Clinical trials: Renal Dysfunction
Hepatitis C, Kidney Diseases
VX-950-TiDP24-C132: A Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics of Telaprevir.
The purpose of this study is to investigate the effect of severe renal impairment or failure on the single-dose pharmacokinetics of telaprevir (TVR).
- Trial name
- NCT00903773
- Testing
- telaprevir
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tibotec BVBA
Acute Kidney Injury (AKI), Postnatal AKI
NIRS Monitoring in the NICU and AKI
The primary objective of this study is to describe the pattern of renal tissue oxygen saturation (SrSO2) using near-infrared spectroscopy (NIRS) in premature infants <30 weeks gestational age.
- Trial name
- NCT07222722
- Testing
- NIRS Monitoring
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Nephropathy
Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease
Patients with chronic kidney disease (CKD) have a defect in the tubular reabsorption of sodium, and therefore the ability to excrete a sodium load is diminished compared to healthy subjects.
- Trial name
- CASE (NCT01623661)
- Testing
- hypertonic saline
- Where
- Denmark
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Chronic Kidney Diseases
Intestinal Phosphate Transporter Expression in CKD Patients
The aim of the present study is to study the expression of the various phosphate transporters in patients with normal or moderately impaired renal function or in patients on dialysis.
- Trial name
- PeTRA (NCT02539680)
- Testing
- endoscopy
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Renal Impairment
EVP-6124 Renal Impairment Study
The purpose of this study is to assess the pharmacokinetics of EVP-6124 and metabolites after a single oral dose in subjects with mild, moderate and severe renal impairment compared with subjects with normal renal function.
- Trial name
- NCT01984723
- Testing
- Experimental: EVP-6124
- Where
- 2 sites in Czechia, Hungary
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- FORUM Pharmaceuticals Inc
Renal Impairment
Pharmacokinetics Of CP-690,550 In Patients With Impaired Renal Function
A study to evaluate the pharmacokinetics of CP-690,550 in subjects with mild, moderate or severe renal impairment, who do not require hemodialysis, compared to healthy controls.
- Trial name
- NCT01740362
- Testing
- CP-690,550
- Where
- 4 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Contrast Enhancement in Magnetic Resonance Imaging
A Study to Evaluate the Pharmacokinetics (How it Moves Into, Through and Out From the Body) of a New Gadolinium-based Contrast Agent (GBCA) After Injection and How Safe it is in Participants With Normal and Impaired Renal Function
Researchers in this study want to learn how a new contrast agent for magnetic resonance imaging (MRI) called BAY1747846 moves into, through and out of the body (pharmacokinetics) after injection in participants with normal and…
- Trial name
- NCT05061979
- Testing
- BAY1747846
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
Migraine
Study of Oral Lasmiditan in Participants With Normal and Impaired Renal Function
This is a multi-center, open-label, non-randomized, parallel-group, adaptive, single dose study. This study will enroll up to 32 participants using an adaptive design that can include up to 3 groups of 8 participants with…
- Trial name
- NCT03009162
- Testing
- Lasmiditan
- Where
- 2 sites in Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Chronic Kidney Diseases, Cardio-Renal Syndrome
Left Ventricular Fibrosis in Chronic Kidney Disease
This study aims to understand the onset an functional consequences of left ventricular interstitial fibrosis in patients with chronic kidney disease (stage 2 to 5), as well as assess whether transplantation results in a…
- Conditions
- Chronic Kidney Diseases, Cardio-Renal Syndrome, Myocardial Fibrosis, Uraemic Cardiomyopathy
- Trial name
- FibroCKD (NCT03176862)
- Testing
- cardiac magnetic resonance scan, Cardiopulmonary exercise test with stress echocardiogram, 24-hour ECG holter monitor
- Where
- United Kingdom
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Dr Manvir Kaur Hayer
Cardiovascular Diseases, Metabolic Syndrome
Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials.
- Conditions
- Cardiovascular Diseases, Metabolic Syndrome, Obesity, Prediabetes
- Trial name
- NCT07106879
- Testing
- Blood Work
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Clindove Research LLC
Renal Disease, End Stage Renal Disease
A Multi-Center, Open-Label Study
This study will be an open-label, single-treatment, single-dose, parallel group study to evaluate the pharmacokinetics (PK) of droxidopa in subjects with mild, moderate, and severe renal dysfunction and End Stage Renal Disease…
- Trial name
- NCT01468259
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chelsea Therapeutics
Acute Kidney Injury, Hypotension
Is Permissive Hypotension Truly Harmless? Early Biomarker Evidence of Subclinical Kidney Injury in Rhinologic Surgery
This study aims to investigate the effects of permissive hypotension, which is routinely used in rhinologic surgeries such as rhinoplasty, septoplasty, and functional endoscopic sinus surgery (FESS), on renal function.
- Trial name
- NCT07328620
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Gazi University
Chronic Kidney Insufficiency, Hypertension
Renal and Systemic Vascular Resistance in Chronic Kidney Disease (CKD)
Patients with reduced kidney function have a higher risk of heart disease and death. Studies have shown that blood vessels in patients with hypertension change with a decrease of lumen size and growth of the vessel wall.
- Conditions
- Chronic Kidney Insufficiency, Hypertension, Vasodilation
- Trial name
- RenVas (NCT01380717)
- Testing
- Beta-blocker, ACE-inhibitor, Calcium Channel Blockers, ACE-Inhibitor
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Renal Impairment
Pharmacokinetic, Pharmacodynamic and Tolerability Study of Otamixaban in Patients With Mild, Moderate and Severe Renal Impairment
Primary Objective: To study effect of mild, moderate and severe renal impairment on the pharmacokinetics of Otamixaban. Secondary Objective: To assess the pharmacodynamic effects of Otamixaban on subjects with mild, moderate and…
- Trial name
- NCT01120314
- Testing
- OTAMIXABAN (XRP0673)
- Where
- 4 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sanofi
Healthy, Renal Insufficiency
Safety, Tolerability and Pharmacokinetics of KBP-5074 in Healthy Subjects and Subjects With Renal Impairment
This multiple ascending dose (MAD) study in healthy subjects and subjects with mild to moderate renal impairment will evaluate the safety, tolerability and pharmacokinetics of KBP-5074.
- Trial name
- NCT02653014
- Testing
- KBP-5074
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- KBP Biosciences
Renal Insufficiency
Assessing the Behavior of Met DR in Subjects With Kidney Dysfunction
This study evaluated how a single dose of delayed-release metformin (Met DR) behaves in subjects with normal kidney function, mild kidney dysfunction, moderate kidney dysfunction, or severe kidney dysfunction.
- Trial name
- NCT01658514
- Testing
- Met DR, Met XR
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Elcelyx Therapeutics, Inc.
Aging, Frailty
Renal Ageing-sarcopenia Network
Frailty is a syndrome in which the accumulation of small, individually insignificant deficits leads to heightened vulnerability to adverse events and predisposes to potential catastrophic decompensation.
- Conditions
- Aging, Frailty, Hypertension, CKD
- Trial name
- NCT04630132
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
End Stage Renal Disease
Effect of Behavioral Intervention on Interdialytic Weight Gain in Patients Undergoing Hemodialysis
A randomized clinical trial will be conducted in which effect of behavioral intervention (Text message of dietary salt and fluid restriction) on inter-dialytic weight gain in hemodialysis patients.
- Trial name
- NCT04892225
- Testing
- Technology-supported behavioral intervention (text message)
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Farooq Hospital - West Wood Branch
Chronic Kidney Disease
Pilot Study of Sodium Bicarbonate in Generally Healthy People With Low Bicarbonate
The goal of this pilot study is to determine whether oral sodium bicarbonate can raise low serum bicarbonate concentration in people without chronic kidney disease (CKD).
- Trial name
- NCT02743650
- Testing
- Sodium bicarbonate
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Utah
Chronic Kidney Diseases, Healthy
Identification of P-cresyl Sulfate Producer Phenotype by Oral Tyrosine Challenge Test: Interactions Among Diet, Gut Microbiota, and Host Genome
Patients with chronic kidney disease (CKD) display a substantial increase in cardiovascular disease (CVD). Moreover, the prognosis of CVD in CKD is extremely poor.
- Trial name
- NCT04204174
- Testing
- Tyrosine, brand name: myprotein
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
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