Clinical trials: Regression
Adolescent Idiopathic Scoliosis
Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery?
Adolescent idiopathic scoliosis surgery is an extensive procedure associated with significant blood loss frequently requiring the transfusion of blood.
- Trial name
- NCT01813058
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Colorectal Cancer
Protein Recommendation to Increase Muscle
This is a feasibility study to test the potential efficacy of diets of different amounts of protein and calories for patients with cancer.
- Trial name
- PRIMe (NCT02788955)
- Testing
- Dietary counselling, Dietary Protein
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Prediction Hypothyroidism Patients Using Machine Learning Algorithms, Identification of Important Symptoms of Hypothyroidism
Identification of Important Symptoms and Diagnostic Hypothyroidism Patients Using Machine Learning Algorithms
Hypothyroidism (HT) is one of the most common endocrine diseases. It is, however, usually challenging for physicians to diagnose due to non-specific symptoms. The usual procedure for diagnosis of HT is a blood test.
- Trial name
- NCT06112886
- Testing
- There was no intervention in this study
- Where
- Iran
- Volunteers
- 1,296 people, healthy volunteers welcome
- Sponsor
- Kerman University of Medical Sciences
Congestive Heart Failure, Heart Failure, Diastolic
Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs
Perform a randomized, double blind, placebo-controlled Phase 2a feasibility study to determine whether treatment of HFpEF patients with intracoronary allogeneic CDCs affects clinical functional status (QOL scores), exercise…
- Trial name
- RegressHFpEF (NCT02941705)
- Testing
- Allogeneic Derived Cells
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Cedars-Sinai Medical Center
Obstructive Coronary Artery Disease, Coronary Artery Disease
YELLOW II Study: Reduction in Coronary Yellow Plaque, Lipids and Vascular Inflammation by Aggressive Lipid Lowering
Coronary artery disease (CAD) remains a leading cause of death in most countries. It is well known that the reduction of cholesterol levels by statin therapy is associated with significant decreases in plaque burden.
- Trial name
- NCT01837823
- Testing
- rosuvastatin
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Drug-induced Liver Injury
Correlative Cohort Study on the Clinical Features and Prognosis of Drug-induced Liver Injury
This was a retrospective study of a clinical observational cohort. The patients were admitted and definitely diagnosed by liver biopsy as drug-induced liver injury from September 2014 to September 2019, in the Second Department…
- Trial name
- NCT04302506
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Ditan Hospital
Treatment Efficacy
Randomized-controlled Trial of the Effectiveness of COVID-19 Early Treatment in Community
There is an urgent need to identify effective treatments for SARS-CoV-2 infection that helps people recover quicker and reduces the need for hospital admission.
- Trial name
- NCT05087381
- Testing
- FluvoxaMINE Maleate 50 MG, Fluvoxamine, Bromhexine, Fluvoxamine, Cyproheptadine
- Where
- 3 sites in Thailand
- Volunteers
- 1,200 people
- Sponsor
- Chulalongkorn University
Metastatic Cancer
Gene Therapy Using Anti-Her-2 Cells to Treat Metastatic Cancer
Background: Human epidermal growth factor receptor-2 (Her-2) is a gene found in both normal cells and cancer cells. Extra copies of the gene (overexpression) can cause too many Her-2 proteins (receptors) to appear on the cell…
- Trial name
- NCT00924287
- Testing
- in vitro tumor reactive, chimeric T cell receptor (CAR ) gene-transduced PBL plus IV aldesleukin, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
Myopia, Myopic Astigmatism
Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia
The objectives of this study are to evaluate the safety and efficacy of a treatment regimen for high myopia and myopic astigmatism: LASIK followed by crosslinking performed with the KXL Crosslinking-System and VibeX Xtra…
- Conditions
- Myopia, Myopic Astigmatism, Crosslinking, Corneal Ectasia
- Trial name
- NCT03913338
- Testing
- LasikXtra, LASIK
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Surgery, Blood Transfusion
Machine Learning Model for Perioperative Transfusion Prediction
This study aimed to develop and interpret a machine learning model to predict red blood cell (RBC) transfusion.
