Clinical trials: Regression
Anti-p53 TCR-Gene
Phase II Study of Metastatic Cancer That Overexpresses P53 Using Lymphodepleting Conditioning Followed by Infusion of Anti-P53 TCR-Gene Engineered Lymphocytes
Background: The p53 gene normally suppresses tumor growth, but when it is mutated, or damaged, tumors can grow unchecked. In cancers where the p53 gene has mutated, an increased level of p53(overexpression of p53) can be measured…
- Trial name
- NCT00393029
- Testing
- anti-protein 53 or tumor protein 53 (p53) T-cell receptor transduced peripheral blood lymphocytes, aldesleukin, filgrastim
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Atrial Fibrillation
Stepwise Strategy for Modifying Atrial Fibrillation Substrate Study - MRI
The investigators will conduct an observational trial, with outcome ascertainment at 3 months and 6 months after cardioversion. The primary objective is to demonstrate how cardioversion may aid in the regression of left atrial…
- Trial name
- SAFE-MRI (NCT05099783)
- Testing
- late gadolinium enhanced magnetic resonance imaging
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Anastomotic Leak
Decreasing Leak Rate in Colorectal Surgery Using Near Infra-red (NIR) Imaging
Anastomotic leak is a devastating complication of colorectal surgery. There is no widespread means of assessing the viability of a laparoscopic anastomosis.
- Trial name
- NCT02459405
- Testing
- NIR anastomotic perfusion assessment, Near infrared camera
- Where
- 4 sites in Ireland, Italy and 2 more
- Volunteers
- 504 people
- Sponsor
- University Hospital, Geneva
Carotid Artery Disease
CARotid plaqUe StabilizatiOn and Regression With Evolocumab.
The CARUSO trial aims at investigating the efficacy of evolocumab in promoting carotid plaque morphological stabilization and regression as compared to traditional lipid lowering therapy (LLT).
- Trial name
- CARUSO (NCT04730973)
- Testing
- Evolocumab, lipid-lowering therapy (LLT)
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda Ospedaliera Ordine Mauriziano di Torino
Rectal Cancer
RadioPathomics Artificial Intelligence Model to Predict Tumor Regression Grading in Locally Advanced Rectal Cancer
In this study, investigators apply a radiopathomics artificial intelligence (AI) supportive model to predict neoadjuvant chemoradiotherapy (nCRT) response before the nCRT is delivered for the patients with locally advanced rectal…
- Trial name
- RPAI-TRG (NCT04273451)
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
First Episode Psychosis
Socially Inappropriate Behaviour in People With First Episode Psychosis: A Caregivers' Perspective
Social impairment is one of the core symptoms in first episode psychosis (FEP). Despite negative symptoms and social cognition impairment found in patient suffering from FEP, clinicians occasionally identified socially…
- Trial name
- NCT03501160
- Testing
- Face-to face semi-structured in-depth interview
- Where
- 2 sites in Hong Kong
- Volunteers
- 8 people
- Sponsor
- Chinese University of Hong Kong
Dehydration, Seizure
Point of Care Device Use in the Pediatric Emergency Department
To compare the effect of "point-of-care" (POC) analysis of blood work with traditional laboratory methods on length of stay in a pediatric emergency department (PED).
- Conditions
- Dehydration, Seizure, Gastroenteritis, Hyperglycemia
- Trial name
- NCT00285285
- Testing
- Point of Care Device; i-Stat Analyzer
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale University
Contrast Induced Nephropathy
Effect of Sodium Bicarbonate Solution in Decreasing the Incidence of Contrast Induced Nephropathy (CIN)
Radio Contrast Induced Nephropathy (RCIN) remains a well recognized complication in patients undergoing diagnostic or interventional procedures requiring radiographic contrast agents.
- Trial name
- NCT00514150
- Testing
- Sodium Bicarbonate plus normal saline 0.9%, normal saline 0.9%
- Where
- Iran
- Volunteers
- 265 people
- Sponsor
- Tehran University of Medical Sciences
Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques
Ticin Pilot Study: Sirolimus-Eluting Balloon for Stabilization and Regression of Non-Obstructive Coronary Plaques.
The goal of this pilot clinical trial is to evaluate the use of the Selution SLR sirolimus-eluting balloon, in addition to guideline-directed medical therapy (GDMT), for the preventive treatment of non-flow-limiting vulnerable…
- Conditions
- Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Multivessel Coronary Artery Disease, Coronary Vessel
- Trial name
- NCT06928883
- Testing
- Sirolimus drug eluting ballooon therapy, Optimal guidelines-directed medical therapies (GDMT)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Cardiocentro Ticino
Autism
Efficacy and Safety of Lenalidomide for Treatment of Autistic Spectrum Disorders
The purpose of this study is to determine if lenalidomide (Revlimid®)reduces proinflammatory cytokines including TNF-alpha and may actually alter the clinical course of autism for some children.
