Clinical trials: Renal Insufficiency, Acute
Kidney Injury in Cardiac Surgery - Expression of microRNAs
MicroRNAs in Acute Kidney Injury
Profiling of microRNAs and long noncoding RNAs (lncRNAs) in patients undergoing cardiac surgery. Analysis: Prediction of acute kidney injury by plasma expression profile of microRNAs?
- Trial name
- MIRAKI (NCT03089242)
- Testing
- observation of microRNA expression
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Acute Kidney Injury
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)
The central hypothesis of this research study is that perioperative administration of the proton pump inhibitor (PPI) pantoprazole could reduce the development of acute kidney injury (AKI) following cardiac surgery by activation…
- Trial name
- P2 AKI PPI (NCT06706258)
- Testing
- Protonix (Pantoprazole) 40 mg q 12 hrs for 3 days, Pepcid (Famotidine) 20 mg q 12 hrs for 3 days
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Health Science Center, Houston
Renal Insufficiency, Acute Kidney Injury
Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast
Point-of-care (POC) creatinine devices allow rapid measurement of creatinine levels and calculation of estimated glomerular filtration rate (eGFR) which give an indication of renal function.
- Conditions
- Renal Insufficiency, Acute Kidney Injury, Contrast-induced Nephropathy
- Trial name
- EPIC (NCT04597892)
- Testing
- serum creatinine assay
- Where
- Netherlands
- Sponsor
- Maastricht University Medical Center
Intensive Care Unit, Acute Kidney Injury
Effects of Vena Cava Inferior Measurements on AKI and Mortality.
Fluid overload is harmful in critically ill patients; In addition to increasing mortality, it may increase the incidence of acute kidney injury (AKI), length of ICU stay, and duration of mechanical ventilation by causing…
- Trial name
- NCT06331234
- Testing
- Vena cava inferior diameter
- Volunteers
- 100 people
- Sponsor
- Inonu University
Acute Kidney Injury, VExUS
VExUS Score and AKI in Critically Ill Adult patients-a Prospective Observational Study.
Introduction Renal perfusion is dependent on the renal perfusion pressure across the renal capillaries. Venous congestion due to excess fluid therapy can drastically reduce the renal perfusion pressure in spite of a normal mean…
- Trial name
- NCT06889116
- Where
- Nepal
- Volunteers
- 52 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Acute Kidney Injury
Predictors of Acute Kidney Injury in Critically Ill Children Admitted to PICU.
Predictors of Acute Kidney Injury in critically ill children admitted to PICU during one year.
- Trial name
- NCT06328478
- Testing
- Observational prospective study.
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Kidney Injury
The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
The purpose of study is to test whether perioperative sodium bicarbonate infusion can prevent acute kidney injury following open heart surgery in infective endocarditis patients.
- Trial name
- NCT01920126
- Testing
- sodium bicarbonate, Saline
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
Thrombotic Microangiopathy
Ravulizumab in Thrombotic Microangiopathy Associated With a Trigger
This study will investigate the efficacy and safety of ravulizumab compared to placebo in adult participants with thrombotic microangiopathy (TMA) associated with a trigger.
- Trial name
- NCT04743804
- Testing
- Ravulizumab, Best Supportive Care
- Where
- 97 sites in United States, Belgium and 11 more
- Volunteers
- 16 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Acute Kidney Injury, Kidney Transplant
MEMRI and Kidney Disease
Acute kidney injury (AKI) is common and costly.1 Although patients who suffer an episode of AKI may recover, many will go on to develop cardiovascular disease and chronic kidney disease (CKD).
- Conditions
- Acute Kidney Injury, Kidney Transplant, Vasculitis, Chronic Kidney Disease(CKD)
- Trial name
- NCT06698614
- Testing
- MRI, Blood tests, Urine tests
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Edinburgh
Septic Shock, Acute Kidney Injury
MCO Membrane Efficiency in Septic Shock Patients
This is a monocentre randomized pilot study. All patients received two consecutive RRT: CVVHD with MCO filter (Ultraflux® EMiC®2) and post-Continuous Veno-Venous Hemodiafiltration (CVVHDF) with HFF(AV1000S®) in a controlled…
- Trial name
- NCT04834921
- Testing
- Ultraflux® EMiC®2
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fiorenza Ferrari
Septic Shock, Acute Kidney Injury
Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock
Sepsis is the most severe complication of infections. Sepsis-associated Acute kidney injury (AKI) is commonly encountered in critically ill patients and independently predicts poor outcome.
- Trial name
- DORESEP (NCT01473498)
- Testing
- Haemodynamic management
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Diseases, Cardio-pulmonary Bypass
A Monitoring System Based on the Multifactorial Dynamic Perfusion Index to Predict and Prevent the Onset of Postoperative Acute Kidney Injury After Cardiac Surgery, Based on a Dynamic Collection of Hemodynamic and Clinical Parameters During Cardiopulmonary Bypass
This project is based on a predictive alghorithm (Multifactorial Dynamic Perfusion Index-MDPI) already published and covered by a patent.
- Conditions
- Cardiac Diseases, Cardio-pulmonary Bypass, Acute Kidney Injury, Adult Cardiac Surgery
- Trial name
- PEQUOD 2 (NCT06786416)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Policlinico S. Donato
Cardiac Surgery and Cardiopulmonary Bypass
High-Dose N-Acetylcysteine in Cardiac Surgery
At least 14% of patients develop kidney failure after cardiac surgery. Although this kidney failure can usually be treated effectively, a longer stay in intensive care is often required.
- Trial name
- NCT00332631
- Testing
- N-acetylcysteine
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Austin Health
Acute Kidney Injury, Metabolic Acidosis
Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury
The study investigates whether sodium bicarbonate is able to reduce the occurrence of major adverse kidney events on day 90 (MAKE90) in critically ill patients with metabolic acidosis and acute kidney injury (AKI).
- Conditions
- Acute Kidney Injury, Metabolic Acidosis, Critical Illness
- Trial name
- ESCALATE (NCT07464431)
- Testing
- Sodium Bicarbonate 8.4% Solution for Injection, Balanced crystalloid solution
- Where
- Germany
- Volunteers
- 660 people
- Sponsor
- Universität Münster
Acute Kidney Injury (Nontraumatic), Pneumoperitoneum
A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)
In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these…
- Trial name
- NCT05612802
- Testing
- IGF-1
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Baskent University
Extracorporeal Membrane Oxygenation Complication
Estimation of Glomerular Filtration Flow in Patients of Resuscitation Under Extra-bodily Assistance
The aim of the study will be to evaluate the quality of the GFR estimate of the two estimation equations (CKD-EPI and Cockcroft's formula) against the measured clearance of creatinine, which can be performed routinely in…
- Trial name
- CREA-ECMO (NCT03525483)
- Testing
- Ultrasound for renal resistivity index measurement
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Renal Replacement Therapies, Outcome Assessment
Outcomes of Critically Ill Patients Undergoing RRT- a Registry Based Study.
Rationale: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is a frequently occurring entity among critically ill patients.
- Trial name
- NCT06897254
- Where
- Nepal
- Volunteers
- 516 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Renal Failure, Impaired Renal Function
Linezolid Pharmacokinetics In Patients With Impaired Renal Function (PPT6)
Renal failure patients were treated with linezolid (LZD) for proven or suspected infections by multiresistant Gram-positive cocci.
- Trial name
- LZDPPT6 (NCT02087566)
- Testing
- 600 mg linezolid
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Malaria, Sepsis
Optimal Fluid Management in Adult Severe Malaria
Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited.
- Trial name
- DRIPICCO (NCT01936766)
- Where
- Bangladesh
- Volunteers
- 156 people
- Sponsor
- University of Oxford