Clinical trials: Red Blood Cells
White Blood Cells Engulfing Red Blood Cells
Usefulness of White Blood Cell Count (WBCC) During Infection in Geriatric Patient
In the general population, increased WBCC and neutrophil count are widely used as markers for infection during inflammatory states 1. However, 32% of geriatric patients with an infection do not develop an increase in WBCC 2.
- Trial name
- NCT03943277
- Testing
- No intervention, observational study
- Where
- Belgium
- Volunteers
- 62 people
- Sponsor
- Universitair Ziekenhuis Brussel
Red Blood Cell Health, Biological Aging
Effect of Pentadecanoic Acid Supplementation on Red Blood Cell Health and Biological Aging in Healthy Older Adults
This Phase II randomized, double-blind, placebo-controlled, parallel-group study will evaluate the effects of pentadecanoic acid (C15:0) supplementation on red blood cell (RBC) health and predicted biological age in healthy…
- Conditions
- Red Blood Cell Health, Biological Aging, Healthy Aging
- Trial name
- NCT07812792
- Testing
- Pentadecanoic Acid
- Where
- Canada
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- ReCellience15, Inc
Erythrocyte Destruction
A Multi-dimensional Evaluation of the Effects of Linear Accelerator X-ray Irradiation on Red Blood Cells
This study aims to investigate the effects of linear accelerator X-ray irradiation on the structure, mechanics and functional characteristics of red blood cells recovered from patients with malignant tumors during surgery.
- Trial name
- NCT07416045
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer Disease, Oxidative Stress
Isolated Erythrocyte Membrane Susceptibility to Photo-oxidative Stress in Alzheimer's Disease
High lipid peroxidation and altered antioxidant defenses have been frequently reported in Alzheimer's disease patients. The purpose of this study is to investigate susceptibility to photo-oxidation of isolated erythrocyte…
- Conditions
- Alzheimer Disease, Oxidative Stress, Adrenocortical Hyperfunction
- Trial name
- NCT01707719
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Raffaele Antonelli Incalzi
Lung Cancer, Red Blood Cells
The Red Blood Cells Based Blood Test for Lung Cancer EARLY Detection
This study plan to enroll 852 patients with pulmonary nodules smaller than 3 cm in diameter, whose DNA and RNA will be extracted from mature red blood cells isolated from peripheral blood.
- Conditions
- Lung Cancer, Red Blood Cells, Methylation
- Trial name
- NCT05380999
- Testing
- Methylation tests of nucleic acids extracted from mature red blood cells (RBCs)
- Volunteers
- 852 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Blood Disease, Blood Transfusion, Autologous
Using DNA-Typing and Erythrocyte Microparticle Analysis to Detect Blood Doping
A total of 12 subjects will be recruited for participation in this study. 6 subjects will receive re-infusion of autologous blood, and 6 subjects (anemic patients) will receive a homologous transfusion.
- Conditions
- Blood Disease, Blood Transfusion, Autologous, Blood Doping, Blood Transfusion, Homologous
- Trial name
- Transfusion (NCT03548766)
- Testing
- Homologous Blood Transfusion, Autologous Blood Transfusion
- Where
- Qatar
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Cardiac Surgery
Red Cell Distribution With to Lymphocyte Ratio in Cardiac Surgery
It is aimed to investigate whether red cell distribution with (RDW) to lymphocyte ratio (RLR) can predict early comorbidity among cardiac surgery patients.
- Trial name
- NCT05341037
- Where
- Turkey (Türkiye)
- Volunteers
- 700 people
- Sponsor
- Ankara City Hospital Bilkent
Myelodysplastic Syndrome With Low-grade Lesions, Iron Overload Due to Repeated Red Blood Cell Transfusions
Effect of Deferiprone on Oxidative-Stress and Iron-Overload in Low Risk Transfusion-Dependent MDS Patients
The effect oral iron chelator Deferiprone on the Oxidative stress and on Iron Overload status in transfusion dependent, iron-overloaded low risk MDS patients; Primary Objective: To evaluate the effect of Deferiprone on oxidative…
- Trial name
- NCT02477631
- Testing
- Deferiprone
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Sheba Medical Center
Acute Lymphoblastic Leukemia
Asparaginase Encapsulated in Erythrocytes for Patients With ALL and Hypersensitivity to PEG-asparaginase
Pegylated-asparaginase (PEG-ASP) is an important part of the treatment of childhood acute lymphoblastic leukaemia (ALL). Unfortunately 13% of patients develops allergy and further treatment is impossible.
