Clinical trials: Regional Pain Syndrome
Complex Regional Pain Syndrome
Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome
The purpose of this study is to determine whether epidural and ketamine infusions are effective in the treatment of Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT02094352
- Testing
- Ketamine Infusion + Epidural Infusion, Control Group + Epidural infusion, Ketamine Booster Infusion
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Complex Regional Pain Syndrome (CRPS)
Mechanism and Treatment of Sympathetically Maintained Pain
40 CRPS patients will be recruited over a three-year period (target of 160 patients at all sites). Assessment of exclusion criteria will be undertaken during initial recruitment.
- Trial name
- NCT01813149
- Testing
- phenylephrine and clonidine, punch biopsy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- The Cleveland Clinic
Ulcer
Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450216
- Testing
- Ibuprofen/famotidine, Ibuprofen
- Volunteers
- 906 people
- Sponsor
- Amgen
Complex Regional Pain Syndrome Type I, Complex Regional Pain Syndrome Type II
Neurotropin to Treat Chronic Neuropathic Pain
This study will examine the effectiveness of the drug neurotropin in treating chronic pain after injury to a limb or a large nerve.
- Trial name
- NCT00006289
- Testing
- Neurotropin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Nursing Research (NINR)
Complex Regional Pain Syndrome I of Lower Limb
"Liposomal Encapsulated Vitamin C in Complex Regional Pain Syndrome"
Abstract: Complex regional pain syndrome (CRPS) is a significant complication in operated osteoarticular pathology and may adversely affect patient's quality of life. Vitamin C is an anti-oxidant and a neuro-modulating agent.
- Trial name
- NCT04204200
- Testing
- liposomal vitamin C, standard vitamin C
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier de Ham
Reflex Sympathetic Dystrophy
Investigation of the Efficacy of tDCS in the Treatment of Complex Regional Pain Syndrome (CRPS) Type 1
The efficacy of the current standard non-pharmacological treatments for complex regional pain syndrome (CRPS), a painful syndrome mostly occurring after musculoskeletal trauma, is suboptimal.
- Trial name
- NCT01960400
- Testing
- Graded motor imagery (GMI)
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Université de Sherbrooke
Osteoarthritis, Rheumatoid Arthritis
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501, a fixed-dose combination oral tablet of 800 mg ibuprofen and 26.6 mg famotidine for patients that require long-term NSAID treatment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- NCT00984815
- Testing
- HZT-501
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Amgen
Neuralgia, Postherpetic Neuralgia
Effects of Pennsaid on Clinical Neuropathic Pain
The purpose of this study is to see if the drug Pennsaid (Diclofenac) can help reduce pain felt by people with chronic nerve pain. The drug will be used 2-4 times each day for 2 weeks. The U.S.
- Conditions
- Neuralgia, Postherpetic Neuralgia, Reflex Sympathetic Dystrophy, Complex Regional Pain Syndrome (CRPS)
- Trial name
- NCT01508676
- Testing
- Pennsaid
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Massachusetts General Hospital
Complex Regional Pain Syndrome (CRPS)
TARGET Post-Approval Study
The purpose of this prospective, multicenter, single arm post-approval study is to demonstrate continued safety of the Axium and Proclaim Neurostimulator System for dorsal root ganglion (DRG) stimulation.
- Trial name
- TARGET PAS (NCT02800863)
- Testing
- Dorsal Root Ganglion (DRG) Stimulation (Axium™ Neurostimulator System), Dorsal Root Ganglion (DRG) Stimulation (Proclaim™ Neurostimulator System)
- Where
- 44 sites in United States
- Volunteers
- 426 people
- Sponsor
- Abbott Medical Devices
Complex Regional Pain Syndrome I (CRPS I)
Treatment of Complex Regional Pain Syndrome With Once Daily Gastric-Retentive Gabapentin (Gralise)
The purpose of this study is to see if an FDA-approved drug (Gralise) can help people with certain types of neuropathic pain without causing too many side effects.
- Trial name
- NCT01623271
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Complex Regional Pain Syndrome, Type I
Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1
The purpose of this multicenter, double-blind, placebo-controlled study is to evaluate the efficacy and safety of Lenalidomide in adult subjects with Complex Regional Pain Syndrome (CRPS) Type 1.
- Trial name
- CRPS-002 (NCT00109772)
- Testing
- lenalidomide
- Where
- 27 sites in United States
- Volunteers
- 184 people
- Sponsor
- Celgene Corporation
Neuropathic Pain, Reflex Sympathetic Dystrophy
Effects of Vaporized Marijuana on Neuropathic Pain
This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.
- Conditions
- Neuropathic Pain, Reflex Sympathetic Dystrophy, Peripheral Neuropathy, Post-herpetic Neuralgia
- Trial name
- NCT01037088
- Testing
- Mild dose cannabis, Low dose cannabis, Cannabis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Davis
Complex Regional Pain Syndromes, Back Pain
Virtual Reality Guided Imagery for Chronic Pain
To assess treatment with an at-home Virtual Reality Guided Imagery (VR-GI) intervention, 36 patients with chronic pain (18 with chronic back pain, CBP, and 18 with complex regional pain syndrome, CRPS) will complete a 2-week…
- Trial name
- VRGI (NCT04849897)
- Testing
- Experimental: Virtual Reality Guided Imagery, Active Comparator: Audio Only Guided Imagery
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Southern California
Dyspareunia
Treating Postmenopausal Dyspareunia Where it Hurts
The purpose of this study is to compare the effectiveness of two low doses of estrogen cream applied to a new location for the treatment of moderate or severe pain during sexual intercourse in postmenopausal women.
- Trial name
- NCT03240081
- Testing
- 50mcg estradiol cream, 100mcg estradiol cream
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Complex Regional Pain Syndrome (CRPS)
TMS for CRPS - Pilot Study
The purpose of this pilot study is to test whether Transcranial Magnetic Stimulation (TMS) may alleviate the symptoms of Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT01926119
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Stanford University
Pain
The Effect of Intravenous Lidocaine on Allodynia
The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
- Trial name
- NCT00659633
- Testing
- lidocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Complex Regional Pain Syndrome
Safety of Intravenous Neridronic Acid in CRPS
The aim of this trial was to investigate the safety of intravenous neridronic acid in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT02972359
- Testing
- Neridronic acid
- Where
- 46 sites in United States, Germany
- Volunteers
- 580 people
- Sponsor
- Grünenthal GmbH
Complex Regional Pain Syndrome (CRPS)
Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS)
The aim of this trial was to investigate the efficacy and safety of intravenous neridronic acid in subjects with Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT03560986
- Testing
- Neridronic acid 100 mg
- Where
- 71 sites in United States, Canada and 5 more
- Volunteers
- 267 people
- Sponsor
- Grünenthal GmbH
Chronic Pain, Failed Back Surgery Syndrome
Sensory Testing of Multiple Forms of Spinal Cord Stimulation for Pain
Doctors sometimes treat chronic pain with devices that send mild electrical currents into the spinal cord. This type of treatment is referred to as neurostimulation.
- Conditions
- Chronic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes, Neuropathic Pain
- Trial name
- NCT04732325
- Testing
- Spinal cord stimulation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc