Clinical trials: Refractive Error - Myopia
Myopia, Hyperopia
Clinical Evaluation of Two Frequent Replacement Soft Spherical Contact Lenses
This was a single-blind (participant masked), interventional, prospective, direct refit, bilateral wear short-term fitting study.
- Trial name
- NCT05656885
- Testing
- Lens A, Lens B
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Myopia, Myopic Astigmatism
Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia
The objectives of this study are to evaluate the safety and efficacy of a treatment regimen for high myopia and myopic astigmatism: LASIK followed by crosslinking performed with the KXL Crosslinking-System and VibeX Xtra…
- Conditions
- Myopia, Myopic Astigmatism, Crosslinking, Corneal Ectasia
- Trial name
- NCT03913338
- Testing
- LasikXtra, LASIK
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Myopia
Clinical Evaluation of Etafilcon A Contact Lenses Using a Novel Molding Process 2
This study is a multi-site, group sequential, adaptive, randomized, double-masked, 2×2 crossover design, 1-week dispensing study.
- Trial name
- NCT03701516
- Testing
- etafilcon A with novel molding process, etafilcon A with current molding process
- Where
- 12 sites in United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia, Refractive Error
Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface
The purpose of this study is to utilize in-vivo confocal microscopy to describe differences in corneal epithelial immune status across three lens care regimens in new contact lens wearers.
- Trial name
- NCT01250925
- Testing
- ReNu MultiPlus® MultiPurpose Solution, OPTI-FREE® RepleniSH®, Clear Care®
- Where
- 2 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Myopia, Accommodation
Dynamic Change in Accommodation After Wearing Multifocal Soft Contact Lenses for Myopia Control
The purpose of this study is to report the changes in accommodation, aberrations, and myopia in patients wearing multifocal soft contact lens for various durations. The study objectives are to: 1.
- Trial name
- NCT04763694
- Testing
- Multifocal soft contact lenses
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- State University of New York College of Optometry
Myopia
Safety and Efficacy Study of A Viscoelastic-free Method for Implantable Collamer Lens (ICL) Implantation
This study evaluates the safety and efficacy of a viscoelastic-free method for Implantable Collamer Lens(ICL) implantation to treat high myopia.
- Trial name
- NCT03059043
- Testing
- viscoelastic-free implantation system, standard viscoelastic-assisted Implantation system
- Where
- 5 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Myopia, Astigmatism
Wavefront-guided Photorefractive Keratectomy (PRK) Versus Wavefront-guided Lasik for Myopia
A prospective comparison of eyes undergoing wavefront-guided LASIK in one eye and wavefront-guided PRK in their fellow eye for myopia.
- Trial name
- NCT01140594
- Testing
- Photorefractive keratectomy, Laser in-situ keratomileusis
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Stanford University
Myopia, Preschool
Early Intervention for Premyopic Children
The purpose of this research project is to add evidence of pharmacological (0.01% atropine) and optical (Defocus Integrated Multiple Segments spectacle lenses) approaches for myopia prevention among premyopic preschoolers, which…
- Trial name
- NCT06200194
- Testing
- MiyoSmart Spectacles, 0.01% atropine
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Myopia, Myopia, Progressive
Multicenter RCT: LED Red Light Dose-Response in Myopia Progression Control
The goal of this clinical trial is to verify the effectiveness and safety of non-laser LED red light combined with defocus lens therapy for controlling myopia progression and evaluate the impact of different intervention…
- Trial name
- NCT07330180
- Testing
- Yingtong Vision Rehabilitation Instrument, Hoya DIMS multi-point myopia defocus lens
- Where
- 7 sites in China
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Myopia
Overall Performance of a 1-day Silicone Hydrogel Lens When Habitual Soft Lens Wearers Are Refit
The objective of the study is to compare the overall subjective comfort profile over 8 hours of lens wear in two groups of habitual soft contact lens wearers (daily disposable hydrogel lenses and frequent replacement lenses) when…
- Trial name
- NCT02588573
- Testing
- etafilcon A (control), somofilcon A (test)
- Where
- 2 sites in Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Juvenile Myopia
Control of Myopia Using Novel Spectacle Lens Designs
Randomized, controlled, multisite, subject-and observer-masked, 3-arm parallel group clinical trial of 36-month duration to evaluate the safety and efficacy of a novel spectacle lens design in reducing the progression of juvenile…
- Trial name
- CYPRESS (NCT03623074)
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- 14 sites in United States, Canada
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Presbyopia, Near Vision
Validation of an Activities-of-daily-living Framework at Different Light Conditions
Primary objective of this study is the construction and validation of an experimental environment for the simulation of a variety of near- and intermediate-vision activities of daily living (ADLs) in different combinations of…
- Conditions
- Presbyopia, Near Vision, Reading, Daily Activities
- Trial name
- NCT05005624
- Testing
- ADL performance
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Myopia
Wavelength Intervention for Nearsighted Kids
The goal of this clinical trial is to learn if daily brief periods of specialized soft contact lens wear work to slow the progression of nearsightedness in children.
