Clinical trials: Renal Failure, End-stage
End-stage Renal Disease
Ellipsys Vascular Access System Registry
Ellipsys Vascular Access System Registry will enroll up to 100 patients to evaluate the use and performance of the Ellipsys Vascular Access System when it is used within its intended use in accordance with standard of care in a…
- Trial name
- NCT03454113
- Testing
- Ellipsys Vascular Access
- Where
- 5 sites in Germany
- Volunteers
- 17 people
- Sponsor
- Medtronic Endovascular
Kidney Diseases, End Stage Renal Disease
Non- Clinical Coagulation Activation During Hemodialysis
Every patient included in the study will undergo 1 conventional hemodialysis treatment, ie 1 study visit. During the conventional hemodialysis treatment lasting 4 hours, 2 blood samples will be taken at different time points (5…
- Conditions
- Kidney Diseases, End Stage Renal Disease, Hemodialysis Complication
- Trial name
- NC-Coact (NCT04063423)
- Testing
- blood sample
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- Universitair Ziekenhuis Brussel
Critical Illness, Acute Kidney Injury
Sup-Icu RENal (SIREN)
Data show that episodes of bleeding may often be observed in critically ill patients with dialysis-dependent acute renal failure (ARF) on renal replacement therapy (RRT).
- Conditions
- Critical Illness, Acute Kidney Injury, End-stage Renal Disease, Renal Replacement Therapy
- Trial name
- SIREN (NCT02718261)
- Testing
- Pantoprazole
- Where
- 2 sites in Denmark, Switzerland
- Volunteers
- 3,350 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
End Stage Renal Disease
Trial of Hemodialysis Based Exercise for Strength Improvement Study
Study Hypothesis: The combination of aerobic and resistance exercise training will improve walking speed compared to either individual intervention.
- Trial name
- THESIS (NCT01962597)
- Testing
- aerobic exercise, resistance training
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Joseph's Healthcare Hamilton
End Stage Renal Disease
Effects of Empagliflozin on Endogenous Glucose Production in End Stage Renal Disease(ESRD).
A study of the effects of empagliflozin, a SGLT-2 inhibitor, on endogenous glucose production and plasma glucagon levels in patients with end-stage renal disease (ESRD)
- Trial name
- NCT03713190
- Testing
- Empagliflozin
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Pisa
End-stage Renal Disease, Hyperphosphatemia
Effect of Restriction of Foods Containing Phosphorus Additives
Hyperphosphatemia is related to the increase in morbidity and mortality. There is greater risk for cardiovascular disease, atherosclerotic disease, secondary hyperparathyroidism, and bone disease .
- Trial name
- NCT01965379
- Testing
- Restriction on food containing phosphorus additives, Standard care
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Renal Insufficiency
A Pharmacokinetic Study of Abiraterone Acetate in Male Participants With Impaired Renal Function Compared to Individuals With Normal Renal Function
The purpose of this study is to determine the pharmacokinetic (how the drug concentrations change over time) profile of abiraterone acetate 1000 mg when administered as a single dose in male participants with impaired renal…
- Trial name
- NCT01715259
- Testing
- Abiraterone acetate: participants with end-stage renal disease, Abiraterone acetate: matched control participants with normal renal function
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cougar Biotechnology, Inc.
End Stage Renal Disease
Local Anaesthesia vs Regional Block for Arteriovenous Fistulae
End stage renal failure (ESRF)describes an irreversible loss in renal function. The majority of these patients will opt for haemodialysis (HD)as their chosen method of renal replacement therapy (RRT).
- Trial name
- NCT01706354
- Testing
- Local Anaesthetic, Regional anaesthetic
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- Emma Aitken
Chronic Renal Failure
Incremental Hemodialysis as a Starting Way of Renal Replacement Therapy
The Hemodialysis Unit of the Hospital Ramon y Cajal is a pioneer in the implementation of a program of incremental hemodialysis, starting with two sessions a week in patients with residual renal function.
- Trial name
- NCT03302546
- Testing
- Incremental hemodialysis, Conventional hemodialysis
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
End Stage Renal Disease, Renal Impairment
A Study of Belzutifan (MK-6482) in Participants With Renal Impairment (MK-6482-021)
The primary purpose of this study is to compare the plasma pharmacokinetics (PK) of belzutifan (MK-6482) following a single oral 120 mg dose in participants with end stage renal disease (ESRD) before and after hemodialysis (HD)…
- Trial name
- NCT04994522
- Testing
- Belzutifan
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension, End Stage Renal Disease
RAAS Inhibitor Drugs in Dialysis Patients
Hypertensive haemodialysis patients are at high risk for cardiovascular events. This study was undertaken to ascertain whether the upstream of aliskirne, a direct renin inhibitor improves mortality and cardiovascular outcomes in…
- Trial name
- NCT01635387
- Testing
- aliskiren
- Volunteers
- 350 people
- Sponsor
- University of Campania Luigi Vanvitelli
End Stage Renal Disease
A Study to Evaluate the Efficacy and Safety of an Experimental Solution for Peritoneal Dialysis
Objective: The purpose of this study is to demonstrate: -the non-inferiority of an experimental peritoneal dialysis solution compared to a current solution for the management of end stage renal disease (ESRD) in peritoneal…
- Trial name
- NCT00214721
- Testing
- Experimental Peritoneal Dialysis Solution
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Vantive Health LLC
Anemia, Chronic Kidney Diseases
Effect of rEPO in FGF23 in ESRD Patients
Objective: To evaluate the effects of recombinant Erythropoietin (rEPO) in plasma levels of Fibroblast Growth Factor 23 (FGF23) in End-Stage Renal Disease (ESRD) patients in hemodialysis.
- Trial name
- NCT03803514
- Testing
- Recombinant EPO
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
End Stage Renal Disease (ESRD)
Effect of Medium Cut-Off Hemodialysis on Protein Energy Wasting: The EMCOPEW Study
In patients on maintenance hemodialysis (HD), protein energy wasting (PEW) defined as loss of muscle mass and fuel reserves of the body is frequent and associated with severe morbidity and mortality.
- Trial name
- EMCOPEW (NCT05309109)
- Testing
- Hemodialysis sessions
- Where
- 2 sites in France
- Volunteers
- 65 people
- Sponsor
- Poitiers University Hospital
Chronic Hepatitis C, End Stage Renal Disease
Interferon Treatment for Patients With Chronic Hepatitis C and End Stage Renal Disease
The treatment response with conventional interferon alpha alone in patients with end stage renal disease and chronic hepatitis C is about 33-39%. However, the drop-out rate is 17-29.6%.
- Trial name
- NCT00172809
- Testing
- Peginterferon alfa-2a, Interferon alfa-2a
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
End Stage Renal Disease, Chronic Kidney Diseases
Ferric Citrate in ESRD Pilot Project
This research study is for participants that have End Stage Renal Disease (ESRD). ESRD is the last stage of chronic kidney disease.
- Trial name
- NCT03055598
- Testing
- Ferric Citrate
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Sreedhar Mandayam
End Stage Renal Disease, Hypertension
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation.
- Conditions
- End Stage Renal Disease, Hypertension, Extracellular Volume Overload, Intradialytic Hypotension
- Trial name
- NCT04163614
- Testing
- IBPS-Guided Ultrafiltration
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
End Stage Renal Disease, Inflammation
Evaluation of Biocompatibility and Performances of 4 Dialyzers in Different Mode Treatments
Prospective multicenter randomized cross-over study Number of patients : 32 (8 patients per group) Obtain objectives data to advise each hemodialyzer according to dialysis treatment and patient profile.
- Trial name
- BIOMODAL (NCT03262272)
- Testing
- VIE A Hemodialyzer, Rexsys 27H hemodialyzer, Leoceed 21HX hemodialyzer
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Hemotech
End Stage Renal Disease
Central Blood Pressure and Pulse Wave Velocity in Kidney Transplant Recipients
An observational cohort study will be conducted to non-invasively investigate central blood pressure and pulse wave velocity in children with kidney disease and controls.
- Trial name
- NCT04212143
- Testing
- there is no intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's National Research Institute
Cardiovascular Disease, End Stage Renal Disease
Safety and Tolerability of Coenzyme Q10 in Hemodialysis Patients
The purpose of this study is to determine the safety and tolerability of the dietary supplement Coenzyme Q10 in hemodialysis patients.
- Conditions
- Cardiovascular Disease, End Stage Renal Disease, Atherosclerosis, Oxidative Stress
- Trial name
- NCT00908297
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
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