Clinical trials: Reference Values, open to volunteers
GERD (Gastroesophageal Reflux Disease)
Normal Values of Ambulatory 24-hour Oesophageal pH-impedance Monitoring in an Indian Cohort of Participants
This study aims to determine normal 24-hour pH-impedance monitoring values, including acid exposure time (AET), in healthy Indian adults. It will help improve GERD diagnosis in India by providing population-specific data.
- Trial name
- NCT06928350
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Thyroid Volume, Thyroid Ultrasound
Ultrasound Measurement of Thyroid Volume in Term Newborns
First, to date, no data are available on the thyroid volume of full-term newborns in Italy, making it essential to conduct studies to establish reference values for normality.
- Conditions
- Thyroid Volume, Thyroid Ultrasound, Congenital Hypothyroidism, Healthy Newborns
- Trial name
- NEOTIR (NCT07579988)
- Testing
- Thyroid ultrasound
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Healthy Participants
Global Reference Ranges - Singapore
We aim to undertake the Global Reference Range Study (GRR) to establish a set of healthy adult reference values for measures of fibroinflammation, fat and size/volumes for the liver, and other abdominal and thoracic organs to…
- Trial name
- GRR Singapore (NCT07166471)
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Perspectum
Dysphagia, Oropharyngeal
Reference Values for Videofluoroscopic Measures of Swallowing
Dysphagia (swallowing impairment) is a serious health condition seen in many age-related disease and injury processes. Although videofluoroscopy (VF) is an international "gold standard" dysphagia diagnostic exam, there is a…
- Trial name
- NIA_RV (NCT05497219)
- Testing
- Videofluoroscopic Swallowing Study (VF)
- Where
- 5 sites in United States, Canada
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Reference Intervals, Biomarker in Early Diagnosis
Generating Intervals of Reference FFor Early Life Brain Biomarkers.
Highly sensitive immunoassays for the detection of neuro-specific biomarkers are becoming more accessible. Currently, the majority of these biomarkers are detected with the use of labour-intensive and highly skilled wet lab work.
- Conditions
- Reference Intervals, Biomarker in Early Diagnosis, Neonatal
- Trial name
- GIRAFFE (NCT07585149)
- Where
- Ireland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University College Cork
Healthy Volunteers, Imaging Evaluation
Multimodal Cardiovascular and Hepatic Population Imaging
Medical imaging is increasingly important for understanding diseases, detecting them early, and personalizing treatments. New imaging techniques, which can measure processes in the body without surgery, are opening the door to a…
- Trial name
- ICONIC (NCT06906042)
- Testing
- Imaging examinations, Paramedical examinations, Medical examination
- Where
- France
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hearing Aids, 3D Printing
Effectiveness Comparison of 3D-Printed and Conventional Ear Tip Comfort in Individuals With Hearing in the Normal Range
Access to affordable and timely hearing healthcare remains a major challenge for many individuals, partly due to the high cost and long turnaround time.
- Trial name
- NCT07216937
- Testing
- BTE hearing aid with compatible earmolds
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Healthy Adults, Pulmonary Hypertension
A Multicenter Study on the Normal Reference Range and Clinical Significance of the Right Atrioventricular Coupling Index Assessed by Artificial Intelligence-Based Three-Dimensional Echocardiography
This multicenter study aims to establish the normal reference range of the Right Atrioventricular Coupling Index (RACI) in healthy Chinese adults using AI-based 3DE technology.
- Conditions
- Healthy Adults, Pulmonary Hypertension, Tricuspid Regurgitation, Heart Failure
- Trial name
- NCT07292896
- Where
- 25 sites in China
- Volunteers
- 2,640 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Muscle Strength, Healthy
Reference Equations and Normative Data for Isometric Quadriceps and Handgrip Muscles STrength in Southern European Populations - RESTart: a Multicentre Study
This observational study aims to learn about peripheral muscle strength in healthy adults and people with chronic respiratory diseases.
- Conditions
- Muscle Strength, Healthy, Chronic Respiratory Diseases
- Trial name
- RESTart (NCT07628530)
- Where
- Spain
- Volunteers
- 2,815 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Child Development
LIFE Child (LIFE Leipzig Research Centre for Civilization Diseases)
The Leipzig Research Centre for Civilization Diseases (LIFE) Child Study is a prospective longitudinal population-based study with a life course approach to health and disease.
- Trial name
- NCT02550236
- Where
- Germany
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Effect of Drug
PFA 100 Evaluation and Reference Interval HOACNY
The purpose of this research is to evaluate instrument functionality and develop a reference range of normal data by healthy volunteers.
- Trial name
- NCT06100510
- Testing
- Aspirin 325mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hematology Oncology Associates of Central New York
Iron Deficiency (Without Anemia), Reference Values
Iron Status of Non-anemic Pregnant Women in First Trimester
This cross-sectional study aims to establish reference intervals for iron biomarkers-including serum iron, ferritin, total iron-binding capacity (TIBC), and transferrin saturation (TSAT)-in healthy pregnant women during the first…
- Conditions
- Iron Deficiency (Without Anemia), Reference Values, Iron Deficiency Without Anemia
- Trial name
- NCT06990373
- Where
- Vietnam
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
Ischemic Heart Disease
Myocardial Perfusion Imaging by 15O-H2O PET/CT
The trial will include 5000 patients with evident or suspected ischemic heart disease refered to Department of Nuclear Medicine \& PET Centre, Aarhus University Hospital, for perfusion imaging by 15O-H2O PET/CT scan of the heart…
- Trial name
- NCT04451551
- Where
- Denmark
- Volunteers
- 5,000 people
- Sponsor
- University of Aarhus
Healthy
Non-contrast Enhanced Cardiac Magnetic Resonance Normal Values and Imaging Protocols
One of the main problems in cardiac magnetic resonance (MR) investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations and it is…
- Trial name
- CMR-TECH (NCT01728597)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Chronic Kidney Disease on Hemodialysis
Reference Values for Lower-Limb Dynamometry in Patients With Chronic Kidney Disease (REHAD-CKD)
Patients with chronic kidney disease (CKD) undergoing hemodialysis present musculoskeletal complications, such as sarcopenia, which impair their functionality and are associated with an increased risk of mortality.
- Trial name
- REHAD- CKD (NCT07642778)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Cardenal Herrera University
Hypopharyngeal Peak Pressure
Normative Swallowing Physiological Metrics of Pharyngeal High-Resolution Impedance Manometry in Chinese Adults
As Taiwan enters a super-aged society in 2025, the number of elderly patients and patients with multiple comorbidities continues to increase, and the risk of dysphagia rises with advancing age.
- Trial name
- NCT07594561
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Development, Child, Activity, Motor
Reference Values for the Muscle Power Sprint Test
The goal of this prospective, cross-sectional study is to develop updated reference values for the Muscle Power Sprint Test (MPST) in children aged 5-12 years.
- Trial name
- Ref MPST (NCT06448520)
- Testing
- Muscle Power Sprint Test
- Where
- Netherlands
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Healthy Participants, Reference Values
Cardiac Normal Values Assessed by Magnetic Resonance Imaging
This study carried out a study enrolled healthy volunteers to comprehensively provide age and sex specific reference values of the normal cardiac structure and function of Chinese adults, using the steady-state free precession…
- Trial name
- NCT05346094
- Testing
- No intervention
- Where
- China
- Volunteers
- 938 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Knee Ligament Injury
Reference Values for Knee Rotational Amplitudes in a Population of Athletes
Rupture of the anterior cruciate ligament (ACL) is a frequent and disabling injury in pivot sports, leading to knee laxity and instability, reduced performance and an increased risk of early osteoarthritis.
- Trial name
- PRELAX (NCT07013019)
- Testing
- Measures of overall (internal+external) knee rotational amplitudes
- Where
- 2 sites in France
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Gastrointestinal Transit Time
A Study on Gastrointestinal Transit Time at the Population Level
The goal of this study is to investigate the baseline of gastrointestinal transit time (GITT) and explore its relationship with other health indicators in 932 healthy adult volunteers.
- Trial name
- GITTPop (NCT07309250)
- Testing
- Diet
- Where
- Belgium
- Volunteers
- 932 people, healthy volunteers welcome
- Sponsor
- KU Leuven