Clinical trials: Rejection
Transplant Rejection, Kidney Transplantation
Study of Tolerant Kidney Transplant Recipients
The purpose of this multi-center (observational) registry study is to establish a database of clinical and laboratory information that may help to identify any unique characteristics of tolerant participants that differ from…
- Conditions
- Transplant Rejection, Kidney Transplantation, Renal Transplantation, Renal Transplant
- Trial name
- FACTOR (NCT01338779)
- Where
- 4 sites in United States
- Volunteers
- 197 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplant Rejection
Reduced-dose Alemtuzumab for Kidney Transplant Rejection
Prospective, follow-up study of kidney transplant recipients treated with alemtuzumab anti-rejection therapy for severe or glucocorticoid-resistant kidney transplant rejection.
- Trial name
- ROSETTE (NCT06100965)
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Erasmus Medical Center
Overweight
Effects of a Computer Game on Activity Choices
The study seeks to discover whether peer rejection increases the value of food relative to peer interaction in overweight individuals.
- Trial name
- NCT00875511
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University at Buffalo
Kidney Transplantation
Chronic Transplant Glomerulopathy and Regulation of Expression of Ephrin B1
The principal purpose is the study of the regulation of the expression of ephrin-B1 by immunofluorescence in kidney biopsies of patients with Chronic transplant glomerulopathy (CTG) compared to biopsies prior to the CTG, in same…
- Trial name
- GARRE (NCT02147210)
- Testing
- biological analysis
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Kidney Transplant, Chronic Kidney Disease
Empagliflozin Treatment in Kidney Transplant Recipients
Kidney transplantation improves the health and quality of life for those Veterans with end stage kidney disease (ESKD). While early patient and graft survival are excellent, long-term outcomes continue to be challenging.
- Trial name
- SEKTR (NCT06013865)
- Testing
- Empagliflozin
- Where
- 5 sites in United States
- Volunteers
- 264 people
- Sponsor
- VA Office of Research and Development
Hematological Malignancies
Mesenchymal Stem Cell Infusion as Prevention for Graft Rejection and Graft-versus-host Disease
Mesenchymal Stem Cell Infusion as Prevention for Graft Rejection and Graft-Versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation With Nonmyeloablative Conditioning from HLA-mismatched PBSC or cord blood: a Pilot…
- Trial name
- NCT00504803
- Testing
- Mesenchymal stem cell infusion
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Liege
Corneal Neovascularization
Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization
To determine the effect of subconjunctival Bevacizumab in corneal neovascularization
- Trial name
- NCT00555594
- Testing
- Bevacizumab (Avastin)
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Lung Transplant Recipient, Donor Specific Antibodies
DSA Intragraft in Lung Transplantation: Diagnostic and Prognostic Value in Antibody Mediated Rejection
The diagnosis of AMR in lung transplant recipients is difficult and often comes too late, because of lack of standardized definition.
- Conditions
- Lung Transplant Recipient, Donor Specific Antibodies, Antibody Mediated Rejection
- Trial name
- NCT03702257
- Testing
- bronchoscopy.
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Lung Transplant
Alveoscopy, Endoscopic Confocal Microscopy and Lung Rejection, Parenchymal Lung Diseases in Vivo
Lung transplantation is indicated when end-stage lung diseases no longer respond to available standard therapy, making life expectancy short and associated with disability.
- Trial name
- NCT01033201
- Testing
- Confocal imaging
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Mayo Clinic
Kidney Transplant Rejection, Kidney Transplantation
Precision Risk Stratification in Kidney Transplant Patients - EU-TRAIN
Main objective: To design a precision risk stratification system that predicts individual risk of rejection
- Conditions
- Kidney Transplant Rejection, Kidney Transplantation, Risk Stratification, Prognosis
- Trial name
- EU-TRAIN (NCT03652402)
- Testing
- kidney transplantation
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 558 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Transplant Rejection, Antibody-mediated Rejection
Lung Transplant Plasmapheresis/Belatacept/Carfilzomib for Antibody Mediated Rejection and Desensitization
Antibody mediated rejection (AMR) post transplant contributes to poor long term outcomes after lung transplantation. Additionally, high antibodies detected pre transplant in candidates limit donor availability for lung…
- Trial name
- NCT03805178
- Testing
- Belatacept, Carfilzomib
- Sponsor
- Duke University
Kidney Transplantation
Concentration Controlled Everolimus With Reduced Dose Cyclosporine Versus Mycophenolate Mofetil With Standard Dose Cyclosporine in de Novo Renal Transplant Adult Recipients Treated With Basiliximab and Corticosteroids
The 12 Month Core Study (CRAD001A1202) was designed to evaluate the efficacy and safety comparing concentration-controlled everolimus (1.5 mg/day starting dose) with reduced dose cyclosporine and corticosteroids versus 2 g/day…
- Trial name
- NCT00658320
- Testing
- Everolimus, Mycophenolate mofetil (MMF), Basiliximab
- Where
- Japan
- Volunteers
- 122 people
- Sponsor
- Novartis
Sensitized Kidney Transplant Recipients
Identification of Donor Specific B Cells and Antibody Mediated Rejection
Many people who are on the wait list for a kidney transplant have harmful antibodies, called donor specific antibodies (DSA), which will attack foreign tissue such as the transplanted organ.
- Trial name
- NCT02133248
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Borderline Personality Disorder
Acetaminophen and Social Processes
Recent research has identified heightened sensitivity to social rejection as a core feature of BPD. Rejection sensitivity can trigger the aggressive, impulsive, and self-injurious behaviors characteristic of the disorder.
- Trial name
- NCT02108990
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Ohio State University
Kidney Transplantation
Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation
The objective of the study will be to evaluate the effect of different therapeutic immunosuppressive strategies currently employed in common clinical practice on regulatory T lymphocytes and to verify the hypothesis that the…
- Trial name
- EVERTWIST (NCT01640743)
- Testing
- Tacrolimus + Methylprednisolone, Tacrolimus + Everolimus + Methylprednisolone
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
End Stage Renal Failure
Gengraf Conversion Study in Stable Renal Allograft Transplant Recipients
The purpose of this study is to establish the therapeutic equivalence of Gengraf® with the standard treatment Neoral® for a treatment period of 6 months in stable renal allograft transplant recipients with respect to drug levels…
- Trial name
- NCT01990118
- Testing
- Neoral, Gengraf® capsule containing 25mg or 100mg cyclosporine
- Where
- Malaysia
- Volunteers
- 106 people
- Sponsor
- Penang Hospital, Malaysia
Evidence of Liver Transplantation, Hyperglycemia
Study of Glycemic Control on Liver Transplantation Outcomes
Many but not all studies have shown improvement in morbidity and mortality with intensive glycemic management postoperatively. In this study, the investigators propose to determine whether improved glycemic control using…
- Conditions
- Evidence of Liver Transplantation, Hyperglycemia, Rejection
- Trial name
- NCT01211730
- Testing
- Insulin
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Northwestern University
Liver Transplantation, Graft Versus Host Disease
The Effect of Human Leukocyte Antigen Macthing on Guiding Tacrolimus Regimen After Liver Transplantation
The aim of this research is to design a randomized controlled clinical study, which is based on HLA matching rate to guide tacrolimus regimen.
- Conditions
- Liver Transplantation, Graft Versus Host Disease, Graft Rejection, Drug-Related Side Effects and Adverse Reactions
- Trial name
- NCT03147157
- Testing
- tacrolimus regimen guided by HLA matching rate
- Volunteers
- 120 people
- Sponsor
- The First Hospital of Jilin University
HIV Infections, Renal Transplant Rejection
Switch to Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/F/TAF) After Renal Transplant
This is an open-label study, where participants will be switched from their current HIV medication to the study drug, BIC/F/TAF. Open-label means both the investigator and the participant will know what drug will be given.
- Trial name
- NCT04530630
- Testing
- BIC/F/TAF 50Mg-200Mg-25Mg Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Cardiac Allograft Vasculopathy, Heart Transplant Rejection
Extracorporeal Photopheresis and Early Cardiac Graft Vasculopathy
Heart transplantation is a golden standard for the treatment of terminal heart failure. The major cause of death in late posttransplant period is cardiac allograft vasculopathy (CAV).
- Trial name
- ECP-OCT (NCT04226521)
- Testing
- Extracoropreal photopheresis
- Where
- Croatia
- Volunteers
- 38 people
- Sponsor
- Bosko Skoric