Clinical trials: Renal Dysfunction, open to volunteers
Hypertension, Vascular Diseases
Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension
The purpose of the SPYRAL SWYFT sub-study is to evaluate whether renal denervation with the Symplicity Spyral system performed in the main and first order branch renal arteries yields a shorter procedure time and is as effective…
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
- Trial name
- SWYFT (NCT07115953)
- Testing
- Symplicity Spyral™ multi-electrode renal denervation system
- Where
- 21 sites in Australia, Belgium and 7 more
- Volunteers
- 130 people
- Sponsor
- Medtronic Vascular
Renal Failure Chronic Requiring Dialysis, Peritoneal Dialysis
Bisacodyl Oral for Lowering Dysfunction (of Tenckhoff Catheter)
Doctors need to insert catheter for patients who are going to have peritoneal dialysis. These peritoneal catheters can be obstructed or blocked afterward. The chance of not having smooth flow can be up to 12 and 31%.
- Trial name
- BOLD (NCT07351357)
- Testing
- Bisacodyl 5 mg
- Where
- 6 sites in Hong Kong
- Volunteers
- 398 people
- Sponsor
- Chinese University of Hong Kong
Hypertension, Renal Insufficiency
Food Frequency Questionnaire to Assess Sodium Intake
EvalSel can precisely assess the salt intake of hospitalized patients in nephrology and cardiology or in medical consultation. It can determine salt consumption to the nearest gram.
- Trial name
- EVALSEL (NCT05533645)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 99 people
- Sponsor
- University Hospital, Lille
End-Stage Renal Disease, Hemodialysis Complication
The Effect of Intradialytic Exercise on Postural Abnormalities
This randomized, assessor-blinded controlled trial will evaluate the preliminary efficacy and safety of a 12-week supervised intradialytic multimodal exercise program for improving postural abnormalities in adults receiving…
- Trial name
- NCT07720401
- Testing
- Supervised Intradialytic Multimodal Exercise Program
- Where
- Iran
- Volunteers
- 98 people
- Sponsor
- Pardis Specialized Wellness Institute
Emergency Surgery, Acute Kidney Injury
Preoperative Hemoglobin and Acute Kidney Injury in Emergency Surgery
Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of blood…
- Conditions
- Emergency Surgery, Acute Kidney Injury, Hemoglobin
- Trial name
- NCT06857630
- Testing
- Observational
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Samsun University
Chronic Kidney Disease (CKD), Coronary Artery Disease (CAD)
Coronary Artery Disease Screening in Patients With Chronic Kidney Disease
Patients with chronic kidney disease (CKD) have a markedly increased cardiovascular risk, with coronary artery disease being a leading cause of morbidity and mortality.
- Trial name
- EVACKD (NCT07585695)
- Where
- France
- Volunteers
- 283 people
- Sponsor
- University Hospital, Grenoble
SARS-CoV Infection, Covid19
KIDney Injury in Times of COVID-19 (KIDCOV)
There is an unmet need to evaluate the impact of sub-clinical/mild COVID19 disease in the outpatient setting on prevalent and incident renal injury, as this data is currently unavailable.
- Conditions
- SARS-CoV Infection, Covid19, Corona Virus Infection, Acute Kidney Injury
- Trial name
- KIDCOV (NCT04705766)
- Testing
- Urine Collection
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Renal Insufficiency
A Pharmacokinetics and Safety Study of Azvudine Tablets in Subjects With Mild-To-Moderate GFR Decline in Renal Insufficiency and in Healthy Subjects
Azvudine(FNC)，a nucleoside reverse transcriptase inhibitor, make itself a better candidate to be co-formulated in other anti-HIV therapies, thus to improve patient's compliance.
- Trial name
- NCT07001436
- Testing
- Azvudine tablets
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Henan Genuine Biotech Co., Ltd.
Acute Kidney Injury After Open Heart Surgery, Venous Congestion After Open Heart Surgery
Evaluation of the Association Between the VEXUS Score and Hemodynamic Status and the Occurrence of Acute Kidney Injury After Open-Heart Surgery
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass and is associated with prolonged intensive care unit stay, increased morbidity, and mortality.
- Trial name
- NCT07805564
- Where
- Vietnam
- Volunteers
- 135 people
- Sponsor
- Hanoi Medical University
Chronic Kidney Diseases
Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine
This study is designed to determine the efficacy and safety of colchicine in patients with chronic kidney disease.
- Trial name
- NCT04500665
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Diseases
KNOW-CKD Cohort, Phase II Study
The goals of KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease) study are 1) to establish a CKD cohort representing Korean CKD population for up to 10-year follow-up, and 2) to investigate the…
- Trial name
- NCT03929900
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Seoul National University Hospital
End Stage Renal Disease
Efficacy and Safety of XyloCore Peritoneal Dialysis Solution.
Randomized, controlled, parallel groups, open-label, blinded end-point assessment, multicenter study, comparing the effects of a low glucose peritoneal dialysis solution, XyloCore, to glucose solutions (Physioneal, Fixioneal…
- Trial name
- ELIXIR (NCT03994471)
- Testing
- XyloCore Low Strenght, XyloCore Medium Strenght, XyloCore High Strenght, 1.36%, 1.5%, 2.27%, 2.5%, 3.86%, 2.25% Glucose PD Solution
- Where
- 41 sites in Denmark, Germany and 4 more
- Volunteers
- 170 people
- Sponsor
- Iperboreal Pharma Srl
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Acute Kidney Injury
Ultra-Low Contrast Angiography in AKI
The aim of this study is to evaluate the safety of ultra-low contrast coronary angiography in patients with pre-existing acute kidney injury.
- Trial name
- NCT05906758
- Testing
- Angiography
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Tulane University
Overweight/Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease/Steatohepatitis (MASLD/MASH)
A Single-Dose Pharmacokinetic Study of HRS-4729 Injection in Healthy Participants and Patients With Renal Impairment
This study aims to evaluate the pharmacokinetic effects of a single dose of HRS-4729 injection in participants with mild, moderate, and severe renal impairment, with 8 participants enrolled in each renal impairment group and 8…
- Conditions
- Overweight/Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease/Steatohepatitis (MASLD/MASH), Type 2 Diabetes Mellitus
- Trial name
- NCT07807059
- Testing
- HRS-4729
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Hyperkalaemia, Chronic Kidney Disease Stage 3 and 4
Patiromer and Diet/hrQoL in Chronic Dialysis
This is a phase III, prospective, randomized, double-blind, placebo-controlled, single-center, pilot trial, aimed at assessing whether treatment with the oral potassium binder patiromer as compared to placebo allows withdrawal or…
- Conditions
- Hyperkalaemia, Chronic Kidney Disease Stage 3 and 4, Dietary Intervention
- Trial name
- PRINCE (NCT06858280)
- Testing
- Patiromer 8400 MG [Veltassa]
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Type 2 Diabetes, Chronic Kidney Disease
Sweet & Sour: Dietary Acid Load in Type 2 Diabetes and Kidney Disease Across Sex and Ethnic Groups
Chronic kidney disease (CKD) is a common condition and a major global cause of illness and mortality. The most common cause of kidney damage is diabetes, a condition that disrupts metabolism, leading to increased risk of damage…
- Trial name
- Sweet & Sour (NCT07587918)
- Testing
- Low Dietary Acid Load
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Erasmus Medical Center
Liver Transplant; Complications, AKI - Acute Kidney Injury
The Efficacy of Intravenous Amino Acids in Reducing the Occurrence of AKI After Live Donor Liver Transplant
This prospective, open-label, randomized controlled trial aims to evaluate the efficacy of intravenous amino acid infusion in reducing AKI after LDLT.
- Trial name
- NCT07132697
- Testing
- L-Amino acid mixture, Standard of care
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Anemia, Iron Deficiencies
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CTX001 in Healthy Adults.
This study is testing CTX001 for certain conditions where the body does not have enough available iron or has difficulty storing or moving iron properly.
- Conditions
- Anemia, Iron Deficiencies, Chronic Kidney Disease
- Trial name
- NCT07577817
- Testing
- CTX001 With and Without Iron, CTX001 With Iron, CTX001 Multiple Dose
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cajal Therapeutics Inc.
Chronic Kidney Disease
Evaluation of the Effect of a Daily Dose of Wakame Seaweed on Reducing Circulating Concentrations of Advanced Glycation End Products in Patients With Stage III Chronic Kidney Disease
Persistent glomerular hyperfiltration is a characteristic feature of the early stages of kidney disease and represents a factor in the progression of chronic kidney disease (CKD).
- Trial name
- Ckd-WEED (NCT07729683)
- Testing
- Consumption of wakame
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
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