Clinical trials: Reflex, Abnormal
Reflex, Abnormal, Bilateral Vestibulopathy
Covert Saccade Triggers in Bilateral Vestibular Hypofunction
Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia.
- Conditions
- Reflex, Abnormal, Bilateral Vestibulopathy, Healthy Volunteers
- Trial name
- CS-TRIGGER (NCT04268615)
- Testing
- Covert Saccades and Virtual Reality, Actives versus passives Head Impulses, Visually guided saccades
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cerebral Palsy, Spastic Cerebral Palsy
Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy
12 adults with spastic CP will complete 6 baseline sessions and 24 down conditioning sessions held 3 times/week. All clinical and physiological assessments collected at baseline will be reassessed after study completion, and…
- Trial name
- SRC-CP (NCT05571033)
- Testing
- Spinal reflex conditioning
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Burke Medical Research Institute
Stroke, Chronic Stroke
Reflex Excitability in Post-stroke Stiff-Knee Gait
The purpose of this study is to examine the reflex excitability of the rectus femoris in individuals with and without post-stroke Stiff-Knee gait.
- Conditions
- Stroke, Chronic Stroke, Gait, Hemiplegic, Gait, Spastic
- Trial name
- NCT04947865
- Testing
- Peripheral nerve stimulation, Commercial knee brace
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Reflex, Abnormal
Reliability of Methods for Determining the Vibration Threshold
It is known that whole-body vibration (TVV) has beneficial neuromuscular effects such as muscle strength increase. These beneficial effects are explained by the muscular reflex response induced by TVV.
- Trial name
- IPMTRH (NCT05129982)
- Testing
- whole body vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Radiculopathy, Hoffman's Reflex
The Diagnostic Role of Adding the Hoffman Reflex Study for L5 Radiculopathy in the Electrodiagnostic Laboratory
The H-reflex is one of the most popular topics in reflexology and one of the late responses involved in routine nerve conduction studies in the electromyography (EMG) laboratory.
- Trial name
- NCT05269602
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- TC Erciyes University
Lumbar Radiculopathy, Hoffman's Reflex
High-power Laser Versus Pulsed Electromagnetic Therapy in Lumbar Radiculopathy.
To compare between high-power laser versus pulsed electromagnetic therapy on pain and Hoffman reflex in lumbar radiculopathy.
- Conditions
- Lumbar Radiculopathy, Hoffman's Reflex, Pulsed Electromagnetic Therapy, Laser Therapy
- Trial name
- NCT07393750
- Testing
- high-power laser, Pulsed electromagnetic field, physiotherapy program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Muscle Spasticity
Peripheral Modulation of Muscle Stiffness and Spasticity
This is a single-center, double-blind, randomized, placebo-controlled, sequential Phase II trial of human recombinant hyaluronidase injections in individuals with post-stroke upper limb muscle stiffness.
- Trial name
- NCT03306615
- Testing
- Hyaluronidase
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Johns Hopkins University
Vestibular Hypofunction, Binocular Vision Abnormalities
Visual Influences on Vestibular Adaptation
The goal of this study is to learn whether a balance-training exercise called incremental vestibulo-ocular reflex adaptation (IVA) is safe and effective for adults with vision impairments, with or without additional vestibular…
- Conditions
- Vestibular Hypofunction, Binocular Vision Abnormalities, Reduced Vision
- Trial name
- NCT07380256
- Testing
- StableEyes: Incremental Vestibulo-Ocular Reflex Adaptation (IVA)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Amputation, Phantom Limb Pain
Neuromodulation in Lower Limb Amputees
The goal of this study is to investigate the role of transcutaneous spinal cord stimulation on spinal cord excitability in lower limb amputees.
- Conditions
- Amputation, Phantom Limb Pain, Hoffman's Reflex
- Trial name
- NCT04543786
- Testing
- Transcutaneous spinal cord stimulation
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Pittsburgh
Muscle Hypertonia, Reflex, Abnormal
Optimal Interstimulus Interval For Consecutive H-Reflex Responses In Patients With Spasticity
This study evaluates the optimal interstimulus interval for consecutive H-reflex responses in patients with spasticity.
- Trial name
- NCT04005937
- Testing
- H-reflex
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Reflex, Abnormal
Prepulse Inhibition in Youth Contact Sports Players
The study's main research question will be investigating whether or not there is a significant difference in Prepulse Inhibition (PPI) as well as startle response probability and magnitude between contact and noncontact youth…
- Trial name
- NCT04058184
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Stroke
Validation of a Spasticity Measurement Tool
The objective of this project is to investigate the validity of a handheld spasticity measurement tool against standard clinical measurements of spasticity.
- Trial name
- NCT05374174
- Testing
- Tardieu Scale for Spasticity
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab
Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology
Accuracy of the Red Reflex Test in the Pediatric Population
This study is designed to investigate the sensitivity and specificity of the Red Reflex Test (RRT), with and without dilation, for early detection of ocular abnormalities in children and newborns.
- Conditions
- Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology, Optic Nerve Diseases, Retinal Disease
- Trial name
- NCT04125043
- Testing
- Direct ophthalmoscope
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Reflex, Ankle, Decreased
The Reflex Mechanism Underlying Neuromuscular Effects Of The Whole Body Vibration
This study was conducted to determine whether the spinal reflex mechanism underlying the neuromuscular effects of whole body vibration (WBV) is tonic vibration reflex.
- Trial name
- WBV-IRM (NCT04516798)
- Testing
- vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Spasticity
Long-term Surveillance of the MedStream Programmable Infusion System
This post-approval study will primarily evaluate the long-term safety of the MedStream Programmable Infusion System when used in combination with Baclofen for the treatment of severe spasticity.
- Trial name
- NCT01712087
- Testing
- MedStream Programmable Infusion System
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Codman & Shurtleff
Reflex, Abnormal
Determination of Onset Point of Mechanical Stimulation
The difference between latencies of the tonic vibration reflex or T-reflex and whole body vibration-induced muscular reflex may be related to the distance between their stimulation point and the muscle spindles.
- Trial name
- TrueRL (NCT04347083)
- Testing
- Electrodiagnostic test
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Muscle Weakness
Controlled Trial of 3,4-Diaminopyridine (3-4DAP) in Lambert-Eaton Myasthenic Syndrome (LEMS)
The main purpose for this study is to provide access to 3,4 DAP, a drug which has demonstrated to be effective in treating weakness associated with Lambert-Eaton Myasthenic Syndrome.
- Trial name
- 3-4DAP (NCT02090725)
- Testing
- 3-4 Diaminopyridine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeffrey A. Cohen, MD
Increased Lordosis/Scoliosis, Hyporeflexia
Biomarker for Duchenne Muscular Dystrophy
International, multicenter, observational, longitudinal study to identify biomarker/s for Duchenne Muscular Dystropy (DMD) and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s.
- Conditions
- Increased Lordosis/Scoliosis, Hyporeflexia, Duchenne Muscular Dystrophy, Red-Green Color Blindness
- Trial name
- BioDuchenne (NCT02994030)
- Where
- 12 sites in Albania, Egypt and 6 more
- Volunteers
- 103 people
- Sponsor
- CENTOGENE GmbH Rostock
Anesthesia; Adverse Effect, Reflex, Abnormal
The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea
The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.
- Conditions
- Anesthesia; Adverse Effect, Reflex, Abnormal, Tinnitus, Spontaneous Oto-Acoustic Emission
- Trial name
- NCT02062333
- Testing
- Dexmedetomidine, esmolol
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- TC Erciyes University
Primary Biliary Cholangitis, Intrahepatic Bile Duct Cancer
Patients With Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a chronic autoimmune disease characterized by progressive destruction of the small intrahepatic bile ducts, leading to cholestasis and potential progression to cirrhosis.
- Conditions
- Primary Biliary Cholangitis, Intrahepatic Bile Duct Cancer, Cancer Liver
- Trial name
- BILIFLEX (NCT07573514)
- Testing
- Reflex AMA and ANA testing
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS