Clinical trials: Refractory Hypertension
Kidney Failure, Chronic, Renal Dialysis
Renal Denervation in End Stage Renal Disease Patients With Refractory Hypertension
The purpose of this this study is to investigate the clinical utility of renal denervation in the treatment of ESRD patients with refractory hypertension.
- Trial name
- NCT00753116
- Testing
- Renal Denervation with a catheter-based procedure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medtronic Vascular
Glaucoma, Glaucoma, Open Angle
SOLX Gold Shunt Versus Control Implant: Randomized Trial for Refractory Glaucoma
Study Objective: To establish the substantial equivalence of the SOLX Gold Shunt to commercially available aqueous shunts, specifically the Ahmed™ Glaucoma Valve Model FP7, in the ability to reduce intraocular pressure (IOP)…
- Trial name
- NCT00382395
- Testing
- SOLX Gold Shunt GMS-plus, Ahmed FP7 Glaucoma Valve
- Where
- 15 sites in United States, Canada and 3 more
- Volunteers
- 180 people
- Sponsor
- SOLX, Inc.
Refractory Glaucoma
Ahmed Valve Glaucoma Implant With Adjunctive Subconjunctival Bevacizumab in Refractory Glaucoma
The investigators aim to demonstrate the efficacy and safety of subconjunctival injection of Avastin as an adjunctive therapy for Ahmed valve glaucoma implant in patients with refractory glaucoma.
- Trial name
- NCT01128699
- Testing
- Subconjunctival Avastin, Ahmed Valve implant
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vanak Eye Surgery Center
Resistant Hypertension, Primary Aldosteronism
Prospective Study on Primary Aldosteronism in Resistant Hypertension
Prevalence of primary aldosteronism (PA) in resistant hypertension is not clear. In addition, emerging evidence supports the role of elevated serum aldosterone in promoting cardiovascular disease, independently from high blood…
- Conditions
- Resistant Hypertension, Primary Aldosteronism, Refractory Hypertension, Hypertensive End-Organ Damage
- Trial name
- PrePARe (NCT04213963)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Turin, Italy
Glaucoma
Comparison of Silicone and Porous Plate Ahmed Glaucoma Valves
The purpose of this study is to evaluate and compare the clinical outcomes after implantation of the porous plate (polyethylene) (Model M4) Ahmed Glaucoma Valve with the silicone plate Ahmed Glaucoma Valve (Model FP7) in…
- Trial name
- NCT01883856
- Testing
- Silicone plate Ahmed Glaucoma Valve (Model FP7), Porous Plate Ahmed Glaucoma Valve (Model M4)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Peter Netland, MD
Hypertension, Resistant to Conventional Therapy
Renal Denervation in Refractory Hypertension
Open, multicenter, randomized study is enrolling patients in 3 sites in Czech Republic. Patients with refractory hypertension will be randomized in 1:1 manner either to renal denervation plus optimal medical antihypertensive…
- Trial name
- PRAGUE-15 (NCT01560312)
- Testing
- Renal denervation (Symplicity® Catheter System™)
- Where
- 3 sites in Czechia
- Volunteers
- 106 people
- Sponsor
- Charles University, Czech Republic
Glaucoma, Glaucoma, Open-Angle
Treatment Outcomes of a Novel Glaucoma Tube Shunt Implant for Intraocular Pressure Control in Eyes With Refractory Glaucoma
The aim of this study is to determine the effectiveness of lowering intraocular pressure and safety profile of the Paul Glaucoma Implant (Advanced Ophthalmic Innovations, Singapore).
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Surgery, Intraocular Pressure
- Trial name
- NCT04297930
- Testing
- Paul Glaucoma Implant Surgery
- Where
- Singapore
- Volunteers
- 82 people
- Sponsor
- National University Hospital, Singapore
Sleep Apnea, Hypertension
Effect of Continuous Positive Airway Pressure (CPAP) Treatment in the Control of Refractory Hypertension
The working hypothesis for the present study is that treatment with CPAP in patients with an sleep apnea (IAH>15) and AHT-r is capable of producing significant reductions in blood-pressure levels.
- Trial name
- NCT00616265
- Testing
- CPAP
- Where
- Spain
- Volunteers
- 210 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Hypertension
A Safety Evaluation of Renal Denervation Using Focused Therapeutic Ultrasound on Patients With Refractory Hypertension
This study is a prospective, single-institution trial wherein twenty subjects with refractory hypertension will receive the experimental focused ultrasound renal denervation therapy.
