Clinical trials: Reflux, active
Gastroesophageal Reflux
RETHINK REFLUX Registry
The RETHINK REFLUX Registry is a post-market prospective, multi-center, observation, single arm, long-term safety surveillance registry of subjects implanted with the LINX device.
- Trial name
- NCT04253392
- Testing
- LINX Reflux Management System
- Where
- 28 sites in United States, Austria and 4 more
- Volunteers
- 500 people
- Sponsor
- Ethicon Endo-Surgery
Mitral Regurgitation
Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial
Evaluate the safety and efficacy of Medtronic Intrepid™ TMVR TF System in patients with moderate-to-severe or severe symptomatic mitral regurgitation, or moderate symptomatic mitral regurgitation combined with mitral stenosis in…
- Trial name
- APOLLO-EU (NCT05496998)
- Testing
- Medtronic Intrepid™ TMVR TF System
- Where
- 38 sites in Denmark, France and 6 more
- Volunteers
- 400 people
- Sponsor
- Medtronic Cardiovascular
Paraesophageal Hernia, GERD
Mesh Vs Pledgets for Repair of Paraesophageal Hernia
The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at…
- Trial name
- NCT05974722
- Testing
- OviTex Mesh, Pledgeted sutures
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- David Krpata
Obese Adults
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity
This study will assess whether a single subcutaneous dose of tirzepatide 7.5 mg , compared with saline placebo, increases total esophageal acid exposure time during a 96-hour wireless pH recording beginning about 48 hours after…
- Trial name
- NCT07893457
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Erosive Gastroesophageal Reflux Disease
Post-Marketing Surveillance to Evaluate the Safety and Effectiveness of Zastaprazan Citrate
This post-marketing surveillance aims to evaluate the safety and effectiveness of zastaprazan citrate administered in Korean patients receiving the drug in accordance with the approved prescribing information.
- Trial name
- NCT07894939
- Testing
- zastaprazan citrate
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Hiatus Hernia, Gastreoesophageal Reflux Disease
Phrenoesophageal Ligament Reconstruction With Mesh
Introduction: The phrenoesophageal ligament (PEL) is a crucial structure that attaches the esophagus to the diaphragm, allowing for independent movement during respiration and swallowing.
- Trial name
- NCT07251010
- Testing
- Phrenoesophageal Ligament Reconstruction with Mesh: A New Approach to Hiatal Hernia Repair (Alinasser's Technique), Classic approach
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Clinical Trial Aseer
Early Gastric Cancer, Adenocarcinoma of the Stomach
SPADE Clinical Trial.
Purpose: This multicenter, prospective, single-arm phase 2 clinical trial aims to evaluate the safety, feasibility, and clinical outcomes of the SPADE operation (Spade-Shaped Anastomosis) in patients undergoing laparoscopic or…
- Conditions
- Early Gastric Cancer, Adenocarcinoma of the Stomach, Proximal Gastric Cancer, SPADE Operation
- Trial name
- SPADE (NCT07892183)
- Testing
- Spade-Shaped Anastomosis after Laparoscopic or Robotic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomac
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- National Cancer Center, Korea
Gastro Esophageal Reflux Disease
Endoscopic Treatment of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) occurs when stomach acid repeatedly flows back into the tube connecting your mouth and stomach (esophagus). This backwash (acid reflux) can irritate the inner lining of the esophagus.
- Trial name
- NCT05678491
- Testing
- Endoscopic mucosal band ligation
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- St. Olavs Hospital
Abdominoplasty, Diaphragm
Gastroesophageal Reflux and Respiratory Function in Patients Undergoing Abdominoplasty
The objective of this observational study is to compare parameters of diaphragmatic mechanics, respiratory muscle function, and thoracoabdominal kinematics among women with gastroesophageal reflux disease (GERD) and a history of…
- Conditions
- Abdominoplasty, Diaphragm, Respiratory Mechanics, Gastroesophageal Reflux Disease
- Trial name
- NCT07868562
- Testing
- Assessment of anthropometric and sociodemographic data and clinical history, Assessment of Symptoms, Quality of Life, and Physical Activity, Spirometric assessment
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Omentopexy, Sleeve Gastrectomy
De Novo Gastroesophageal Reflux Disease After Sleeve Gastrectomy With and Without Omentopexy
The goal of this clinical trial is to compare the effects of sleeve gastrectomy with and without omentopexy on gastroesophageal reflux disease (GERD) in patients with obesity.
- Conditions
- Omentopexy, Sleeve Gastrectomy, Gastroesophageal Reflux Disease
- Trial name
- NCT07854613
- Testing
- Sleeve Gastrectomy With Omentopexy, Sleeve Gastrectomy Without Omentopexy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- China-Japan Friendship Hospital
GERD
PROPER-GERD: A Prospective Crossover Study to Evaluate Probe Placement Optimization for Reflux Testing in Women and Lower-BMI Patients
This is a prospective, within-subject controlled study involving simultaneous dual placement of wireless Bravo pH probes in each participant.
- Trial name
- PROPER-GERD (NCT07716592)
- Testing
- Bravo pH monitoring sessions
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Valvular Heart Disease Stenosis and Regurgitation (Diagnosis), Pulmonary Hypertension (Diagnosis)
Prospective Evaluation of AI-ECG for SHD Detection
AI-ECG-SHD is a multicentre prospective observational diagnostic accuracy study evaluating artificial intelligence-enhanced electrocardiography (AI-ECG) for the detection of structural heart disease in adults undergoing…
- Conditions
- Valvular Heart Disease Stenosis and Regurgitation (Diagnosis), Pulmonary Hypertension (Diagnosis), Heart Failure With Reduced Ejection Fraction (HFrEF; Diagnosis), Heart Failure With Preserved Ejection Fraction (HFpEF; Diagnosis)
- Trial name
- AI-ECG-SHD (NCT07057466)
- Testing
- Traditional 12-lead Electrocardiogram, Apple Watch Series 4 Single-lead Electrocardiogram, Eko Core 500 Digital Stethoscope 3-lead Electrocardiogram
- Where
- 6 sites in United Kingdom
- Volunteers
- 590 people
- Sponsor
- Imperial College London
Gastroesophageal Reflux Disease, Emotional Distress
Mindfulness Intervention for Emotional Distress (MIED) in Patients With GERD
The goal of this multicenter randomized waitlist-controlled clinical trial is to evaluate whether an online Mindfulness-Based Intervention for Emotional Distress (MIED) can reduce emotional distress and reflux-related symptoms in…
- Trial name
- NCT07667894
- Testing
- TAU, MIED
- Where
- 15 sites in China
- Volunteers
- 500 people
- Sponsor
- Xinghua Liu
Symptomatic Non-erosive Gastroesophageal Reflux Disease
A Study to Evaluate the Efficacy and Safety of Vonoprazan 10 mg Compared to Placebo for Relief of Episodic Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease Through 24 Weeks
The main objective is to assess the efficacy of vonoprazan (10 mg as needed) compared to placebo (as needed) in relief of episodic heartburn at 2 hours that is sustained for 24 hours over 12 weeks of treatment in participants…
- Trial name
- NCT07752407
- Testing
- Vonoprazan
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Phathom Pharmaceuticals, Inc.
Gastro Esophageal Reflux
Assessment of Esophageal Epithelium Integrity With Use of a Novel Mucosal Impedance Device
The objective of this study is to design and use a novel, minimally invasive mucosal impedance (MI) technology to inexpensively and accurately test mucosal health in suspected gastroesophageal reflux disease (GERD) and nonerosive…
- Trial name
- NCT03103789
- Testing
- single catheter mucosal impedance testing, balloon assembly mucosal impedance testing
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Stress Ulcers, Reflux Episodes
Efficacy and Safety of Esomeprazole 40 mg IV in Post-Surgical Patients Admitted to the ICU
Critically ill patients admitted to intensive care units (ICUs) are predisposed to upper gastrointestinal (GI) bleeding secondary to stress-related mucosal damage.
- Trial name
- NCT07399054
- Testing
- Esomeprazole
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Obesity & Overweight, Gastroesophageal Reflux Disease
Effect of Omeprazole on Gut Microbiota in Adults With Obesity and GERD
This randomized, open-label, parallel-group study will evaluate the effect of short-term omeprazole therapy on gut and oral microbiota in adults aged 50-65 years with obesity and symptomatic gastroesophageal reflux disease.
- Trial name
- NCT07850960
- Testing
- Omeprazole, Standard Non-pharmacological Recommendations for GERD
- Where
- Russia
- Volunteers
- 26 people
- Sponsor
- Federal State Budgetary Scientific Institution
Gastroesophageal Reflux Disease With Esophagitis
PPI Dosing Per CYP2C19 Genotype
This study is being done to determine if the dosing of proton pump inhibitor (PPI) medication based on CYP2C19 genotype-derived phenotype leads to improved healing of erosive esophagitis compared to conventional PPI medication…
- Trial name
- NCT07843264
- Testing
- CYP2C19 based dosing Proton Pump Inhibitors, Conventional proton pump inhibitor dose
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Florida
Digestive System Disorder, Dyspepsia
Domperidone in Treating Patients With Gastrointestinal Disorders
This phase III trial studies how well domperidone works in treating patients with gastrointestinal disorders. Domperidone may help control chronic gastrointestinal disorders and their symptoms, such as pain, bloating, and nausea…
- Conditions
- Digestive System Disorder, Dyspepsia, Esophagitis, Gastroesophageal Reflux Disease
- Trial name
- NCT01696734
- Testing
- Domperidone, Questionnaire Administration
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- M.D. Anderson Cancer Center
Gastroesophageal Reflux
Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of Gastroesophageal Reflux Disease (GERD)
GERD affects roughly 20% of the U.S. population and the direct and indirect costs of GERD are substantial, totaling close to 50 billion dollars per year.
- Trial name
- NCT04960566
- Testing
- Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Northwestern University