Clinical trials: Reduced Sperm Motility
Asthenozoospermia
Epididymal U.S Findings in Asthenozoospermic &Correlation With L.Carnitine Level
To evaluate the epididymal findings by U.S and study its correlation with seminal parameters including L.carnitine level in infertile males
- Trial name
- NCT05436080
- Testing
- U/S
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pentoxifylline Allergy
Beneficial Effect of Adding Pentoxifylline to Processed Semen Samples on ICSI Outcome in Infertile Males
To evaluate the effect of pentoxifylline used in preparation of semen samples that will be used for ICSI in infertile men complaining of mild and moderate asthenozoospermia (i.e.
- Trial name
- NCT01793272
- Testing
- effect of pentoxifylline on ICSI outcome
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Adam International Hospital
Asthenozoospermia
The Effect of Royal Vaginal Gel Compared to IUI Technique on Fertility Rate of Women With Low-fertility Husbands
The present Pocock clinical trial study was conducted In the city of Mashhad in Iran between 2015 and 2016. The study inclusion criteria were men with low fertility of sperm motility<25% and total motility <50%…
- Trial name
- NCT03463005
- Testing
- Royal jelly, IUI
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Gonabad University of Medical Sciences
Asthenozoospermia
The Effects of Administration of Combined Docosahexaenoic Acid and Vitamin E Supplements on Spermatogram and Seminal Plasma Oxidative Stress in Infertile Men With Asthenozoospermia
Since docosahexaenoic acid (DHA) level in sperm membrane has been shown to be decreased in asthenozoospermic men, the investigators hypothesized that DHA supplementation may improve it.
- Trial name
- NCT01846325
- Testing
- vitamin E, DHA
- Volunteers
- 180 people
- Sponsor
- National Nutrition and Food Technology Institute
Asthenozoospermia
Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen
There are several causes leading to male infertility, like oxidative stress, and nutritional deficiency of trace elements like zinc.
- Trial name
- supplement (NCT01612403)
- Testing
- zinc sulfate
- Where
- 2 sites in Iraq
- Volunteers
- 37 people
- Sponsor
- mahmoud hussein hadwan
Asthenozoospermia
Alpha Lipoic Acid Plus Coenzyme Q10 Versus Coenzyme Q10 Alone in Asthenozoospermia
The goal of the clinical trial is to learn if Alpha-lipoic acid plus Coenzymeq10 work to treat asthenozoospermia in subfertile male. It will also learn about the safety of drug Alpha-lipoic acid plus Coenzymeq10.
- Trial name
- CoQ10 ALA (NCT07455890)
- Testing
- ALA 500mg once daily for 3 month, CoenzymeQ10
- Where
- Bangladesh
- Volunteers
- 40 people
- Sponsor
- Mst.Sumyara Khatun
Male Infertility, Asthenozoospermia
Efficacy and Safety of Linggui Yangyuan Paste in Patients With Male Infertility
Male infertility affects millions of males worldwide and is rising in prevalence due to social and environmental conditions. Asthenozoospermia (AZS) and oligoasthenozoospermia (OA) are the major causes of male infertility.
- Conditions
- Male Infertility, Asthenozoospermia, Oligoasthenozoospermia
- Trial name
- NCT05792813
- Testing
- LGYY, LGYY mimetic, WZYZ
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Oligozoospermia, Asthenozoospermia
Effect of Walnuts on Sperm Parameters and Male Fertility
The investigators are testing the hypothesis that two ounces of whole-shelled walnuts/day added to the diet of men seeking care for infertility will beneficially affect sperm parameters and fertility.
- Conditions
- Oligozoospermia, Asthenozoospermia, Teratozoospermia, Fertility
- Trial name
- NCT01954498
- Testing
- Walnuts, OTC multivitamin
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Reduced Sperm Motility, IVF
Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods
Purpose: To compare the effects of the density gradient centrifugation and microfluidic chip sperm preparation methods on embryo development in a study population with astheno-teratozoospermia.