- Trial name
- NCT01638195
- Testing
- Focused Ultrasound
- Where
- Australia
- Volunteers
- 18 people
- Sponsor
- Kona Medical Inc.
Hypertension
Renal Denervation in Patients With Refractory Hypertension
To investigate the clinical utility of renal denervation in the treatment of refractory hypertension.
- Trial name
- NCT00483808
- Testing
- Ardian Symplicity™ Catheter
- Where
- 3 sites in Australia, Poland
- Volunteers
- 73 people
- Sponsor
- Medtronic Vascular
Glaucoma, Glaucoma, Open Angle
AqueSys XEN 45 Glaucoma Implant in Refractory Glaucoma
To establish the safety and performance of the AqueSys XEN 45 Glaucoma Implant in eyes with refractory glaucoma.
- Trial name
- NCT02036541
- Testing
- AqueSys XEN 45 Glaucoma Implant
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- AqueSys, Inc.
Hypertension
Renal Denervation in Patients With Refractory Hypertension
The purpose of this study is to investigate the clinical utility of renal denervation for the treatment of refractory hypertension.
- Trial name
- NCT00753285
- Testing
- Renal Denervation
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Medtronic Vascular
Refractory Hypertension
TC-5214 as Augmentation Therapy in Patients With Refractory Hypertension
A pilot study of subjects with refractory hypertension (on 3 concomitant agents with SBP > 140 mmHg and a DBP > 90 mmHg) randomized in a double-blind fashion to receive 4 single escalating doses of study medication in clinic.
- Trial name
- NCT00899977
- Testing
- TC-5214
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Targacept Inc.
Glaucoma, Glaucoma, Open-Angle
AqueSys Microfistula Implant in Refractory Glaucoma
To establish the safety and performance of the AqueSys Microfistula Implant in eyes with refractory glaucoma.
- Trial name
- NCT01640756
- Testing
- AqueSys Microfistula Implant
- Where
- 14 sites in United States
- Volunteers
- 60 people
- Sponsor
- AqueSys, Inc.
Severe Brain Injury
Study of PbiO2 Variation by Body Temperature and Capnia in Severe Head Trauma Patients Treated With Targeted Temperature Control
Serious head trauma is a common and pathology and responsible of high morbidity and mortality. The major challenge, from the very first hours, is to limit cerebral ischemia by controlling secondary brain injury factors.
- Trial name
- TODAY (NCT04109430)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Glaucoma
Glaucoma Treatment by Circular Cyclocoagulation Using High Intensity Focused Ultrasound With the EYEOP Medical Device
The aim of the study is to evaluate the effectiveness and the safety of the EYEOP treatment using High Intensity Focused Ultrasound in refractory glaucoma patients.
- Trial name
- NCT01338467
- Testing
- EYEOP device
- Where
- 9 sites in France
- Volunteers
- 52 people
- Sponsor
- EyeTechCare
Hypertension
Sympathetic Activity and Renal Denervation
Primary hypothesis: Catheter-based renal denervation reduces central sympathetic activation in patients with refractory hypertension. Secondary hypotheses: 1.
- Trial name
- ReD (NCT01355055)
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Hannover Medical School
Liver Cirrhosis, Refractory Ascites
Fiber-Optic Navigation During TIPS Creation: A Prospective Pilot Study
Transjugular intrahepatic portosystemic shunt (TIPS) creation is an established minimally invasive treatment for complications of portal hypertension such as refractory ascites and variceal bleeding.
- Conditions
- Liver Cirrhosis, Refractory Ascites, Variceal Bleeding, Portal Hypertension
- Trial name
- FLIGHT (NCT07470515)
- Testing
- Fiber-Optic Navigation System
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University Innsbruck
Glaucoma
Intraluminal Stenting Versus External Ligation of Ahmed Glaucoma Valve
Objectives: To compare the intraluminal stenting and external ligation of Ahmed Glaucoma Valve (AGV) regarding refractory glaucoma management and postoperative hypotony prevention.
- Trial name
- NCT04508881
- Testing
- Ahmed Glaucoma Valve
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Menoufia University
Baroreflex Failure Syndrome, Hypertension, Resistant to Conventional Therapy
UK Registry for Baroreflex Activation Therapy
This study is a post-marketing open label single arm, single centre clinical trial of electrical carotid sinus stimulation with the Barostim Neo device to target sub-optimally controlled arterial hypertension or highly variable…
- Trial name
- UK-BAT (NCT03730519)
- Testing
- Baroreflex Activation Therapy with Barostim Neo
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Queen Mary University of London