Clinical trials: Renal Failure, End Stage
End Stage Renal Disease
Comparison of Efficacy in Removal of Advanced Glycation End Products (AGEs) Between Super High-flux Hemodialysis and Postdilution Online Hemodiafiltration: A Single-center, Prospective, Open-label, Crossover Randomized Controlled Trial
The goal of this clinical trial is to compare efficacy in advanced glycation end products removal between Super high-flux Hemodialysis and high-volume post-dilution online hemodiafiltration.
- Trial name
- NCT05777148
- Testing
- super high-flux hemodialysis, postdilution online hemodiafiltration
- Where
- Thailand
- Volunteers
- 22 people
- Sponsor
- Mahidol University
End-Stage Renal Disease, Prosthetic Arteriovenous Access
Immediate Maintained Cannulation of a Newly Implanted Prosthetic Arteriovenous Access for Acute Hemodialysis
Objectives: Examine the acute utility of immediate maintained cannulations of a newly implanted prosthetic arteriovenous access. Background: Recurrent failure of central catheterization is not uncommon.
- Trial name
- NCT00711750
- Where
- Taiwan
- Volunteers
- 39 people
- Sponsor
- Far Eastern Memorial Hospital
End Stage Renal Disease
Hemoglobin Maintenance in Pediatric ESRD (End-stage Renal Disease) Patients by Ferric Pyrophosphate Citrate (FPC)
The main purpose is to determine the safety of Triferic iron administered via dialysate and intravenously in pediatric patients with chronic kidney disease on chronic hemodialysis (CKD-5HD).
- Trial name
- NCT04239391
- Testing
- Triferic
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 150 people
- Sponsor
- Rockwell Medical Technologies, Inc.
Hyperparathyroidism, Secondary, Kidney Failure, Chronic
Hyperparathyroidism and Dialysis Adequacy in Hemodialysis Patients
This cross-sectional study aims to determine the prevalence of secondary hyperparathyroidism among end-stage renal disease patients on regular hemodialysis and to evaluate its relationship with dialysis adequacy at Assiut…
- Conditions
- Hyperparathyroidism, Secondary, Kidney Failure, Chronic, Chronic Kidney Diseases
- Trial name
- NCT07820150
- Volunteers
- 130 people
- Sponsor
- Assiut University
Vitamin D Deficiency, Vascular Calcification
Effects of Cholecalciferol on Osteoprotegerin Levels in Patients on Peritoneal Dialysis
Aim: To investigate whether cholecalciferol (4800 U/daily) or placebo for 16 weeks reduces proteins levels associated with vascular calcification (osteoprotegerin, osteopontin, osteocalcin) in patients treated with peritoneal…
- Conditions
- Vitamin D Deficiency, Vascular Calcification, Renal Insufficiency, End Stage Renal Failure on Dialysis
- Trial name
- NCT02598635
- Testing
- Cholecalciferol
- Where
- Mexico
- Volunteers
- 58 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Chronic Kidney Diseases
Impact of Dapagliflozin on Intestinal Microbiota Composition and on the Metabolites Derived From the Intestinal Microbiota in Non-diabetic Chronic Renal Failure Patients
Chronic kidney disease (CKD) is a common disease affecting 10-12% of the adult population and characterize with high-risk cardiovascular morbidity and mortality with progression of CKD.
- Trial name
- DAPA-GUT (NCT05965440)
- Testing
- impact of Dapagliflozin on Intestinal Microbiota on chronic renal failure patients
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Renal Failure, End Stage Renal Disease
Safety and Efficacy Assessment of HAV in Patients Needing Vascular Access for Dialysis
This is a Phase 2, prospective, multicenter, open-label, single-arm study of the Human Acellular Vessel (HAV).
- Conditions
- Renal Failure, End Stage Renal Disease, Vascular Access, Hemodialysis
- Trial name
- NCT04135417
- Testing
- HAV
- Where
- 2 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Humacyte, Inc.
End Stage Renal Disease on Dialysis
Home-based vs Intradialysis Exercise Guided by Nursing Staff
Participants will be randomized either to home-based exercise or to intradialysis exercise guided by nurses of the renal unit. The programs will last 16 weeks.
- Trial name
- HoBIDnurse (NCT04051515)
- Testing
- Intradialysis exercise training, Home-based exercise training
- Where
- 7 sites in Belgium, Greece and 2 more
- Volunteers
- 70 people
- Sponsor
- Cardenal Herrera University
End Stage Renal Disease
The Impact of Mindfulness-Based Intervention on Psychophysical Health
Background: Hemodialysis is considered as an effective therapy to remove harmful wastes from the body and to improve the quality of life in patients suffering from end-stage renal disease (ESRD).
