Clinical trials: Refractory Hypertension
Uncontrolled Hypertension
Netrod-Pilot Study of Renal Denervation With NetrodTM Sixelectrode Radiofrequency RDN System
This single-arm, non-randomized, open-label investigation aims to collect safety and efficacy data of the CE-Marked Netrod™ RDN System in treating European patients with primary hypertension in the absence of anti-hypertensive…
- Trial name
- NCT07061054
- Testing
- Netrod™ six-electrode radiofrequency renal denervation system
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Open Angle Glaucoma
Surgical Treatment of Refractory Open Angle Glaucoma
The primary objective of this study is to evaluate the safety, efficacy, and performance of the Suprachoroidal Dissection Instrument in creating a fistula between Schlemm's canal and the suprachoroidal space in refractory, open…
- Trial name
- NCT01212861
- Testing
- Suprachoroidal Dissection Instrument (SDI)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- iScience Interventional Corporation
Ascites, Liver Cirrhosis
Proximal Splenic Artery Embolization (PSAE) for the Treatment of Refractory Ascites in Decompensated Cirrhosis
The purpose of this study is to learn whether a procedure called Proximal Splenic Artery Embolization (PSAE) can lower the need for repeat fluid drainage in adults with cirrhosis and a buildup of fluid in the abdomen (ascites)…
- Conditions
- Ascites, Liver Cirrhosis, Hypertension, Portal
- Trial name
- NCT07755059
- Testing
- Proximal Splenic Artery Embolization
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Glaucoma, Glaucoma, Open Angle
SOLX Gold Shunt for Refractory Glaucoma
To establish the clinical performance of the SOLX Gold Shunt for its ability to reduce intraocular pressure (IOP) in eyes with refractory glaucoma where medical and conventional surgical treatments have failed.
- Trial name
- NCT01282346
- Testing
- SOLX Gold Shunt
- Where
- 17 sites in United States, Brazil and 3 more
- Volunteers
- 116 people
- Sponsor
- SOLX, Inc.
Refractory Hypertension
TC-5214 as Augmentation Therapy in Patients With Refractory Hypertension
A pilot study of subjects with refractory hypertension (on 3 concomitant agents with SBP > 140 mmHg and a DBP > 90 mmHg) randomized in a double-blind fashion to receive 4 single escalating doses of study medication in clinic.
- Trial name
- NCT00899977
- Testing
- TC-5214
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Targacept Inc.
Hypertension
Feasibility Study to Evaluate Renal Denervation Using Focused Ultrasound
This study is a prospective, multi-center trial wherein each included subject will receive the experimental externally focused ultrasound renal denervation therapy.
- Trial name
- NCT01704170
- Testing
- Kona Externally Focused Ultrasound Therapy
- Where
- 4 sites in Australia, Canada and 1 more
- Volunteers
- 31 people
- Sponsor
- Kona Medical Inc.
Hypertension
Addition of Spironolactone in Patients With Resistant Arterial Hypertension
The purpose of this study is to evaluate the efficacy of spironolactone on lowering blood pressure when added to therapy in patients with resistant arterial hypertension.
- Trial name
- ASPIRANT (NCT00524615)
- Testing
- spironolactone
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- Jan Vaclavík
Advanced Glaucoma, Refractory Glaucoma
Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage Glaucoma
The aim of this study is to compare the safety and efficacy of conventional and micropulse transscleral diode laser in the treatment of end-stage glaucoma.
- Trial name
- NCT00349414
- Testing
- Micropulse Transscleral Cyclophotocoagulation, Conventional Transscleral Cyclophotocoagulation
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Refractory Ascites, Hepatic Hydrothorax
Glutamine Challenge as Predictor of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Transjugular intrahepatic portosystemic shunt (TIPS) is the first-line therapy for patients with cirrhosis and refractory ascites. However, mental changes known as hepatic encephalopathy (HE) frequently occur after TIPS.
- Conditions
- Refractory Ascites, Hepatic Hydrothorax, Hepatic Encephalopathy, Cirrhosis
- Trial name
- NCT02026609
- Testing
- Oral glutamine challenge, Psychometric Tests
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 3 people
- Sponsor
- University of Arkansas
Glaucoma
Investigation of the Glaukos® Trabecular Micro-Bypass System, Model iS3, in Subjects With Refractory Glaucoma
Prospective, multi-center, single-arm clinical trial to evaluate the safety and effectiveness of the Glaukos® Trabecular Micro-Bypass System Model iS3 (three stents per study eye) in subjects with refractory glaucoma.
- Trial name
- NCT03639870
- Testing
- Model iS3 three-stent trabecular micro-bypass system
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Glaukos Corporation
Refractory Primary Open Angle Glaucoma
Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Glaucoma
The purpose of this study is to compare three-year outcomes of re-trabeculectomy with those of Ahmed glaucoma valve implantation in secondary surgical management of patients with primary open angle glaucoma (POAG) and a history…
- Trial name
- NCT01633775
- Testing
- Implantation of Ahmed glaucoma tube shunt, and Trabeculectomy with MMC
- Where
- 3 sites in Iran
- Volunteers
- 100 people
- Sponsor
- Vanak Eye Surgery Center
Glaucoma
The AVB Study: Prospective Study Comparing the Ahmed Valve and the Baerveldt Implant for Treating Refractory Glaucoma
The purpose of this study is to compare the safety and efficacy of the Ahmed valve and the Baerveldt implant in treating refractory glaucoma.
- Trial name
- NCT00940823
- Testing
- Ahmed FP7 Valve, Baerveldt-350 Tube
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 238 people
- Sponsor
- Credit Valley EyeCare
Idiopathic Intracranial Hypertension
Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension
Increased Intracranial Hypertension (IIH), also known as Pseudotumor Cerebri, is defined by increased cerebral spinal fluid (CSF) pressure in the absence of intracranial, metabolic, toxic or hormonal causes of intracranial…
- Trial name
- NCT02143258
- Testing
- Stenting of the venous sinus
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Ottawa Hospital Research Institute
Hypertension Intracranial
Decompressive Craniectomy for Severe Traumatic Brain Injury in Children With Refractory Intracranial Hypertension
Severe traumatic brain injury (TBI) is the leading cause of mortality and severe disability in the pediatric population. The prognosis of these patients depends on the severity of the initial lesions but also on the effectiveness…
- Trial name
- RANDECPED (NCT03766087)
- Testing
- decompressive craniectomy
- Where
- France
- Sponsor
- Fondation Lenval
Glaucoma
Results of Different Location of Ahmed Glaucoma Valve Implantation in Refractory Glaucoma, Superior Versus Inferior
Purpose:To compare the efficacy and safety of Ahmed Glaucoma Valve (AGV) implantation in the superior versus inferior quadrants.
- Trial name
- NCT00628173
- Testing
- AGV implantation
- Volunteers
- 106 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Glaucoma, Glaucoma, Open-Angle
AqueSys Microfistula Implant in Refractory Glaucoma
To establish the safety and performance of the AqueSys Microfistula Implant in eyes with refractory glaucoma.
- Trial name
- NCT01640756
- Testing
- AqueSys Microfistula Implant
- Where
- 14 sites in United States
- Volunteers
- 60 people
- Sponsor
- AqueSys, Inc.
Glaucoma
Intraluminal Stenting Versus External Ligation of Ahmed Glaucoma Valve
Objectives: To compare the intraluminal stenting and external ligation of Ahmed Glaucoma Valve (AGV) regarding refractory glaucoma management and postoperative hypotony prevention.
- Trial name
- NCT04508881
- Testing
- Ahmed Glaucoma Valve
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Menoufia University
Refractory Glaucoma
Real-world Evidence Study of XEN in Chinese Patients With Refractory Glaucoma
Real-world evidence study to assess the safety and effectiveness of XEN® Glaucoma Treatment System in Chinese patients with refractory glaucoma.
- Trial name
- NCT04303897
- Testing
- XEN Glaucoma Stent
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Allergan
Refractory Glaucoma
Ahmed Glaucoma Valve Alone, With Amniotic Membrane or With Mitomycin C (MMC) for Treatment of Refractory Glaucoma
This randomized, controlled trial (RCT) compares the efficacy and safety of Ahmed Glaucoma Valve (AGV) implantation alone, with 3 minutes MMC application or with a single layer coverage of amniotic membrane.
- Trial name
- NCT00893490
- Testing
- Ahmed Glaucoma Valve (AGV), Mitomycin C (MMC), amniotic membrane coverage
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Refractory Glaucoma
The Vizio Clinical Study
Evaluate the Safety and Efficacy of the Vizio Aqueous Microshunt for the Treatment of Refractory Glaucoma
- Trial name
- NCT06591117
- Testing
- Vizio Aqueous Microshunt
- Where
- El Salvador
- Volunteers
- 50 people
- Sponsor
- Ocumedex