Clinical trials: Rejection
Diabetes, Graft Rejection
Thymoglobulin in Calcineurin Inhibitor and Steroid Minimization Protocol
This study has been designed to test whether using Thymoglobulin with low dose Cyclosporine and early steroid dosage reduction will minimize both kidney rejection and the development of new onset diabetes mellitus after renal…
- Trial name
- NCT00706680
- Testing
- Thymoglobulin
- Where
- 3 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Renal Transplantation, Graft Rejection
A Study to Evaluate the Effect of Thymoglobulin and Reduced Doses of Steroids to Prevent Renal Transplant Rejection
This study involves the use of a drug called Thymoglobulin, which is approved in the US to treat kidney transplant rejection and in Canada to treat and to prevent kidney transplant rejection.
- Trial name
- NCT00089947
- Testing
- Thymoglobulin [Anti-Thymocyte Globulin (Rabbit)]
- Where
- 19 sites in United States
- Volunteers
- 150 people
- Sponsor
- Genzyme, a Sanofi Company
Kidney Transplantation, Renal Transplantation
Envarsus XR® in Adolescent Renal Transplant Recipients
Adolescents commonly experience barriers to adherence that entail forgetfulness, distraction, poor planning, and scheduling problems.
- Conditions
- Kidney Transplantation, Renal Transplantation, Grafting, Kidney
- Trial name
- EnvarsusXR (NCT03266393)
- Testing
- Envarsus XR, Tacrolimus
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, Los Angeles
Bronchiolitis Obliterans Syndrome
Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation
A major source of graft failure and dysfunction in lung transplantation is known to be bronchiolitis obliterans (BO)and its clinical correlate called bronchiolitis obliterans syndrome(BOS).
- Trial name
- NCT00528853
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Kidney Transplant Rejection, Kidney Transplant; Complications
Basiliximab vs Low-dose Thymoglobulin Induction Therapy in Low Risk Kidney Transplant Patients
Demonstrate that low dose (3 mg/kg total ) rATG (thymoglobulin) has similar efficacy (delayed graft function, slow graft function, biopsy proven acute rejection episodes, infections, hospitalizations, adverse events, graft loss…
- Trial name
- NCT03006419
- Testing
- Basiliximab, Thymoglobulin
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Cardiac Allograft Vasculopathy, Acute Cellular Graft Rejection
Cardiac Mitochondrial Function After Heart Transplantation
Studies have shown that cardiac function is affected immediately after heart transplantation (HTx), but seems to recover to some extent over the first year.
- Conditions
- Cardiac Allograft Vasculopathy, Acute Cellular Graft Rejection, Primary Graft Failure, Mitochondrial Function
- Trial name
- ENERGY-HTX (NCT04105803)
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Aarhus
End-Stage Renal Disease, Chronic Allograft Nephropathy
Prevention of Kidney Transplant Rejection
The purpose of this study is to see how effective 2 drugs, irbesartan and pravastatin, are at slowing kidney transplant failure. Many kidney transplant patients have some type of chronic rejection.
- Trial name
- NCT00005010
- Testing
- Irbesartan, Pravastatin
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Corneal Transplant
Neovascularization Patterns in Corneal Graft Rejection
Corneal transplantation is the most commonly performed human tissue transplant worldwide. Over 40,000 corneal transplants occur in the US each year. .
- Trial name
- NCT01695655
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Allosensitization, Heart Transplant Failure and Rejection
Study of Daratumumab for Decreasing Circulating Antibodies in Sensitized Patients Awaiting Heart Transplantation
The purpose of this study is to test whether daratumumab, a drug that eliminates antibody-producing plasma cells, can effectively lower the level of preformed antibodies in patients awaiting heart transplantation.
- Trial name
- NCT04088903
- Testing
- Daratumumab
- Sponsor
- Ronald Witteles
Heart Transplant Rejection
Molecular Diagnosis of Heart Allograft Rejection Using Intra-Graft Targeted Gene Expression Profiling.
The goal of this observational study is to develop and validate a molecular heart rejection diagnostic system based on targeted transcriptome as a novel monitoring companion tool for heart allograft precision diagnostics…
- Trial name
- Nano-Heart (NCT06436027)
- Testing
- Nano-Heart tool: Intra-Graft Targeted Gene Expression Profiling
- Where
- 3 sites in United States, France and 1 more
- Volunteers
- 496 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Transplant; Failure, Kidney
Pilot Study of Contrast-Enhanced Ultrasound of Transplanted Kidney
To check the possibility of the acquisition of a number of parameters through real-time contrast-enhanced ultrasound and sonoelastography images and to verify the correlation with pathologic results from ultrasound guided biopsy…
- Trial name
- NCT01883583
- Testing
- Contrast-enhanced Ultrasound And Sonoelastography
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Kidney Transplantation, Rejection Acute Renal
Metabolite Biomarkers Related to Acute Rejection in Kidney Transplantation
The development of acute rejection can only be considered in cases with increasing serum creatinine in patients with kidney transplantation.
