Clinical trials: Renal Insufficiency, Acute
Acute Kidney Injury
A Study to Determine the Pharmacokinetic Profile, Safety and Tolerability of Sildenafil (REVATIO®) in Cardiac Surgery
The objectives of the study are the following: To evaluate the pharmacokinetic profile of Sildenafil in cardiac surgery patients at risk of acute kidney injury To determine the safety and tolerability of Sildenafil in cardiac…
- Trial name
- Revaki-001 (NCT02136329)
- Testing
- Sildenafil
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Leicester
Acute Kidney Injury, Dialysis; Complications
LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)
An estimated 10-15% of critically ill patients with acute kidney failure in the intensive care unit receive acute dialysis therapy.
- Trial name
- WISDOM (NCT06446739)
- Testing
- Continuous Renal Replacement Therapy (CRRT)
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Renal Colic, Acute Renal Failure
Urinary Markers for Unilateral Kidney Obstruction
Renal colic is usually caused from an obstructing stone along the ureter. Some of the patients present with a high level of creatinin in the blood, even though there is a normal functioning contralateral kidney.
- Trial name
- NCT01979042
- Where
- Israel
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Acute Kidney Injury
Transcriptional and Proteomic Analysis of Acute Kidney Injury
Acute kidney injury is associated with worsened outcome for critically ill patients. Sepsis-associated and non-septic cardiothoracic surgery associated AKI have been reported, nonetheless, precise pathomechanistic differences as…
- Trial name
- TPA-AKI (NCT06064305)
- Testing
- No study-specific interventions
- Volunteers
- 60 people
- Sponsor
- University Hospital Muenster
Acute Kidney Injury
Electronic Alert for Acute Kidney Injury in Geriatric Wards
Operating acute kidney injury electronic alert in geriatric wards; Acute authenticity evaluation of acute kidney injury electronic alert; To explore the clinical value of electronic alert for acute kidney injury prevention and…
- Trial name
- NCT04464031
- Testing
- electronic alert
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital
ST Elevation (STEMI) Myocardial Infarction, Contrast Induced Nephropathy (CIN)
Beyond the Mehran Risk Score: Predictive Value of Total Ischemic Time for Contrast-Induced Nephropathy in ST Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.
Contrast-Induced Nephropathy (CIN) is a serious complication following primary percutaneous coronary intervention (PCI) in patients presenting with acute ST-segment elevation myocardial infarction (STEMI).
- Conditions
- ST Elevation (STEMI) Myocardial Infarction, Contrast Induced Nephropathy (CIN), Acute Kidney Injury
- Trial name
- NCT07826572
- Testing
- Total Ischemic Time Evaluation
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Kidney Failure
Ioxaglate Versus Iodixanol for the Prevention of Contrast-induced Nephropathy in High-risk Patients (IDPC Trial)
Contrast media-induced nephropathy following diagnostic and therapeutic cardiac catheterization.
- Trial name
- IDPC (NCT02991742)
- Testing
- contrast media
- Volunteers
- 2,262 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Acute Kidney Injury, Liver Transplant; Complications
Effect of Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients
The goal of this clinical trial is to evaluate the effect of intraoperative terlipressin on the incidence of early postoperative acute kidney injury in deceased doner liver transplantation.
- Trial name
- NCT06108362
- Testing
- Terlipressin, normal saline
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Acute Kidney Injury, Renal Artery Blood Flow
Characteristics of Renal Blood Flow in AKI Patients in ICU and Its Clinical Significance
To study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical…
- Conditions
- Acute Kidney Injury, Renal Artery Blood Flow, Renal Venous Return, Renal Microcirculation
- Trial name
- NCT06090773
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking Union Medical College Hospital
Assesse Prevalence of Acute Kidney Injury and Myocardial Injury After Non Cardiac Surgery
Assessment of Acute Kidney Injury as a Risk Factor for Myocardial Injury After Non Cardiac Surgery in Critical Patients
Acute kidney injury (AKI) affects approximately 20% of hospitalized patients and up to 67% of those admitted to an intensive care unit (ICU), making it among the most common organ dysfunctions among the critically ill.Major…
- Trial name
- clinical audit (NCT03135483)
- Volunteers
- 50 people
- Sponsor
- Assiut University
Contrast Nephropathy
Renal Insufficiency Following Contrast Media Administration Trial III
The urine flow rate (UFR)-guided and the left-ventricular end-diastolic pressure (LVEDP)-guided hydration regimens have been proposed to prevent contrast-induced acute kidney injury (CI-AKI).
- Trial name
- REMEDIALIII (NCT02489669)
- Testing
- RenalGuard system™® (PLC Medical Systems, Inc. Franklin, MA, USA)
- Volunteers
- 700 people
- Sponsor
- Clinica Mediterranea
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
Acute Kidney Injury, Intra-dialytic Hypotension
Low Dialysate Temperature During SLED
Objectives: This study is evaluating the hemodynamic effects of lowering the dialysate temperature in acute kidney injury (AKI) patients submitted to sustained low efficiency dialysis (SLED) in a single large center.
- Trial name
- NCT03397992
- Testing
- Changing dialysate temperature
- Volunteers
- 38 people
- Sponsor
- Washington University School of Medicine
Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy
Effect of Urine-guided Hydration on Acute Kidney Injury After CRS-HIPEC
Acute renal injury (AKI) is a common complication after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), and is associated with worse outcomes.
- Conditions
- Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, Hydration, Diuresis
- Trial name
- NCT05939193
- Testing
- Urine-guided hydration, Routine hydration, Forced administration of furosemide
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Peking University First Hospital
Acute Kidney Injury, VExUS
VExUS Score and AKI in Critically Ill Adult patients-a Prospective Observational Study.
Introduction Renal perfusion is dependent on the renal perfusion pressure across the renal capillaries. Venous congestion due to excess fluid therapy can drastically reduce the renal perfusion pressure in spite of a normal mean…
- Trial name
- NCT06889116
- Where
- Nepal
- Volunteers
- 52 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Coronary Artery Disease
Fenoldopam for Prevention of Acute Kidney Injury
Patients with acute coronary syndromes (ACS) are at increased risk for acute kidney injury (AKI) when they undergo urgent/emergency coronary angiography.
- Trial name
- FANCY (NCT01690832)
- Testing
- standard saline infusion, fenoldopam infusion
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Acute Kidney Injury, Septic Shock
Macro and Micro Haemodynamic Responses to Shock in the Renal and Systemic - MICROSHOCK - RENAL
An observational study of the state of the renal and systemic circulations in patients with early septic shock. Both macro and microvascular parameters will be assessed using echocardiography, sublingual incident dark field…
- Trial name
- NCT03713307
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College London
Renal Neoplasm, Renal Injury
The Effect of Remote Ischemic Preconditioning on Kidney Function in Patients Undergoing Partial Nephrectomy
This study is intended to evaluate the renal protective effect of Remote Ischemic Preconditioning (RIPC) in patients undergoing partial nephrectomy.
- Trial name
- NCT03273751
- Testing
- Remote Ischemic Preconditioning
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Hospital
Acute Renal Failure, Critical Illness
Metabolic Aspects of Citrate Anticoagulation in Renal Replacement Therapy
Citrate anticoagulation is associated with metabolic side effects which are linked to a portion of citrate reaching systemic circulation.
- Trial name
- Citrate (NCT01361581)
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic
Acute Kidney Injury
A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the COPE-AKI Trial
The COPE-AKI study is a randomized, pragmatic, parallel-arm trial comparing a multimodal intervention to usual care on hospital-free days through 90 days of study follow up.
- Trial name
- COPE-AKI (NCT05805709)
- Testing
- Study Physician/Advance Practice Provider, Nurse Navigator, Pharmacist
- Where
- 9 sites in United States
- Volunteers
- 2,145 people
- Sponsor
- University of Pittsburgh
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