Clinical trials: Renal Dysfunction
Acute-On-Chronic Liver Failure, Hepatorenal Syndrome
Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.
Acute on chronic liver failure (ACLF) is a distinct entity where, because of severe acute hepatic injury, a rapid loss of liver function develops in a patient with previous chronic liver disease(4).
- Conditions
- Acute-On-Chronic Liver Failure, Hepatorenal Syndrome, Acute Kidney Injury
- Trial name
- NCT04416282
- Testing
- Terlipressin, Albumin
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Renal Insufficiency, Chronic, Proteinuria
Effect of RAS Blockers on CKD Progression in Elderly Patients With Non Proteinuric Nephropathies (PROERCAN01)
This study evaluates the effect of renin-angiotensin blockers on chronic kidney disease progression in elderly (>65 years old) patients with non-proteinuric nephropathies.
- Trial name
- PROERCAN01 (NCT03195023)
- Testing
- Lisinopril, Amlodipine
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Kidney Transplantation, Kidney Disease
Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in Adults
Transplant rejection occurs when a patient's body does not recognize the new organ and attacks it. Patients who have kidney transplants must take drugs to prevent transplant rejection.
- Trial name
- NCT00078559
- Testing
- Alemtuzumab, Sirolimus, Tacrolimus
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Wisconsin, Madison
Multiple Myeloma, Renal Failure
Pilot Study Dara-CyBorD in Newly Diagnosed Multiple Myeloma Patients With Renal Failure
The goal of this study is to assess the efficacy of induction treatment with daratumumab-hyaluronidase (dara SC) with cyclophosphamide, bortezomib, and dexamethasone (Dara-CyBorD) for four cycles in patients with newly diagnosed…
- Trial name
- NCT06142396
- Testing
- Daratumumab-hyaluronidase in Combination with Bortezomib, Cyclophosphamide, and Dexamethasone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Augusta University
Advanced Malignancies
To Evaluate the Safety, and Pharmacokinetics of Parscaclisib in Participants With Normal Renal Function and Renal Impairment.
The purpose of the study is to evaluate the pharmacokinetics and safety of parsaclisib in participants With normal renal function and participants with renal impairment.
- Trial name
- NCT04831996
- Testing
- parsaclisib
- Where
- 4 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Incyte Corporation
Autosomal Dominant Polycystic Kidney Disease
Somatostatin In Patients With Autosomal Dominant Polycystic Kidney Disease And Moderate To Severe Renal Insufficiency
The general aim of the trial is to assess the efficacy of one year treatment with long-acting somatostatin analogue (Octreotide LAR) compared with placebo in slowing kidney and liver growth rate in patients with ADPKD and…
- Trial name
- ALADIN2 (NCT01377246)
- Testing
- Octreotide-LAR, Saline solution.
- Where
- 6 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Critical Illness, Acute Kidney Injury
Sup-Icu RENal (SIREN)
Data show that episodes of bleeding may often be observed in critically ill patients with dialysis-dependent acute renal failure (ARF) on renal replacement therapy (RRT).
- Conditions
- Critical Illness, Acute Kidney Injury, End-stage Renal Disease, Renal Replacement Therapy
- Trial name
- SIREN (NCT02718261)
- Testing
- Pantoprazole
- Where
- 2 sites in Denmark, Switzerland
- Volunteers
- 3,350 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Urolithiasis, Urologic Diseases
Effectiveness of Drainage by PCN vs. JJ in Patients With Symptoms of Obstructive Kidney Disease Caused by Urolithiasis
To investigate the effectiveness of percutaneous nephrostomy catheter placement versus retrograde double J catheter placement in patients with symptoms of obstructive kidney disease (with either infection and/or pain and/or…
- Conditions
- Urolithiasis, Urologic Diseases, Urinary Calculi, Urinary Obstruction
- Trial name
- STONE (NCT04594161)
- Testing
- Percutaneous Nephrostomy, Double J catheter
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Kidney Disease
Chronic Kidney Disease and Bone - Correlation Between 18F-PET-TT Imaging and Histomorphometry of Bone in CKD Patients
Chronic kidney disease (CKD) is an increasing public health problem and the number of patient with chronic kidney disease is increasing worldwide.
- Trial name
- CKD-Bone (NCT02967042)
- Testing
- 18F-PET-TT
- Where
- Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Chronic Kidney Diseases
External Validation of Clinical Prediction Tools for Estimating Salt and Potassium Intake in Nephrology Patients.
There is no validated self-questionnaire to assess salt and potassium intake in nephrology patients. Using Bayesian models, researchers developed clinical prediction tools to estimate salt and potassium intake in nephrology…
- Trial name
- UniverSel (NCT05783960)
- Testing
- administration questionary
- Where
- 5 sites in France
- Volunteers
- 629 people
- Sponsor
- Hospices Civils de Lyon
End Stage Renal Disease
Improving Outcomes in Vascular Access
The IMPROVA study is designed to identify novel predictors of vascular access success or failure. Clinical assessment complimented by Doppler ultrasound is the only currently employed methods of assessing suitability for…
- Trial name
- IMPROVA (NCT02334696)
- Volunteers
- 32 people
- Sponsor
- University Hospital Birmingham
Acute Kidney Injury, Renal Replacement Therapy
Effects of Variation of Sodium Dialysate in ICU
Intermittent hemodialysis/diafiltration is a current renal replacement therapy (RRT) institued for ICU patients with AKI. For a better clinical tolerance, iinternational guidelines advise to use cold dialysate, increase duration…
- Trial name
- NADIRA (NCT03329313)
- Testing
- Lowering sodium concentration dialysate, Highing sodium concentration dialysate
- Where
- France
- Volunteers
- 158 people
- Sponsor
- University Hospital, Montpellier
Kidney Disease, Chronic
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study.
- Trial name
- NCT06531824
- Testing
- BI 690517, Empagliflozin
- Where
- 562 sites in United States, Argentina and 18 more
- Volunteers
- 8,371 people
- Sponsor
- Boehringer Ingelheim
Acute Kidney Injury, Postoperative Complications
Incidence, Risk Factors and Consequences of Acute Kidney Injury in Patients Undergoing Esophageal Cancer Surgery
Esophagectomy serves as an exemplar of major operative trauma, with well-known risk of pulmonary, cardiac, anastomotic, and septic complications and the presence of postoperative complications after esophagectomies for cancer is…
- Trial name
- NCT04773080
- Where
- Italy
- Volunteers
- 254 people
- Sponsor
- Azienda Ospedaliera di Padova
Chronic Kidney Disease, Hypertension
Diuretics and Volume Overload in Early CKD
Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes.
- Trial name
- DOCK (NCT05171686)
- Testing
- Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- VA Office of Research and Development
Renal Failure, End Stage Renal Disease
Safety and Clinical Performance of a Dialyzer With a Modified Polysulfone Membrane
The clinical investigation will be performed to generate clinical data on clearances and removal rates (for ß2-microglobulin, myoglobin, phosphate, creatinine, and urea) as well as biocompatibility of the modified polysulfone…
- Trial name
- eMPORA (NCT03315624)
- Testing
- Dialyzer
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Injury of Kidney, Acute Renal Failure
A Dose Escalation and Safety Study of I5NP in Patients Undergoing Major Cardiovascular Surgery
This is a Phase 1, randomized, double-blind, dose escalation, safety and pharmacokinetic study. The study will be conducted in approximately 8-10 centers in the United States and Switzerland.
- Trial name
- NCT00554359
- Testing
- I5NP (a small interfering RNA)
- Where
- 11 sites in United States, Israel and 1 more
- Volunteers
- 16 people
- Sponsor
- Quark Pharmaceuticals
Diabetes Mellitus, Type 2, Obesity
A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function
Novo Nordisk is developing the study medicine NNC0487-0111 to treat people living with type 2 diabetes and/or people living with overweight or obesity.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Overweight
- Trial name
- NCT06559527
- Testing
- NNC0487-0111
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Novo Nordisk A/S
Renal Impairment, Type 2 Diabetes Mellitus
Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Ertugliflozin in Participants With Type 2 Diabetes Mellitus (MK-8835-009)
This is a study to evaluate the effect of renal impairment on the pharmacokinetics, pharmacodynamics, safety and tolerability of ertugliflozin in participants with type 2 diabetes mellitus (T2DM) and in healthy participants with…
- Trial name
- NCT01948986
- Testing
- Ertugliflozin
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Kidney Disease Due to Hypertension, Chronic Kidney Disease Due to Type 2 Diabetes Mellitus
Fecal Microbiota Transplantation as a Therapeutic Strategy in the Progression of Chronic Kidney Disease
What the investigators want to achieve with the protocol is to identify the impact of intestinal microbiota transplantation on the progression of chronic kidney disease.
- Trial name
- NCT04361097
- Testing
- Faecal microbiota transplant
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
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