- Trial name
- NCT03267030
- Testing
- GRASPA
- Where
- 23 sites in Denmark, Estonia and 4 more
- Volunteers
- 55 people
- Sponsor
- Birgitte Klug Albertsen
Sickle Cell Anemia
Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea
The primary goal of the Phase III TWiTCH trial is to compare 24 months of alternative therapy (hydroxyurea) to standard therapy (transfusions) for pediatric subjects with sickle cell anemia and abnormally high (≥200 cm/sec)…
- Trial name
- TWiTCH (NCT01425307)
- Testing
- Hydroxyurea
- Volunteers
- 159 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute
Use of Saline-Washed Platelet and Red Cell Transfusions in Adult Acute Leukemia
The purpose of this study is to determine whether a novel standard of care protocol, washing red cell and platelet transfusions for younger patients with acute leukemia, has yielded improved clinical outcomes at Strong Memorial…
- Trial name
- NCT01976442
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Rochester
Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication
Red Blood Cell Transfusion in ECMO - A Feasibility Trial
Extracorporeal Membrane Oxygenation (ECMO) is an invasive and resource intense treatment used to support critically ill patients who have suffered severe cardiac arrest, cardiac failure or respiratory failure (including severe…
- Conditions
- Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication, Disability Physical, Cognitive Ability, General
- Trial name
- ROSETTA (NCT05814094)
- Testing
- Red Blood Cell Transfusion
- Where
- 2 sites in Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Aplastic Anemia, Pure Red Cell Aplasia
A Study to Determine Whether Therapy With Daclizumab Will Benefit Patients With Bone Marrow Failure
Participants in this study are suffering from rare and serious blood disorders. In aplastic anemia, the bone marrow stops producing red blood cells, platelets, and white blood cells.
- Conditions
- Aplastic Anemia, Pure Red Cell Aplasia, Diamond Blackfan Anemia
- Trial name
- NCT00001962
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myelodysplastic Syndrome
Efficacy and Safety of Lenalidomide in Combination With Cyclosporine A in Patients With Myelodysplastic Syndromes
Lenalidomide has shown significant efficacy in the treatment of anemia associated with both 5q- and non 5q- MDS patients. The mechanism(s) of action of lenalidomide in MDS is still to be determined, but given the differences in…
- Trial name
- NCT00840827
- Testing
- lenalidomide, cyclosporine A
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Weill Medical College of Cornell University
Necrotizing Enterocolitis
SMA Flow Patterns in Neonatal Transfusion
This study aims to measure the changes induced by packed red blood cell (PRBC) transfusion in the superior mesenteric artery (SMA) flow velocity and intestinal oxygenation indices in premature neonates.
- Trial name
- SPARTAN (NCT02347475)
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University of Calgary
Sickle Cell Disease, Thalassemia
Red Blood Cell - IMProving trAnsfusions for Chronically Transfused Recipients
Red Blood Cell - IMProving trAnsfusions for Chronically Transfused recipients (RBC-IMPACT) is an observational cohort study to assess donor, component, and recipient factors that contribute to RBC efficacy in chronically and…
- Conditions
- Sickle Cell Disease, Thalassemia, Pediatric Cancer
- Trial name
- RBC-IMPACT (NCT05255445)
- Testing
- Red Blood Cell (RBC) Transfusion
- Where
- 14 sites in United States, Brazil
- Volunteers
- 157 people
- Sponsor
- Westat
Rheumatoid Arthritis
Association Between Methotrexate Erythrocyte Polyglutamate Concentration and Biological Drug Concentration and Clinical Response in Rheumatoid Arthritis Patients Treated With Subcutaneous Injectable Methotrexate and a First Biological Drug
The combination of methotrexate (MTX) with a biological disease-modifying antirheumatic drugs (bDMARD) is the next step in treatment with MTX monotherapy in rheumatoid arthritis (RA).
- Trial name
- POLYbio (NCT04470453)
- Testing
- Blood sample, CRQ
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy
Effects of Pistachio Consumption on Body Composition and Blood and Bone Indicators
Research investigating beneficial effects of regular pistachio feedings on body composition (BC) and blood lipids are limited, and there are no studies that have investigated the effects of feeding pistachios on bone density or…
- Trial name
- CPsPistachio (NCT02849392)
- Testing
- Pistachio added 20% of kcals to diet
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- California State Polytechnic University, Pomona
Contraception
Study of Treatment With the Combination of Drospirenone Plus Ethinyl Estradiol Plus Levomefolate Calcium in Mexican Women Seeking Contraception
The objective of this study is to compare the red blood cell (RBC) and plasma concentrations of folate in subjects treated with drospirenone (DRSP)/ethinyl estradiol (EE) plus levomefolate calcium (L-5-MTHF) at 24 weeks with…
- Trial name
- NCT01902264
- Testing
- EE20/DRSP/L-5-MTHF (Beyaz, BAY98-7071)
- Where
- Mexico
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bayer
Pyruvate Kinase Deficiency, Pyruvate Kinase Deficiency Anemia
Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms
This cross-sectional prevalence assessment study involves a single blood draw in specific patient populations to assess for enzymatic and genomic evidence for acquired pyruvate kinase deficiency.
- Conditions
- Pyruvate Kinase Deficiency, Pyruvate Kinase Deficiency Anemia, Hereditary Hemolytic Anemia, Myelodysplastic Syndromes
- Trial name
- NCT04902833
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital