Clinical trials: Refractive Surgery
Refractive Surgery
Comparison Between the SBK Microkeratome Versus Femtosecond Laser in Flap Creation During LASIK Surgery for Myopia
LASIK is the most commonly performed refractive surgery worldwide. It has been shown to be safe and effective procedure with predictable results over long term follow ups.
- Trial name
- NCT05406973
- Testing
- SBK microkeratome versus femtosecond laser in flap creation
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Cataract, Nuclear Sclerosis
Evaluating the Need for the Pseudophakic Intraoperative Abberrometry in Toric IOL Implantation
To determine clinically significant difference in results obtained from cataract surgery using IA. One eye will receive aphakic measurements only and the fellow eye will receive aphakic and then pseudophakic measurements when…
- Conditions
- Cataract, Nuclear Sclerosis, Cortical Cataract, Posterior Subcapsular Cataract
- Trial name
- NCT03819842
- Testing
- Pseudophakic Measurement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alterman, Modi, & Wolter Ophthalmic Physicians & Surgeons
Post-operative Pain Control
Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone
Photorefractive keratectomy (PRK) is a refractive error correction procedure that helps eliminate or reduce the dependence on corrective lenses. An important aspect of PRK is post-operative pain management.
- Trial name
- NCT04399122
- Testing
- acetaminophen/codeine vs acetaminophen/oxycodone
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Corneal Astigmatism
Toric IOL vs Non-toric IOL With LRI for Corneal Astigmatism
The purpose of the study is to compare the astigmatism reducing effect of a toric intraocular lens (IOL) (model MX60T - Bausch \& Lomb) with that of limbal relaxing incisional surgery combined with a non toric IOL (model MX60 …
- Trial name
- NCT03633851
- Testing
- Toric intraocular MX60T lens, Standard MX60 plus corneal incisions
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ashford and St. Peter's Hospitals NHS Trust
Cataract, Presbyopia
Multifocal Intraocular Lens x Monovision x Hybrid Monovision After Bilateral Cataract Surgery
To compare refractive outcomes and patient's visual quality after bilateral cataract surgery when implanting multifocal intraocular lens, monofocal with monovision or hybrid monovision.
- Trial name
- NCT02595177
- Testing
- Cataract surgery with intraocular lens implantation.
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Myopia
A Prospective, Contralateral, Eye to Eye Comparison of SMILE Surgery to LASIK Surgery
Subjects will undergo SMILE surgery in one eye and LASIK surgery in their other eye to correct myopia.
- Trial name
- NCT03067077
- Testing
- SMILE, LASIK
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cataracts
Accuracy of the Galilei Analyzer to Calculate the Effective Corneal Power After Corneal Refractive Surgery
The purpose of this study is to determine the accuracy of the Galilei corneal analyzer to calculate the effective corneal power (keratometry, corneal curvature) in patients who have undergone both corneal refractive surgery and…
- Trial name
- Galilei (NCT00934804)
- Testing
- Galilei dual Scheimpflug analyzer
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cataract; Surgery; Phacoemulsification; Biometry; Intraocular Lens Power
Comparison of SRK-T With Kane Formula for Prediction of Refractive Outcome After Phacoemulsification
Cataract is a leading cause of blindness in the world. Cataract surgery is one of the most commonly performed ocular procedures.
- Trial name
- NCT05564455
- Testing
- Biometry with Kane formula, Biometry with SRK-T formula
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Myopia, Astigmatism
A Study to Investigate the Safety and Effectiveness of Aspheric Laser Refractive Surgery Treatments for Myopia
The objective of this study was to compare the safety and effectiveness of two versions of the Bausch \& Lomb Zyoptix Tissue Saving Aspheric Algorithm versus the current Zyoptix Tissue Saving Algorithm when used for myopia and…
- Trial name
- NCT00365677
- Testing
- The Bausch & Lomb Zyoptix Tissue Saving Aspheric algorithm, The Bausch & Lomb Zyoptix Tissue Saving algorithm
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Visual Acuity
Visual Outcomes of a Segmental Refractive Multifocal Intraocular Lens
To evaluate visual outcomes of a segmental refractive multifocal intraocular lens (IOL) after cataract surgery.
- Trial name
- NCT03452969
- Testing
- Implantation of multifocal intraocular lens
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Cataract Extraction
Microincision Versus Smallincision Combined Surgery
The purpose of this study is to compare refractive outcomes after two different types of combined cataract surgery, namely microinscision cataract surgery and smallincision cataract surgery, and sutureless 23-gauge vitrectomy in…
- Trial name
- NCT01198483
- Testing
- Combined Micro- Surgery, Combined Small-Surgery
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Refractive Errors, Refractive Surgery
Femto-flap Versus SBK Flap,Predictability and Variability
Laser Insitu keratomileusis (LASIK) has become the most popular procedure for refractive error correction. Lasik flap creation is the first and critical step during LASIK surgery because of its consensual effect on a residual…
- Trial name
- NCT04684888
- Testing
- Visumax Femto-flap, Sub Bowman's keratomileusis (SBK)-flap
- Where
- Iraq
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Suzan A Rattan
Myopia, Astigmatism
A Three-Phase Contralateral Comparison of Ray-Tracing Guided LASIK Versus Three Other Refractive Surgery Platforms to Correct Myopia or Myopia With Astigmatism
This purpose of this study is to compare a new form of LASIK called Ray Tracing Guided LASIK to 3 other forms of corneal refractive surgery: 1. KLEx (KeratoLenticule Extraction) using the Zeiss Visumax 800 Laser, 2.
- Trial name
- NCT07201298
- Testing
- Ray-Tracing Guided LASIK, Keratorefractive Lenticule Extraction (KLEx), WaveFront Optimized LASIK
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hoopes Vision
Bilateral LASIK Surgery
A Study to Compare the Safety and Efficacy of a New Eye Drop Formulation With REFRESH PLUS® in Participants Following LASIK Refractive Surgery
This study will compare the safety and efficacy of a new eye drop formulation with REFRESH PLUS® in participants following LASIK surgery.
- Trial name
- NCT01886690
- Testing
- carboxymethylcellulose sodium based new eye drop formulation, carboxymethylcellulose sodium based eye drops
- Where
- 2 sites in Australia, Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Allergan
Myopia
Long-term Effects of Laser Refractive Surgery
This study will determine if there are short- and long-term postoperative differences in visual and corneal outcomes between different laser refractive surgical procedures.
- Trial name
- NCT00350246
- Testing
- Laser Refractive Surgery
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Image, Body
Whole Eye Optical Coherence Tomography (OCT) to Improve Refractive Surgery and Eye Care
The overall objective is to develop the hardware systems and software algorithms necessary to make accurate measurements of the whole eye with optical coherence tomography (OCT).
- Trial name
- NCT03219567
- Testing
- Optical Coherence Tomography (OCT), Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Duke University
Refractive Surgery
The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study
To determine patient preference and treatment outcomes with an intracanalicular dexamethasone (0.4mg) insert compared to standard steroid drop regimen in the contralateral eye following bilateral PRK surgery.
- Trial name
- NCT04396990
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical Prednisolone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Cornea, Refractive Surgery
Evaluation of the Effect of Myopic Femtosecond Laser Assisted-LASIK on Anterior Chamber Flare Values and Corneal Endothelial Cells: A Prospective Before-and-After Study
This study aimed to investigate whether femtosecond laser-assisted LASIK (FS-LASIK) surgery causes inflammation in the anterior chamber and to analyze its effect on endothelial cells.
- Conditions
- Cornea, Refractive Surgery, Anterior Chamber Inflammation
- Trial name
- NCT04899258
- Testing
- Femtosecond laser assisted LASIK
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Myopia, Astigmatism
SMILE (Small Incision Lenticule Extraction) in the DoD (Department of Defense)
The Use of the VisuMaxTM Femtosecond Laser Small-Incision Lenticule Extraction (SMILE) Procedure for the Correction of Myopia with or without Astigmatism study is a prospective, non-randomized, multicenter clinical study that…
- Trial name
- NCT04072289
- Testing
- Visumax spherocylindrical treatment
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Refractive Errors
Clinical and Refractive Outcomes After Contoura® Refractive Surgery Planned Using Phorcides Surgery Planning Software
The objective of the current study is to prospectively evaluate 3-month clinical outcomes from LASIK performed using the Phorcides surgical planning software with Contoura topography-guided ablation in both eyes of subjects with…
- Trial name
- NCT04495829
- Testing
- Phorcides Analytical Engine
- Where
- 5 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- American Corneal Consultants