Clinical trials: Regression
Endstage Renal Disease, Diabetes
Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) Agonist in Diabetic End-Stage Renal Disease Patients
To test the hypothesis that PPAR-gamma agonist, rosiglitazone, induces carotid plaque regression in diabetic ESRD patients on maintenance PD via its anti-inflammatory property.
- Trial name
- NCT00745914
- Testing
- Pioglitazone
- Where
- 2 sites in Hong Kong
- Volunteers
- 22 people
- Sponsor
- The University of Hong Kong
Catheterization, Pain
Efficacy of Art Intervention on Decreasing Pain and Anxiety During Intravenous Cannulation
Peripheral Intravenous Cannulation (PIVC), one of the most common therapeutic procedures in medical care, can be difficult even for experienced medical practitioners.
- Conditions
- Catheterization, Pain, Anxiety, Art
- Trial name
- NCT04714255
- Testing
- Trace Image and Coloring for Kids-Book (TICK-B)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Witten/Herdecke
Intraocular Lens, Cataract
Predicting Intraocular Lens Tilt Using OCT Measurements and Partial Least Squares Regression Modelling
During cataract surgery an artificial intraocular lens (IOL) is implanted in the eye to replace the lens and to correct the refraction for distance vision. Misalignment of IOLs can cause severe loss of visual quality.
- Trial name
- Tilt (NCT06305338)
- Testing
- Optical Coherence Tomography
- Where
- Austria
- Volunteers
- 110 people
- Sponsor
- Johannes Kepler University of Linz
Knee Osteoarthritis
Digital Motivation to Decrease Inactive Behaviour in Patients With Knee Osteoarthritis
Physical inactivity is a major risk behaviour with a potential for causing premature death, particularly among people with mobility limitations, such as knee osteoarthritis.
- Trial name
- NCT03339011
- Testing
- Motivational SMS text message
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Marius Henriksen
Cervical Intraepithelial Neoplasia
Testing Use of Condoms on Regression of Cervical Intraepithelial Neoplasia
Women who are diagnosed with CIN2 and who have a pregnancy wish are followed up 6 months after the diagnosis with new examinations. The regression rate is based solely on the woman's own ability to clear the cervical lesions.
- Trial name
- NCT02907333
- Testing
- Advice to use condoms
- Where
- Denmark
- Volunteers
- 285 people
- Sponsor
- University of Copenhagen
Rectal Cancer Patients, Total Neoadjuvant Therapy
Nodal Downstaging Versus Primary Tumor Regression as Predictors of Survival After Total Neoadjuvant Therapy for Rectal Cancer: A Retrospective Study
To evaluate the prognostic impact of post-TNT pathological nodal status (ypN) on LRFS, DMFS, and OS, and compare it with that of primary tumor response
- Trial name
- NCT07557316
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Cervical Radiculopathy
Role of Nerve Mobilizations in Decreasing Pain and Disability Among Patients With Cervical Radiculopathy
Objective of the study is to find out the effectiveness of nerve mobilization in patients with cervical radiculopathy. It is a single blinded randomized controlled trial using non-probability convenient sampling.
- Trial name
- NCT04896749
- Testing
- Nerve mobilization, Conventional physical therapy
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- University of Lahore
Delirium
Efficacy of Melatonin in Decreasing the Incidence of Delirium in End of Life Patients
The purpose of this study is to determine if melatonin administration to end-of-life patients is effective in preventing the development of delirium compared with those who do not receive this treatment.
- Trial name
- NCT02536417
- Testing
- Melatonin, Sugar pill
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Fraser Health
Acne Vulgaris
Decreasing Severity of Acne Vulgaris After the Use of a Combination of Anti-Acne Cream
This study was conducted to see whether there was a decrease in the degree of acne vulgaris / pimple, to find out what proportion of respondents experienced a decrease in severity and who did not experience a decrease in the…
- Trial name
- NCT04118296
- Testing
- Anti-Acne Preparations for Topical Use
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- Sukma Skin Treatment
Acute Respiratory Distress Syndrome, Respiration, Artificial
Impact of Decreasing Respiratory Rate on Lung Injury Biomarkers in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a form of acute lung injury of inflammatory origin, which represents a public health problem worldwide due to its prevalence, and its high mortality rate, close to 40%.
