Clinical trials: Refractive Error - Myopia
Myopia
Performance Comparison Between Fanfilcon A and Senofilcon A Sphere Lenses
Prospective, multi-center, bilateral, double-masked, randomized, cross-over, daily wear, 1 month dispensing study (2 weeks each lens pair)
- Trial name
- NCT02956460
- Testing
- fanfilcon A, senofilcon A
- Where
- 4 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Myopia
A Contralateral Dispensing Clinical Trial of Study Test Silicone Hydrogel Lens Against Enfilcon A Silicone Hydrogel Lens
This will be a 1-month dispensing, double-masked, randomized, contralateral study comparing the test lens against the control lens. The assignment of lenses to eyes (i.e.
- Trial name
- NCT02537717
- Testing
- Sapphire Lens, enfilcon A
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Nearsightedness
Effect of Defocus in Soft Contact Lenses on Internal Retinal Vascularization
The purpose of this study is to gain a better understanding of the retinal vascular changes that occur in response to the optical effect of a myopic defocus daily disposable soft contact lens (MDSL) in a group of healthy young…
- Trial name
- NCT06527274
- Testing
- Experimental: Myopic defocus soft lens design (MDSL), Active Comparator: Single vision soft lens design (SVSL
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Myopia
Lacritin and Heparanase Levels in Human Tears After Laser Refractive Surgery
The purpose of this study is to measure tear lacritin and heparanase levels before and following surgery using a minimal risk procedure to collect tears from patients undergoing PRK or LASIK.
- Trial name
- NCT01049724
- Testing
- Tear collection
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Fort Belvoir Community Hospital
Myopia, Randomized Controlled Trials
Effect of a Myopia Prediction System on Myopia Prevention and Control
The global rise in myopia, particularly among children and adolescents in China, underscores the inadequacy of current prevention strategies, indicating that conventional screening and education alone are insufficient to curb the…
- Conditions
- Myopia, Randomized Controlled Trials, Artificial Intelligence (AI)
- Trial name
- NCT06633393
- Testing
- Feedback on Predicted High Myopia Risk at Age 18 Using the Myopia Prediction System, Feedback on Ophthalmic Examinations
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia
Adaptation To and Satisfaction With Contact Lens Wear In Myopic Young Adults
The purpose of this study was to assess whether young adults could adapt to and achieve satisfaction with a daily disposable contact lens.
- Trial name
- NCT04857723
- Testing
- daily disposable contact lens
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Myopia, Hyperopia
Comparative Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions
A new multi-purpose solution (MPS)was clinically evaluated against Opti-Free RepleniSH MPS at specific time points over the course of four days. The study was conducted with PureVision lenses.
- Conditions
- Myopia, Hyperopia, Astigmatism
- Trial name
- NCT01024855
- Testing
- RevitaLens OcuTec MPS (Investigational MPS) and Opti-Free RepleniSH MPS (control)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Myopia
Myopia Control Efficacy of Second-generation DIMS Spectacle Lenses on Fast Progressing Myopes
The purpose of this study is to examine the efficacy and performance of the variant of Defocus Incorporated Spectacle lenses on controlling myopia progression in fast progressing myopic children.
- Trial name
- NCT05888792
- Testing
- Variant of Defocus Incorporated Spectacle lens (DG2)
- Where
- Hong Kong
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Myopia
Topical Application of Low-concentration (0.01%) Atropine on the Human Eye With Fast and Slow Myopia Progression Rate
Our project is a 24-month longitudinal randomized controlled trial that aims to investigate the myopia development after topical application of 0.01% atropine in children with either fast or slow myopia progression classified…
- Trial name
- NCT03374306
- Testing
- Atropine (0.01%), Artificial tear
- Where
- Hong Kong
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Myopia, Progressive
Safety, Tolerability and Pharmacodynamics Evaluation of CBT-009 Eye Drop
This is a Two-Stage Phase 1/2 study to evaluate the safety, tolerability and pharmacodynamics of CBT-009 eye drop in healthy volunteers.
- Trial name
- NCT05372991
- Testing
- CBT-009, Vehicle, Atropine Sulfate
- Where
- Australia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cloudbreak Therapeutics, LLC
Myopia
Ambient Light Levels in the Kindergarten and Schools and the Relation to Refractive Development
Myopia, the most common human eye disorder, is a phenomenon characterized by an unconstrained elongation of the eye globe There are number of theories concerning the environmental effect on the emmetropization process, most are…
- Trial name
- NCT02854891
- Testing
- autorefractometer, A-scan ultrasound
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Myopia, Hyperopia
Evaluation of the Performance of Monthly Replacement Sphere Lens Designs in Habitual Soft Contact Lens Wearers
The objective of the study is to evaluate the clinical performance of two monthly silicone hydrogel contact lenses in habitual wearers of frequent replacement (FRP) lenses when worn for one month.
- Trial name
- NCT05114564
- Testing
- Lens A (comfilcon A lens), Lens B (lehfilcon A lens)
- Where
- 4 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Near Vision, Refractive Error Correction
Clinical Outcomes of the Use of a Femtosecond Laser Treatment in a Patient With Implanted Monofocal IOLs
This study aims to assess the safety and efficacy of evaluating near vision or refractive error in eyes implanted with a mono focal intraocular lens (IOL) using a low-energy femtosecond laser.
- Trial name
- NCT07447622
- Testing
- Device
- Where
- Czechia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Perfect Lens, LLC
Myopia
Comparison of Femto LDV Z8 Corneal Lenticule Extraction for Advanced Refractive Correction (CLEAR) and Visumax Small Incision Lenticule Extraction (SMILE)
This observational study aims to compare two laser corrective procedures for treating myopia and myopic astigmatism: a novel refractive technique, the CLEAR procedure, and the established SMILE procedure.
- Trial name
- NCT06774651
- Testing
- Procedure: Corneal lenticule extraction for advanced refractive correction (CLEAR), Procedure: Small Incision Lenticule Extraction (SMILE)
- Where
- Singapore
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Singapore Eye Research Institute
Myopia
Pilot Study to Assess the Efficacy of Short Exposure to Defocus to Slow the Progression of Myopia in Children
The objective of this pilot study is to establish whether brief periods of high levels of acutely imposed myopic defocus can be used to slow the progression of myopia in children, as measured by changes in spherical equivalent…
- Trial name
- NCT00400140
- Testing
- Hyperopic lens
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Myopia
SEED-LVPEI Myopia Study
This randomized clinical trial study aims to investigate the efficacy of novel SEED's EDOF based mid-lens design in controlling the myopia progression in Indian children with these specific objectives: 1.
- Trial name
- SLIMS (NCT04618510)
- Testing
- SEED 1-dayPure EDOF soft contact lens, Single Vision Spectacles
- Where
- India
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- L.V. Prasad Eye Institute
Myopia
Comparing Silicone Hydrogel Contact Lens Wearers to Hydrogel Contact Lens Wearers and Non-lens Wearers
This study was a multi-site, prospective, randomized, non-masked, unilateral, non-dispensing study.
- Trial name
- NCT04886479
- Testing
- Control, Test Lens
- Where
- 2 sites in Canada, United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Myopia, Myopia, Progressive
Can Distance Center and Near Center Multifocal Contact Lenses Control Myopia Progression in Children?
Myopia has been increasing in prevalence and severity throughout the world over the last 30 years. Increasing levels of myopia are associated with increased frequency and severity of various ocular pathologies.
- Trial name
- ADPADP (NCT03519490)
- Testing
- Hybrid Contact Lens
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas A. Aller, OD
Obesity, Myopia
Beijing (Peking)---Myopia and Obesity Comorbidity Intervention (BMOCI)
Based on the RE-AIM framework, this project intends to integrate the prevention and control measures of myopia and obesity, and establish a set of key suitable technical packages and guarantee systems for the…
- Trial name
- NCT05275959
- Testing
- A cluster randomized trial of a comprehensive intervention nesting family and clinic into school centered implementation to reduce myopia and obesity among children and adolescents in Beijing, China
- Where
- 3 sites in China
- Volunteers
- 3,963 people, healthy volunteers welcome
- Sponsor
- Peking University
Myopia, Progressive
Adverse Events Related to Low Dose Atropine
Progressive myopia can lead to severe vision loss and is associated with retinal detachment, glaucoma, and other comorbidities. Several studies have shown that off-label, low-dose atropine eye drops slow the progression of…
- Trial name
- AELDA (NCT05683535)
- Testing
- Atropine Sulfate
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Scripps Health