Clinical trials: Refractive Error - Myopia
Myopia
Atropine and Spectacle Combination Treatment (ASPECT): 12-month Results of a Randomized Clinical Trial for Myopia Control
Phase IV clinical trial to evaluate whether there is a significant difference in the control of myopia progression in myopic children treated with 0.025% atropine and DIMS spectacle lenses compared to 0.025% atropine and single…
- Trial name
- ASPECT (NCT06431841)
- Testing
- Atropine 0,025%, DIMS Lenses, Monofocal lenses
- Where
- Spain
- Volunteers
- 111 people
- Sponsor
- Hospital San Carlos, Madrid
Myopia
Effects of Projected Peripheral Defocus on Ocular Biometrics
Acucela Inc. intends to develop a medical device to significantly halt or reverse myopic progression, which is a significant public health concern across the world, especially in Asian demographics.
- Trial name
- NCT04388020
- Testing
- Tabletop prototype of eSpecs: Active projection of defocused image in the peripheral visual field, Tabletop prototype of eSpecs: No Active projection of defocused image in the peripheral visual field
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Kubota Vision Inc.
High Myopia
Evaluation of the Prophylactic Use of Mitomycin C 0.02% to Inhibit Haze Formation After Photorefractive Keratectomy for High Myopia: 15 x 30 Seconds
To evaluate and compare the effect of the prophylactic use of two different exposure times of mitomycin C (MMC) 0.02% to inhibit haze formation after photorefractive keratectomy (PRK) for high myopia (> -7.0 D).
- Trial name
- BQ-01-07-ARVO (NCT00564213)
- Testing
- PRK and a single intraoperative topical application of mitomycin C 0.02% for 15 seconds
- Volunteers
- 36 people
- Sponsor
- Instituto de Olhos de Goiania
Cataract, Presbyopia
Retrospective Clinical Investigation of the Safety and Performance of 640PM Trifocal IOL Implantation in Patients With Cataract and/or Ametropia (Hyperopia, Myopia) and/or Presbyopia
The clinical investigation objective is to evaluate safety and performance outcomes of trifocal IOL implantation to improve vision in patients with cataract and/or ametropia (hyperopia, myopia) and/or presbyopia.
- Conditions
- Cataract, Presbyopia, Hyperopia, Myopia
- Trial name
- NCT05735990
- Testing
- Intraocular lens
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Medicontur Medical Engineering Ltd
Emmetropia, Myopia
Effects of Light on the Choroid and Pupil
Monochromatic light creates longitudinal chromatic aberration, with short wavelength blue light forming a focal point in front of the retina and long wavelength red light forming a focal point behind the retina.
- Trial name
- NCT05852782
- Testing
- White Light therapy, Blue light therapy, Red light therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Houston
Astigmatism, Myopia
Comparative Clinical Evaluation of Soft Toric Lens Designs
This study is evaluating the initial fit of toric contact lenses.
- Trial name
- NCT01552876
- Testing
- etafilcon A, nelfilcon A, Filcon II 3
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Presbyopia, Refractive Error
Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia
Phase 3 study to evaluate the safety and effectiveness of LNZ100 \& LNZ101 for the treatment of Presbyopia.
- Conditions
- Presbyopia, Refractive Error, Eye Diseases, Near Vision
- Trial name
- CLARITY 1 (NCT05656027)
- Testing
- Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Brimonidine
- Where
- 25 sites in United States
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Myopia
Effect of Increasing Time Spent Outdoors on Myopia Prevention in School-Aged Children in Northeast China
The purpose of this study is to develop a school-based intervention aimed at prevent the onset and development of myopia among school aged children by increasing time spent outdoors in northeast China.
- Trial name
- NCT02271373
- Testing
- increasing time spent outdoors
- Volunteers
- 3,521 people
- Sponsor
- Anhui Medical University
Myopia
LASIK Flap Thickness and Visual Outcomes Using the WaveLight FS200 Femtosecond Laser
The objective of this study is to evaluate the visual outcome, accuracy, predictability and complications of LASIK flap creation using the Alcon Wavelight FS200 Femtosecond laser and compare these results to those obtained using…
- Trial name
- FS200 (NCT02060461)
- Testing
- FS200 femtosecond laser LASIK, IntraLase femtosecond laser LASIK
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The Cleveland Clinic
Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression.
This is a mono-centre, prospective, one-arm, unmask clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation compared to a single vision spectacle lens from…
- Trial name
- NCT05534022
- Testing
- Test myopia control lenses (BSL)
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Essilor International
Presbyopia
A Dose-ranging Study to Evaluate the Safety and Efficacy of UNR844 in Subjects With Presbyopia.
Study of safety and efficacy of UNR844 in subjects with presbyopia.
- Trial name
- READER (NCT04806503)
- Testing
- UNR844
- Where
- 20 sites in United States, Australia and 2 more
- Volunteers
- 234 people
- Sponsor
- Novartis Pharmaceuticals
Myopia
Clinical Evaluation of the Safety and Efficacy of Yung Sheng 38% Color Contact Lens
This was a single group, open-label clinical study to assess the safety and efficacy of Yung Sheng 38% color contact lens for vision correction.
- Trial name
- NCT06128473
- Testing
- Soft Contact Lens
- Volunteers
- 71 people
- Sponsor
- Yung Sheng Optical Co., Ltd.
Visual Fatigue, Myopia
Exploring the Impact of Dynamic Defocus Display Schemes on Ocular Health Indicators
The present study is designed to explore the effects of dynamic defocus display technology on ocular health parameters using rigorous scientific approaches.
- Trial name
- NCT07291856
- Testing
- Dynamic Defocus Mode
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Myopia
Atropine Eyedrops for Myopia Progression in Children and Adolescents (MODERATO STUDY)
Myopia, or shortsightedness, is a multifactorial disorder, governed by environmental and genetic factors. Myopia is the most common ocular disorder worldwide with an increasing prevalence over the past few decades and affecting…
- Trial name
- MODERATO (NCT07028827)
- Testing
- 0.05% atropine eye drops, 0.025% atropine eye drops
- Where
- 11 sites in Albania, Italy and 3 more
- Volunteers
- 234 people
- Sponsor
- Ocus Innovation Ireland Limited
Myopia, Left Eye
Short Term Refractive and Ocular Parameter Changes After Topical Atropine
In order we had designed a prospective clinical trial. Spherical equivalent refractive error (SER), axial length (AL), mean keratometric value (Mean-K), anterior chamber depth (ACD), and intraocular pressure (IOP) were measured…
- Trial name
- NCT03839888
- Testing
- 0.125% Atropine
- Volunteers
- 96 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Myopia, Mental Health
Intervention for Preventing Myopia and Multimorbidity in Children
This study aims to develop and evaluate a scalable, hybrid intervention model for the co-prevention of myopia, obesity, and mental health issues among children.
- Conditions
- Myopia, Mental Health, Cardiovascular Health Status
- Trial name
- NCT07294222
- Testing
- Standard School Health Education, Multi-component Health Promotion Package
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Myopia
Comparison of Somofilcon A Daily Disposable Test Contact Lens and Somofilcon A Daily Disposable Control Contact Lens
The purpose of this study is to investigate the overall clinical performance of the somofilcon A daily disposable test soft contact lens compared to the somofilcon A daily disposable control soft contact lens.
- Trial name
- NCT03372551
- Testing
- somofilcon A 1 day test lens, somofilcon A 1 day control lens
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- CooperVision, Inc.
Full Spectrum
A Self-controlled Study of the Effect of Partial Spectral Absence of Visible Light on the Pupil
Previous studies have shown that the spectrum of light influences myopia. LED lights with a partially absent light spectrum increase the risk of myopia progression compared to LEDs with a full spectrum, potentially mediated by…
- Trial name
- NCT06501131
- Testing
- full-spectrum light exposure, specific spectrum absence light exposure
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia
Comparative Study to Evaluate the Cosmetic Appearance of Two Brands (Coopervision (CVI) vs. Competitor) of Color Soft Contact Lenses.
Comparative Study to Evaluate the Cosmetic Appearance of Two Brands (Coopervision (CVI) vs. Competitor)of Color Soft Contact Lenses
- Trial name
- NCT02299869
- Testing
- Verde (Competitor-control), Green (CVI-test), Cinza (Competitor-control)
- Where
- Mexico
- Volunteers
- 41 people
- Sponsor
- CooperVision, Inc.
Presbyopia, Myopia
Intrastromal Correction of Ametropia by a Femtosecond Laser
This study evaluates the intrastromal correction of ametropia with a femtosecond laser made by 20/10 PERFECT VISION. This laser generates a beam of ultrashort, infrared pulses which enables very precise cuts in the cornea.
- Conditions
- Presbyopia, Myopia, Hyperopia, Astigmatism
- Trial name
- ISCAF (NCT00928122)
- Testing
- Intrastromal Correction of Presbyopia, Intrastromal correction of Myopia, Intrastromal Correction of Hyperopia
- Where
- 3 sites in Germany
- Volunteers
- 200 people
- Sponsor
- 20/10 Perfect Vision
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