Clinical trials: Rejection of Renal Transplant
Kidney Transplant Rejection
Impact of the Microbiota on the Likelihood of Renal Graft Rejection
Identification of a bacterial signature in the blood or stool that may be associated with acute rejection in patients treated with Nulojix during their first year of transplant.
- Trial name
- MERRLIN (NCT04736381)
- Testing
- Belatacept Injection [Nulojix]
- Where
- 10 sites in France
- Volunteers
- 70 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pediatric Heart Transplantation, Immunosuppression
Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score
The TEAMMATE Trial will enroll 210 pediatric heart transplant patients from 25 centers at 6 months post-transplant and follow each patient for 2.5 years.
- Conditions
- Pediatric Heart Transplantation, Immunosuppression, Chronic Kidney Diseases, Cardiac Allograft Vasculopathy
- Trial name
- TEAMMATE (NCT03386539)
- Testing
- Everolimus, Tacrolimus, Mycophenolate Mofetil
- Where
- 25 sites in United States
- Volunteers
- 211 people
- Sponsor
- Boston Children's Hospital
Kidney Transplant
GraftAssure Lowering Allograft rejeCTIon by Combination- (GALACTIC) Trial
The GALACTIC Registry study purpose is to validate the Combination Model-score (CM-score) for increased accuracy in the percentage of the positive predictive value (PPV) of allograft rejection results for the GraftAssure…
- Trial name
- GALACTIC (NCT07551531)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Insight Molecular Diagnostics
Kidney Transplant Rejection
Safety and Efficacy of Tegoprubart in Patients Undergoing Kidney Transplantation
This study will evaluate the safety and efficacy of AT-1501 compared with tacrolimus in patients undergoing kidney transplantation.
- Trial name
- NCT05983770
- Testing
- AT-1501, Tacrolimus
- Where
- 43 sites in United States, Australia and 5 more
- Volunteers
- 127 people
- Sponsor
- Eledon Pharmaceuticals
Kidney Transplant Rejection
Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA
Kidney transplant rejection remains a significant challenge to long-term graft survival. While histological biopsy continues to be the gold standard for diagnosing rejection, noninvasive biomarkers such as donor-derived cell-free…
- Trial name
- NCT07415876
- Testing
- Retrospective Cohort Enrollment, Prospective Cohort Enrollment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Kidney Transplant, Rejection of Renal Transplant
Development and Validation of HistoMX, a Gene-Expression Platform for Molecular Interpretation of Kidney Allograft Biopsies
This retrospective multicentre observational study developed and validated HistoMX, an automated gene-expression-based platform for multidimensional molecular interpretation of kidney allograft biopsies.
- Conditions
- Kidney Transplant, Rejection of Renal Transplant, Antibody Mediated Rejection, BK Virus Nephropathy
- Trial name
- HistoMX (NCT07700563)
- Volunteers
- 2,410 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Renal Transplant Rejection, Pediatric Kidney Disease
VIRTUUS Children's Study
The objective of the VIRTUUS Children's Study is to adapt identified and validated adult noninvasive diagnostic and prognostic biomarkers for the characterization of allograft status in pediatric recipients of kidney allografts.
- Conditions
- Renal Transplant Rejection, Pediatric Kidney Disease, End Stage Renal Disease, Nephropathy
- Trial name
- VIRTUUS (NCT03719339)
- Where
- 13 sites in United States, Canada
- Volunteers
- 445 people
- Sponsor
- Children's Hospital of Philadelphia
Kidney Transplant Rejection, End Stage Renal Disease
Safety & Tolerability Study of Chimeric Antigen Receptor T-Reg Cell Therapy in Living Donor Renal Transplant Recipients
The purpose of this study is to evaluate the safety and tolerability of TX200-TR101 and its effects on the donated kidney in living donor kidney transplant recipients.
- Trial name
- STEADFAST (NCT04817774)
- Testing
- TX200-TR101
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Volunteers
- 26 people
- Sponsor
- Sangamo Therapeutics
Antibody-mediated Rejection in Kidney Transplant
Use of Extracorporeal Photopheresis in Kidney Transplantation: Effects on Antibody-Mediated Rejection
This study aims to describe, over a one-year period, the clinical, biological, and histological evolution of a cohort of kidney transplant recipients who developed antibody-mediated rejection and were treated with extracorporeal…
- Trial name
- PETRUM (NCT07663669)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Renal Transplant Rejection, Induction Therapy
Induction in Sensitized Kidney Transplant Recipients Without Pre-existing Donor-specific antiboDies
Induction therapy decreases the rate of acute allograft rejection in kidney transplant recipients (KTRs) and is strongly recommended.
- Trial name
- INSTEAD (NCT05385432)
- Testing
- Rabbit Anti thymocyte globulin (rATG), Basiliximab
- Where
- France
- Volunteers
- 244 people
- Sponsor
- University Hospital, Tours
Kidney Transplant Rejection
Screening for Subclinical Antibody Mediated Rejection and Efficacy of Belatacept in the Context of de Novo Donor Specific Antibody After Kidney Transplantation (BELA-M-R)
Antibody mediated rejection (ABMR) is a major cause of graft loss after kidney transplantation (KT) and is mainly associated with preformed anti-HLA donor specific antibodies (DSAs) (phenotype 1) or de novo DSAs (dnDSAs)…
- Trial name
- BELA-M-R (NCT06291103)
- Testing
- Conversion to Belatacep, Standard of care treatment (SOC regimen) with Tacrolimus
- Where
- France
- Volunteers
- 290 people
- Sponsor
- University Hospital, Rouen
BK Viremia, Kidney Transplant Infection
A Trial to Treat Polyomavirus Infections (BKPyV) in Kidney and Simultaneous Kidney Pancreas Transplant Recipients
BEAT-BK will see the effect of immunosuppression reduction/modification with and without IVIG on BKPyV infection, allograft function, allograft loss, acute transplant rejection, immunosuppression load and death in kidney and…
- Conditions
- BK Viremia, Kidney Transplant Infection, Kidney Transplant Failure and Rejection
- Trial name
- BEAT-BK (NCT05325008)
- Testing
- Immunosuppression reduction/modification + intravenous immunoglobulin, Immunosuppression reduction/modification
- Where
- 13 sites in Australia
- Volunteers
- 280 people
- Sponsor
- The University of Queensland
Kidney Transplant Rejection
Trifecta-Kidney cfDNA-MMDx Study
Demonstrate the relationship between DD-cfDNA levels and HLA antibodies in blood, and the Molecular Microscope® (MMDx) Diagnostic System results in indication biopsies.
- Trial name
- NCT04239703
- Testing
- MMDx, Prospera, HLA antibody
- Where
- 31 sites in United States, Australia and 8 more
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Liver Transplant, Hepatitis C
Proteogenomic Monitoring and Assessment of Liver Transplant Recipients
This study is being done to test blood, urine and tissue samples to see if this can help decide if CKD (Chronic Kidney Disease), AR (Acute Rejection) and HCV (Hepatitis C Virus) can be identified in its early stages.
- Conditions
- Liver Transplant, Hepatitis C, Chronic Kidney Disease, Acute Rejection
- Trial name
- "Mini-Liver" (NCT01644903)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Northwestern University
Renal Transplant Rejection, Tolerance
Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister Donor
The purpose of this study is to find out if an investigational treatment will allow kidney transplant recipients to better accept their new kidney and stop immunosuppressive medicines.
- Conditions
- Renal Transplant Rejection, Tolerance, Kidney Transplant
- Trial name
- NCT03707262
- Testing
- Donor CD34+ and CD3+ cells
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Jeffrey Veale, MD
Kidney Transplant Rejection, Kidney Transplantation
Observational Cohort Study Renal Transplantation University Hospitals Leuven
This observational cohort study aims to compile routinely collected clinical, histological and outcome data of kidney transplant recipients, to evaluate risk factors for post-transplant injury, phenotypes of injury, and impact on…
- Conditions
- Kidney Transplant Rejection, Kidney Transplantation, Kidney Transplant Failure
- Trial name
- NCT06505200
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 1,891 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Kidney Transplant; Complications, Rejection of Renal Transplant
Urine CXCL10 Monitoring Trial in Kidney Transplant
This is a Phase II-III multi-center prospective randomized controlled clinical trial of incident adult renal transplant patients.
- Trial name
- NCT03206801
- Testing
- Kidney transplant biopsy
- Where
- 9 sites in Australia, Canada
- Volunteers
- 260 people
- Sponsor
- University of Manitoba
Kidney Transplant Infection, Kidney Transplant Rejection
Immune Monitoring of Prevalent Kidney Transplant Recipients Using Torque Teno Virus: A Single-Center, Prospective Cohort Study
Kidney transplant recipients (KTRs) suffer from immunosuppression-related adverse events (iRAEs), such as infections and malignancy from chronic immunosuppression exposure but are also at risk of graft loss from rejection with…
- Conditions
- Kidney Transplant Infection, Kidney Transplant Rejection, Kidney Transplant; Complications
- Trial name
- TTV-KTR-SGH (NCT05836636)
- Testing
- Torque teno virus DNA measurement
- Where
- Singapore
- Volunteers
- 172 people
- Sponsor
- Singapore General Hospital
Kidney Transplant, Chronic Kidney Disease
Empagliflozin Treatment in Kidney Transplant Recipients
Kidney transplantation improves the health and quality of life for those Veterans with end stage kidney disease (ESKD). While early patient and graft survival are excellent, long-term outcomes continue to be challenging.
- Trial name
- SEKTR (NCT06013865)
- Testing
- Empagliflozin
- Where
- 5 sites in United States
- Volunteers
- 264 people
- Sponsor
- VA Office of Research and Development
Renal Transplant Rejection
Simulect Versus ATG in Sensitized Renal Transplant Patient
Induction therapy by either T-cell depleting polyclonal antibodies such as anti-thymocyte globulins (ATG) or non-depleting anti-interleukine 2 receptor monoclonal antibodies (anti-CD25 moAb: basiliximab or daclizumab) are used to…
- Trial name
- SATIR (NCT02377193)
- Testing
- Simulect, ATG Fresenius
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse