Clinical trials: Renal Blood Flow
Obstructive Sleep Apnea, Hypertension
Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans
The study has been designed to assess the effect of cyclooxygenase inhibition on blood pressure, cerebral blood flow, ventilation and renal hemodynamics following chronic intermittent hypoxia exposure.
- Conditions
- Obstructive Sleep Apnea, Hypertension, Cardiovascular Diseases, Stroke
- Trial name
- NCT01280006
- Testing
- Intermittent hypoxia, Indomethacin, Celecoxib
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Kidney Diseases
The Effects of Glucagon on Renal Regional Blood Flow in Humans Measured by Magnetic Resonance.
This study will investigating the effects of glucagon on renal blood flow in humans using MRI technology. Glucagon, a hormone produced by the pancreas, plays a key role in regulating blood sugar levels.
- Trial name
- NCT06872060
- Testing
- Glucagon, Glucagon+Exendin9-39, Sodium chloride
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Cardiovascular Diseases, Nephropathy
Effect of the Aquaretic Tolvaptan on Nitric Oxide System (TORA)
The purpose of this study is to investigate the effect of tolvaptan on renal water, sodium and potassium excretion, plasma concentration of vasoactive hormones,central blood pressure, pulse wave velocity (PWV) and augmentation…
- Trial name
- NCT01638663
- Testing
- Tolvaptan
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Hypertension, Chronic Kidney Disease
Accuracy of 1.5 T Versus 3 T Magnetic Resonance Arterial Spin Labeling to Measure Renal Blood Flow
In this study we want to compare the accuracy of two methods to measure renal perfusion by MRI spin labelling technique: the first measurement done with the 1.5 T MRI versus the second one obtained with the 3.0 T MRI (Siemens MRI…
- Trial name
- NCT02746549
- Testing
- renal perfusion
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cardiovascular Diseases, Chronic Kidney Disease
Evaluating the Effect of Standard-of-care Erythropoiesis-stimulating Agents on Forearm Blood Flow in Nondialysis-dependent Subjects With Anaemia Associated With Chronic Kidney Disease.
In people diagnosed with chronic kidney disease (CKD) anaemia is a common problem and is often treated with EPO (Erythropoietin). One form of EPO used is Darbepoetin (Aranesp®).
- Trial name
- OPERA-CKD (NCT02987465)
- Testing
- Darbepoetin Alfa, Acetylcholine, Noradrenaline
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Renal Circulation, Renal Plasma Flow
Effect of Elevated Plasma-Free-Fatty-Acids on Renal Hemodynamic Parameters
Type 2 diabetes is frequently associated with elevation of plasma-free fatty acids (FFA). Studies indicate that elevation of plasma-FFA induces insulin resistance and also causes endothelial dysfunction as well as hemodynamic…
- Conditions
- Renal Circulation, Renal Plasma Flow, Glomerular Filtration Rate, Fatty Acids, Nonesterified
- Trial name
- NCT00431665
- Testing
- NG-monomethyl-L-Arginine (L-NMMA), triglycerides (Intralipid 20%), heparin
- Where
- Austria
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Renal Failure, Renal Artery Stenosis
Renal Blood Flow Measurement With Positron Emission Tomography (PET)
Two investigational chemical tracers, 62Cu-ethylglyoxal bis(thiosemicarbazone) (62Cu-ETS) and 15O-water, will be used in this study to look at how blood moves through the kidneys.
- Trial name
- NCT00714142
- Testing
- 62Cu-ethylglyoxal bis(thiosemicarbazone), 15O-water, Positron Emission Tomography
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jeffrey L. Lacy
Type 2 Diabetes
Effect of Angiotensin Converting Enzyme Inhibitor, Lisinopril, on Renal Blood Flow and Its Correlation With Proteinuria Reduction in Subjects With Type 2 Diabetes and Kidney Disease
The purpose of the study is to investigate the effect of a blood pressure medication, Lisinopril, or similar drugs in that class, on the flow of blood to the kidneys.
- Trial name
- NCT01101269
- Testing
- ACEI or ARB, Lisinopril
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Kidneys
Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET/CT and MRI
This randomized crossover study aims to validate measurements of renal perfusion in healthy males with PET/CT, using 15-oxygen labeled water as tracer, against the validated multiparametric MRI technique.