- Trial name
- NCT03134625
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Kidney Transplant, Rejection of Renal Transplant
Development and Validation of HistoMX, a Gene-Expression Platform for Molecular Interpretation of Kidney Allograft Biopsies
This retrospective multicentre observational study developed and validated HistoMX, an automated gene-expression-based platform for multidimensional molecular interpretation of kidney allograft biopsies.
- Conditions
- Kidney Transplant, Rejection of Renal Transplant, Antibody Mediated Rejection, BK Virus Nephropathy
- Trial name
- HistoMX (NCT07700563)
- Volunteers
- 2,410 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Kidney Transplant
Prediction of Acute Rejection in Renal Transplant
Acute rejection is still a major risk factor affecting the prognosis of kidney transplant patients. Alloreactive cells of the recipient infiltrate the kidney graft and cause inflammatory reaction which damages the graft structure…
- Trial name
- NCT00205257
- Sponsor
- University of Wisconsin, Madison
Kidney Transplant Rejection
Mesenchymal Stromal Cells in Kidney Transplant Recipients
The general aim of the present study is to test a cell therapy with autologous ex-vivo expanded mesenchymal stromal cells (MSCs) as a strategy to induce tolerance in living-donor kidney transplant recipients.
- Trial name
- NCT02012153
- Testing
- Mesenchymal Stromal Cells
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Antibody-mediated Rejection, Hyperacute Rejection of Cardiac Transplant
The De-novo Use of Eculizumab in Presensitized Patients Receiving Cardiac Transplantation
All individuals who receive a heart transplant are at risk for developing antibody-mediated rejection (AMR). An antibody is a protein produced by the body's immune system when it detects a foreign substance, called an antigen.
- Conditions
- Antibody-mediated Rejection, Hyperacute Rejection of Cardiac Transplant, Left Ventricular Dysfunction, Cardiac Allograft Vasculopathy
- Trial name
- DUET (NCT02013037)
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Cedars-Sinai Medical Center
Renal Transplant Rejection, Chronic Kidney Diseases
Pathology and Imaging in Kidney Allografts
This study will perform multi-parametric renal MRI in 70 patients with a renal transplant who are undergoing a clinically indicated biopsy of their transplant.
- Conditions
- Renal Transplant Rejection, Chronic Kidney Diseases, Fibrosis
- Trial name
- PIKA (NCT03780101)
- Testing
- Multi-parametric renal MRI
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- NHS Greater Glasgow and Clyde
Heart Transplanted Patients, Lung Transplanted Patients
Unraveling Mechanism of Action of Extracorporeal Photopheresis in Heart and Lung Transplant Patients
This is a prospective observational single center national study. Lung and heart transplant patients with a definite diagnosis of chronic lung allograft dysfunction (CLAD) or cardiac allograft vasculopathy (CAV) will be assigned…
- Conditions
- Heart Transplanted Patients, Lung Transplanted Patients, Chronic Lung Allograft Dysfunction (CLAD), Cardiac Allograft Vasculopathy
- Trial name
- URRAH (NCT06899828)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Heart Transplant Rejection
Surveillance HeartCare® Outcomes Registry
This is an observational registry to assess the clinical utility of surveillance using HeartCare testing services, in association with clinical care of heart transplant recipients.
- Trial name
- SHORE (NCT03695601)
- Testing
- Standard of Care
- Where
- 67 sites in United States
- Volunteers
- 2,743 people
- Sponsor
- CareDx
Kidney Transplant Failure and Rejection
Anti-Angiotensin II Type 1 Receptor Antibodies and Kidney Transplant Outcomes
Incompatibility between non-genetically identical donors and recipients has been increasingly recognized as the main contributing factor to solid allograft rejection and failure, through the triggering of donor-specific responses…
- Trial name
- NCT03466775
- Testing
- Anti-angiotensin II type 1 receptor antibody measurement, Measurement of ENDAT expression level allograft, Allograft survival
- Where
- 2 sites in France
- Volunteers
- 1,845 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation