Clinical trials: Remineralization
Dental Caries
To Determine the Ability of a New Product Formulation to Remineralize an Early Caries Lesion by an In-situ Study
This is a double blind, cross-over, controlled clinical trial utilizing thirty (30) adults to evaluate remineralization of early caries lesions.
- Trial name
- NCT02388178
- Testing
- Control toothpaste containing no anti-cavity ingredients, Experimental toothpaste containing fluoride and amino acid (arginine), Fluoride toothpaste containing fluoride as the anti-cavity ingredient
- Volunteers
- healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Remineralization, Enamel Lesions
Clinical Study to Evaluate Remineralization Using an in Situ Model.
This is a phase III clinical trial that aims to evaluate the enamel remineralization efficacy of three dentifrices on artificial caries lesions using an in situ model.
- Conditions
- Remineralization, Enamel Lesions, Enamel Subsurface Lesion
- Trial name
- REMINSITU (NCT07625670)
- Testing
- Fluoride toothpaste containing 750 ppm MFP in a Dical base, Fluoride toothpaste containing 1450 ppm MFP in a Dical base, Fluoride-free toothpaste in a Dical base
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Tooth Erosion
In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste
This will be a randomized, controlled, single center, single- blind, 3 period, 3 treatment, cross-over, in situ design which consists of placing pre-eroded bovine enamel specimens intra orally using a palatal appliance and…
- Trial name
- NCT03296072
- Testing
- 0.254% w/w sodium fluoride and 5% KNO3, 0.454% w/w stannous fluoride, 5% KNO3
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Erosion, Acid Wear
Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion
The purpose of this study is to compare and evaluate the ability of two European Union (EU) regulated gel to foam toothpaste formulations versus a non-fluoride toothpaste using a modified in-situ model of dental erosion and…
- Trial name
- NCT01657903
- Testing
- Sodium Fluoride, Potassium nitrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Caries
In Situ Caries Efficacy of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentifrices on enamel with artificial caries lesions in an in situ model
- Trial name
- NCT00708097
- Testing
- NaF, NaMFP
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization
The goal of this clinical trial is to evaluate whether BlueCheck® can accurately detect and monitor early-stage dental caries (tooth decay) and their remineralization in adults.
- Trial name
- NCT07100626
- Testing
- BlueCheck
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Incisive Technologies Pty Ltd
Caries
In-situ Evaluation of Anti-caries Technology
Three toothpastes will be compared, two toothpastes in each subject, to establish whether changes in the depth or area of an artificially created area of tooth decay is the same for each toothpaste.
- Trial name
- NCT01650493
- Testing
- Clinpro 5000, MI Paste Plus, Tom's of Maine
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Dental Caries
Assessment of Prevident Sodium Fluoride 1.1% Toothpaste Using an Intra-oral Remineralization-demineralization Model
This is a double blind, cross-over, controlled clinical trial utilizing thirty (30) adults to evaluate remineralization of early caries lesions.
- Trial name
- NCT02708160
- Testing
- Fluoride Free toothpaste, 1.1% Fluoride toothpaste, 0.243% Fluoride toothpaste
- Volunteers
- healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Enamel Lesions, Demineralization, Tooth
Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model
Clinical study to evaluate the anti-cavity efficacy of three dentifrices using an intra-oral enamel Demineralization - Remineralization In-Situ Model. This is a Phase III, single-center, triple-blind with a crossover design.
- Conditions
- Enamel Lesions, Demineralization, Tooth, Remineralization, Dental Cavity
- Trial name
- REPAIR (NCT06732518)
- Testing
- Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Tooth Demineralization
Impact of Chewing Gum With CPP-ACP on Tooth Mineralisation in Situ
Monocentric, randomised, double-blind, cross-over controlled study with two arms. This study aims to analyse the impact on mineralisation of Sugar Free Gum (SFG) containing CPP-ACP in healthy adults.
- Trial name
- NCT03971084
- Testing
- Sugar free gum without CPP-ACP, Sugar free gum with CPP-ACP
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Dental Caries
Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste
This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices: a fluoride-free negative control, a positive…
- Trial name
- NCT07419763
- Testing
- Negative Control Toothpaste, Active Comparator, Test toothpaste
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Enamel Erosion
Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions
The proposed study will evaluate the performance of fluoride delivered from a new dentifrice formulation without potassium nitrate.
- Trial name
- NCT01641237
- Testing
- sodium fluoride, no added fluoride in a silica base
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth; Lesion, White Spot Lesions
Remineralisation of White Spot Lesions by Elmex® gelée in Post-orthodontic Patients
The aim of this study is to monitor the effect of intraoral topical high fluoride application on the development of white spot lesions (WSL) after orthodontic treatment with multibracket appliances and to compare it to a placebo.
- Trial name
- NCT01329731
- Testing
- elmex® gelée
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Gaba International AG
Healthy Subjects, Partial Denture Wearers
In Situ Caries of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentifrices on enamel with artificial caries lesions in an in situ model.
- Conditions
- Healthy Subjects, Partial Denture Wearers, Caries
- Trial name
- NCT00708123
- Testing
- Sodium fluoride toothpaste
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Oral Hygiene
The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ
This study will evaluate the effect of experimental sodium fluoride-silica dentifrice formulations, with and without zinc, on remineralization of enamel in situ.
- Trial name
- NCT02195583
- Testing
- Sodium fluoride (1426 ppm), Sodium fluoride (1150 ppm), Sodium fluoride (250 ppm)
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste
This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices-one fluoride-free negative control, one positive…
- Trial name
- NCT07419685
- Testing
- Negative Control Toothpaste, Active Comparator, Test Toothpaste
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Tooth Erosion
An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel
The purpose of this study is to investigate the ability of an experimental dentifrice containing 1150 parts per million (ppm) fluoride to remineralize acid-softened dental enamel and help prevent further demineralization compared…
- Trial name
- NCT06242444
- Testing
- Experimental Dentifrice, Reference Dentifrice
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- HALEON
Tooth Erosion
Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion
An in situ model will be used to evaluate and compare enamel remineralization of bovine enamel specimens.
- Trial name
- NCT01128972
- Testing
- Sodium fluoride, Sodium monoflurophosphate, Sterile water
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Caries
In Situ Caries Model of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentrifrices on enamel with artificial caries lesions in an in situ model
- Trial name
- NCT01005966
- Testing
- Sodium Fluoride Toothpaste, Amine Fluoride Toothpaste, Sodium monofluorophosphate/Sodium Fluoride Toothpaste
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
White Spot Lesion
Clinical Evaluation of an Experimental Remineralization Product
The study is designed as a split-mouth randomised controlled study. This means within the mouth of one patient one tooth with an initial lesion is treated and coated with the Experimental Remineralization product whereas another…
- Trial name
- NCT06166849
- Testing
- Experimental Fluoride Application
- Where
- Romania
- Volunteers
- 43 people
- Sponsor
- Ivoclar Vivadent AG