- Trial name
- NCT06555211
- Testing
- MRI, PET/CT
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Kidney Transplant Failure
Kidney Transplantation and Renal and Myocardial Perfusion
The cardiovascular morbidity and mortality is significantly higher in chronic kidney disease (CKD) patients, especially in dialysis patients, than in normal population.
- Trial name
- Transkidney (NCT02960802)
- Testing
- kidney transplantation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Hypertension
The Effect of Hypertension Medications on Renal Blood Flow Measurements in Healthy Males (MK-0000-127)
This study will evaluate the effect of Aliskiren and Losartan on renal blood flow using PAH clearance, PC MRA and ASL MRI methodologies.
- Trial name
- NCT00856960
- Testing
- Aliskiren, Comparator: Losartan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Kidney
Assessment of Changes in Renal Cortical and Medullary Blood Flow by Contrast Ultrasound
The purpose of this study is to determine if contrast enhanced ultrasound (CEU) using microbubbles, is useful in assessing changes in kidney blood flow.
- Trial name
- NCT00631553
- Testing
- perflutren lipid microspheres
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Fluid Overload, Water Electrolyte Imbalance
The Effect of Crystalloids and Colloids on Visceral Blood Flow
Patients often require fluid replacement during and after an operation. This is usually given through veins in the arm using an intravenous cannula and doctors have traditionally used fluid containing sodium chloride (saline).
- Conditions
- Fluid Overload, Water Electrolyte Imbalance, Acid Base Imbalance
- Trial name
- NCT01087853
- Testing
- Crystalloid, Colloid
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hypertension, Renal Failure
The Efficacy of Color-Doppler Ultrasonography to Assess the Renal Blood Flow With the Estimation of GFR
It is generally assumed that renal blood flow is symmetric in the absence of renal artery stenosis. The importance of studying the function of both kidneys separately is because it cannot be assumed that they are functionally…
- Trial name
- NCT00470769
- Testing
- Color-Doppler Ultrasound, 99mTc-DTPA scintigraphy
- Where
- 3 sites in Italy
- Volunteers
- 2,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Hairy Cell Leukemia (HCL), Chronic Lymphocytic Leukemia (CLL)
Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment
Background: Researchers who are studying hairy cell leukemia, and how the disease compares with other disorders, are interested in obtaining additional samples from leukemia patients and healthy volunteers.
- Conditions
- Hairy Cell Leukemia (HCL), Chronic Lymphocytic Leukemia (CLL), Non-Hodgkins Lymphoma (NHL), Cutaneous T Cell Lymphoma (CTCL)
- Trial name
- NCT01087333
- Where
- United States
- Volunteers
- 1,263 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Hypertension, Blood Pressure
The Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function
To determine the effect of (1) increased sodium intake and (2) increased potassium intake on blood pressure, vascular function and renal function in untreated (pre)hypertensive subjects.
- Conditions
- Hypertension, Blood Pressure, Vascular Function, Renal Function
- Trial name
- KaNa (NCT01575041)
- Testing
- Sodium, Potassium
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Liver Cirrhosis, Liver Failure
Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure"
The purpose of this study is to evaluate the effects on plasma exchange with 5% albumin on albumin functional capacity, cardiocirculatory, renal and cerebral function in cirrhotic patients with "acute-on-chronic liver failure".
- Trial name
- NCT01201720
- Testing
- Plasma exchange with albumin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Instituto Grifols, S.A.
Chronic Kidney Disease
Exploring the Effects of Exercise Combined With BFRT on Healthy and Patients With CKD
Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in healthy and CKD patients
- Trial name
- NCT07288905
- Testing
- Aerobic exercise, Blood flow restriction, Resistance exercise
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Cheng Kung University
Ketosis, Ketonemia
Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subjects
This is a randomized, placebo-controlled, double-blinded crossover design. Fifteen healthy subjects will be randomized to receive either ketone bodies (KE4) or placebo delivered by KetoneAid.
- Trial name
- KETO (NCT05980858)
- Testing
- Beta-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Change of Transit or Circulation, Effects of Immunosuppressant Therapy
Gastrointestinal Transit and Motility in Renal Transplant Recipients
Gastrointestinal (GI) complications after renal transplantation are commonly reported as side effects of immunosuppressive agents. Despite this, motility disorders have been scantily studied.
- Trial name
- NCT01777204
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Ciências da Saúde de Alagoas