Clinical trials: Remineralization
Molar Incisor Hypomineralization
Remineralization of Molar Incisor Hypomineralization (MIH) With a Hydroxyapatite Toothpaste
This study tests the remineralization of donor teeth (donorMIH) in situ in participants using 10% hydroxyapatite (HAP) toothpaste and sodium fluoride toothpaste.
- Trial name
- NCT05485662
- Testing
- Hydroxyapatite toothpaste, Sodium Fluoride Toothpaste
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Tooth Demineralization
Impact of Chewing Gum With CPP-ACP on Tooth Mineralisation in Situ
Monocentric, randomised, double-blind, cross-over controlled study with two arms. This study aims to analyse the impact on mineralisation of Sugar Free Gum (SFG) containing CPP-ACP in healthy adults.
- Trial name
- NCT03971084
- Testing
- Sugar free gum without CPP-ACP, Sugar free gum with CPP-ACP
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Molar Incisor Hypomineralization
Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated Lesions
Molar-incisor hypomineralization (MIH) is a qualitative defect of dental enamel, in which low mineral content and high protein content compromise the effectiveness of remineralizing treatments.
- Trial name
- ECLIPSE (NCT07653373)
- Testing
- Sodium hypochlorite 5.25%, CPP-ACPF
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidade Ceuma
Initial Dental Caries
Remineralizing Effect of Nano-eggshell, Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), and Sodium Fluoride on Initial Enamel Caries
This randomized controlled clinical trial aims to evaluate and compare the remineralizing effect of nano-eggshell varnish, CPP-ACP paste (GC Tooth Mousse), and sodium fluoride varnish on initial enamel caries among adolescents…
- Trial name
- CPP-ACP (NCT07711132)
- Testing
- nano-eggshell varnish, Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP)Dental Paste, Sodium Fluoride Varnish (5%)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University
White Spot Lesions
P11-4 and Fluoride Varnish for Remineralization of Post-orthodontic Lesions
This clinical study aims to compare the remineralizing effects of self-assembling peptide P11-4 (SAP11-4) with fluoride varnish in the treatment of post-orthodontic non-cavitated carious lesions (NCLs).
- Trial name
- NCT06749977
- Testing
- Remineralization with SAP11-4, Remineralization with sodium fluoride varnish
- Where
- Bulgaria
- Volunteers
- 45 people
- Sponsor
- Medical University of Sofia
Dental Caries
Effect of CPP-ACP Paste on Dental Caries in Primary Teeth
The purpose of this study is to determine if adding daily application of CPP-ACP containing paste for one year is superior to regular fluoride tooth brushing in preventing dental caries in high caries risk Thai preschool children.
- Trial name
- NCT01604109
- Testing
- 10 % w/v CPP-ACP paste, the paste without CPP-ACP
- Where
- Thailand
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Dental Caries
Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste
This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices: a fluoride-free negative control, a positive…
- Trial name
- NCT07419763
- Testing
- Negative Control Toothpaste, Active Comparator, Test toothpaste
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Enamel Erosion
Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions
The proposed study will evaluate the performance of fluoride delivered from a new dentifrice formulation without potassium nitrate.
- Trial name
- NCT01641237
- Testing
- sodium fluoride, no added fluoride in a silica base
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth; Lesion, White Spot Lesions
Remineralisation of White Spot Lesions by Elmex® gelée in Post-orthodontic Patients
The aim of this study is to monitor the effect of intraoral topical high fluoride application on the development of white spot lesions (WSL) after orthodontic treatment with multibracket appliances and to compare it to a placebo.
- Trial name
- NCT01329731
- Testing
- elmex® gelée
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Gaba International AG
Dental Caries Extending Into Dentine
Digital Subtraction Radiography Evaluation of SMART Restoration With Partial Caries Removal in Primary Teeth
The objective of this study was to analyze the radiographic density of digital subtraction radiographs after SMART restoration with partial caries removal in primary molars at 6 and 12 months.
- Trial name
- DSR (NCT01749267)
- Testing
- partial caries removal only at enamel dentin junction.
- Where
- Thailand
- Volunteers
- 38 people
- Sponsor
- Mahidol University
Healthy Subjects, Partial Denture Wearers
In Situ Caries of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentifrices on enamel with artificial caries lesions in an in situ model.
- Conditions
- Healthy Subjects, Partial Denture Wearers, Caries
- Trial name
- NCT00708123
- Testing
- Sodium fluoride toothpaste
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gastro Esophageal Reflux, Dental Erosion
Domiciliary Management of Dental Erosion in Patients With GERD With Biomimetic Hydroxyapatite
The aim of the present study is to evaluate dental erosion in patients with gastroesophageal reflux disease (GERD). Patients consenting to participate to the study will undergo periodontal evaluation at the baseline.
- Trial name
- NCT05371717
- Testing
- Domiciliary use of Biorepair Total Protection + Biorepair Shock Treatment, Biorepair Total Protection
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Molar Incisor Hypomineralization
Clinical Efficacy of Biomimetic Hydroxyapatite in the Treatment of Molar Incisor Hypomineralization.
The aim of the following study is to evaluate che clinical efficacy of a toothpaste with biomimetic hydroxyapatite for the management of Molar-Incisor Hypomineralization.
- Trial name
- NCT04808180
- Testing
- Biorepair Shock Treatment, No treatment
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Pavia
Remineralization Potential, Dentin Caries
Clinical Performance and Remineralization Potential of Self- Assembling Peptide P11-4 Containing Fluoride Versus Er, Cr: YSGG Laser Treatment and Micro Tensile Bond Strength of Giomer Restoration in Carious Lesions
This study will be performed in two parts, in vivo and in vitro to assess the effect of the remineralization potential of self-assembling peptide P11-4 containing Fluoride on caries-affected dentin compared to untreated…
- Trial name
- NCT07065305
- Testing
- Curodont Repair Fluoride Plus (Self-assembling peptide remineralization agent)P11-4 peptide, fluoride, mild acidic buffer (pH ~4.5) , Credentis AG, Switzerland, Beautifil II LS
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Molar Incisor Hypomineralization
Assessment of the Remineralization Efficacy of Vitamin D in the Treatment of MIH. In Vitro Study and In Situ Randomized Double-Blind Placebo Clinical Trial.
In child patients with molar incisor hypo mineralization, Will Vitamin D mouth wash offer more success for patients with MIH as regards better MIH TNI index, decrease plaque accumulation, more gingival health and less bleeding on…
- Trial name
- NCT06515548
- Testing
- Vitamin D3 mouth wash
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Erosion
A New Protocol for the Management of Dental Erosion in Rugby Players
The aim of the present study is to provide a new domiciliary oral care treatment for enamel remineralization in rugby players patients using mouthguards.
- Trial name
- NCT05140538
- Testing
- SRP + toothpaste + mouthwash, SRP + toothpaste
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Dental White Spots, Dental Caries
MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study
The objective of this clinical study is to evaluate the efficacy of multiple applications of MI Varnish in combination with MI Paste Plus in caries protection and remineralization in comparison to the use of a control (Crest…
- Trial name
- GC-WS (NCT02424097)
- Testing
- CPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste, 1,100pm F-toothpaste and 0.5%NaF rinse
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Oral Hygiene
The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ
This study will evaluate the effect of experimental sodium fluoride-silica dentifrice formulations, with and without zinc, on remineralization of enamel in situ.
- Trial name
- NCT02195583
- Testing
- Sodium fluoride (1426 ppm), Sodium fluoride (1150 ppm), Sodium fluoride (250 ppm)
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Caries, Dental, Remineralization
Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Patients
To evaluate the remineralizing capability of biosmart S-PRG barrier coat varnish and its employment in clinical practice
- Conditions
- Caries, Dental, Remineralization, White Spot Lesion
- Trial name
- NCT05306691
- Testing
- Bio-smart Light Cured Protective Shield with bioactive S-PRG (Surface Pre- Reacted Glass ionomer) filler technology (PRG Barrier Coat) by (By SHOFU Inc., Japan).
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Moringa Oleifera
Remineralization Efficacy of Moringa Oleifera Varnish Vs MI Varnish in Initial Carious Lesions Over 6 Months Follow Up: a Randomized Controlled Clinical Trial
This randomized clinical trial aimed to test the remineralization effect of laboratory prepared Moringa Oleifera based varnish compared to MI varnish (CPP-ACP) on incipient carious lesions.
- Trial name
- NCT06905379
- Testing
- Moringa Oleifera, Varnish
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University