Clinical trials: Relapsing Remitting MS
Multiple Sclerosis
Effect of Adrenocorticotropin Injection With Weekly Interferon Beta in Patients With Relapsing Remitting Multiple Sclerosis (MS)
The purpose of this study is to evaluate whether the use of ACTH in addition to Avonex is effective in the treatment of relapsing remitting multiple sclerosis.
- Trial name
- ACTH (NCT00986960)
- Testing
- repository corticotropin injection, Saline
- Where
- United States
- Sponsor
- University at Buffalo
Relapsing-Remitting Multiple Sclerosis
Behavior and Activity Monitoring in MS
The investigators propose to conduct a randomized 6-month intervention study comparing cognitive functioning in individuals with relapsing-remitting multiple sclerosis assigned to either a physical activity or an active…
- Trial name
- NCT03244696
- Testing
- Step Tracking, Water Tracking
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Ohio State University
Relapsing Remitting Multiple Sclerosis
Advanced MRI Measures of Repair in Alemtuzumab Treated Patients
There are two parts to this investigator sponsored trial (IST): 1. To perform advanced serial MRI studies on patients initiating alemtuzumab therapy. 2.
- Trial name
- iCAMMS-IST (NCT01307332)
- Testing
- MabCampath-1h
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Multiple Sclerosis
Safety and Tolerability of Interferon-Beta-1a and Estroprogestins Association in MS Patients
Clinical and experimental evidences suggests an immunomodulatory effect of sex hormones in multiple sclerosis. The role of oral estroprogestins in the pathogenesis and in the clinical course of the disease is actually unknown.
- Trial name
- NCT00151801
- Testing
- estroprogestins, interferon-beta 1a
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- S. Andrea Hospital
Relapsing Remitting Multiple Sclerosis, Sleep Initiation and Maintenance Disorders
Eszopiclone for Improving Sleep in Multiple Sclerosis (MS)
The purpose of this study is to determine if people with multiple sclerosis (MS) and fatigue have disrupted sleep, as was suggested in previous studies, and whether treating the disruptions of sleep improves the fatigue.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Sleep Initiation and Maintenance Disorders, Fatigue
- Trial name
- NCT00594087
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Vermont
Relapsing-remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis
Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition
Approximately 50% of people diagnosed with Multiple Sclerosis (MS) will develop problems with cognition. Currently, there are no FDA-approved treatments targeting cognitive function in Multiple Sclerosis.
- Conditions
- Relapsing-remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis, Primary-progressive Multiple Sclerosis
- Trial name
- NCT01466114
- Testing
- estriol, Norethindrone
- Where
- 4 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of California, Los Angeles
Multiple Sclerosis
Study to Evaluate the Feasibility of [18F]Florbetapir PET for Assessment in MS Patients
The purpose of this study is to evaluate the feasibility of [18F]Florbetapir positron emission tomography (PET) for assessment of demyelination in the patients with relapsing remitting multiple sclerosis.
- Trial name
- NCT01767493
- Testing
- [18F]Florbetapir PET imaging
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Multiple Sclerosis, Relapsing Remitting
Sexual Dysfunction, Disability and Quality of Life in Patients With Multiple Sclerosis (MS)
This is an observational, prospective, non-interventional, non-controlled study planned to be conducted in subjects with Relapsing-Remitting Multiple Sclerosis (RRMS).
- Trial name
- NCT01080053
- Where
- Argentina
- Volunteers
- 306 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Multiple Sclerosis, Relapsing-Remitting
Zenapax (Daclizumab) to Treat Relapsing Remitting Multiple Sclerosis
This study will examine the safety of Zenapax (daclizumab) in patients with multiple sclerosis (MS). MS is thought to be caused by an over-reactive immune response.
- Trial name
- NCT00071838
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
A Pilot Study to Characterize the Biological Effect of a Pre-planned 12 Week Dose Interruption of Natalizumab
This is an open-label study of patients with relapsing forms of MS is designed to assess the biochemical, immunological, and kinetic profiles of natalizumab being used with specific brief dosing interruption.
- Trial name
- NCT04048577
- Testing
- Dosing Interruption of Natalizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Berkovich, Regina MD, PhD Inc.
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting
MS Synchronous vs Asynchronous Exercise Study
This randomized controlled study aims to compare the effects of synchronous and asynchronous exercise programs on individuals diagnosed with relapsing-remitting multiple sclerosis (RRMS).
- Trial name
- NCT07233902
- Testing
- Combined Exercise Program (Synchronous Delivery), Combined Exercise Program (Asynchronous Delivery)
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Yeditepe University
Multiple Sclerosis
Safety and Efficacy Study of Fingolimod in Taiwanese Adults (≥ 20years) With Relapsing Remitting Multiple Sclerosis
The purpose of the study is to describe the safety profile of fingolimod in the Taiwanese multiple sclerosis population. This study aims to collect the safety data in patients newly initiated on fingolimod for one year.
- Trial name
- SPRING (NCT04480853)
- Testing
- Fingolimod
- Where
- 6 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Relapsing Remitting Multiple Sclerosis
Evaluating the Efficacy and Safety of Transitioning Patients From Natalizumab to Ocrelizumab
The primary objective of this study is to assess the efficacy of Ocrelizumab (OCR) in Relapsing Multiple Sclerosis patients who have been previously treated with natalizumab (NTZ) by evaluating relapse rate, progression on MRI…
- Trial name
- OCTAVE (NCT03157830)
- Where
- 5 sites in United States
- Volunteers
- 43 people
- Sponsor
- Providence Health & Services
Multiple Sclerosis (MS), Relapsing Remitting Multiple Sclerosis
Assessment of ANK-700 in Patients With Relapsing Remitting Multiple Sclerosis
A safety study of ANK-700 in patients with relapsing remitting multiple sclerosis. The study has two parts: Part A - first in human study in which patients receive a single dose of ANK-700 Part B - patients will receive three…
- Trial name
- MoveS-it (NCT04602390)
- Testing
- ANK-700
- Where
- 15 sites in United States
- Volunteers
- 34 people
- Sponsor
- Anokion SA
Relapsing-remitting Multiple Sclerosis
Development of a Motivational Intervention to Improve Treatment Adherence in MS
As many as 50% of MS patients prematurely discontinue their disease modifying medications. For this study, we will develop a telephone-based talk therapy intervention and then conduct a randomized controlled trial.
- Trial name
- MIMS (NCT01925690)
- Testing
- Motivational Interviewing-Cognitive Behavioral Therapy, Brief Education
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Missouri, Kansas City
Multiple Sclerosis, Relapsing-Remitting
Multiple Sclerosis Treatment With Autologous Hematopoietic Stem Cell Transplantation in the Netherlands
The goal of this observational study is to study the long-term effects of autologous hematopoietic stem cell transplantation (aHSCT) in people with highly active relapsing-remitting multiple sclerosis.
- Trial name
- MS-ACT (NCT06567197)
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people
- Sponsor
- Amsterdam UMC, location VUmc
Multiple Sclerosis, Relapsing-Remitting
Safety and Efficacy of Natalizumab in Combination With Avonex in the Treatment of Multiple Sclerosis
The purpose of this study is to determine if natalizumab in combination with AVONEX is safe and effective in delaying progression of individuals diagnosed with relapsing remitting Multiple Sclerosis (MS).
- Trial name
- NCT00030966
- Testing
- Natalizumab
- Where
- 88 sites in United States, Austria and 5 more
- Volunteers
- 1,200 people
- Sponsor
- Biogen
Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting
Extracorporeal Shock Wave Therapy in Enhancing Sensitivity and Postural Stability in Multiple Sclerosis
This randomized controlled trial aimed to investigate the efficacy of Extracorporeal Shock Wave Therapy (ESWT) on plantar somatosensory function, knee joint proprioception, and spatiotemporal gait parameters in individuals…
- Conditions
- Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting, Sensorimotor Gait Disorder
- Trial name
- NCT07514104
- Testing
- Extracorporeal Shock Wave Therapy (ESWT)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Furkan Bilek
Multiple Sclerosis (MS) - Relapsing-remitting, Upper Extremity Dysfunction
Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
This pilot mixed-method study will evaluate the feasibility, preliminary efficacy, and user experience of a home-based wearable Focal Vibration Therapy (FVT) intervention for improving upper extremity (UEx) function in people…
- Trial name
- NCT07376772
- Testing
- wearable focal vibration therapy
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Florida