Clinical trials: Reflux Esophagitis
Gastroesophageal Reflux Disease With Esophagitis
PPI Dosing Per CYP2C19 Genotype
This study is being done to determine if the dosing of proton pump inhibitor (PPI) medication based on CYP2C19 genotype-derived phenotype leads to improved healing of erosive esophagitis compared to conventional PPI medication…
- Trial name
- NCT07843264
- Testing
- CYP2C19 based dosing Proton Pump Inhibitors, Conventional proton pump inhibitor dose
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Florida
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease
Morphological Markers of Gastroesophageal Reflux Disease (GERD)
The purpose of this project is to learn more about a new and promising way to diagnose acid reflux disease using a very high-powered microscope.
- Trial name
- NCT01921686
- Testing
- Sample collection and Questionnaire
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Gerd, Eosinophilic Esophagitis
Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:
Background \& Significance Chronic benign esophageal disorders such as Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis are common gastrointestinal disorders affecting nearly 20% and 0.1% of the population…
- Trial name
- NCT07227506
- Testing
- MuVI Esophageal mucosal impedance testing
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Healthy Volunteers
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of X842 in Human: A Single/Multiple Ascending Dose Study
The purpose of this study is to assess and analyze the safety, tolerability and PK/PD data following single ascending and multiple ascending doses of X842 in healthy subjects.
- Trial name
- NCT03105375
- Testing
- Single ascending dose of X842, Multiple ascending dose of X842, Losec
- Where
- Sweden
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy
Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy
The goal of this observational study is to learn whether bile acids and pepsin in saliva can help identify adults at higher risk of developing reflux-related esophageal disease after sleeve gastrectomy, including Los Angeles…
- Conditions
- Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy, Saliva Collection, Reflux Esophagitis (RE)
- Trial name
- ABSORB (NCT07607067)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Esophageal Diseases, Achalasia
PRospective Registry of Esophageal Motility
Digestive physiopathology is a branch of gastroenterology aiming to study patients with upper GI symptoms, mainly gastro-esophageal, potentially indicating the presence of Gastroesophageal Reflux Disease (GERD)/Barrett Esophagus…
- Conditions
- Esophageal Diseases, Achalasia, Eosinophilic Esophagitis, Motility Disorder
- Trial name
- PREM (NCT07506746)
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Eosinophilic Esophagitis (EoE)
BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS (ESCAPE STUDY)
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disorder of the esophagus that can lead to symptoms such as dysphagia and food impaction.
- Trial name
- ESCAPE (NCT07102329)
- Where
- Italy
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Gastroesophageal Reflux Disease
Mass Balance Study of [14C]X842 in Healthy Adult Male Subjects
This study is a single-site, single-dose, non-randomized, open-label study to assess the absorption, metabolism, and excretion profile of [14C]X842 in healthy adult male subjects.
- Trial name
- NCT07107672
- Testing
- [14C]X842
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
GERD, Reflux
Role of ARMA in Selective Subset of Refractory GERD Patients.
To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).
- Conditions
- GERD, Reflux, Reflux Esophagitis
- Trial name
- NCT05899491
- Testing
- ARMA, UGI Endoscopy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Erosive Esophagitis, Heartburn
A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily
The primary objective is to determine the pharmacokinetics (PK) of vonoprazan in breast milk of healthy lactating women who have received vonoprazan administered once daily or vonoprazan 20 mg administered twice daily for 4…
- Conditions
- Erosive Esophagitis, Heartburn, Symptomatic Nonerosive Gasroesophageal Reflux Disease, Helicobacter Pylori Infection
- Trial name
- NCT06391177
- Testing
- Vonoprazan
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Phathom Pharmaceuticals, Inc.
Esophagitis, Gastro Oesophageal Reflux Disease
Clinical Investigation to Assess the Acid Neutralisation Activity of a Calcite Chewing Gum
This investigation is designed to evaluate the acid neutralisation action of a new test product versus unmatched placebo.
- Trial name
- NCT05129670
- Testing
- Calcite chewing gum
- Where
- Ireland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Esophageal Adenocarcinoma, Barrett's Esophagus
Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome
This is a randomized, open-label pilot study to assess whether treatment with chlorhexidine mouthwash can alter the esophageal and gastric cardia microbiome
- Conditions
- Esophageal Adenocarcinoma, Barrett's Esophagus, Reflux Esophagitis
- Trial name
- Mouthwash (NCT02513784)
- Testing
- Chlorhexidine gluconate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Esophageal Diseases, Esophagitis
Twenty Four Hour Ambulatory pH & Impedance Testing: Normative Data for Indian Population
GERD is common in Indian population and the normative data which is used to diagnose \& manage GERD and its complications are based on western data which is not validated in the Indian population.
- Conditions
- Esophageal Diseases, Esophagitis, Reflux Disease
- Trial name
- NCT05004155
- Testing
- 24 hour pH & impedance monitoring
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Gastroesophageal; Reflux With Esophagitis, Gastroesophageal Reflux
Study of Dietary Patterns and Food Diversity in Russian GERD Patients
The aim of the study is to assess food diversity and dietary patterns in Russian GERD patients
- Conditions
- Gastroesophageal; Reflux With Esophagitis, Gastroesophageal Reflux, GERD, Heartburn
- Trial name
- NCT04252144
- Testing
- Dietary assessment
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Eosinophilic Esophagitis
Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies
The purpose of this research study is to compare the safety and effectiveness of three commonly used techniques for delivering anesthesia during a procedure known as esophagogastroduodenoscopy.
- Trial name
- NCT02038894
- Testing
- Intubated with Sevoflurane (IS), Intubated with Propofol (IP), Zofran - no intubation
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Healthy Volunteers
Single-dose and Multiple-dose X842 Phase 1 Study
The purpose of this study is to evaluate the safety and tolerability of X842 after administration of single and multiple doses in healthy subjects
- Trial name
- NCT04293965
- Testing
- Single ascending dose of X842, Multiple ascending dose of X842, Food Effect
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Gastroesophageal Reflux Disease With Esophagitis
Evaluate the Intestinal Microbiome in Patients With Erosive Gastroesophageal Reflux Disease and in Asymptomatic Healthy Controls
. In this study, we investigated intestinal microbiomes, in individuals with Gastroesophageal Reflux Disease and healthy individuals, using metagenomic techniques.
- Trial name
- NCT04248296
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Gastro Esophageal Reflux, Barrett Esophagus
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
- Trial name
- NCT03228407
- Testing
- Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGuire Research Institute
Gastroesophageal Reflux Disease, Minimal Change Disease
Diagnostic Value of Linked Color Imaging for Minimal Change Esophagitis in Nonerosive Reflux Esophagitis and GERD
Linked color imaging(LCI),a new system for endoscopy modality,creates clear and bright endoscopic images by using short-wavelength narrow-band laser light combined with white laser light on the basis of magnifying blue laser…
- Conditions
- Gastroesophageal Reflux Disease, Minimal Change Disease, Non-Reflux Esophagitis
- Trial name
- NCT03068572
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Dysphagia, Dysplasia
Esophageal Cytology With FISH in Detecting Esophageal Cancer
This clinical trial studies whether esophageal cytology plus fluorescence in situ hybridization (FISH) is equal to or better than esophago-gastro-duodenoscopy (EGD) or upper endoscopy for the early detection of esophageal cancer.
- Conditions
- Dysphagia, Dysplasia, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT02100189
- Testing
- Cytology Specimen Collection Procedure, Esophagogastroduodenoscopy, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute