Clinical trials: Renal Blood Flow
Kidney Transplant Failure and Rejection
Using the Speckle Doppler to Quantify Blood Flow in Kidney and Pancreas Grafts
Kidney and Pancreas transplantation is considered the treatment of choice for many people with End Stage Renal Disease and Type 1 diabetes because quality of life and survival is often better after transplantation.
- Trial name
- NCT04202237
- Testing
- Speckle Doppler imaging, Blood sample
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Manchester University NHS Foundation Trust
Chronic Kidney Disease 5D, Heart Failure
Cardio-fistular Recirculation in Patients With Chronic Heart Failure and Preserved Left Ventricle Ejection Fraction
This is a single-arm cohort study aimed to evaluate change of arteriovenous fistula volume blood flow / cardiac output ratio in patients with chronic heart failure (NYHA I-II classes) and with preserved ejection fraction as a…
- Conditions
- Chronic Kidney Disease 5D, Heart Failure, Heart Failure NYHA Class I, Heart Failure NYHA Class II
- Trial name
- NCT06394986
- Testing
- Hemodialysis session
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Diabetes Mellitus, Type 2, Kidney Diseases
Effect of Weekly High-dose Vitamin D3 Supplementation on the Association Between Circulatory FGF-23 and A1c Levels
Among Jordanians, there is a high prevalence of T2DM. VDD has also spread rapidly in the past decade. Preliminary results of recent studies have shown that VD3 has a potential role in reducing FBG.
- Trial name
- NCT04682626
- Testing
- Soft gelatin capsules each contains 50 000 IU VD3 (cholecalciferol) equivalents to 1.25 mg.
- Where
- Jordan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Applied Science Private University
Prostate Cancer
Hydroxyethyl Starch and Renal Function After Radical Prostatectomy
The purpose of this project is to investigate if hydroxyethyl starch (HES) is potential nephrotoxic and examine the effects on the circulation and kidneys during administration of HES during surgery.
- Trial name
- VORA (NCT01486563)
- Testing
- Voluven (Hydroxyethyl starch 130/0,4), Sodium Chloride 9 mg/ml
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Regional Hospital Holstebro
Cardiovascular Disease
Evaluation of Patients With Heart Disease Not Eligible for Research Protocols
An important mission of the National Institutes of Health (NIH) is to develop and carry out research studies designed to improve understanding of disease processes and treatments.
- Trial name
- NCT00001458
- Where
- United States
- Volunteers
- 7,829 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Kidney Injury, Renal Artery Blood Flow
Characteristics of Renal Blood Flow in AKI Patients in ICU and Its Clinical Significance
To study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical…
- Conditions
- Acute Kidney Injury, Renal Artery Blood Flow, Renal Venous Return, Renal Microcirculation
- Trial name
- NCT06090773
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking Union Medical College Hospital
Acute Kidney Injury
Perfusion - Pressure - Creatinine Trial
In Denmark around 3500 procedures are conducted involving a heart-lung-machine per year. An increase in the prevalence of postoperative kidney insufficiency have been observed following these procedures, during the last years.
- Trial name
- PPC (NCT01408420)
- Testing
- MAP > 60 mmHg
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Kidney Injury, Renal Insufficiency, Acute
Effects of Levosimendan in Acute Kidney Injury After Cardiac Surgery
Acute kidney injury (AKI) is a common complication after cardiac surgery. Mismatch in renal oxygen demand-supply may be an important pathogenetic factor.
- Trial name
- LEVOAKI (NCT02531724)
- Testing
- Levosimendan
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Healthy Volunteers
Mapping of Cardiac Power in Healthy Humans and Testing of a New Blood Pressure Sensor
Brief Summary: The study will record hemodynamic data from 20 healthy volunteers at rest and during moderate bicycle exercise in the recumbent and half sitting position for the following purposes: Sub-study 1 Testing the overall…
- Trial name
- NCT05008133
- Testing
- Bicycle exercise
- Where
- Norway
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Acute Kidney Injury, Hypotension, Controlled
Evaluation of Renal Resistive Index in Patients with Controlled Hypotension
In recent studies, it has been reported that the renal resistive index is effective in detecting postoperative acute kidney injury in the early period.
- Conditions
- Acute Kidney Injury, Hypotension, Controlled, Renal Failure, Ultrasonography, Doppler
- Trial name
- NCT05945706
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Ankara Diskapi Training and Research Hospital
Chronic Kidney Disease
Measurement of Kidney Blood Flow and Oxygen Levels by MRI
Comparison of renal blood flow measurements by PAH clearance and MRI
- Trial name
- NCT01318967
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University
Hypertension, Renal Failure
The Efficacy of Color-Doppler Ultrasonography to Assess the Renal Blood Flow With the Estimation of GFR
It is generally assumed that renal blood flow is symmetric in the absence of renal artery stenosis. The importance of studying the function of both kidneys separately is because it cannot be assumed that they are functionally…
- Trial name
- NCT00470769
- Testing
- Color-Doppler Ultrasound, 99mTc-DTPA scintigraphy
- Where
- 3 sites in Italy
- Volunteers
- 2,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Renal Blood Flow, Anesthesia
MR-Evaluation of Renal Function in Anesthetized Pediatric Patients
The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys.
- Conditions
- Renal Blood Flow, Anesthesia, MRI, Renal Oxygenation
- Trial name
- MERAPED (NCT06876870)
- Testing
- Anesthesia Maintenance Agent
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Nephropathy
Effect of the Aquaretic Tolvaptan on Nitric Oxide System. A Dose-response Study (DOVA)
Tolvaptan is a selective vasopressin receptor antagonist (V2R) that increases free water and sodium excretion. Inhibition of V2R increases vasopressin concentration in plasma, which stimulates V1-receptors in the vascular bed and…
- Trial name
- DOVA (NCT02078973)
- Testing
- 15 mg tolvaptan, 30 mg tolvaptan, 45 mg tolvaptan
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Kidney Failure, Chronic, Catheter-Related Infections
Study Assessing Safety & Effectiveness of a Catheter Lock Solution in Dialysis Patients to Prevent Bloodstream Infection
The purpose of this study is determine safety and effectiveness of Neutrolin, a catheter lock solution, for prevention of central venous catheter associated bloodstream infection in hemodialysis patients.
- Trial name
- NCT02651428
- Testing
- Neutrolin, Heparin
- Where
- 5 sites in United States
- Volunteers
- 806 people
- Sponsor
- CorMedix Therapeutics
Healthy, Physiology
Assessment of the Changes in Cortical and Medullary Renal Blood Flow During Exercise in Healthy Subjects Using Contrast Enhanced Ultrasound
Renal parenchymal blood flow can be divided in cortical and medullary blood flow. Changes and factors affecting renal medullary blood flow have not been studied in detail previously as investigators/doctors did not have tools to…
- Trial name
- NCT02672722
- Testing
- Definity, Exercise, Kidney Ultrasound
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diminished Ovarian Reserve, Infertility, Female
Efficacy of Traditional Chinese Medicine on Ameliorating IVF-ET Outcomes of Diminished Ovarian Reserve Patients
Patients with diminished ovarian reserve (DOR) who undergo in vitro fertilization and embryo transfer (IVF-ET) are included as the research subjects.
- Trial name
- NCT05577455
- Testing
- Medical prescription before ovulation, Medical prescription after ovulation
- Volunteers
- 266 people
- Sponsor
- Peking University Third Hospital
Hypovolemic Shock, Cardiogenic Shock
Renal Resistive Index in Patients With Shock
This study consists of two substudies. The first substudy: 'Renal resistive index in critically ill patients with cardiogenic and septic shock' Design: cross-sectional observational Aim of this project is: 1.
- Conditions
- Hypovolemic Shock, Cardiogenic Shock, Septic Shock, Kidney Failure, Acute
- Trial name
- NCT02558166
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Amsterdam UMC, location VUmc
Coffee, Pregnancy
Coffee Consumption and Pregnancy
Coffee, tea, and cocoa contain caffeine, a plant alkaloid. They are frequently consumed during pregnancy. We examined the effect of coffee consumption on fetal renal artery blood flow and amniotic fluid index (AFI) in the third…
- Trial name
- NCT03798275
- Testing
- coffee
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Acute Kidney Injury
Patients Undergoing Continuous Venovenous Hemodiafiltration: Effects of Increased Blood Flow
Acute Kidney Injure (AKI) is a syndrome with high incidence and prevalence in Intensive Care Units (ICU). It is estimated that 50% of the in the sector present AKI at some point and 10 to 15% require renal replacement therapy…
- Trial name
- NCT05796661
- Testing
- Effects of increased blood flow during regional anticoagulation with 4% trisodium citrate in patients undergoing continuous venovenous hemodiafiltration
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Hospital Israelita Albert Einstein