- Trial name
- WINK (NCT06598423)
- Testing
- Specialized soft contact lens 1, Specialized soft contact lens 2
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Asthenopia, Myopia
The Impact of Soft Contact Lens Attributes on Symptoms Associated With Digital Eye Strain in Symptomatic Soft Contact Lens Wearers
Despite its prevalence, the ocular causes of eye fatigue or unknown and may be related to the cornea/contact lens surface, the accommodative system, the convergence system, overall postural/muscle fatigue, or a combination of…
- Trial name
- NCT03585790
- Testing
- Contact lens with Multifocal Optics, Contact lens with Single Vision Optics
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pete Kollbaum, OD, PhD
Presbyopia, Refractive Errors
Evaluation of the Safety and Effectiveness of Aceclidine (LNZ101) and Aceclidine + Brimonidine (LNZ100) in the Treatment of Presbyopia
To evaluate the safety and effectiveness of Aceclidine/Brimonidine (LNZ101) compared with Aceclidine (LNZ100) and vehicle in the treatment of Presbyopia.
- Conditions
- Presbyopia, Refractive Errors, Eye Diseases
- Trial name
- NCT05431543
- Testing
- Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle proprietary ophthalmic solution
- Where
- 5 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Myopia
Effect of Axial Length of the Globe on Retinal Nerve Fibre Thickness
the goal of this obsrevational study is to learn about retinal nerve fibres and if their numbers changed with axial length of the globe or not.
- Trial name
- NCT05716776
- Testing
- Optical coherence tomography (OCT)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Glaucoma, Myopia
Efficacy of Retinal Nerve Fiber Layer (RNFL) / Retinal Thickness Ratio by Cirrus OCT Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma
Glaucoma is presumed to be an axonal disease which starts at the lamina cribrosa. This assumption has led to the monitoring of the retinal nerve fiber layer thickness for the diagnosis and monitoring of progression of glaucoma.
- Trial name
- NCT00772993
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Myopia, Amblyopia
Myopia Control With Three Lever Irradiance of PBM Therapy in Children and Adults
Photobiomodulation therapy, that is, Low-level red-light technology provides a new and innovative myopia control approach. This strategy enables relatively high energies of light to be delivered at much shorter durations of…
- Conditions
- Myopia, Amblyopia, Refractive Error - Myopia Axial, Ametropia
- Trial name
- MCPT (NCT05957458)
- Testing
- Airdoc device of red light for Myopia
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Airdoc Technology Co., Ltd.
Myopia, Astigmatism
LASIK Using the Alcon Allegretto Wavefront-Guided Excimer Laser vs AMO Visx Wavefront-Guided Excimer Laser
The purpose of the study is to compare the results of LASIK surgery when using Alcon Allegretto wavefront-guided excimer laser system compared to AMO Visx Custom wavefront-guided excimer laser system in patients with…
- Trial name
- LASIK (NCT01454843)
- Testing
- Wavefront-guided LASIK - Allegretto, Wavefront-guided LASIK - AMO
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Myopia, Astigmatism
Early Changes Between Lenticule Extraction and Small-Incision Lenticule Extraction
The aim is to evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures.
- Trial name
- NCT02540785
- Testing
- lenticule extraction, small-incision lenticule extraction
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University