- Trial name
- NCT05228548
- Testing
- Perioperative blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 6,121 people
- Sponsor
- Diskapi Teaching and Research Hospital
White Spot Lesion
Evaluation of Remin Pro Forte Versus Remin Pro on Treatment of White Spot Lesions Post Orthodontic Treatment
randomized clinical trial to evaluate caries regression, the change in colour and mineral content of the demineralized enamel after treatment with Remin Pro Forte paste (fluoride, hydroxyapatite, xylitol, ginger, and curcuma) and…
- Trial name
- NCT04017884
- Testing
- Remin Pro Forte, Remin Pro
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm >= 5.5 Centimeters in Male (Disorder)
Endurant Stent Graft System vs Excluder Endoprothesis: ADVANCE Trial
The purpose of this trial is to generate clinical evidence related to key performance outcomes of Endurant II/IIs Stent Graft Systems verses Gore Excluder / Excluder Conformable AAA Endoprosthesis in subjects with Abdominal…
- Conditions
- Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm >= 5.5 Centimeters in Male (Disorder), Abdominal Aortic Aneurysm >= 5.0 Centimeters in Female (Disorder)
- Trial name
- ADVANCE (NCT05378347)
- Testing
- Medtronic Endurant II or Endurant IIs Stent Graft System, Gore Excluder or Gore/ Excluder Conformable AAA Endoprosthesis
- Where
- 68 sites in United States, Finland and 10 more
- Volunteers
- 600 people
- Sponsor
- Medtronic Cardiovascular
Sedentary Lifestyle, Quality of Life
The Effect of Experimentally Decreasing Sedentary Behaviour on Subjective Well-being
This study will explore the causality between outcomes of subjective well-being and sedentary behavior, through experimentally decreasing the sedentary behavior levels of university students.
- Trial name
- NCT03694951
- Testing
- HAPA behavioural counseling
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Cardiomyopathy
CMR to Assess Fibrosis in Cardiomyopathy Using Eplerenone
The aim of this study is to determine if therapy with the aldosterone antagonist, Eplerenone, is associated with improved remodeling of the left ventricle in patients with cardiomyopathy.
- Trial name
- NCT00401856
- Testing
- Eplerenone
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Polypoidal Choroidal Vasculopathy
Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy
The purpose of this study is to determine whether double-dose Ranibizumab are effective to regress the polyps and benefit to the visual outcome in the polypoidal choroidal vasculopathy (PCV).
- Trial name
- NCT02769169
- Testing
- Lucentis® (Raibizumab) double-dose, Lucentis® (Raibizumab) regular-dose
- Where
- 4 sites in China
- Volunteers
- 5 people
- Sponsor
- Sun Yat-sen University
Polypoidal Choroidal Vasculopathy
Interval of Disease Inactivity After Complete Polypoidal Regression in PCV Receiving Aflibercept
Polypoidal choroidal vasculopathy (PCV), a subtype of neovascular age-related macular degeneration (NV AMD), is an important cause of central visual loss, especially among Asian and African descendants.
- Trial name
- NCT04707027
- Testing
- Aflibercept Injection (2 mg/0.05 ml), Defer treatment
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Chiang Mai University
Chin Regression, Chin Asymmetry
Evaluation of Filler Injection for Chin Profile Enhancement
The goal of this prospective study is to analyze volumetric changes in the lower face after hyaluronic acid filler injections over 90 days.
- Conditions
- Chin Regression, Chin Asymmetry, Jawline Contour Deficit
- Trial name
- NCT07777926
- Testing
- HA Filler
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Contrast Induced Nephropathy
Preventing Contrast Nephropathy With Sodium Bicarbonate in Patients With Pulmonary Edema,Heart Failure,Uncontrolled HTN
Radio Contrast Induced Nephropathy (RCIN) remains a well recognized complication in patients undergoing diagnostic or interventional procedures requiring radiographic contrast agents.
- Trial name
- NCT00513825
- Testing
- Sodium Bicarbonate
- Where
- Iran
- Volunteers
- 72 people
- Sponsor
- Tehran University of Medical Sciences
Airway Management
Airway Changes in Patients Undergoing Elective Surgical Procedures in the Prone and Trendelenburg Positions
The goal of this study is to track the intraoperative changes that occur in the airways of patients undergoing 1) laparoscopic surgeries in the Trendelenburg position, and 2) spinal surgeries in the prone position, as well as the…
- Trial name
- NCT02738788
- Testing
- Intubation
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Tufts Medical Center
Endometriosis
Antilipidemic Ezetimibe Induces Regression of Endometriotic Explants in a Rat Model of Endometriosis
Current endometriosis therapy is based on interrupting the menstrual cycle and suppression of estrogen synthesis in order to induce atrophy of endometrial tissue.
- Trial name
- NCT04844996
- Testing
- Surgical induction of endometriotic explants
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mersin University