Clinical trials: Remodeling, Vascular
Vascular Diseases
Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support
Contemporary left ventricular assist device (LVAD) therapy improves survival during advanced heart failure but vascular aging develops rapidly leading to major adverse events including stroke and bleeding in nearly half of…
- Trial name
- NCT06510322
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Montefiore Medical Center
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Cold-Region Exposure and Cardiac Remodeling After PCI
This multicenter prospective observational cohort study aims to investigate the association between cumulative cold-region exposure and adverse left ventricular remodeling and cardiovascular outcomes in patients with coronary…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention (PCI), Left Ventricular Remodeling, Cold Exposure
- Trial name
- COLD-PCI (NCT07773870)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Peripheral Arterial Disease
POWER: Pulse Intravascular Lithotripsy (Pulse IVL) to Open Vessels With Calcific Walls and Enhance Vascular Compliance and Remodeling
The POWER-PAD-1 Study is a first-in-human evaluation of the safety and performance of the Pulse Peripheral Intravascular Lithotripsy (IVL) Balloon Catheter to enroll up to twenty (20) subjects.
- Trial name
- POWER-PAD-1 (NCT05192473)
- Testing
- Pulse Intravascular Lithotripsy System
- Where
- 3 sites in Australia, Dominican Republic and 1 more
- Volunteers
- 9 people
- Sponsor
- Amplitude Vascular Systems, Inc.
Myocardial Infarction, Myocardial Fibrosis
Modulation of Fibrosis-inducing Pathways in Acute Myocardial Infarction
This is a single-center, prospective, observational controlled cohort study designed to describe the role of WNT/B-catenin signaling and adenosine system after an acute myocardial infarction, correlating it with clinical markers…
- Conditions
- Myocardial Infarction, Myocardial Fibrosis, Myocardial Remodeling, Ventricular
- Trial name
- BETA-MI (NCT05122741)
- Testing
- P2Y12 Potent Inhibitor + Aspirin for STEMI patients, Clopidogrel + Aspirin for CCS patients
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Messina
Acute Aortic Dissection
PERSEVERE- A Trial to Evaluate AMDS in Acute DeBakey Type I Dissection
Prospective, non-randomized, multicenter clinical investigation to assess the safety and effectiveness of AMDS in the treatment of patients with acute DeBakey type I dissection, with evidence of malperfusion, through open…
- Trial name
- PERSEVERE (NCT05174767)
- Testing
- AMDS
- Where
- 25 sites in United States
- Volunteers
- 115 people
- Sponsor
- Artivion Inc.
Myocardial Infarction
The Impact of Compound Danshen Dropping Pills (CDDP) on the Post-myocardial Infarction Ventricular Remodeling
This study is designed to evaluate the efficacy and safety of compound Danshen dropping pills (CDDP) in improving ventricular remodeling and cardiac function after acute anterior wall ST-Elevation myocardial infarction(STEMI).
- Trial name
- NCT05000411
- Testing
- Compound Danshen Dropping Pills (CDDP)
- Where
- China
- Volunteers
- 268 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
ST Elevation Myocardial Infarction, Remodeling, Left Ventricle
Predictors of Adverse Left Ventricular Remodeling and Final Infarct Size After Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction: A Strain Analysis Study Using Echocardiography and Feature Tracking Cardiac Magnetic Resonance
ST-segment elevation myocardial infarction (STEMI) is one of the most important causes of death and disability around the world.
- Trial name
- NCT04773652
- Testing
- speckle tracking echo
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Myocardial Infarction, Anterior Wall, Myocardial Remodeling, Ventricular
Effect of Methotrexate Carried by a Lipid Nanoemulsion on Left Ventricular Remodeling After STEMI
Prospective, randomized, double-blind, placebo-controlled, proof of concept study. Patients with first anterior wall STEMI will be randomized with 4±2 days after symptoms beginning to receive ddMTX-LDE at the dose of 40 mg/m2 IV…
- Trial name
- NCT03516903
- Testing
- Methotrexate, Folic Acid
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- University of Sao Paulo
Myocardial Infarction, Diabetes Mellitus, Type 2
SGLT2 Inhibitors on Clinical Outcomes and Left Ventricular Remodeling in Type 2 Diabetic Patients with Acute Myocardial Infarction, a Prospective, Multi-center Registry Study
Prospective trials performed on type 2 diabetes patients without established cardiovascular disease has shown that SGLT2 inhibitors reduce cardiovascular risk.
- Trial name
- RECORD-AMI (NCT05770687)
- Testing
- SGLT2 inhibitor
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Kiyuk Chang
Myocardial Infarction
BELIEVE Study: Nesiritide and Post Myocardial Infarction Left Ventricular Modeling
This study is being done to determine the effects (good and bad) of intravenous infusion of a human brain natriuretic peptide (BNP), Natrecor (nesiritide), a hormone produced by the heart in persons who have just suffered a heart…
- Trial name
- NCT00252213
- Testing
- Human BNP
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Myocardial Infarction
Two- Dimensional Speckle Tracking Echocardiography After Primary Percutaneous Coronary Intervention
ST-segment elevation myocardial infarction (STEMI) is a major cause of morbidity and mortality worldwide. In spite of decrease in acute and long-term mortality following STEMI in parallel with more use of reperfusion therapy…
- Trial name
- NCT04228510
- Testing
- 2D speckle tracking echocardiography
- Volunteers
- 204 people
- Sponsor
- Assiut University
Heart Failure, Cardiomyopathy
Impella Reverse Remodeling in End-Stage Heart Failure
This observational study is being done to learn more about heart attack recovery in patients supported with the Impella 5.5 left ventricular assist device (LVAD) as part of their standard of care.
- Trial name
- NCT06800716
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Columbia University
Stenosis, Internal Carotid Artery
Pilot Study of Autoarterial Remodeling of Bifurcation of the Common Carotid Artery
Comparison of two methods for revascularization of the bifurcation of common carotid artery: carotid endarterectomy with longitudinal incision carotid endarterectomy patch angioplasty compared with new technique of carotid…
- Trial name
- NCT03027752
- Testing
- Operation carotid endarterectomy with plastic of xenopericardial patch, New method of operation сarotid endarterectomy with autoarterial remodeling of bifurcation CCA
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Myocardial Infarction
The Impact of Dose of Angiotensin-receptor Blocker Valsartan and Genetic Polymorphism on the Post-MI Ventricular Remodeling
Angiotensin-converting enzyme inhibitors and angiotensin-receptor blocker valsartan ameliorate ventricular remodeling after myocardial infarction (MI).
- Trial name
- VALID (NCT01340326)
- Testing
- high dose of valsartan, usual dose of valsartan
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Dong-A University
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Renal Artery Stenosis
Ultrasound Wave Therapy for Post-stenotic Microvascular Remodeling
Researchers are evaluating a noninvasive treatment with ultrasound waves for Atherosclerotic Renal Artery Stenosis (ARAS).
- Trial name
- NCT03914157
- Testing
- Low-energy extracorporeal ultrasound shockwave therapy (SWT)
- Sponsor
- Mayo Clinic
STEMI - ST Elevation Myocardial Infarction, Myocardial Dysfunction
Percutaneous Revascularization in Infarction With Late Presentation and Absence of Viability: Effects on Left Ventricular Remodeling and Contractility
The purpose of this study is to evaluate whether late recanalization in patients with ST elevation myocardial infarction (STEMI) without Viability on Cardiovascular Magnetic Resonance Image (MRI) can reduce the reverse remodeling…
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Myocardial Dysfunction, Percutaneous Coronary Intervention
- Trial name
- NCT05160311
- Testing
- Optimized Medical Treatment (OMT), Drug Eluting Stent (DES) Coronary Angioplasty
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Varicose Veins of Lower Limb, Varix
Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins
The study is aimed at assessing the dynamics of changes in biochemical markers of venous wall remodeling (type 1 plasminogen activation inhibitor (PAI-1), fibronectin (fibronectin, FN), vimentin (vimentin, VM), von Willebrand…
- Conditions
- Varicose Veins of Lower Limb, Varix, Vascular Diseases, Leg Edema
- Trial name
- NCT06367166
- Testing
- "Venarus®" (diosmin and hesperidin), Endovenous laser ablation (EVLA) with miniphlebectomy, Elastic compression
- Where
- Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
Myocardial Infarction, Diabetes Mellitus, Type 2
Evaluation of the Effect of SGLT-2 Inhibitors on Cardiac Remodeling in Post Myocardial Infarction Patients
A prospective, randomized, controlled study will be conducted at Clinical Cardioglogy department, Ain Shams University Hospitals, assessing the efficacy and tolerability of SGLT2 inhibitors (dapagliflozin) addition on the…
- Conditions
- Myocardial Infarction, Diabetes Mellitus, Type 2, Myocardial Remodeling, Ventricular
- Trial name
- NCT05335629
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ain Shams University