- Conditions
- Acute Respiratory Distress Syndrome, Respiration, Artificial, Ventilator-Induced Lung Injury
- Trial name
- NCT04641897
- Testing
- Respiratory rate modification
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Urinary Tract Infections, Spinal Cord Injuries
Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury
A non-randomized study evaluating the efficacy of intravesical gentamicin on the occurrence rate of urinary tract infections and bladder complications in patients after spinal cord injury (SCI), and to assess its effectiveness in…
- Conditions
- Urinary Tract Infections, Spinal Cord Injuries, Spinal Cord Diseases, Neurogenic Bladder
- Trial name
- NCT03503513
- Testing
- Gentamicin Sulfate
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Anesthesia, General
Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in Elderly
Laryngeal mask airway (LMA) is currently the most widely used supraglottic airway device with advantages of simple and fast placement, reduced anesthesia drug use, more stable hemodynamics, and less throat discomfort after…
- Trial name
- LMA (NCT05310110)
- Testing
- 10% lidocaine spray, Cisatracurium, Propofol
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Polypoidal Choroidal Vasculopathy
Interval of Disease Inactivity After Complete Polypoidal Regression in PCV Receiving Aflibercept
Polypoidal choroidal vasculopathy (PCV), a subtype of neovascular age-related macular degeneration (NV AMD), is an important cause of central visual loss, especially among Asian and African descendants.
- Trial name
- NCT04707027
- Testing
- Aflibercept Injection (2 mg/0.05 ml), Defer treatment
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Chiang Mai University
Primary Open Angle Glaucoma, Hypertension Ocular
Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion.
Glaucoma is among the leading causes for blindness in the western world. Elevated intraocular pressure (IOP) has been identified as the most important risk factor.
- Trial name
- GME (NCT02300818)
- Testing
- Pulsed Electromagnetic Field Therapy, Seawater eyedrops
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American Society Of Thermalism And Climatology Inc
Obstructive Coronary Artery Disease, Coronary Artery Disease
YELLOW II Study: Reduction in Coronary Yellow Plaque, Lipids and Vascular Inflammation by Aggressive Lipid Lowering
Coronary artery disease (CAD) remains a leading cause of death in most countries. It is well known that the reduction of cholesterol levels by statin therapy is associated with significant decreases in plaque burden.
- Trial name
- NCT01837823
- Testing
- rosuvastatin
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Heart Failure, Kidney Dysfunction
The Effects of Decreasing the Lasix Dose on the Cardiorenal System
The investigators' objective is to define the effects of decreasing the furosemide dose on heart, kidney and humoral function in people with compensated heart failure and kidney dysfunction and also in people with compensated…
- Trial name
- Aim1 (NCT00982423)
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Leptospirosis
Preventive Strategies for Early and Late Complications of Leptospirosis
The goal of this clinical trial is to learn if complement factor I (CFI) works to predict development of complications in participants with leptospirosis.
- Trial name
- NCT07127718
- Testing
- Prophylactic Plasma Transfusion, Hemoperfusion, Extracorporeal Membrane Oxygenation
- Where
- 3 sites in Philippines
- Volunteers
- 678 people
- Sponsor
- National Kidney and Transplant Institute, Philippines
Proliferative Diabetic Retinopathy
The Individually Marked Panretinal lasEr phoTokoagUlation for Proliferative Diabetic Retinopathy Study - DETECT
The purpose of this study is to determine the threshold level of proliferative diabetic retinopathy progression and regression after standard panretinal photocoagulation.
- Trial name
- IMPETUS-D (NCT02157350)
- Testing
- Panretinal laser photocoagulation
- Where
- Denmark
- Volunteers
- 65 people
- Sponsor
- Odense University Hospital
This Study Mainly Focus on the Eras Protocol Decreasing Time of Npo and Early Discharge From Hospital to Avoid Hospital Acquired Infections
A Comparative Study of Preoperative Carbohydrate Loading Dose and Fasting on Postoperative Recovery Time in Elective Abdominal Surgery Patients
This randomized controlled trial aims to compare the effect of preoperative carbohydrate loading versus standard overnight fasting on postoperative recovery time in patients undergoing elective abdominal surgery.
- Trial name
- NCT07562776
- Testing
- Patients will be given 400 mL of a carbohydrate-rich clear drink (10% daxtrosewater) approximately 2-3 hours before induction of anesthesia, according to ERAS guidelines., Standard pre operative fasting
- Volunteers
- 144 people
- Sponsor
- Gulab Devi Hospital
Myopic Regression
Effect of Timolol on Refractive Outcomes in Eyes With Myopic Regression After LASIK: a Randomized Clinical Trial
In this randomized controlled clinical trial, we compare the effects of timolol versus placebo for treatment of myopic regression after LASIK
- Trial name
- NCT01506635
- Testing
- Timolol
- Where
- Iran
- Volunteers
- 45 people
- Sponsor
- Shahid Beheshti University of Medical Sciences