- Trial name
- NCT00996931
- Testing
- lenalidomide
- Volunteers
- 6 people
- Sponsor
- Sutter Medical Foundation
Hyperandrogenism, Metabolic Cardiovascular Syndrome
Phlebotomy and Polycystic Ovary Syndrome
AIMS To study the effects of the decrease in iron tissue depots after scheduled bloodletting on insulin sensitivity, carbohydrate metabolism, classic and non-classic cardiovascular risk factors in patients with functional…
- Trial name
- NCT02460445
- Testing
- Phlebotomy, ethinylestradiol, Cyproterone Acetate
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Manuel Luque Ramírez
Respiratory Distress Syndrome
Comparing Weaning of Nasal Continuous Positive Airway Pressure (CPAP) From Preterm Infants
To compare the 2 methods of weaning of nasal continuous positive airway pressure (CPAP) in premature babies born between 26 and 32 weeks
- Trial name
- NCT02126501
- Testing
- Gradual pressure wean
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Maimonides Medical Center
Peripheral Vascular Disease
Guided Meditation to Decrease Perioperative Anxiety and Increase Patient Intraoperative Compliance in Vascular Surgery
The primary purpose of this clinical trial is to test the feasibility of implementing a perioperative guided meditation program for patients undergoing peripheral vascular interventions that are performed under procedural…
- Trial name
- NCT05837481
- Testing
- Meditation
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Patient Satisfaction
Patient Satisfaction in Post-LASIK Patients With Presbyopia-Correcting IOLs vs. Post-Lasik Patients With Monofocal IOLs
Compare functional visual outcomes and patient satisfaction of post-LASIK patients having received presbyopia-correcting IOLs versus post-LASIK patients having received monofocal IOLs
- Trial name
- NCT04134507
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bucci Laser Vision Institute
Cervical Intraepithelial Neoplasia Grade 2 (CIN2)
Biomarkers Predictive for Cervical Intraepithelial Neoplasia Grade 2 (CIN2) Evolvement
Introduction Cervical intraepithelial neoplasia CIN1 (low grade), CIN2 (moderate grade), CIN3 (severe grade) defines cervical precancer lesions derived from the squamous epithelial cell line.
- Trial name
- NCT05049252
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- University of Aarhus
No Evidence of Disease
Celecoxib in Decreasing the Damaging Effects of Sunburn in Healthy Volunteers
This clinical trial studies celecoxib in decreasing the damaging effects of sunburn in healthy volunteers. Celecoxib may reduce skin damage by blocking enzymes associated with sunburn in healthy volunteers.
- Trial name
- NCT02090933
- Testing
- Celecoxib, Laboratory Biomarker Analysis, UV Light Therapy
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Nausea, Postoperative, Vomiting, Postoperative
Decreasing Post-Operative Nausea and Vomiting in the Bariatric Surgical Patient
From the research and current studies, post-operative nausea and vomiting is a common complaint after bariatric surgery. Nausea relief inhalers could improve post-operative nausea and vomiting without the need for further…
- Trial name
- NCT06110416
- Testing
- nausea relief inhaler
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Methodist Health System
COPD
Forced Oscillation Technique (FOT) and Expiratory Flow Limitation (EFL)
The aim of this study is to distinguish COPD patients with expiratory flow limitation in body plethysmography (open loop) from the patients without expiratory flow limitation in body plethysmography (closed loop) with the…
- Trial name
- NCT00499304
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Metastatic Cancer
Gene Therapy Using Anti-CEA Cells to Treat Metastatic Cancer
Background: Carcinoembryonic antigen (CEA) is a protein present mostly in cancer cells. An experimental procedure developed for treating patients with cancer uses blood cells found in their tumors or bloodstream.
- Trial name
- NCT00923806
- Testing
- PG13-CEA_TCR (Anti-CEA TCR PBL), Aldesleukin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Cancer Institute (NCI)
Resistant Hypertension
Effects of REnal Denervation for Resistant Hypertension on Exercise Diastolic Function and Regression of Atherosclerosis and the Evaluation of NEW Methods Predicting A successfuL Renal Sympathetic Denervation (RENEWAL-EXERCISE, -REGRESS, and -PREDICT Trial From RENEWAL RDN Registry)
1. (RENEWAL-EXERCISE trial) The investigators hypothesize that the increased sympathetic nervous system activation that is associated with resistant hypertension is a major contributor in the pathogenesis of exercise diastolic…
- Trial name
- NCT01918111
- Testing
- Renal denervation, adenosine infusion treatment
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Yonsei University