Clinical trials: Refractory GERD
Systemic Sclerosis (SSc), GERD (Gastroesophageal Reflux Disease)
PPI Refractory - GERD Mechanisms in Systemic Sclerosis
The goal of this observational study is to learn about the mechanisms of gastroesophageal reflux disease (GERD) in patients with systemic sclerosis (SSc) who continue to experience reflux symptoms despite treatment with proton…
- Trial name
- NCT07022912
- Testing
- educational healthcare intervention, Objective assessment of GI motility, Evaluation of GERD severity
- Volunteers
- 147 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Gastroesophageal Reflux Disease With Ulceration
Anti-Reflux Mucosectomy in the Treatment of Refractory Gastro-esophageal Reflux
Gastroesophageal reflux disease (GERD) is one of the most common digestive diseases in Western countries, affecting 8% of the population in its typical and frequent form.
- Trial name
- MARRGO (NCT05745012)
- Testing
- endoscopic mucosal resection
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
GERD, Reflux
Role of ARMA in Selective Subset of Refractory GERD Patients.
To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).
- Conditions
- GERD, Reflux, Reflux Esophagitis
- Trial name
- NCT05899491
- Testing
- ARMA, UGI Endoscopy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Refractory Chronic Cough
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
- Trial name
- MACS-1 (NCT05110144)
- Testing
- Duloxetine 30 MG, Duloxetine 60 MG, Amitriptyline 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Gastro Esophageal Reflux, Barrett Esophagus
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
- Trial name
- NCT03228407
- Testing
- Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGuire Research Institute
GERD, Bariatric Surgery
Endoscopic Cardiac Band Ligation for the Management of Refractory GERD After Laparoscopic Sleeve Gastrectomy
GERD is a prevalent condition worldwide, estimated to be around 20-30 % in North America. Obesity is rapidly increasing with an estimated prevalence of 66% in the adult population in the United States.
- Conditions
- GERD, Bariatric Surgery, Laparoscopic Sleeve Gastrectomy
- Trial name
- CLEAR (NCT04771247)
- Testing
- Cardia Band Ligation
- Sponsor
- Johns Hopkins University
GERD (Gastroesophageal Reflux Disease)
Endoscopic Injection of Autologous Fat-Derived Cells (SVF) for Adults With Refractory Gastroesophageal Reflux Disease (GERD). (The GERD-REVIVE Pilot Study)
The purpose of this pilot clinical study is to evaluate the feasibility and safety of an innovative endoscopic treatment for adults with gastroesophageal reflux disease (GERD) that does not respond adequately to standard…
- Trial name
- GERD-REVIVE (NCT07638423)
- Testing
- Autologous Stromal Vascular Fraction (SVF) Endoscopic Injection
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
GERD
Prucalopride Treatment for Refractory Gastro-esophageal Reflux Disease
Up to date there is no placebo-controlled trial to investigate the effect of prucalopride in patients with proven refractory GERD.
- Trial name
- NCT03676374
- Testing
- Prucalopride
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Refractory Reflux Esophagitis
Double-blind Comparative Study of E3810 Tablets (10 or 20 mg b.i.d.) to Evaluate Efficacy and Safety in Patients With Refractory Reflux Esophagitis
The purpose of this study is to evaluate the efficacy and safety of E3810 tablets in patients with Proton Pump Inhibitor-resistant reflux esophagitis.
- Trial name
- NCT00770913
- Testing
- E3810
- Where
- 54 sites in Japan
- Volunteers
- 337 people
- Sponsor
- Eisai Co., Ltd.
Gastroesophageal Reflux Disease, Eosinophilic Esophagitis
The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibitors
Background: Up to 40% of patients who are treated with PPIs for symptoms that are thought to be due to GERD experience only incomplete relief of their symptoms.
- Trial name
- NCT01404832
- Testing
- Treat with lansoprazole 30 mg BID for 2 weeks, endoscopic examination with esophageal biopsy for patients with persistent symptoms
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Dallas VA Medical Center
Reflux Esophagitis
The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD
The purpose of this study is to assess the efficacy and safety of Newrabell® Tab. in patients with refractory reflux esophagitis to the prior standard PPIs regimen.
- Trial name
- NCT01860482
- Testing
- Newrabell® Tablet 10mg
- Where
- 2 sites in South Korea
- Volunteers
- 39 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Gastro-esophageal Reflux Disease (GERD)
FODMAPs and Refractory GERD
The aim of this study is to determine the effects of a low Fermentescible Oligosaccharides Disaccharides Monosaccharides and Polyols (FODMAP) diet in patients with documented refractory GERD on proton pump inhibitor (PPI) therapy.
- Trial name
- EFFORR (NCT02471989)
- Testing
- Low-FODMAP diet, GERD diet
- Where
- 6 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Bordeaux
Digestive System Disease
Clinical Applications of Domperidone in Patients With Delayed Gastric Emptying
The purpose of the study is to treat patients with on-going slow stomach emptying(gastroesophageal reflux disease), who have failed to respond to standard therapy
- Trial name
- NCT01844622
- Testing
- Domperidone
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Mt. Sinai Medical Center, Miami
Gastroesophageal Reflux Disease
Lesogaberan in Chinese Patients With Refractory Reflux Symptoms
Lesogaberan may be used in Chinese GERD patients with partial response to PPI.
- Trial name
- NCT02818309
- Testing
- Lesogaberan
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- National Taiwan University Hospital
Refractory Gastroesophageal Reflux Disease, Gastroesophageal Reflux Disease
Oral Fosamprenavir for GERD
The goal of this clinical trial is to learn if study drug Fosamprenavir administered orally improves symptoms for Proton Pump Inhibitor (PPI)-refractory Gastro Esophageal Reflux Disease (GERD).
- Trial name
- NCT06704100
- Testing
- Fosamprenavir Calcium 700 MG Oral Tablet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
GERD
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
Background: Gastroesophageal reflux disease (GERD), which affects at least 20% of adult Americans, may be especially common and severe in Veteran patients.
- Trial name
- NCT01265550
- Testing
- Nissen fundoplication, baclofen, Desipramine
- Where
- 15 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
GERD, Gastroesophageal Reflux
Compassionate Use of Domperidone for Refractory Gastroparesis
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard…
- Conditions
- GERD, Gastroesophageal Reflux, Gastroparesis
- Trial name
- NCT04699591
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jose Cocjin
Refractory GERD, NERD
Vonoprazan Test for PPI Refractory GERD
Among patients suffering from gastroesophageal reflux disease (GERD) symptoms, esophageal pH monitoring and the assessment of symptom-reflux correlation can identify two distinct subgroups characterized by normal acid exposure…
- Conditions
- Refractory GERD, NERD, PCAB
- Trial name
- NCT07437768
- Testing
- Patients received a 4-week treatment of vonoprazan 20 mg once daily (VOCINTI®)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fu Jen Catholic University Hospital
Gastroesophageal Reflux Disease (GERD)
One-year Clinical Outcomes of Endoscopic Cardia Banding Plication for Refractory Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy
This single-center retrospective cohort study was conducted at the Center for Bariatric and Metabolic Surgery, China-Japan Friendship Hospital, Beijing, China, and is reported in accordance with the STROBE guidelines for…
- Trial name
- NCT07749352
- Testing
- endoscopic cardia banding plication
- Where
- China
- Volunteers
- 47 people
- Sponsor
- China-Japan Friendship Hospital
Gastroesophageal Reflux Disease
An Explorative Trial to Evaluate the Pharmacodynamic Effect of SPD557 on Reflux Parameters in Refractory GERD Patients
The purpose of this trial is to investigate the pharmacodynamic effect on reflux parameters of SPD557 tablets (0.5 mg t.i.d., on top of PPI treatment) in patients with Gastroesophageal Reflux Disease (GERD) with persistent…
- Trial name
- NCT01370863
- Testing
- SPD557
- Where
- 15 sites in Belgium, France and 4 more
- Volunteers
- 67 people
- Sponsor
- Shire