Clinical trials: Remodeling, Left Ventricle
STEMI
Short and Intermediate Term Effect of Dapagliflozin on Left Ventricular Remodeling in Anterior STEMI Patients
Methodology This study will enroll (120) patients presenting with acute anterior STEMI who will undergo early reperfusion presenting at Helwan University Hospitals and Ain Shams University Hospitals.
- Trial name
- NCT05957887
- Testing
- Dapagliflozin
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mohamed Nabil Elkholy
Heart Failure, Myocardial Infarction
Diffusion MRI in Heart Failure
The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood.
- Conditions
- Heart Failure, Myocardial Infarction, Left Ventricular Hypertrophy
- Trial name
- NCT02973633
- Testing
- Diffusion Tensor MRI (DTI), Gadolinium DOTA Meglumine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heart Failure With Preserved Ejection Fraction
Mechanisms of LV Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Arctic
The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.
- Trial name
- NCT05839028
- Where
- Russia
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Myocardial Infarction
BELIEVE Study: Nesiritide and Post Myocardial Infarction Left Ventricular Modeling
This study is being done to determine the effects (good and bad) of intravenous infusion of a human brain natriuretic peptide (BNP), Natrecor (nesiritide), a hormone produced by the heart in persons who have just suffered a heart…
- Trial name
- NCT00252213
- Testing
- Human BNP
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Aortic Regurgitation
Diastolic Dysfunction in Aortic Regurgitation
Follow-up study in patients with severe aortic regurgitation after successful valve replacement. Systolic and diastolic function were assessed and persistent diastolic dysfunction was observed late (7-10 years) after operation.
- Trial name
- NCT00976625
- Testing
- Aortic Valve Replacement
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bern
Hypertension,Essential
Endothelial Function in Prehypertension
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and…
- Trial name
- NCT06316271
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Athletes Heart
Semmelweis Sport Study
The aim of the present proposal is to investigate the development of distinct morphological, functional, biochemical and molecular aspects of short- and long-term sport-induced changes in the heart, to get a better understanding…
- Trial name
- NCT03025737
- Where
- Hungary
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Semmelweis University Heart and Vascular Center
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Heart Failure, Heart Failure With Reduced Ejection Fraction
AI-ECG for Time-Resolved Prediction of HFrEF
This study aims to develop and validate a deep learning-based electrocardiogram (ECG) model for predicting the future risk of heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Left Ventricular Dysfunction, Cardiac Remodeling
- Trial name
- NCT07519434
- Where
- China
- Volunteers
- 286,709 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital