Clinical trials: Renal Injury, Acute
Acute Kidney Injury
Early RRT in AKI After Cardiac Surgery
Acute kidney injury (AKI) is one of the major complications after cardiac surgery that may affects 20% to 40% of patients according to the definitions.
- Trial name
- NCT05175053
- Testing
- Renal replacement therapy, Best medical management
- Where
- 2 sites in South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Injury, Sepsis
Continuous Renal Replacement Therapy With Oxiris in Acute Kidney Injury and Sepsis
It is an epidemiology study to explore outcomes in patients with acute kidney injury (AKI) and sepsis submitted to continuous renal replacement therapy (CRRT) with Oxiris™.
- Trial name
- NCT06253377
- Testing
- Adsorption membrane filter Oxiris™
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nefro Consultoria de Doenças Renais Ltda
Sepsis, Septic Shock
The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients
The high chloride content of 0.9%sodium chloride (0.9%NaCl) leads to adverse pathophysiological effects in both animals and healthy human volunteers.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT03277677
- Testing
- Normal saline, Ringer's Acetate
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Chulalongkorn University
Acute Kidney Injury, COVID-19
Incidence of Acute Kidney Injury in Covid-19
Acute kidney injury (AKI) in Covid-19 patients is a topic that receives little attention in the literature, although being important in clinical practice in the ICU, particularly in Oman.
- Conditions
- Acute Kidney Injury, COVID-19, Critically Ill
- Trial name
- COVIDAKI (NCT05467956)
- Testing
- Covid-19
- Where
- Oman
- Volunteers
- 286 people
- Sponsor
- Sultan Qaboos University
COVID -19, Acute Kidney Injury
Acute Kidney Injury in Critical COVID-19: Outcomes and Risks
This retrospective observational study aims to determine the incidence of acute kidney injury (AKI) associated with COVID-19, risk factors, and effects on mortality for intensive care unit patients.
- Conditions
- COVID -19, Acute Kidney Injury, Intensive Care Unit (ICU) Admission, Mortality
- Trial name
- NCT07089693
- Where
- Turkey (Türkiye)
- Volunteers
- 238 people
- Sponsor
- Ankara University
Chronic Kidney Diseases, Acute Kidney Injury
Development of a Decision-making Aid for Referring Severe Kidney Injury Patients for Nephrology Consultations
Acute kidney injury is a frequent and growing complication associated with a risk of progressing into a chronic kidney disease. Recent guidelines have recommended systematic consultations with a nephrologist 3-6 months following…
- Trial name
- IRA Cible (NCT03192189)
- Testing
- monitoring for progression to chronic kidney disease
- Where
- France
- Volunteers
- 319 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury, End-stage Renal Disease
Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy
Purpose of this study is to evaluate the short-term hemodynamic effects of changes in blood flow rates in critically ill patients receiving continuous renal replacement therapy.
- Trial name
- NCT03078504
- Testing
- continuous renal replacement therapy using System One (TM) setup (Nxstage)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- St. Louis University
Intraabdominal Hypertension, Abdominal Compartment Syndrome
Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry
The Accuryn Registry Study is an open-ended, global, multi-center, retrospective and prospective, single-arm data collection study with an FDA cleared device. The target population are cardiovascular surgery patients.
- Conditions
- Intraabdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury, Cardiovascular Surgery
- Trial name
- NCT04669548
- Testing
- Accuryn Monitoring System
- Where
- 9 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Potrero Medical
AKI - Acute Kidney Injury, Delirium, Postoperative
Metabolomics Analysis of Acute Kidney Injury and Delirium After Cardiac Surgery
Clinical evidence suggests that renal injury leads to changes in the structure of the cerebral cortex in patients, suggesting the existence of the renal brain axis.
- Trial name
- NCT06508593
- Testing
- Serum metabolic profile
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Acute Kidney Injury
Hematologic Ratios in Postoperative Acute Kidney Injury
Acute kidney injury (AKI) is a common complication after surgery for congenital heart disease and is associated with significant morbidity and mortality.
- Trial name
- NCT03658148
- Testing
- Cardiac Surgery with Cardiopulmonary Bypass
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Kidney Injury, Fluid Overload
Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury
Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a mediator of complications.
- Conditions
- Acute Kidney Injury, Fluid Overload, Ultrasonography
- Trial name
- ECHO-AKI (NCT04095143)
- Testing
- Portal vein flow, Intra-renal flow, Hepatic vein flow
- Where
- 6 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Postoperative Acute Kidney Injury, Arthroplasty
Risk Factors for Acute Kidney Injury in Patients Undergoing Arthroplasty
The authors aimed to determine the risk factors associated with postoperative acute kidney injury in patients undergoing total joint arthroplasty.
- Trial name
- NCT06296108
- Testing
- acute kidney injury
- Where
- Turkey (Türkiye)
- Volunteers
- 911 people
- Sponsor
- Ankara University
Traumatic Haemorrhagic Shock, AKI (Acute Kidney Injury) Due to Trauma
Renal Perfusion and the Development of AKI Following Traumatic Injury
Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk.
- Conditions
- Traumatic Haemorrhagic Shock, AKI (Acute Kidney Injury) Due to Trauma, AKI - Acute Kidney Injury
- Trial name
- PERTAKI (NCT06917053)
- Testing
- Ultrasound (including contrast enhanced ultrasound), Sublingual incident dark field videomicroscopy, Urinary oxygen tension.
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College Hospital NHS Trust
Acute Kidney Injury, Acute Renal Failure
Minimizing Contrast Utilization With IVUS Guidance in Coronary Angioplasty to Avoid Acute Nephropathy
Contrast-induced acute kidney injury (CI-AKI) is an important adverse effect of percutaneous coronary interventions. Despite various efforts, very few preventive measures have been shown effective in reducing its incidence.
- Conditions
- Acute Kidney Injury, Acute Renal Failure, Acute Renal Injury
- Trial name
- Mozart-II (NCT02743156)
- Testing
- IVUS-guided PCI, Angiography-guided PCI
- Where
- 2 sites in Brazil, Spain
- Volunteers
- 300 people
- Sponsor
- InCor Heart Institute
Sepsis, Acute Kidney Injury
VExUS Combined With CVP to Predict Clinical Outcomes in Sepsis Participants
Introduction: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response to infection, and it is a common critical condition in the ICU.
- Trial name
- NCT06524622
- Testing
- Point-of-care ultrasound (POCUS)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Second People's Hospital of Yibin
Postoperative Acute Kidney Injury, Pediatric Liver Transplantation
Acute Kidney Injury and Recovery Mode in Pediatric Liver Transplantation
Acute kidney injury (AKI) is a common complication after pediatric liver transplantation (PLT), and renal impairment after LT has proven to be related with increased graft failure and mortality.
- Trial name
- NCT06598228
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Tianjin First Central Hospital
Kidney Injury, Acute, Transcatheter Aortic Valve Implantation
Renal Regional Oxygen Saturation During Transcatheter Aortic Valve Implantation
This prospective observational study evaluates the association of peri-procedural changes in renal regional oxygen saturation and post-procedural acute kidney injury in patients undergoing transcatheter aortic valve implantation.
- Trial name
- NCT04921475
- Testing
- Regional oxygen saturation monitoring
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Disease, Chronic Kidney Disease
Perioperative Nitric Oxide Prevents Acute Kidney Injury in Cardiac Surgery Patients With Chronic Kidney Disease
The protective nitric oxide (NO) effects are mediated by selective pulmonary vasodilation and improvement of arterial oxygenation in hypoxemic patients by reducing intrapulmonary shunting and improving ventilation-perfusion…
- Conditions
- Acute Kidney Disease, Chronic Kidney Disease, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- DEFENDER (NCT05757557)
- Testing
- 80-ppm NO
- Where
- Russia
- Volunteers
- 136 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Acute Kidney Injury, Critical Illness
Predicting Poor Outcomes of Cardiac Surgery-Associated Acute Kidney Injury Using Novel Biomarkers
The aim of this study was to identify and validate novel biomarkers including functional tests for detecting AKI, AKI progression and other poor outcomes.
- Trial name
- NCT04962412
- Testing
- Standard care "bundle"
- Where
- China
- Volunteers
- 3,152 people
- Sponsor
- Guowei Tu
Advanced Breast Cancer
Evaluating the Incidence of Pseudo-Acute Kidney Injuries in Patients With Metastatic Breast Cancer on CDK4/6 Inhibitors Trough Cystatin C Analysis
CDK4/6 inhibitors have led to an improvement of both progression free survival (PFS) and overall survival (OS) in patients with advanced estrogen positive (ER+)/HER2- breast cancer when applied in the first or second line of…
- Trial name
- CYSTATINcDK4/6 (NCT06338605)
- Testing
- no intervention, observational study of AKI under CDK4/6 inhibitor treatment
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Erasmus Medical Center
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