Clinical trials: Regression
Analgesia
Effectiveness of Pre-administered Natural Sweet-tasting Solution (Honey) for Decreasing Pain of Needle Insertion
This study aims to assess Effectiveness of Pre-administered Natural Sweet-tasting Solution (honey) for Decreasing Pain Associated with Dental Injections (infiltration) prior to dental extraction in 6-8 years old healthy Children…
- Trial name
- NCT06393777
- Testing
- honey
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sensory Modulation Disorder, Sensory Over-Responsivity
Examining the Efficiency of Neurofeedback Therapy on Adults With Sensory Over Responsivity
Sensory Over-Responsivity (SOR) is characterized by a disruption in regulating sensory stimuli and can significantly impact pain perception and restrict daily participation and quality of life.
- Trial name
- NCT03837795
- Testing
- Neurofeedback treatment
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Breast Biopsy
The Role of Pre-deployment Retraction in Decreasing Biopsy Clip Migration During Stereotactic Breast Biopsies
This will be a single-center prospective randomized control trial that is Institutional Review Board (IRB) approved. The study plans to enroll 250 female patients presenting to the University of Alabama at Birmingham (UAB) for…
- Trial name
- NCT04398537
- Testing
- 5mm retraction of clip deployment apparatus., No retraction of clip deployment apparatus.
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- University of Alabama at Birmingham
Anxiety, Preoperative Anxiety
Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively
The goal of this clinical trial is to compare the effect of melatonin, diazepam, and placebo on the level of anxiety in patients undergoing surgery.
- Trial name
- NCT06103188
- Testing
- Diazepam, Melatonin
- Where
- Jordan
- Volunteers
- 87 people
- Sponsor
- University of Jordan
Hypertrophic Cardiomyopathy
Study to Determine if Atorvastatin Reduces Size and Stiffness of Muscle in the Left Ventricle of the Heart
The purpose of this study is to determine if a drug called atorvastatin will reduce the size and stiffness of the muscle in the left ventricle of the heart.
- Trial name
- NCT00317967
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Calgary
Hypercholesterolemia
GLobal Assessment of Plaque reGression With a PCSK9 antibOdy as Measured by intraVascular Ultrasound
This study will evaluate whether low-density lipoprotein (LDL-C) lowering with evolocumab (AMG 145) results in greater change from baseline in percent atheroma volume (PAV) at week 78 than placebo in adults with coronary artery…
- Trial name
- GLAGOV (NCT01813422)
- Testing
- Evolocumab
- Where
- 226 sites in United States, Argentina and 30 more
- Volunteers
- 970 people
- Sponsor
- Amgen
Bleeding, Surgical Blood Loss
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
The aim is to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing cardiac surgery at the…
- Trial name
- DEPOSITION (NCT03376061)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Population Health Research Institute
Hypertension
Comparison of Diuretic-based With Non-diuretic Based Hypertension Therapy Using Echocardiographic Measures
MAIN: The benefits of treating high blood pressure successfully to normal levels on heart function are the same regardless of which particular combination of drugs are used.
- Trial name
- NCT00229242
- Testing
- Diuretic-Based or Non-Diuretic Based Hypertension Therapy
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Queen's University
Obesity
Activation of Brain Centers by Short-term Walnut Consumption in Obesity
The purposes of the study are: Study Aim 1. To assess the mechanisms underlying the biological effects of short-term walnut consumption on appetite with functional magnetic resonance imaging (fMRI) and assessing neurocognitive…
- Trial name
- NCT02673281
- Testing
- Walnut shake
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Type2 Diabetes, Weight Loss
Improving Glucose and Lipid Metabolism Through Caloric Restriction Using Diet or Surgery (CRUDOS)
In this explorative randomized clinical study, the investigators aim to study metabolic, cellular, and molecular changes that occur during weight loss in obese subjects with and without type 2 diabetes.
- Conditions
- Type2 Diabetes, Weight Loss, Insulin Sensitivity, Metabolism and Nutrition Disorder
- Trial name
- CRUDOS (NCT02988011)
- Testing
- Gastric by-pass surgery, Low-caloric diet
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Wound Care, Pain Intensity
Pain Medicine for Wound Care Procedures
This is a randomized double-blind study to determine if the administration of a small-dose of ketamine (an anesthetic)added to morphine (an opioid) contributes to reducing pain intensity during open wound care procedure (WCP)in…
- Conditions
- Wound Care, Pain Intensity, Hyperalgesia, Nausea
- Trial name
- NCT00701909
- Testing
- Morphine plus Ketamine
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Bacteraemia Caused by Gram-Negative Bacteria
Antibiotic Durations for Gram-negative Bacteremia
Gram-negative bacteremia (GNB) is a frequent hospital \& community-acquired infection, yet there is as yet no evidence from randomized studies on the optimal duration of antibiotic therapy.
- Trial name
- PIRATE (NCT03101072)
- Testing
- "Fixed long" antibiotic course of 14 days, "Fixed short" antibiotic course of 7 days, "Individualized duration" of antibiotic therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 504 people
- Sponsor
- University of Geneva, Switzerland
Distracted Driving, Impaired Driving
Increasing Seat Belt Wearing and Decreasing Handheld Phone Use While Driving
The study team is proposing to conduct a randomized controlled trial to determine the effectiveness of behavioral and financial incentives on phone use while driving and seat belt adherence.
- Conditions
- Distracted Driving, Impaired Driving, Driving Behaviors
- Trial name
- NCT05469477
- Testing
- Persuasive education, WOOP (aka, mental contrasting with implementation intentions., Wish, Outcome, Obstacle, Plan), Customized Habit Tips
- Where
- United States
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Surgical Procedure, Unspecified
Decreasing Emergence Agitation With Personalized Music
The purpose of the study is to assess the impact of personalized music on emergence agitation (EA), as measured by Pediatric Anesthesia Emergence Delirium scores in pediatric patients recovering from elective procedures under…
- Trial name
- NCT05044832
- Testing
- Personalized Music
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Carotid Atherosclerosis
Sonodynamic Therapy in the Treatment of Carotid Atherosclerosis
Sonodynamic therapy (SDT) is a new treatment for carotid atherosclerotic plaque. The purpose of this study is to evaluate the safety and initial effectiveness of this technique.
- Trial name
- SMART-C (NCT03871725)
- Testing
- Sonodynamic therapy (SDT)
- Where
- China
- Volunteers
- 12 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
HIV Infections
Evaluation of the Efficacy of Hydroxychloroquine in Decreasing Immune Activation in Asymptomatic HIV-infected Patients
The purpose of this pilot study is to find out if taking hydroxychloroquine will decrease immune activation (stimulation of the body's defence system) in people with early HIV infection.
- Trial name
- HCQ-01 (NCT01067417)
- Testing
- Hydroxychloroquine
- Volunteers
- 83 people
- Sponsor
- Medical Research Council
Stress, Complete Psychological Check Up
Cognition and Health in Adolescents, Mindfulness as Prevention of Stress.
The purpose of this study is to determine whether mindfulness is useful as primary prevention for psychological health in highschool students, primarily related to stress, and whether mindfulness can improve cognitive function.
- Conditions
- Stress, Complete Psychological Check Up, Sleep, Cognition - Other
- Trial name
- CHAMPS (NCT01457222)
- Testing
- Mindfulness intervention, Music relaxation
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Region Skane
Injury
Is Kinesio Taping Application Effective on Decreasing Injury Risk for Tennis Players
Research design: The study protocol was approved and required permissions were taken from related tennis club officials, and a written consent was obtained from all the participants' parents about the study.
- Trial name
- NCT04059575
- Testing
- Kinesio Taping (Performance Plus), Kinesio taping (Gold Tex)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Guven Health Group
Hypertension, Blood Pressure
The Effect of Household-based Screening on Blood Pressure Changes in South Africa
This study will evaluate the effect of household-based screening and care encouragement for blood pressure on subsequent changes in blood pressure.
- Trial name
- NCT03762304
- Testing
- Household blood pressure screening with care encouragement
- Volunteers
- 3,986 people
- Sponsor
- Till Bärnighausen
Adenocarcinoma, Rectal Diseases
Molecular, Pathologic and MRI Investigation of the Prognostic and Redictive Importance of Extramural Venous Invasion in Rectal Cancer (MARVEL) Trial
Extramural venous invasion (EMVI) is the spread of microscopic tumour cells into the veins around the tumour. Rectal cancer treatment has improved greatly over recent years.
- Conditions
- Adenocarcinoma, Rectal Diseases, Colorectal Neoplasms, Adenocarcinoma, Mucinous
- Trial name
- MARVEL (NCT01995942)
- Where
- 19 sites in United Kingdom
- Volunteers
- 246 people
- Sponsor
- Royal Marsden NHS Foundation Trust