- Trial name
- NCT06064708
- Testing
- Mindfulness-based intervention
- Where
- 2 sites in Jordan
- Volunteers
- 64 people
- Sponsor
- Jordan University of Science and Technology
Hyperphosphatemia
The Efficacy of Niacin on Hyperphosphatemia in Patients Undergoing Haemodialysis
Hyperphosphatemia is a common complication of end-stage renal disease and particularly affects haemodialysis patients. Elevated serum phosphorus contributes to the development of secondary hyperparathyroidism, Mineral bone…
- Trial name
- NCT03163576
- Testing
- Niacin, Phosphate Binder
- Volunteers
- 150 people
- Sponsor
- Assiut University
End-Stage Renal Disease
Pharmacokinetics Study of Donepezil HCl in Subjects Receiving Haemodialysis.
The purpose of this study is to investigate the pharmacokinetics of donepezil HCl 3 mg in subjects with end-state renal disease who were receiving haemodialysis.
- Trial name
- NCT01063556
- Testing
- donepezil HCl
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Eisai Co., Ltd.
Chronic Renal Failure, Hemodialysis
Comparing the Hemodiafiltration On-line and Conventional Hemodialysis in Terms of Cost-benefit
The site where the clinical trial will be conducted is at the St-Luc hospital from the CHUM. This is a prospective randomized study that will compare the two treatment modalities, HD and HDF, through economics and…
- Trial name
- PHARMACO-$ (NCT02374372)
- Testing
- conventional hemodialysis, hemodiafiltration On-line
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Chronic Renal Disease
Biomarkers of Cardiovascular Complications in Chronic Kidney Disease
Identification of new retention solutes associated with cardiovascular (CV) toxicity in Chronic Kidney Disease (CKD) patients will help to better understand the pathophysiological mechanisms at stake and to prevent CKD-associated…
- Trial name
- BioClaCK (NCT03274921)
- Testing
- Biological determination
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Toulouse
End Stage Renal Disease
Vascular Access Choice and Outcomes in the Elderly and Very Elderly With End Stage Renal Disease in China
The purpose of the study is to evaluate the clinical outcomes and cost-effectiveness of different vascular access(arteriovenous fistula, tunneled cuffed catheter and arteriovenous graft) in the elderly and very elderly with…
- Trial name
- ACCESS-China (NCT02272374)
- Testing
- AVF creation, TCC placement, AVG creation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Changzheng Hospital
Kidney Diseases, Kidney Failure
Enhance Access to Kidney Transplantation and Living Kidney Donation
Compared to dialysis, kidney transplantation is associated with improved survival, better quality of life and substantial cost savings to healthcare systems.
- Conditions
- Kidney Diseases, Kidney Failure, End Stage Renal Disease
- Trial name
- EnAKT LKD (NCT03329521)
- Testing
- Multicomponent intervention
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
End Stage Renal Disease
Efficacy of Uremic Toxins Clearance With Expanded Hemodialysis
The aim of this study is to quantify the B2-microglobulin reduction rate based on the type of extracorporeal therapy (ET) used: HDx (expanded hemodialysis), HDc (high-flux conventional hemodialysis), or HDF (hemodiafiltration).
- Trial name
- NCT04786535
- Testing
- Expanded Hemodialysis, High-flux Conventional Hemodialysis, Hemodiafiltration
- Where
- Mexico
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
End Stage Renal Disease
Effects of Nutritional Supplementation on Protein and Energy Homeostasis in Malnourished Chronic Hemodialysis Patients
The goal of this study is to evaluate the metabolic effects of concomitant use of three consecutive doses of recombinant human growth hormone over three days and exercise during continuous nutrient infusion in chronic…
- Trial name
- NCT00244075
- Testing
- nutritional supplement, recombinant human growth hormone (rcGH), exercise
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt University
End-stage Renal Failure
Safety and Dialysability of Dotarem® in Dialysed Patients
To evaluate the dialysability of Dotarem®, after an IV injection of 0.1 mmol/kg in patients with chronic renal failure who require hemodialysis treatment.
- Trial name
- NCT01449266
- Testing
- Dotarem® IV injection at 0.1 mmol/kg
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Guerbet
Acute Renal Failure, Chronic Renal Failure
How Much Reliable iv Calcium for the Treatment of Hyperkalemia?
Hyperkalemia is a common problem in the emergency services and one of the life threatening metabolic emergencies. Calcium, insulin, beta adrenoceptor agonists, bicarbonate, diuretics, sodium polystyrene sulfonate and lastly…
- Trial name
- NCT02672930
- Testing
- Electrocardiogram (ECG)
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Haseki Training and Research Hospital
Anemia
An Observational Study of Epoetin Beta [Neorecormon] to Evaluate the Quality of Life in Patients on Dialysis With Chronic Renal Anemia
This multicenter, prospective, observational study will evaluate the quality of life and the factors that influence the quality of life of epoetin beta [Neorecormon] in patients with renal chronic anemia, who are on dialysis.
- Trial name
- NCT01105494
- Testing
- epoetin beta [NeoRecormon]
- Where
- Morocco
- Volunteers
- 6,000 people
- Sponsor
- Hoffmann-La Roche
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