Clinical trials: Regression
Atherosclerosis, Diabetes Mellitus
TART - Troglitazone Atherosclerosis Regression Trial
The purpose of this study is to determine if troglitazone reduces the progression of early preintrusive carotid atherosclerosis in insulin-requiring diabetes patients.
- Trial name
- NCT00116545
- Testing
- troglitazone
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Parke-Davis
Sensory Modulation Disorder, Sensory Over-Responsivity
Examining the Efficiency of Neurofeedback Therapy on Adults With Sensory Over Responsivity
Sensory Over-Responsivity (SOR) is characterized by a disruption in regulating sensory stimuli and can significantly impact pain perception and restrict daily participation and quality of life.
- Trial name
- NCT03837795
- Testing
- Neurofeedback treatment
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Adenocarcinoma, Rectal Diseases
Molecular, Pathologic and MRI Investigation of the Prognostic and Redictive Importance of Extramural Venous Invasion in Rectal Cancer (MARVEL) Trial
Extramural venous invasion (EMVI) is the spread of microscopic tumour cells into the veins around the tumour. Rectal cancer treatment has improved greatly over recent years.
- Conditions
- Adenocarcinoma, Rectal Diseases, Colorectal Neoplasms, Adenocarcinoma, Mucinous
- Trial name
- MARVEL (NCT01995942)
- Where
- 19 sites in United Kingdom
- Volunteers
- 246 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Carotid Artery Disease
CARotid plaqUe StabilizatiOn and Regression With Evolocumab.
The CARUSO trial aims at investigating the efficacy of evolocumab in promoting carotid plaque morphological stabilization and regression as compared to traditional lipid lowering therapy (LLT).
- Trial name
- CARUSO (NCT04730973)
- Testing
- Evolocumab, lipid-lowering therapy (LLT)
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda Ospedaliera Ordine Mauriziano di Torino
Crowding of Anterior Maxillary Teeth
Repeated Injections of i-PRF for Decreasing Root Resorption After the Orthodontic Treatment.
Mandibular incisor crowding is a frequent issue that prompts many adults to seek orthodontic treatment. The treatment may enhance patients' quality of life, facilitate dental plaque control, and improve the quality of periodontal…
- Trial name
- NCT07352241
- Testing
- 4-time i-PRF injection group, Saline injection
- Where
- Syria
- Volunteers
- 36 people
- Sponsor
- Damascus University
Lumbopelvic Postpartum Pain
Efficacy of Unstable Shoes for Instability and Lumbopelvic Pain
During pregnancy, pregnant women adopt an atypical pattern position with the intention to maintain stability and balance.These postural changes can cause instability at the level of the sacroiliac joint with painful condition…
- Trial name
- NCT03065270
- Testing
- Use unstable shoes Masai Barefoot Technology (MBT), Use conventional sport shoes
- Volunteers
- 24 people
- Sponsor
- Universidad Europea de Madrid
Colo-rectal Cancer, Crohn Disease
Anastomotic Leakage and Value Of Indocyanine Green in Decreasing Leakage Rates
Anastomotic leakage (AL) is one of the major complications after gastrointestinal surgery. Compromised tissue perfusion at the anastomosis site increases the risk of AL.
- Conditions
- Colo-rectal Cancer, Crohn Disease, Resectable Colorectal Carcinoma
- Trial name
- AVOID (NCT04712032)
- Testing
- ICG-guided bowel perfusion assessment
- Where
- Netherlands
- Volunteers
- 978 people
- Sponsor
- Leiden University Medical Center
Fibrosis, Liver
Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After SVR
with the introduction of Direct-acting antiviral agents in the management of HCV, the scope of inclusion criteria had been widened to include patients with compensated cirrhosis and even in special situations patients with…
- Trial name
- fib-reversal (NCT03659058)
- Testing
- silymarin, Ursodeoxycholic Acid, Antioxidants
- Volunteers
- 400 people
- Sponsor
- Zagazig University
Shoulder Pain, Nausea
Decreasing Upper and Shoulder Pain After Laparoscopic Surgery
Laparoscopic surgery is becoming a major procedure, owing to smaller incisions, shorter hospitalizations, and less post-operative pain as compared with traditional laparotomies.
- Trial name
- NCT01433874
- Testing
- Pulmonary recruitment maneuver, Intraperitoneal normal saline infusion, combined group
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Prostate Carcinoma
Oral Cryotherapy to Decrease Taste Changes in Prostate Cancer Patients Receiving Taxane Chemotherapy
This clinical trial studies whether cooling the mouth with popsicles (oral cryotherapy) decreases taste changes in prostate cancer patients receiving taxane chemotherapy.
- Trial name
- NCT07218718
- Testing
- Best Practice, Oral Cryotherapy, Survey Administration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- City of Hope Medical Center
Acute Promyelocytic Leukemia With PML-RARA, t(15;17)
Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia
This clinical trial studies how well simplified patient care strategy works in decreasing early death in patients with acute promyelocytic leukemia.
