Clinical trials: Regenerative Endodontics
Regenerative Endodontic Procedures
Regenerative Endodontics of Immature Teeth in Multiple Visits Versus Single Visit
This randomized clinical trial evaluated the clinical and radiographic outcomes of regenerative endodontic procedures performed using different irrigation activation protocols in immature permanent maxillary anterior teeth.
- Trial name
- NCT07427615
- Testing
- Regenerative Endodontic Procedure, Laser-Activated Irrigation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ahmed Ibrahim Salim
Immature Permanent Teeth With Open Apex
Effect of Thickness Variation in Coronal Plug on Root Maturation and Periapical Healing
d. Second visit: After 3 weeks the patients will be randomly divided into 2 groups: Group A: Patients will be anesthetized 1 carpule of mepivacaine without vasoconstrictor (Mepivacaine HCl 3%), the access will be reopened under…
- Trial name
- NCT07123597
- Testing
- 5mm bioceramic putty coronal plug, 3mm bioceramic putty coronal plug
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Rania ElSayed Soliman
Regenerative Endodontics
Regenerative Endodontics Using Different Intracanal Medicaments on Radiographic Outcomes and Periapical MMP-8 Levels
Two-session regenerative endodontic treatment was applied to 20 immature mandibular first molars with symptomatic irreversible pulpitis and symptomatic apical periodontitis.
- Trial name
- NCT05581706
- Testing
- Place the freshly prepared calcium hydroxide in to the root canals, Place the freshly prepared double antibiotic paste in to the root canals, Taking standart periapical radiography with film holder
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ege University
Periapical Periodontitis
Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
To compare the dental survival in a period of one year of mature permanent teeth with apical lesion following the administration of encapsulated Mesenchymal Stem Cells under a regenerative endodontic procedure and a conventional…
- Trial name
- RanoKure (NCT03102879)
- Testing
- Regenerative Endodontic Procedure, Conventional Root Canal Treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidad de los Andes, Chile
Periapical Periodontitis
Effect of Injectable Platelet Rich Fibrin Augmented With Vitamin C Compared to Injectable Platelet Rich Fibrin Alone on Healing of Necrotic Mature Single Rooted Teeth With Chronic Peri-apical Periodontitis Following Regenerative Endodontics (A Randomized Controlled Trial)
The purpose of the study is to investigate the effect of injectable platelet rich fibrin augmented with Vitamin C (ascorbic acid) in healing of chronic peri-apical lesion, by assessing it radiographically 2dimensionally and 3…
- Trial name
- NCT05585359
- Testing
- injectable platelet rich fibrin augmented with Vitamin C
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulpal Necrosis
Evaluation of Regenerative Endodontic Treatment for Immature Teeth
The goal of this clinical trial is to evaluate if regenerative endodontic treatment using two different forms of demineralized dentin matrix (DDM) can effectively treat immature permanent single-rooted teeth compared to treatment…
- Trial name
- NCT07210359
- Testing
- human treated dentin matrix hydrogel, Theracal LC - Demineralized dentin matrix combination, Retro Mta
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Regenerative Endodontic Procedures, Necrotic Pulp
Treated Dentine Matrix and Platelet Rich Fibrin in Induction of Root Formation of Non-Vital Immature Permanent Teeth
This study will be conducted to clinically evaluate the efficacy of human treated dentine matrix paste and Platelet rich fibrin (PRF) in induction of root formation of non-vital immature permanent teeth.
- Trial name
- NCT05775081
- Testing
- Regenerative endodontic procedues
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pulp Necrosis
Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis
This study is to evaluate the effectiveness of regenerative endodontics therapy in single-rooted permanent teeth with pulp necrosis，and compare the clinical efficacy of platelet rich fibrin (PRF) and blood clot (BC) as scaffolds.
- Trial name
- NCT04313010
- Testing
- PRF, BC
- Where
- 3 sites in China
- Volunteers
- 346 people
- Sponsor
- Southern Medical University, China
Endodontics, Regenerative Endodontic Procedures
The Effect of Using Different Scaffolds in Retreated Teeth on The Clinical and Radiological Success of Regenerative Endodontic Treatment
This clinical study aims to compare the clinical and radiographic outcomes of four different scaffolds used in regenerative endodontic treatment of previously root canal-treated permanent teeth requiring retreatment.
- Conditions
- Endodontics, Regenerative Endodontic Procedures, PRF, i-PRF
- Trial name
- NCT07721051
- Volunteers
- 60 people
- Sponsor
- Kırıkkale University
Periapical Diseases, Pulp Necroses
Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT)
Conventional endodontic treatment has been the treatment of choice for the management of signs and symptoms of mature permanent teeth with pulpal necrosis and periapical lesion with predictable and favorable results.
- Trial name
- CARETT (NCT05305417)
- Testing
- Autologous Regenerative Endodontic Treatment, Conventional Root Canal Treatment
- Volunteers
- 228 people
- Sponsor
- Universidad de Valparaiso
Necrosis, Pulp
Antimicrobial Effect of Modified Antibiotic Nanofibers for Regenerative Endodontics Procedures
The treatment for immature teeth with pulp necrosis can be carried out through apexification or regenerative endodontics procedures including platelet rich plasma (PRP), platelet rich fibrin (PRF) and injectable PRF, these…
- Trial name
- NCT03690960
- Testing
- electrospun TAP nanofibers, modified TAP paste
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Necroses
Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents
Evalaution of clinical success of secondary treatment for total 40 permanent incisors with failed root canal treatment with apical radiolucency.
- Trial name
- PRF (NCT05517187)
- Testing
- no intervention, Platelet rich fibrin
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nahda University
Incomplete Root Formation of Anterior Teeth
Efficacy of Combined Scaffolds and Sodium Hypochlorite in Regenerative Endodontics of Immature Teeth
The aim of the study is to evaluate the efficacy of combinations of different scaffolds (blood clot, platelet rich fibrin, collagen) and sodium hypochlorite concentrations (0.5%- 2.5%) in regenerative endodontics of immature…
- Trial name
- NCT05803525
- Testing
- Intra-canal medication protocol
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tanta University
Apical Periodontitis, Mature Teeth
Apical Preparation Size in Regenerative Endodontics of Mature Teeth
The goal of this clinical trial is to learn whether the size of apical preparation affects the success of regenerative endodontic treatment in mature permanent teeth with apical periodontitis.
- Conditions
- Apical Periodontitis, Mature Teeth, Regenerative Endodontic Treatment
- Trial name
- NCT07466433
- Testing
- Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Marmara University
Periapical Periodontitis
Encapsulated Acellular System From Mesenchymal Stem Cells for Dental Pulp Regeneration
To evaluate the security and efficacy in the administration of encapsulated acellular system derived from Mesenchymal Stem Cells as a novel regenerative endodontic procedure which to promote the pulpar regenration.
- Trial name
- NCT05599087
- Testing
- Acellular system
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Universidad de los Andes, Chile
Dental Trauma
Cone-beam Computed Tomographic (CBCT) and Regenerative Endodontic Treatment.
Dental trauma injuries during childhood may have an adverse impact on oral health throughout life. If trauma injuries causes pulpal necrosis, then the root stop forming.
- Trial name
- Regeneration (NCT03544528)
- Testing
- Regeneration
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Umeå University
Apical Periodontitis, Periapical Diseases
Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment
The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment.
- Trial name
- NCT07448571
- Testing
- Non-Surgical Root Canal Retreatment, Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Marmara University
Pulp Necrosis, Immature Permanent Teeth
PRF and CGF Scaffolds With EDTA in Regeneration
This study evaluated the regenerative outcomes of immature permanent teeth with necrotic pulps treated using three scaffold types-blood clot, platelet-rich fibrin (PRF), and concentrated growth factor (CGF)-combined with either…
- Conditions
- Pulp Necrosis, Immature Permanent Teeth, Open Apex, Periapical Periodontitis
- Trial name
- RET-EDTA-CGF (NCT07265804)
- Testing
- Blood Clot + 5% EDTA, Blood Clot + 17% EDTA, PRF + 5% EDTA
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Dental Trauma
Regenerative Endodontic in Immature Permanent Teeth
Compare the clinical and radiographic outcomes of demineralized dentin matrix scaffold to blood clot scaffold in immature permanent incisors with non-vital pulps for one year (in vivo).
- Trial name
- NCT06006052
- Testing
- regeneration technique
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Necrotic Immature Permanent Teeth, Regenerative Endodontic Treatment
Application of Advanced Platelet-Rich Fibrin Plus (A-PRF+) in Revascularisation of Necrotic Immature Permanent Teeth
The goal of this clinical trial is to evaluate the effectiveness of an advanced platelet-rich fibrin plus (A-PRF+) revascularization procedure to promote healing and root development in necrotic immature permanent single-rooted…
- Conditions
- Necrotic Immature Permanent Teeth, Regenerative Endodontic Treatment, Pulp Regeneration, Root Maturation
- Trial name
- A-PRF+ (NCT07092488)
- Testing
- Advanced Platelet-Rich Fibrin Plus (A-PRF+) Revascularization Procedure
- Where
- Croatia
- Volunteers
- 28 people
- Sponsor
- University of Zagreb