- Conditions
- Reduced Sperm Motility, IVF, ICSI, Astheno Teratozoospermia
- Trial name
- NCT04962074
- Testing
- Microfluidic sperm sorting chip, Density gradient
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Maltepe University
Male Contraception
Open Label, Dose Escalation, Repeat Dose Study Evaluating YCT-529 in Healthy Males
This is a Phase 1b/2a open-label, dose escalation 3 part-study, 28-day, 90-day or 180 day repeat dose study of YCT-529 in healthy males who have decided to have a vasectomy and are waiting for the procedure and for men who have…
- Trial name
- NCT06542237
- Testing
- YCT-529
- Where
- New Zealand
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- YourChoice Therapeutics, Inc.
Male Infertility
Administration of Antioxidants to Infertile Men and Sperm Quality
The purpose of this randomized clinical trial is to assess the effect of oral antioxidant administration to infertile men, by evaluating semen variables, sperm DFI and levels of ROS.
- Trial name
- NCT04256278
- Testing
- Spermotrend
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility Unexplained
Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway
Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia…
- Trial name
- NCT03361618
- Testing
- Zinc Sulfate
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Babylon University
Reproductive Issues, Male Infertility
Efficacy and Safety of a New Sperm Capacitation Method
Prospective, multicenter research study with a split-sample design on semen samples, without intervention, to evaluate the efficacy and safety of HyperSperm, a new sperm capacitation method, in 300 semen samples with various…
- Conditions
- Reproductive Issues, Male Infertility, Asthenozoospermia, Oligozoospermia
- Trial name
- HyperSperm01 (NCT06742437)
- Testing
- Standard sperm preparation, HyperSperm
- Where
- 4 sites in Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fecundis Lab SL
Asthenozoospermia
Effect of Antioxidant Food Supplement on Sperm Proteomic Structure and Semen Parameters
Infertility is defined as the inability to become pregnant despite 12 months of regular and unprotected intercourse. Male factors include defects in sperm concentration, morphology and motility, among which low sperm motility…
- Trial name
- Asthenospermia (NCT05826782)
- Testing
- Proxeed Plus 2*1 A arm
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kocaeli University
Asthenozoospermia
The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index
Although several studies have considered the relationship between infertility and semen thiol compounds levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on thiol related enzymes…
- Trial name
- NCT02985905
- Testing
- zinc sulfate
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- mahmoud hussein hadwan
Oligozoospermia, Asthenozoospermia
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of STSP-0902 in Healthy Subjects
This is a Phase 1a, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of STSP-0902.
- Trial name
- NCT06563713
- Testing
- STSP-0902 injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Infertility, Male, Azoospermia
The Association of Gut Microbiota and Spermatogenic Dysfunction
This is a multicenter, case-control study that aims to investigate the relationship between microbiota and sperm quality via stool, blood, and urine microbiome, metabolomics, and collected clinical metadata.
- Conditions
- Infertility, Male, Azoospermia, Oligozoospermia, Asthenozoospermia
- Trial name
- NCT05628987
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Oligozoospermia and/or Asthenozoospermia
A Study to Evaluate the Safety and Efficacy of Multiple Dose of STSP-0902 in Patients With Oligozoospermia and/or Asthenozoospermia.
This is a Phase 2, randomized, double-blind, placebo-controlled, multiple dose study to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of STSP-0902 in Patients with Oligozoospermia and/or Asthenozoospermia.
- Trial name
- NCT07833943
- Testing
- STSP-0902 injection
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Asthenozoospermia
Study the Effect of Oral Zinc Supplementation on Enzymes of Nitric Oxide Pathway
The ability of spermatozoa to produce reactive oxygen species (ROS) has been respected since the 1940's. Oxidative stress limits the functional competence of mammalian spermatozoa via lipid peroxidation, the induction of…
- Trial name
- NCT01684059
- Testing
- zinc sulfate
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Babylon University
Asthenozoospermia
Effect of Fermented Ginseng (GINST) on Sperm Motility
This randomized, double-blind, placebo-controlled study aimed to evaluate the effect of ginseng(GINST) supplementation for 12 weeks on sperm motility.
- Trial name
- NCT03183999
- Testing
- fermented ginseng (GINST)
- Where
- 3 sites in South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jae Hoon Lee