Clinical trials: Renal
Renal Impairment, Gout
Evaluation of Colchicine and Nonsteroidal Anti-inflammatory Drug Combination Therapy and Renal Function in Gout Patients
Our findings are expected to provide real-world evidence of the renal-adverse effects of colchicine and NSAIDs combination therapy in patients with gout, which will guide healthcare professions in optimizing gout treatment…
- Conditions
- Renal Impairment, Gout, Colchicine Adverse Reaction, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT05006001
- Testing
- Colchicine and NSAID
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- En Chu Kong Hospital
Chronic Kidney Disease Requiring Chronic Dialysis
Activation of the Contact System and the Immune System in Patients With Chronic Kidney Disease.
Patients with end-stage renal disease undergoing hemodialysis (HD) are burdened with extremely high mortality rates (15% per year) and during the early stage (≤120days) the mortality rate is even higher (27% per year).
- Trial name
- AKIM-CKD (NCT05266092)
- Testing
- Observational study
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
IBD and Renal Involement, Chronic Kidney Disease
Renal Dysfunction in Patients With Inflammatory Bowel Disease and the General Population (NEPHRO-IBD)
The NEPHRO-IBD study is a multicenter prospective observational study designed to evaluate the prevalence of renal dysfunction and renal complications in adult patients with inflammatory bowel disease (IBD) compared with…
- Conditions
- IBD and Renal Involement, Chronic Kidney Disease, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
- Trial name
- NEPHRO-IBD (NCT07593352)
- Testing
- Prospective assessment of the prevalence of kidney disease and/or renal complications in patients with IBD/the general population based on routine laboratory test and abdominal ultrasound.
- Where
- Poland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji
COVID 19
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects With Renal Impairment and in Healthy Subjects With Normal Renal Function
This is a Phase 1 non-randomized, open-label, multiple dose, parallel-group study of ALG-097558 in subjects with severe renal impairment and subjects without renal impairment, matched for age, body weight and, to the extent…
- Trial name
- NCT06698549
- Testing
- ALG-097558
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aligos Therapeutics
Chronic Kidney Diseases
DYNAMic Renal Assessment: NOvel Methods to Assess KIDNEY Functional Reserve
This is a feasibility study to assess new, more practical ways of measuring renal reserve.
- Trial name
- DYNAMO (NCT06572215)
- Testing
- Dapagliflozin
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Pulmonary Arterial Hypertension, Erectile Dysfunction
A Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients with Renal Insufficiency and Healthy Subjects
To evaluate the effect of renal insufficiency on the pharmacokinetics of TPN171H tablets after single dose oral administration, so as to provide basis for formulating clinical medication plan for patients with renal…
- Trial name
- NCT05208814
- Testing
- TPN171H single dose
- Where
- 2 sites in China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Anemia in Chronic Kidney Disease
Food Effect Study of DDO-3055 Tablets in Healthy Subjects
The study is a randomized , open-label, two-stage crossover food effect study of single doses of DDO-3055 tablets in healthy subjects. 14 healthy subjects were randomly divided into groups A and B, 7 subjects in each group.
- Trial name
- NCT04197778
- Testing
- DDO-3055 tablet
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Living Donor Nephrectomy, Living Kidney Donation
Long-term Risk of Cardiovascular Disease in Living Kidney Donors
The investigative team will conduct a population-based, matched retrospective cohort study across Ontario, Alberta, and British Columbia using linked administrative healthcare databases to evaluate the long-term risk of major…
- Conditions
- Living Donor Nephrectomy, Living Kidney Donation, Living Kidney Donor, Living Kidney Donors
- Trial name
- NCT07431515
- Testing
- Nephrectomy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Healthy Participants
Renal Salt Handling in Postural Tachycardia Syndrome Following Dietary Dopa Administration
The purpose of this study is to learn how plants can play a role in gain/loss of sodium in the urine and in the regulation of blood pressure.
- Trial name
- NCT01064739
- Testing
- Fava beans, Fixed Sodium Diet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Lupus Nephritis
Comparison between2 Drugs in Lupus Nephritis
The aim of this work is to study the effect and side effects of the cyclophosphamide versus mycophenolate in lupus nephritis
- Trial name
- NCT04424602
- Testing
- cyclo phosphamide, mycophenolate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Renal Insufficiency
The Pharmacokinetic, Safety and Tolerability of Tiotropium in Outpatients With Renal Impairment in Comparison to Healthy Subjects
Study to investigate pharmacokinetics of a single i.v. dose of tiotropium (4.8 mcg) in patients with renal impairment in comparison to healthy subjects.
- Trial name
- NCT02172339
- Testing
- Tiotropium, solution ampoules
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Risk Factors, Renal Progression
P-cresol: Correlation With Glomerular Filtration Rate and Outcome in Chronic Kidney Disease
End-stage renal disease is a global epidemia with an estimated incidence of 7% per year and high morbidity-mortality rate. Early detection of chronic kidney disease (CKD) and intervention for CKD complication is important to…
- Conditions
- Risk Factors, Renal Progression, Death
- Trial name
- NCT00888030
- Testing
- there are no interventions currently listed for this study
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Myelofibrosis
To Evaluate the Pharmacokinetics and Safety of TQ05105 Tablet in Renal Impairment Subjects
This is an open, open-label, parallel, single-dose, phase I clinical study designed to evaluate the pharmacokinetic (PK) profile of TQ05105 tablet in patients with renal impairment after a single dose, and to evaluate the urinary…
- Trial name
- NCT06598956
- Testing
- TQ05105
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Kidney Disease, Kidney Transplant
Strategies to Transform Kidney Care and Improve Pursuit of Transplant
Approximately 15% of the U.S. population has chronic kidney disease, and ~700,000 patients are in full kidney failure also called end-stage kidney disease (ESKD).
- Conditions
- Kidney Disease, Kidney Transplant, Deceased Donor Kidney Transplant, Living Donor Kidney Transplantation
- Trial name
- NCT07794631
- Testing
- Digital Health Integration, Training for Early Transplant Access and Support, Kidney Health Mobile Health (mHealth) Application
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
CKD - Chronic Kidney Disease
The Use of Risk Prediction to Identify Patients at Risk for Chronic Kidney Disease: Patient and Provider Interventions for Patients at High Risk for Chronic Kidney Disease
This prospective, cluster-randomized trial is structured as a pragmatic study, embedding the outreach intervention within routine clinical workflows. The intervention reflects real-world provider-patient communication methods.
- Trial name
- RISK (NCT07857200)
- Testing
- Letter Intervention, Letter + Phone Call Intervention:, Augmented usual care
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
Chronic Kidney Disease, Chronic Kidney Failure
Effect of N-acetylcysteine (NAC) on Hydrogen Sulfide (H2S) in Chronic Kidney Disease (CKD)
Cardiovascular morbidity and mortality is high in CKD patients. Nitric oxide (NO) deficiency plays a crucial role in progression of CKD. This leads to endothelial dysfunction, hypertension, and inflammation.
- Conditions
- Chronic Kidney Disease, Chronic Kidney Failure, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- NCT01232257
- Testing
- N-acetylcysteine
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- A.C. Abrahams
Elastography ,CKD Patients
SWE in Assessment of CKD Patients
Elastography is a developing technique to assess tissue elasticity. It is software that can be integrated to the ultrasonography machines.
- Trial name
- NCT05986812
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Renal Impairment
A Phase l Study to Evaluate the Pharmacokinetics and Safety Pasireotide in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Volunteers
The purpose of this study is to assess the effect of renal impairment on the pharmacokinetics (PK) of pasireotide,the PK of pasireotide in subjects with different degrees of renal impairment.
- Trial name
- NCT01578928
- Testing
- SOM230
- Where
- 2 sites in Germany, South Africa
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
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