Clinical trials: Reduced Ejection Fraction
Heart Failure, Heart Failure With Reduced Ejection Fraction
Pilot Study Lp299v Supplementation in Chronic Heart Failure
The goal of this study is to determine the impact of 12 weeks of Lp299v supplementation (20 million cfu/day vs. placebo) on exercise capacity, circulating biomarkers of cardiac remodeling, quality of life, and vascular…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure, Systolic, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT05752760
- Testing
- Lactobacillus Plantarum 299v Freeze Dried Capsule, Freeze Dried Potato Starch Capsule
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical College of Wisconsin
Heart Failure and Reduced Ejection Fraction, Heart Failure
PRIMA-HF: Predicting Myocardial Recovery in Heart Failure Using Cardiac Imaging HAI-HF: High Dosing vs. Standard Dosing Adenosine During Myocardial Perfusion in Heart Failure
Background: Heart failure with reduced ejection fraction (HFrEF) is a heterogeneous condition with variable potential for left ventricular ejection fraction (LVEF) recovery.
- Trial name
- PRIMA-HF (NCT07243119)
- Testing
- HAI-HF: Adenosine Stress [¹⁵O]H₂O PET Imaging, Two different doses of adenosine
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Gødstrup Hospital
Heart Failure, Heart Failure With Reduced Ejection Fraction
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study looks at the effects of weight loss in people who have heart failure with reduced ejection fraction (HFpEF) and are overweight or obese.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Obesity, Overweight
- Trial name
- SLEnDR (NCT05942287)
- Testing
- Diet intervention
- Where
- 2 sites in Jersey, United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Oxford
Heart Failure
Evaluation of the Effects of Sauna Therapy on Congestion and Loop Diuretic Use in Patients With Heart Failure With Reduced or Moderately Reduced Ejection Fraction
This study aims to evaluate the effect of sauna therapy on congestion levels during cardiac rehabilitation in patients with heart failure who have an impaired or moderately impaired ejection fraction, compared to standard cardiac…
- Trial name
- SAUNA-HF RCT (NCT07468344)
- Testing
- Sauna
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure
BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction
The purpose of this registry (NCT02880618) is to evaluate the effect of BAROSTIM THERAPY with the BAROSTIM NEO System in the commercial setting in subjects recently implanted under the CE-Marked indication for heart failure with…
- Trial name
- HFrEF (NCT02880618)
- Testing
- Barostim Neo™ System
- Where
- 30 sites in Germany, Italy
- Volunteers
- 500 people
- Sponsor
- CVRx, Inc.
Heart Failure With Reduced Ejection Fraction, Pulmonary Hypertension
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Pulmonary Hypertension, Right Heart Failure Due to Left Heart Failure
- Trial name
- HALT-RHF (NCT06299436)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
The goal of this clinical trial is to learn which iron treatment works better for adults with congestive heart failure and low iron levels: intravenous (IV) iron given through a vein or oral (PO) iron taken by mouth.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Iron Deficiency
- Trial name
- IRONICA (NCT07053475)
- Testing
- Ferric Carboxymaltose, Ferrous Sulfate
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Syed Hamza Mufarrih
Heart Failure With Reduced Ejection Fraction
Email Nudges to Improve GDMT (MRA) Adherence in Heart Failure
The Email Nudges to Improve GDMT (MRA) Adherence in Heart Failure (ENIGMA-HF) study is a pragmatic parallel-arm randomized control trial of a quality improvement (QI) intervention involving email nudges to cardiology clinic…
- Trial name
- ENIGMA-HF (NCT05806970)
- Testing
- Email Nudge
- Where
- United States
- Sponsor
- University of California, Los Angeles
Heart Failure With Preserved Ejection Fraction
Radiofrequency (RF) Ablation for Atrial Fibrillation (AF) in Patients With Heart Failure With Preserved Ejection Fraction
The purpose of this study is to determine if patients who receive an early radiofrequency ablation will have fewer hospitalizations, unplanned office visits, and emergency room visits than those patients treated with medical…
- Trial name
- AF-HFpEF (NCT04327596)
- Testing
- RF ablation of AF using CARTO 3 and a Thermocool ST SF ablation catheter
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- University of Rochester
Heart Failure With Reduced Ejection Fraction
Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)
DigiCare-HFrEF is an investigator-initiated, multicentre, randomised, open-label, endpoint-blinded, superiority trial designed to evaluate whether a structured digital remote-management platform can optimise guideline-directed…
- Trial name
- DigiCare-HFrEF (NCT07352891)
- Testing
- Digital Remote Management
- Where
- 6 sites in China
- Volunteers
- 252 people
- Sponsor
- Beijing Anzhen Hospital
Ferric Carboxymaltose, Heart Failure With Reduced Ejection Fraction
Iron Intravenous Therapy in Reducing the Burden of Severe Arrhythmias in Heart Failure With Reduced Ejection Fraction
An open label,single-center, non-interventional prospective study with the aim on investigating the effect of intravenous ferric carboxymaltose in restoring iron status and reducing the risk of severe arrhythmic events in…
- Conditions
- Ferric Carboxymaltose, Heart Failure With Reduced Ejection Fraction, Arrhythmias, Cardiac
- Trial name
- RESAFE (NCT04974021)
- Testing
- Ferric carboxymaltose
- Where
- Greece
- Volunteers
- 106 people
- Sponsor
- Aristotle University Of Thessaloniki
Heart Failure With Reduced Ejection Fraction (HFrEF)
Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects With Reduced Ejection Fraction
This study is a small, early-stage clinical trial designed to test whether a new catheter-based procedure is safe and may help people with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- R-HFrEF (NCT07403058)
- Testing
- Right Greater Splanchnic Nerve (GSN) ablation
- Where
- 6 sites in Czechia, Poland and 2 more
- Volunteers
- 50 people
- Sponsor
- Axon Therapies, Inc.
