Clinical trials: Renal Disorder
Renal Pelvic and Ureteral Neoplasms
Irreversible Electroporation(IRE) For Unresectable Renal Pelvic and Ureteral Neoplasms
The purpose of this study is to evaluate the safety and efficacy of irreversible electroporation (IRE) for unresectable Renal Pelvic and Ureteral Neoplasms.
- Trial name
- IRE (NCT02430779)
- Testing
- rreversible electroporation (IRE), NanoKnife
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Kidney Disease
The Reducing Disparities in Access to kidNey Transplantation (RaDIANT) Community Study
The Southeastern Kidney Transplant Coalition is an academic-community collaboration between partners in the kidney disease community who share the common goal of eliminating health disparities in access to kidney transplantation…
- Trial name
- RaDIANT (NCT02092727)
- Testing
- Behavioral Interventions for Dialysis Facilities
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetic Nephropathies
Doppler Ultrasound in Early Detection of Diabetic Nephropathy Type 2 Diabetes Mellitus.
Doppler sonography provides an easily applicable, non-invasive, and well-established method for investigating renal morphologic characteristics and measuring vascular resistance in the renal parenchyma.
- Trial name
- NCT03284996
- Testing
- Doppler ultrasonography
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Kidney Disease
Chronic Kidney Disease and Bone - Correlation Between 18F-PET-TT Imaging and Histomorphometry of Bone in CKD Patients
Chronic kidney disease (CKD) is an increasing public health problem and the number of patient with chronic kidney disease is increasing worldwide.
- Trial name
- CKD-Bone (NCT02967042)
- Testing
- 18F-PET-TT
- Where
- Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Kidney Diseases
Retrospective Study: Long-term Health of Living Kidney Donors
Kidney transplantation, is the preferred treatment option of end stage renal disease. Compared to dialysis, patients who receive kidneys have a 70% reduction in death, a dramatically improved quality of life and cost the health…
- Trial name
- NCT00319527
- Where
- 10 sites in Australia, Canada and 1 more
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Creatinine Clearance Quantitative Trait Locus, Renal Insufficiency, Chronic
How to Dose a Patient According to Renal Function? Glomerular Filtration Rate (GFR) or Creatinine Clearance (ClCr)
Background： The prevalence of chronic kidney disease (CKD) is high in Taiwan. Though there are many factors that may affect the measurement of serum creatinine, it is a well-accepted marker for renal function assessment.
- Trial name
- NCT02206373
- Where
- Taiwan
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Chronic Kidney Disease Mineral and Bone Disorder
Phosphorus Absorption in Healthy Adults and in Patients With Moderate Chronic Kidney Disease
Chronic kidney disease (CKD) affects approximately 26 million Americans with many more at risk for disease development. Elevated serum phosphorus (P) and related abnormalities in P homeostasis due to progressive loss of kidney…
- Trial name
- NCT03108222
- Testing
- Phosphorus Absorption Test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Purdue University
Pregnancy, Gestational Diabetes Mellitus
Predictability of Gestational Diabetes Mellitus in First and Second Trimester
The objective of the study is, if an early oral glucose tolerance test combined with maternal history, condition and multiple biomarker analysis can be used to detect gestational diabetes mellitus in the first trimester (12-14…
- Trial name
- GDMPredict (NCT02035059)
- Where
- Switzerland
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Kidney Diseases
Sleep Disorders in Chronic Kidney Disease Patients
1. Asses sleep disorders in CKD patients and those on haemodialysis and related complications ( uncontrolled blood pressure,glomerular filtration rate (GFR) ,proteinuria and psychological disturbance) 2.
- Trial name
- NCT05240261
- Testing
- Quetiapine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Kidney Disease
Safety and Pharmacokinetics of HRS-1780 in Healthy Subjects and Subjects With Impaired Renal Function
This is a multicenter, non-randomized, open-label, parallel-controlled study. The main objective is to evaluate the safety and pharmacokinetics of HRS-1780 in subjects with mild and moderate renal impairment versus healthy…
- Trial name
- NCT06039254
- Testing
- HRS-1780
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
ADPKD (Autosomal Dominant Polycystic Kidney Disease)
Drug-Drug Interactions of JMKX003142 in Healthy Participants
This is a single-center, non-randomized, open-label, self-controlled, Phase I clinical trial to evaluate the drug-drug interactions (DDI) of JMKX003142 tablets in healthy adult participants.
- Trial name
- NCT07565441
- Testing
- JMKX003142 tablets, Fluconazole Capsules, Cocktail Substrates (Midazolam Oral Solution, Rosuvastatin Calcium Tablets, and Digoxin Tablets)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Jemincare
Hypercholesterolaemia
Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Renal Impairment Study (MK-0616-020)
The primary objective of the study is to compare the plasma pharmacokinetics (PK) of enlicitide decanoate following a single 20 mg dose in participants on a background of statin therapy with varying degrees of renal impairment…
- Trial name
- NCT05934292
- Testing
- Enlicitide Decanoate
- Where
- 5 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
May-Hemalin, Fechtner Syndrome (Disorder)
Phenotypic and Genotypic Identification and Characterization of MYH9-related Constitutional Thrombocytopenia
The research involves the establishment of a cohort including as much as possible cases of macrothrombocytopenia related to a "MYH9 syndrome" and the study of mutations and polymorphisms of MYH9 gene in all these patients.
- Conditions
- May-Hemalin, Fechtner Syndrome (Disorder), Epstein Syndrome (Disorder), MYH9 Related Disorders
- Trial name
- MAGIC-MYH9 (NCT00925236)
- Where
- France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Diseases, Osteoporosis
Guangzhou Nutrition and Health Study (GNHS)
Purpose: The Guangzhou Nutrition and Health Study (GNHS) project aims to assess the determinants of metabolic disease in nutritional aspects, as well as other environmental and genetic factors, and explore possible mechanisms…
- Conditions
- Cardiovascular Diseases, Osteoporosis, Diabetes Mellitus, Type 2, Metabolic Syndrome
- Trial name
- GNHS (NCT03179657)
- Volunteers
- 5,118 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Chronic Kidney Disease
Multiple Dose Study of the Safety, Tolerability, Pharmacokinetics and Effect on Renal Potassium Clearance
The purpose of this study is to investigate the safety and tolerability of LY2623091 after multiple oral dosing in healthy men and women of non-childbearing potential.
- Trial name
- NCT01237899
- Testing
- LY2623091, Eplerenone
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
CKD Stage 4
Serum Hepcidin, Haemoglobin Level and Iron Status in Chronic Kidney Disease Patients (CKD) With Anaemia
The current study is planned to assess possible relationships of serum hepcidin levels with haemoglobin levels, inflammation and iron statuses in stage 4 CKD patients.
- Trial name
- NCT04102319
- Testing
- serum hepcidin
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency
Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)
The aims of this study are to investigate whether mannitol stimulates copeptin (part 1: proof-of-concept) and whether the copeptin levels upon mannitol infusion differ in primary polydipsia and arginine vasopressin deficiency…
- Conditions
- Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency, Primary Polydipsia
- Trial name
- MARS (NCT06542198)
- Testing
- Mannitol Infusion (blinded), Mannitol Infusion (open label)
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Diabetic Kidney Disease
Dosimetry of Tc-99m-Tilmanocept
This proposal will use kidney SPECT/CT of Tc-99m-tilmanocept to evaluate the mesangial changes seen in diabetics across the spectrum of kidney disease as well as persons with hypertensive kidney disease, the next most common…
- Trial name
- NCT05241522
- Testing
- Tc-99m-Tilmanocept
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Healthy Volunteers, Enteric Hyperoxaluria
Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects
The first stage of this study is a prospective, adaptive, Phase 1, first-in-human, randomized, controlled study evaluating safety, tolerability, and pharmacodynamics of NOV-001 in adult healthy volunteers.
- Trial name
- NCT04909723
- Testing
- NOV-001, NB1000S, NB2000P
- Where
- 20 sites in United States, Canada
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Novome Biotechnologies Inc
Proteinuria
Bariatric Surgery and the Kidney
The purpose of the project is to study the relationship between post-bariatric surgery changes in weight and renal parameters.
- Trial name
- NCT01410994
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
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