- Trial name
- NCT03253848
- Testing
- Simplified Patient Care Strategy, Laboratory Biomarker Analysis
- Where
- 294 sites in United States, Puerto Rico
- Volunteers
- 202 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Preterm Birth, Low Birth Weight
Diagnostic Accuracy of Foot Length in Predicting Preterm and Low Birth Weight Using Ultrasound Dating as The Gold Standard in a Rural District of Pakistan
Background: The burden of preterm and low birth weight babies (LBW) is high in low- and middle-income countries (LMICs). Therefore, assessment of gestational age (GA) and birth weight is important.
- Trial name
- NCT05515211
- Testing
- Foot length
- Where
- Pakistan
- Volunteers
- 336 people
- Sponsor
- Aga Khan University
Dental Caries
3D Scanning and Transillumination vs Conventional Examination to Assess Caries Progression, Stability or Regression
The objective of this study is to investigate whether the 3D scanner and accompanying software, as well as the transillumination method, can identify changes in primary caries lesions in caries-active patients, where selected…
- Trial name
- NCT05409625
- Testing
- Intraoral Scanner (TRIOS 4, 3Shape TRIOS A/S, Copenhagen, Denmark), Intraoral camera (DIAGNOcam, KaVo, Biberach, Germany, software version 3.0.1/2.9.1), X-ray device (X-ray device SOREDEX, MINRAY®; Image plates VistaScan; Image plate scanner VistaScan Mini View, Dürr Dental)
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- University of Copenhagen
Type2 Diabetes, Weight Loss
Improving Glucose and Lipid Metabolism Through Caloric Restriction Using Diet or Surgery (CRUDOS)
In this explorative randomized clinical study, the investigators aim to study metabolic, cellular, and molecular changes that occur during weight loss in obese subjects with and without type 2 diabetes.
- Conditions
- Type2 Diabetes, Weight Loss, Insulin Sensitivity, Metabolism and Nutrition Disorder
- Trial name
- CRUDOS (NCT02988011)
- Testing
- Gastric by-pass surgery, Low-caloric diet
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Neoadjuvant Chemoradiotherapy, Locally Advanced Rectal Cancer
THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI Guided Radiotherapy
Neoadjuvant chemoradiation therapy (nCRT) is the standard treatment modality for locally advanced rectal cancer (LARC), and patients achieving complete response (CR) generally have improved local control, metastasis-free…
- Conditions
- Neoadjuvant Chemoradiotherapy, Locally Advanced Rectal Cancer, Pathological Complete Response
- Trial name
- THUNDER2 (NCT04815694)
- Testing
- RT Dose escalation in LARC patients with an Early Regression Index > 13.1 at second week on nCRT
- Where
- Italy
- Volunteers
- 179 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypertension
Comparison of Diuretic-based With Non-diuretic Based Hypertension Therapy Using Echocardiographic Measures
MAIN: The benefits of treating high blood pressure successfully to normal levels on heart function are the same regardless of which particular combination of drugs are used.
- Trial name
- NCT00229242
- Testing
- Diuretic-Based or Non-Diuretic Based Hypertension Therapy
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Queen's University
Biomarker, Lipid
Shotgun Mass Spectrometry-based Lipid Profiling in Chronic Inflammatory Diseases
Collect blood from patients admitted for coronary angiography to tubes with heparin, centrifuge and collect plasma. This will be frozen at -80C.
- Conditions
- Biomarker, Lipid, Inflammation, Cardiovascular Diseases
- Trial name
- NCT04786431
- Testing
- Blood collection for lipid profiling by LC-MS
- Volunteers
- 427 people
- Sponsor
- Universidade Nova de Lisboa
Head and Neck Carcinoma
Neurofeedback in Decreasing Acute Radiotherapy-Induced Pain in Patients With Head and Neck Cancer
This pilot trial studies how well neurofeedback training works in decreasing acute radiotherapy-induced pain in patients with head and neck cancer.
- Trial name
- NCT02543320
- Testing
- LORETA Neurofeedback Training, Questionnaire Administration
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- M.D. Anderson Cancer Center
Airway Management
Airway Changes in Patients Undergoing Elective Surgical Procedures in the Prone and Trendelenburg Positions
The goal of this study is to track the intraoperative changes that occur in the airways of patients undergoing 1) laparoscopic surgeries in the Trendelenburg position, and 2) spinal surgeries in the prone position, as well as the…
- Trial name
- NCT02738788
- Testing
- Intubation
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Tufts Medical Center
Rectal Cancer
RadioPathomics Artificial Intelligence Model to Predict Tumor Regression Grading in Locally Advanced Rectal Cancer
In this study, investigators apply a radiopathomics artificial intelligence (AI) supportive model to predict neoadjuvant chemoradiotherapy (nCRT) response before the nCRT is delivered for the patients with locally advanced rectal…
- Trial name
- RPAI-TRG (NCT04273451)
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University