fear of cancer coming back (recurrence) and anxiety in patients with renal cell carcinoma that is restricted to the site of origin, without evidence…
- Trial name
- NCT04688333
- Testing
- Internet-Based Intervention - Complete iConquerFear program, Quality-of-Life Assessment, Questionnaire Administration
- Sponsor
- City of Hope Medical Center
Recurrent Urinary Tract Infection
The Effect of ASTARTE™ on Recurrent Urinary Tract Infection
Investigate the effect of dietary supplements/probiotic ASTARTE™ ( L. crispatus, L. rhamnosus, L. jensenii, L. gasseri) on the microbiome composition in the intestine and vagina and thereby a reduction of risk factors for the…
- Trial name
- rUTI (NCT05553652)
- Testing
- ASTARTE™ oral capsules
- Where
- Denmark
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Bone Marrow Transplantation in Treating Patients With Severe Aplastic Anemia or Rejection of Previous Bone Marrow Transplant
RATIONALE: Bone marrow from donors may be able to treat patients with severe aplastic anemia and patients whose bodies have rejected previous bone marrow transplantation.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00005852
- Testing
- anti-thymocyte globulin, filgrastim, muromonab-CD3
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Previous Incision, Scar; Previous Cesarean Section
PRP Gel in Wound Closure in Recurrent CS
There is limited application of the use of PRP in obstetrics, therefore there is a need for assessment if it is efficacy in improving skin wound healing in cesarean section.
- Trial name
- PRP-CS (NCT02775747)
- Testing
- platelet rich plasma gel, saline
- Where
- Egypt
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Adhesion; Uterus, Internal
Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions (REpAIR)
Patients suffering of subfertility as a consequence of intrauterine adhesions could be treated with hysteroscopic adhesiolysis. Adhesion recurrence may occur postoperative.
- Trial name
- NCT03446755
- Testing
- intra uterine Cook balloon
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
T Cell Lymphoma, T-cell Lymphoma
Study of Mogamulizumab With DA-EPOCH or CHOEP in Patients With Aggressive T-cell Lymphoma
Single-arm Phase II study evaluating the combination of mogamulizumab (MOGA) added on top of standard of care dose adjusted EPOCH (DA-EPOCH) or CHOEP in patients with newly diagnosed or relapsed/refractory (for CTCL only)…
- Trial name
- NCT05996185
- Testing
- Mogamulizumab, DA-EPOCH Protocol, CHOEP protocol
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Yale University
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