Heart Failure With Reduced Ejection Fraction
Strategy, Efficacy and Safety of Medication Usage in Heart Failure Patients Who Were Intolerable to GDMT
SEMI trial is a single-center, real-world based prospective cohort study. The study enrolled acute heart failure patients admitting to the hospital and intended to accept heart failure therapy.
- Trial name
- SEMI (NCT05799638)
- Testing
- Guideline-Directed Medication Treatment (GDMT)
- Where
- China
- Volunteers
- 263 people
- Sponsor
- Chongqing Medical University
Assessment of the RV Function in Patients With Heart Faliure
Right Ventricular Function in Heart Failure
Only a few studies evaluated the RV systolic function in the three categories of HF, regarding the importance of understanding changes in RV function on clinical presentation and outcome; it was essential to understand the…
- Trial name
- NCT03641599
- Testing
- echocardiography
- Volunteers
- 150 people
- Sponsor
- shaimaa Mostafa
Heart Failure With Reduced Ejection Fraction
Effect of Empagliflozin on NT-Pro Brain Natriuretic Peptide in Heart Failure Patients With Reduced Ejection Fraction
This study aims to evaluate the relationship between NT-proBNP and empagliflozin effects in patients with chronic heart failure with mildly reduced ejection fraction (HFmrEF 41-49%) and reduced ejection fraction (HFrEF ≤40%)…
- Trial name
- NCT05778084
- Testing
- Empagliflozin 10 MG
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Heart Failure, Electric Impedance
Effect of Diuretics Withdrawal in Chronic Heart Failure With Reduced Ejection Fraction
REDICAE trial was designed to evaluate the safety and tolerability of diuretics withdrawal in stable, euvolemic chronic outpatients with heart failure with reduced ejection fraction.
- Conditions
- Heart Failure, Electric Impedance, Dyspnea, Safety
- Trial name
- REDICAE (NCT05964738)
- Testing
- Diuretics withdrawal, Diuretics maintenance
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Heart Failure With Reduced Ejection Fraction, Heart Failure
STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart Failure
This is a multicenter, randomized, open-label pilot study to evaluate whether stepwise withdrawal of two heart failure medications-angiotensin receptor-neprilysin inhibitor (ARNI) and sodium-glucose cotransporter-2 inhibitor…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Heart Failure, Ventricular Dysfunction, Left
- Trial name
- STEP-DOWN HF (NCT07631156)
- Testing
- Stepwise Withdrawal of ARNI and SGLT2i, Continued Guideline-Directed Medical Therapy
- Where
- 5 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Kyungsub Song
Heart Failure
Study to Collect High-Resolution ECG Data and Patient Insights on Heart Failure Care
The purpose of this study is to establish an electrocardiogram (ECG) data library to facilitate future studies on heart disease.
- Trial name
- NCT06809686
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Richmond Research Institute
Heart Failure
NoYA RAISE Trial II (Radiofrequency Ablation-Based Interatrial Shunt for Heart Failure)
A Prospective, Multiple Center, and Objective Performance Criteria Study to Evaluate the NoYA™ Radiofrequency Interatrial Shunt System manufactured by NoYA Medtech (Hangzhou) Co., Ltd.
- Trial name
- NCT05375110
- Testing
- NoYA™ Radiofrequency Interatrial Shunt System
- Where
- 31 sites in China
- Volunteers
- 120 people
- Sponsor
- Hangzhou NOYA MedTech Co. Ltm.
Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction
A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hypertension Associated With Left Heart Failure
It's a phase III, prospective, multicenter, randomized controlled trial to evaluate the safety and efficacy of the pulmonary artery denervation (PADN) for heart failure (HF) patients diagnosed with pulmonary hypertension…
- Conditions
- Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Hypertension, Vascular Diseases
- Trial name
- PADN-HF-PH (NCT05824923)
- Testing
- Pulmonary arterial denervation, Guideline-directed medical therapy (GDMT) for heart failure
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Pulnovo Medical (Wuxi) Co., Ltd.